| UniProt/SwissProt ID: | ELK3_HUMAN |
| Description: | ELK3, ETS-domain protein (SRF accessory protein 2) [Source:HGNC Symbol;Acc:3325] |
| Location: | chr12 q23.1 |
| Node attribute: | substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S357 | FWSSLsPVAPL | JNK1 | RegPhos |
| S357 | FWSSLsPVAPL | JNK2 | RegPhos |
| S363 | PVAPLsPARLQ | MAPK14 | HPRD |
| S115 | SDCKAsPEGRE | PhosphoSitePlus; HPRD; SysPTM | |
| S396 | LDRAAsPVLLS | HPRD | |
| S357 | FWSSLsPVAPL | MAPK9 | HPRD |
| S363 | PVAPLsPARLQ | phosphoELM; RegPhos | |
| S363 | PVAPLsPARLQ | p38a | RegPhos |
| S357 | FWSSLsPVAPL | MAPK8 | HPRD |
| S245 | SSRSPsLSPNS | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S357 | FWSSLsPVAPL | JNK_group | phosphoELM; RegPhos |
| S104 | R.ESLLLQDSDCKASPEGR.E | SysPTM 2.0 | |
| Dephosphorylation site |
| ELK3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000228741 | P95A | COSMIC | Ovarian Cancer | 21720365 | ENSP00000228741 | K165E | BIOMART | Gastric Cancer | 21930507, 21930502 | ENSP00000228741 | P95A | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| ELK3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ELK3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK08_HUMAN | ELK3_HUMAN | kinase -> substrate | HPRD; RegPhos |
| MK09_HUMAN | ELK3_HUMAN | kinase -> substrate | HPRD; RegPhos |
| ZAGL2_HUMAN | ELK3_HUMAN | kinase -> substrate | RegPhos |
| MK14_HUMAN | ELK3_HUMAN | kinase -> substrate | HPRD |
| ELK3_HUMAN | FOS_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| ELK3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045892 | negative regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0042060 | wound healing | IEA | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0003714 | transcription corepressor activity | IDA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0001525 | angiogenesis | IEA | biological_process |
| GO:0005739 | mitochondrion | IDA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0032422 | purine-rich negative regulatory element binding | IDA | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |