Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ELK3_HUMAN
Description:ELK3, ETS-domain protein (SRF accessory protein 2) [Source:HGNC Symbol;Acc:3325]
Location:chr12 q23.1
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S357FWSSLsPVAPLJNK1RegPhos
S357FWSSLsPVAPLJNK2RegPhos
S363PVAPLsPARLQMAPK14HPRD
S115SDCKAsPEGREPhosphoSitePlus; HPRD; SysPTM
S396LDRAAsPVLLSHPRD
S357FWSSLsPVAPLMAPK9HPRD
S363PVAPLsPARLQphosphoELM; RegPhos
S363PVAPLsPARLQp38aRegPhos
S357FWSSLsPVAPLMAPK8HPRD
S245SSRSPsLSPNSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S357FWSSLsPVAPLJNK_groupphosphoELM; RegPhos
S104R.ESLLLQDSDCKASPEGR.ESysPTM 2.0

Dephosphorylation site
ELK3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000228741P95ACOSMICOvarian Cancer21720365
ENSP00000228741K165EBIOMARTGastric Cancer21930507, 21930502
ENSP00000228741P95ATCGAOvarian Cancer21720365, 18772890

Differential expressed protein
ELK3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ELK3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK08_HUMANELK3_HUMANkinase -> substrateHPRD; RegPhos
MK09_HUMANELK3_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANELK3_HUMANkinase -> substrateRegPhos
MK14_HUMANELK3_HUMANkinase -> substrateHPRD
ELK3_HUMANFOS_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
ELK3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0042060wound healingIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0003714transcription corepressor activityIDAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0005739mitochondrionIDAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0032422purine-rich negative regulatory element bindingIDAmolecular_function
GO:0007165signal transductionTASbiological_process


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