| UniProt/SwissProt ID: | 1433E_HUMAN |
| Description: | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide [Source:HGNC Symbol;Acc:12851] |
| Location: | chr17 p13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S64 | SWRIIsSIEQK | HPRD | |
| T218 | SYKDStLIMQL | HPRD | |
| T91 | RQMVEtELKLI | 14-3-3 | PhosphoSitePlus |
| T218 | SYKDStLIMQL | 14-3-3 | PhosphoSitePlus |
| Y122 | SKVFYyKMKGD | 14-3-3 | PhosphoSitePlus |
| S46 | ERNLLsVAYKN | HPRD | |
| Y181 | NFSVFyYEILN | 14-3-3 | PhosphoSitePlus |
| S217 | ESYKDsTLIMQ | HPRD | |
| S213 | TLSEEsYKDST | HPRD | |
| Y49 | LLSVAyKNVIG | 14-3-3 | PhosphoSitePlus |
| T91 | RQMVEtELKLI | HPRD | |
| S210 | ELDTLsEESYK | HPRD; SysPTM | |
| Y131 | GDYHRyLAEFA | 14-3-3 | PhosphoSitePlus |
| S65 | WRIISsIEQKE | 14-3-3 | PhosphoSitePlus |
| T208 | IAELDtLSEES | 14-3-3 | PhosphoSitePlus |
| T38 | MDVELtVEERN | HPRD | |
| S213 | TLSEEsYKDST | 14-3-3 | PhosphoSitePlus |
| S210 | ELDTLsEESYK | 14-3-3 | PhosphoSitePlus; SysPTM |
| S64 | SWRIIsSIEQK | 14-3-3 | PhosphoSitePlus |
| Y214 | LSEESyKDSTL | 14-3-3 | PhosphoSitePlus |
| S46 | ERNLLsVAYKN | 14-3-3 | PhosphoSitePlus |
| T38 | MDVELtVEERN | 14-3-3 | PhosphoSitePlus |
| S65 | WRIISsIEQKE | HPRD | |
| Dephosphorylation site |
| 1433E_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000264335 | Y49C | COSMIC | Lung Cancer | 20668451 | ENSP00000264335 | L44F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000264335 | L44F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000264335 | E15* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000264335 | Y49C | COSMIC | Lung Cancer | 20668451 | ENSP00000264335 | E15* | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000264335 | Breast Cancer | Normal vs. Cancer | tissue | Up | 2.5 | 16470630 | ENSP00000264335 | Breast Cancer | Treatment (chemosensitive vs. adriamycin-resistant) | cell line | Up | 2.7 | 17487377 | ENSP00000264335 | Breast Cancer | Treatment (chemosensitive vs. paclitaxel-resistant) | cell line | Up | 2.3 | 17487377 | ENSP00000264335 | Breast Cancer | Normal vs. Cancer | tissue | Up | 18257521 | ENSP00000264335 | hepatitis B virus | Normal vs. Cancer | cell line | Up | 1.8 | 19626621 | ENSP00000264335 | Non-small cell lung carcinoma | Treatment (none vs CIGB-300 treatment) | cell line | Up | 2.6 | 20804217 | ENSP00000264335 | Breast Cancer | Normal vs. Cancer | tissue | Up | 2.9 | 20005186 | ENSP00000264335 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.3 | 20052998 | ENSP00000264335 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.3 | 20052998 | ENSP00000264335 | Breast Cancer | Metastasis | cell line | Up | 4.5 | 20052998 | ENSP00000264335 | Breast Cancer | Normal vs. Cancer | tissue | Up | 1.8 | 20087651 | ENSP00000264335 | breast ductal carcinoma | Normal vs. Cancer | tissue | Up | 18564057 | ENSP00000264335 | acute myeloid leukemia | Treatment (none vs. NSC606985 treatment) | cell line | Down | 0.49 | 17655343 | ENSP00000264335 | Uterine Cancer | Normal vs. Cancer | tissue | Down | 16051329 | ENSP00000264335 | Uterine Cancer | Normal vs. Cancer | tissue | Down | 19771267 |
| Hyperphosphorylation site |
| 1433E_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | 1433E_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SCYL2_HUMAN | 1433E_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TBK1_HUMAN | 1433E_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TYK2_HUMAN | 1433E_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6B1_HUMAN | 1433E_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK08_HUMAN | 1433E_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| 1433E_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0001764 | neuron migration | IEA | biological_process |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0006915 | apoptotic process | TAS | biological_process |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0042470 | melanosome | IEA | cellular_component |
| GO:0019899 | enzyme binding | IPI | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0042826 | histone deacetylase binding | IPI | molecular_function |
| GO:0006605 | protein targeting | IEA | biological_process |
| GO:0035556 | intracellular signal transduction | TAS | biological_process |
| GO:0035308 | negative regulation of protein dephosphorylation | IEA | biological_process |
| GO:0050815 | phosphoserine binding | IPI | molecular_function |
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0035329 | hippo signaling cascade | TAS | biological_process |
| GO:0021766 | hippocampus development | IEA | biological_process |
| GO:0005871 | kinesin complex | IEA | cellular_component |
| GO:0019899 | enzyme binding | IEA | molecular_function |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0051219 | phosphoprotein binding | IPI | molecular_function |
| GO:0019904 | protein domain specific binding | IEA | molecular_function |
| GO:0033267 | axon part | IEA | cellular_component |
| GO:0021987 | cerebral cortex development | IEA | biological_process |
| GO:0032403 | protein complex binding | IEA | molecular_function |