Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AAPK1_HUMAN
Description:protein kinase, AMP-activated, alpha 1 catalytic subunit [Source:HGNC Symbol;Acc:9376]
Location:chr5 p13.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T481KSGTAtPQRSGphosphoELM
S524VSLTSsVTSLDPhosphoSitePlus
T382FLVAEtPRARHPhosphoSitePlus; HPRD
T174GEFLRtSCGSPLKB1(STK11RegPhos
T490KSGTAtPQRSGPhosphoSitePlus; HPRD
Y457VVNPYyLRVRRHPRD
S496PQRSGsVSNYRPhosphoSitePlus; HPRD
S487PQRSGsVSNYRphosphoELM; RegPhos; SysPTM
T388PRARHtLDELNPhosphoSitePlus
S545VTSLDsSPVDLHPRD
S356FYLATsPPDSFPhosphoSitePlus; HPRD
S498RSGSVsNYRSCPhosphoSitePlus
S467LYQVDsRTYLLPhosphoSitePlus
T198GEFLRtSCGSPHPRD
S347FYLATsPPDSFphosphoELM
S530VTSLDsSPVDLHPRD
Y294PEDPSySSTMIPhosphoSitePlus
T183GEFLRtSCGSPPkinasePhosphoSitePlus
S476LLDFRsIDDEIHPRD
S491LLDFRsIDDEIHPRD
T370DFYLAtSPPDSHPRD
T174GEFLRtSCGSPLKB1phosphoELM
Y247FYTPQyLNPSVPkinasePhosphoSitePlus
T174GEFLRtSCGSPCaMKK2RegPhos
S371FYLATsPPDSFHPRD
T346DFYLAtSPPDSphosphoELM
S178RTSCGsPNYAAphosphoELM
S494ATPQRsGSVSNPhosphoSitePlus
S511PQRSGsVSNYRHPRD
S508CQRSDsDAEAQPhosphoSitePlus; HPRD
T174GEFLRtSCGSPCaMKK1RegPhos
S293FPEDPsYSSTMPhosphoSitePlus
T505KSGTAtPQRSGHPRD
T32YILGDtLGVGTPkinasePhosphoSitePlus
T497IDDEItEAKSGHPRD
S542TSSVTsLDSSPHPRD
Y190CGSPNyAAPEVPkinasePhosphoSitePlus
T397FLVAEtPRARHHPRD
T503EAKSGtATPQRHPRD
S486ITEAKsGTATPPhosphoSitePlus; HPRD
T174GEFLRtSCGSPAMPK_groupphosphoELM; RegPhos
T355DFYLAtSPPDSHPRD
S527TSSVTsLDSSPPhosphoSitePlus; HPRD
S172ADFGLsNMMSDPkinasePhosphoSitePlus
S397LNPQKsKHQGVPhosphoSitePlus
Y442VVNPYyLRVRRPhosphoSitePlus; HPRD
S184EFLRTsCGSPNHPRD
S477ITEAKsGTATPphosphoELM
S499CQRSDsDAEAQRegPhos
T473IDDEItEAKSGphosphoELM
T183GEFLRtSCGSPHPRD
S199EFLRTsCGSPNHPRD
T482IDDEItEAKSGPhosphoSitePlus; HPRD
Y463MSLQLyQVDSRPhosphoSitePlus
T373FLVAEtPRARHphosphoELM
S184EFLRTsCGSPNPkinasePhosphoSitePlus
S538EVSLTsSVTSLHPRD
T479EAKSGtATPQRphosphoELM
S523CQRSDsDAEAQHPRD
T174GEFLRtSCGSPLKB1(STK11) RegPhos
T174GEFLRtSCGSPphosphoELM; RegPhos
S523EVSLTsSVTSLPhosphoSitePlus; HPRD
Y441KVVNPyYLRVRPhosphoSitePlus
S501ITEAKsGTATPHPRD
S521RSCQRsDSDAEHPRD
S506RSCQRsDSDAEPhosphoSitePlus; HPRD
S360TSPPDsFLDDHPhosphoSitePlus
S187RTSCGsPNYAAPkinasePhosphoSitePlus
S6MRRLSsWRKMAPhosphoSitePlus
T488EAKSGtATPQRPhosphoSitePlus; HPRD
S175EFLRTsCGSPNphosphoELM; RegPhos
S176LSNMMsDGEFLPkinasePhosphoSitePlus
Y500GSVSNyRSCQRPhosphoSitePlus

Dephosphorylation site
AAPK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000380317Q16RHPIBreast Cancer16959974

Differential expressed protein
AAPK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
T183PkinaseSDGEFLRtSCGSPNYtype 2 diabetes20938636PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
AAPK2_HUMANAAPK1_HUMANkinase -> substrateRegPhos
AAPK1_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
AAPK1_HUMANF262_HUMANkinase -> substrateHPRD
ZAGL2_HUMANAAPK1_HUMANkinase -> substrateRegPhos
AAPK1_HUMAN2AAB_HUMANkinase -> substrateRobert H Newman (2013)
AAPK1_HUMAN2AAA_HUMANkinase -> substrateRobert H Newman (2013)
AAPK1_HUMANGRIK5_HUMANkinase -> substrateHPRD
AAPK1_HUMANCDK2_HUMANkinase -> substrateRobert H Newman (2013)
AAPK1_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
AAPK1_HUMANEF2K_HUMANkinase -> substrateHPRD
STK11_HUMANAAPK1_HUMANkinase -> substrateKEGG; RegPhos; Robert H Newman (2013)
AAPK1_HUMANMTOR_HUMANkinase -> substrateKEGG; HPRD
AAPK1_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
AAPK1_HUMANACACA_HUMANkinase -> substrateHPRD
AAPK1_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
AAPK1_HUMANRAF1_HUMANkinase -> substrateHPRD
AAPK1_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
AAPK1_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
EF2K_HUMANAAPK1_HUMANkinase -> substrateRobert H Newman (2013)
AAPK1_HUMANRAD51_HUMANkinase -> substrateRobert H Newman (2013)
AAPK1_HUMANTSC2_HUMANkinase -> substrateKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa04920Adipocytokine signaling pathway
hsa04910Insulin signaling pathway
hsa04150mTOR signaling pathway
hsa04140Regulation of autophagy

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0050995negative regulation of lipid catabolic processISSbiological_process
GO:0008610lipid biosynthetic processIEAbiological_process
GO:0010508positive regulation of autophagyISSbiological_process
GO:0031000response to caffeineIEAbiological_process
GO:0035404histone-serine phosphorylationIEAbiological_process
GO:0045542positive regulation of cholesterol biosynthetic prNASbiological_process
GO:0050995negative regulation of lipid catabolic processIEAbiological_process
GO:0042593glucose homeostasisISSbiological_process
GO:0016324apical plasma membraneIEAcellular_component
GO:0004691cAMP-dependent protein kinase activityNASmolecular_function
GO:0019900kinase bindingIEAmolecular_function
GO:0003682chromatin bindingIEAmolecular_function
GO:2000505regulation of energy homeostasisISSbiological_process
GO:0035174histone serine kinase activityISSmolecular_function
GO:0010508positive regulation of autophagyIEAbiological_process
GO:0046320regulation of fatty acid oxidationTASbiological_process
GO:0005622intracellularICcellular_component
GO:0001666response to hypoxiaNASbiological_process
GO:0007050cell cycle arrestTASbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0009631cold acclimationIEAbiological_process
GO:0048511rhythmic processIEAbiological_process
GO:0032007negative regulation of TOR signaling cascadeISSbiological_process
GO:0045821positive regulation of glycolysisISSbiological_process
GO:0042149cellular response to glucose starvationIEAbiological_process
GO:0008022protein C-terminus bindingIEAmolecular_function
GO:0004679AMP-activated protein kinase activityIDAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0045821positive regulation of glycolysisIEAbiological_process
GO:0042752regulation of circadian rhythmISSbiological_process
GO:0004679AMP-activated protein kinase activityIEAmolecular_function
GO:0006695cholesterol biosynthetic processIEAbiological_process
GO:0031669cellular response to nutrient levelsISSbiological_process
GO:0047322[hydroxymethylglutaryl-CoA reductase (NADPH)] kinaIEAmolecular_function
GO:0046318negative regulation of glucosylceramide biosynthetNASbiological_process
GO:0043234protein complexIEAcellular_component
GO:0006950response to stressIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0042752regulation of circadian rhythmIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0071456cellular response to hypoxiaIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0031588AMP-activated protein kinase complexISScellular_component
GO:0006006glucose metabolic processIEAbiological_process
GO:0010628positive regulation of gene expressionIDAbiological_process
GO:0042149cellular response to glucose starvationISSbiological_process
GO:0060627regulation of vesicle-mediated transportIEAbiological_process
GO:0031588AMP-activated protein kinase complexIEAcellular_component
GO:0050321tau-protein kinase activityIEAmolecular_function
GO:0043066negative regulation of apoptotic processISSbiological_process
GO:0000187activation of MAPK activityNASbiological_process
GO:2000505regulation of energy homeostasisIEAbiological_process
GO:0005634nucleusISScellular_component
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0031669cellular response to nutrient levelsIEAbiological_process
GO:0006914autophagyIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0051291protein heterooligomerizationIEAbiological_process
GO:0050405[acetyl-CoA carboxylase] kinase activityIEAmolecular_function
GO:0006950response to stressISSbiological_process
GO:0008610lipid biosynthetic processISSbiological_process
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0055089fatty acid homeostasisISSbiological_process
GO:0071417cellular response to organic nitrogenIEAbiological_process
GO:0019395fatty acid oxidationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0014823response to activityIEAbiological_process
GO:0071361cellular response to ethanolIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0003682chromatin bindingISSmolecular_function
GO:0042593glucose homeostasisIEAbiological_process
GO:0006633fatty acid biosynthetic processIEAbiological_process
GO:0035174histone serine kinase activityIEAmolecular_function
GO:0032007negative regulation of TOR signaling cascadeIEAbiological_process
GO:0055089fatty acid homeostasisIEAbiological_process
GO:0070301cellular response to hydrogen peroxideIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:2001274negative regulation of glucose import in response IEAbiological_process