Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FOXO4_HUMAN
Description:forkhead box O4 [Source:HGNC Symbol;Acc:7139]
Location:chrX q13.1
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T455GTPVLtPPTEAMAPK8phosphoELM
S197RRRAAsMDSSSAKT1(PKB) RegPhos
T451PKALGtPVLTPJNK1(MAPK8RegPhos
S262RPRSSsNASSVAKT1(PKB) RegPhos
S278PLRPEsEVLAEPhosphoSitePlus
T455GTPVLtPPTEAJNK1(MAPK8RegPhos
Y292ASVSSyAGGVPPhosphoSitePlus
S200AASMDsSSKLLRegPhos
T455GTPVLtPPTEAMAPK9phosphoELM
S262RPRSSsNASSVPKB_groupphosphoELM
S272VSTRLsPLRPEPhosphoSitePlus
T451PKALGtPVLTPJNK2(MAPK9RegPhos
T451PKALGtPVLTPMAPK8phosphoELM
S26DFEPQsRPRSCPhosphoSitePlus
T455GTPVLtPPTEAAKT1HPRD; RegPhos
S261FRPRSsSNASSPhosphoSitePlus
S111YAELIsQAIESFork_headPhosphoSitePlus
S197RRRAAsMDSSSPKB_groupphosphoELM
S241AKWSGsPCSRNPhosphoSitePlus
S262RPRSSsNASSVPhosphoSitePlus
T451PKALGtPVLTPMAPK9phosphoELM
T451PKALGtPVLTPPKB_groupphosphoELM
S197RRRAAsMDSSSFork_headPhosphoSitePlus
S30QSRPRsCTWPLPhosphoSitePlus
T32RPRSCtWPLPRAKT1(PKB) RegPhos
T455GTPVLtPPTEAJNK2(MAPK9RegPhos
T455GTPVLtPPTEAPhosphoSitePlus
S230GATPTsPVGHFPhosphoSitePlus
S288EEIPAsVSSYAPhosphoSitePlus
S111YAELIsQAIESRegPhos
T458VLTPPtEAASQPhosphoSitePlus
T227PPEGAtPTSPVPhosphoSitePlus
S262RPRSSsNASSVAKT1HPRD; RegPhos
T451PKALGtPVLTPPhosphoSitePlus
S262RPRSSsNASSVAKT_groupRegPhos
T32RPRSCtWPLPRPhosphoSitePlus; phosphoELM; RegPhos
T451PKALGtPVLTPAKT_groupRegPhos
T32RPRSCtWPLPRAKT2HPRD; RegPhos
T32RPRSCtWPLPRAKT1HPRD; RegPhos
T451PKALGtPVLTPAKT1HPRD; RegPhos
S197RRRAAsMDSSSAKT1HPRD; RegPhos
S244SGSPCsRNREEPhosphoSitePlus
S197RRRAAsMDSSSAKT_groupRegPhos

Dephosphorylation site
FOXO4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000342209S289FTCGANeoplasms by Histologic Type21720365, 18772890

Differential expressed protein
FOXO4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FOXO4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK09_HUMANFOXO4_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
AKT2_HUMANFOXO4_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANFOXO4_HUMANkinase -> substrateRegPhos
MK08_HUMANFOXO4_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
AKT1_HUMANFOXO4_HUMANkinase -> substrateRegPhos
FOXO4_HUMANIBP1_HUMANTF -> target geneTRANSFAC
FOXO4_HUMANBCL6_HUMANTF -> target geneTRANSFAC
FOXO4_HUMANRBL2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
FOXO4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0048863stem cell differentiationIMPbiological_process
GO:0007050cell cycle arrestIDAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiIBAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0008285negative regulation of cell proliferationIDAbiological_process
GO:0005667transcription factor complexIBAcellular_component
GO:0008301DNA binding, bendingIBAmolecular_function
GO:0007095mitotic cell cycle G2/M transition DNA damage checIBAbiological_process
GO:0051151negative regulation of smooth muscle cell differenIDAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0016525negative regulation of angiogenesisIDAbiological_process
GO:0001071nucleic acid binding transcription factor activityIMPmolecular_function
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0007389pattern specification processIBAbiological_process
GO:0009888tissue developmentIBAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0048513organ developmentIBAbiological_process
GO:0006355regulation of transcription, DNA-dependentIDAbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0005829cytosolIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0009790embryo developmentIBAbiological_process
GO:0045944positive regulation of transcription from RNA polyIBAbiological_process
GO:0003690double-stranded DNA bindingIBAmolecular_function
GO:0019901protein kinase bindingIBAmolecular_function
GO:0007095mitotic cell cycle G2/M transition DNA damage checIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0043565sequence-specific DNA bindingIMPmolecular_function
GO:0051090regulation of sequence-specific DNA binding transcIBAbiological_process
GO:0007517muscle organ developmentIEAbiological_process
GO:0008286insulin receptor signaling pathwayIDAbiological_process
GO:0000080G1 phase of mitotic cell cycleIDAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0005829cytosolIDAcellular_component
GO:0019899enzyme bindingIPImolecular_function
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process