Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RAF1_HUMAN
Description:v-raf-1 murine leukemia viral oncogene homolog 1 [Source:HGNC Symbol;Acc:9829]
Location:chr3 p25.2
Node attribute:PPI(source); substrate; kinase; effector; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S301SPNNLsPTGWSPhosphoSitePlus; phosphoELM; RegPhos
T303NNLSPtGWSQPPhosphoSitePlus; HPRD
S259RQRSTsTPNVHAKT1HPRD; RegPhos; SysPTM
S244TFNTSsPSSEGPhosphoSitePlus; HPRD; SysPTM
S306SPTGWsQPKTPPhosphoSitePlus
S289HSESAsPSALSPhosphoSitePlus; phosphoELM; RegPhos
S43YQRRAsDDGKLPhosphoSitePlus; RegPhos; SysPTM
S220RRMREsVSRMPPhosphoSitePlus
S497VKSRWsGSQQVPkinase_TyrPhosphoSitePlus
T213ALPSLtMRRMRPhosphoSitePlus
S285AIRSHsESASPPhosphoSitePlus
T362SGSFGtVYKGKPkinase_TyrPhosphoSitePlus
S619PKINRsASEPSPhosphoSitePlus; HPRD
T310WSQPKtPVPAQPhosphoSitePlus
S259RQRSTsTPNVHPRKACAHPRD; SysPTM
S471HRDMKsNNIFLPkinase_TyrPhosphoSitePlus
S43YQRRAsDDGKLPRKACAHPRD; SysPTM
S339GQRDSsYYWEIPhosphoSitePlus; HPRD; RegPhos
S289HSESAsPSALSMAPK1HPRD
T640NACTLtTSPRLPhosphoSitePlus
T234QHRYStPHAFTPhosphoSitePlus
S291ESASPsALSSSPhosphoSitePlus; HPRD
S621INRSAsEPSLHPKACaRegPhos; SysPTM
Y458AQGMDyLHAKNPkinase_TyrPhosphoSitePlus
S257SQRQRsTSTPNPhosphoSitePlus; HPRD; phosphoELM
S612ELLQHsLPKINPhosphoSitePlus
S642CTLTTsPRLPphosphoELM; SysPTM
S471HRDMKsNNIFLphosphoELM; RegPhos
T268VHMVStTLPVDautocatalysisRegPhos
S296SALSSsPNNLSPhosphoSitePlus; phosphoELM; RegPhos
T491DFGLAtVKSRWHPRD; phosphoELM; RegPhos
S296SALSSsPNNLSMAPK1HPRD
S233SQHRYsTPHAFPKACaRegPhos
T491DFGLAtVKSRWPkinase_TyrPhosphoSitePlus
T324APVSGtQEKNKPhosphoSitePlus
S43YQRRAsDDGKLPKA_groupphosphoELM; RegPhos; SysPTM
S259RQRSTsTPNVHPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y341RDSSYyWEIEAJAK2HPRD; RegPhos
S338RGQRDsSYYWERHEBHPRD
S301SPNNLsPTGWSMAPK1HPRD
T481LHEGLtVKIGDPkinase_TyrPhosphoSitePlus
S252SEGSLsQRQRSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y341RDSSYyWEIEAPhosphoSitePlus
S621INRSAsEPSLHAMPKa1RegPhos; SysPTM
S621INRSAsEPSLHRAF1HPRD; RegPhos; SysPTM
S29GSSCIsPTIVQErk2RegPhos
S621INRSAsEPSLHPRKAA1HPRD; SysPTM
S338RGQRDsSYYWEPhosphoSitePlus; phosphoELM
T258QRQRStSTPNVPhosphoSitePlus; HPRD; phosphoELM
Y38VQQFGyQRRASPhosphoSitePlus
S29GSSCIsPTIVQMAPK1HPRD
S43YQRRAsDDGKLPKACaRegPhos; SysPTM
S283EDAIRsHSESAPhosphoSitePlus
S642CTLTTsPRLPVErk2RegPhos; SysPTM
S259RQRSTsTPNVHPKACaRegPhos; SysPTM
T638DINACtLTTSPPhosphoSitePlus
S259RQRSTsTPNVHAMPK_groupRegPhos; SysPTM
S296SALSSsPNNLSErk2RegPhos
S294SPSALsSSPNNPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S259RQRSTsTPNVHPKB_groupphosphoELM; SysPTM
S233SQHRYsTPHAFPRKACAHPRD
S357STRIGsGSFGTPkinase_TyrPhosphoSitePlus
S233SQHRYsTPHAFPhosphoSitePlus; phosphoELM; RegPhos
S301SPNNLsPTGWSErk2RegPhos
S247TSSPSsEGSLSPhosphoSitePlus
S499SRWSGsQQVEQPKCaRegPhos
S624SASEPsLHRAAPhosphoSitePlus; HPRD
S621INRSAsEPSLHAMPK_groupRegPhos; SysPTM
T239TPHAFtFNTSSPhosphoSitePlus
S621INRSAsEPSLHPRKACAHPRD; SysPTM
S499SRWSGsQQVEQPRKCAHPRD
S339GQRDSsYYWEIPAK1phosphoELM; RegPhos
T269HMVSTtLPVDSPhosphoSitePlus; HPRD; RegPhos
S289HSESAsPSALSErk2RegPhos
S287RSHSEsASPSAPhosphoSitePlus
S259RQRSTsTPNVHAKT_groupRegPhos; SysPTM
S499SRWSGsQQVEQPKC_groupphosphoELM; RegPhos
T268VHMVStTLPVDRAF1HPRD; RegPhos
S259RQRSTsTPNVHPKA_groupphosphoELM; RegPhos; SysPTM
S295PSALSsSPNNLPhosphoSitePlus; HPRD
S339GQRDSsYYWEISRCHPRD
S259RQRSTsTPNVHPKC_groupRegPhos; SysPTM
T260QRSTStPNVHMPhosphoSitePlus; HPRD; phosphoELM
S642CTLTTsPRLPMAPK1HPRD; SysPTM
S338RGQRDsSYYWEPAK2RegPhos
S621INRSAsEPSLHPKA_groupphosphoELM; RegPhos; SysPTM
S338RGQRDsSYYWEPAK_groupphosphoELM; RegPhos
Y341RDSSYyWEIEASrcRegPhos
T269HMVSTtLPVDSKSR1phosphoELM; RegPhos
Y341RDSSYyWEIEASRCHPRD; phosphoELM; RegPhos
Y340QRDSSyYWEIESRCHPRD
Y340QRDSSyYWEIEPhosphoSitePlus; phosphoELM; RegPhos
S494LATVKsRWSGSHPRD; phosphoELM; RegPhos
Y340QRDSSyYWEIEJAK2HPRD; RegPhos
S499SRWSGsQQVEQPkinase_TyrPhosphoSitePlus
S494LATVKsRWSGSPkinase_TyrPhosphoSitePlus
S338RGQRDsSYYWESRCHPRD
S29GSSCIsPTIVQPhosphoSitePlus; phosphoELM; RegPhos
S338RGQRDsSYYWEPAK3HPRD; phosphoELM; RegPhos
S338RGQRDsSYYWEPAK1HPRD; phosphoELM; RegPhos
Y232SSQHRySTPHAPhosphoSitePlus
S250PSSEGsLSQRQPhosphoSitePlus
S642CTLTTsPRLPVPhosphoSitePlus; SysPTM
S621INRSAsEPSLHPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
T641ACTLTtSPRLPHPRD
S211VPALPsLTMRRPhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y340RGQRDSSyYWEIEASCDC25AHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000251849Q335HGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000251849R495HBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000251849A319SDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000251849S259AGreenman2007, HPIOvarian Cancer17344846, 18428421, 16630891, 17344846, 16630891 17344846
ENSP00000401888R515HBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000251849Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineDown0.2415169874

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S259SQRQRSTsTPNVHMVAlzheimer's disease17064357PhosphoSitePlus
S338RPRGQRDsSYYWEIEAlzheimer's disease17064357PhosphoSitePlus
Y341GQRDSSYyWEIEASEAlzheimer's disease17064357PhosphoSitePlus
Y340RGQRDSSyYWEIEASAlzheimer's disease17064357PhosphoSitePlus
S259SQRQRSTsTPNVHMV20679480PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
GBG1_HUMANRAF1_HUMANGprotein -> effectorgpDB
GBG13_HUMANRAF1_HUMANGprotein -> effectorgpDB
GBB2_HUMANRAF1_HUMANGprotein -> effectorgpDB
GBG2_HUMANRAF1_HUMANGprotein -> effectorgpDB
GBB3_HUMANRAF1_HUMANGprotein -> effectorgpDB
GBG10_HUMANRAF1_HUMANGprotein -> effectorgpDB
GBB1_HUMANRAF1_HUMANGprotein -> effectorgpDB
GBB5_HUMANRAF1_HUMANGprotein -> effectorgpDB
GBG12_HUMANRAF1_HUMANGprotein -> effectorgpDB
GBG3_HUMANRAF1_HUMANGprotein -> effectorgpDB
GBG5_HUMANRAF1_HUMANGprotein -> effectorgpDB
GBG11_HUMANRAF1_HUMANGprotein -> effectorgpDB
GBG8_HUMANRAF1_HUMANGprotein -> effectorgpDB
RAF1_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
RAF1_HUMANBAD_HUMANkinase -> substrateKEGG
RAF1_HUMANMP2K1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
RAF1_HUMANAIRE_HUMANkinase -> substrateRobert H Newman (2013)
MK01_HUMANRAF1_HUMANkinase -> substrateHPRD
RAF1_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
RAF1_HUMANPRDX1_HUMANkinase -> substrateRobert H Newman (2013)
RAF1_HUMANTIM23_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANRAF1_HUMANkinase -> substrateRegPhos
PAK2_HUMANRAF1_HUMANkinase -> substrateRegPhos
RAF1_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANRAF1_HUMANkinase -> substrateKEGG
RAF1_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
RAF1_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
RAF1_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
RHEB_HUMANRAF1_HUMANkinase -> substrateHPRD
RAF1_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
RAF1_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
RAF1_HUMANSRXN1_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANRAF1_HUMANkinase -> substrateRegPhos
KSR1_HUMANRAF1_HUMANkinase -> substrateRegPhos
RAF1_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANRAF1_HUMANkinase -> substrateKEGG; HPRD
ZAGL2_HUMANRAF1_HUMANkinase -> substrateRegPhos
RAF1_HUMANIF4H_HUMANkinase -> substrateRobert H Newman (2013)
RAF1_HUMANRAF1_HUMANkinase -> substrateRegPhos
SRC_HUMANRAF1_HUMANkinase -> substrateHPRD; RegPhos
RAF1_HUMANOTU7B_HUMANkinase -> substrateRobert H Newman (2013)
RAF1_HUMANAAKG3_HUMANkinase -> substrateRobert H Newman (2013)
RAF1_HUMANPHAX_HUMANkinase -> substrateRobert H Newman (2013)
RAF1_HUMANBFAR_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANRAF1_HUMANkinase -> substrateHPRD; RegPhos
RAF1_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
AAPK1_HUMANRAF1_HUMANkinase -> substrateHPRD
RAF1_HUMANKCRM_HUMANkinase -> substrateRobert H Newman (2013)
PKN1_HUMANRAF1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
RAF1_HUMANMK01_HUMANkinase -> substrateHPRD; RegPhos
PAK3_HUMANRAF1_HUMANkinase -> substrateHPRD; RegPhos
MP2K1_HUMANRAF1_HUMANkinase -> substrateNetPath
RAF1_HUMANMP2K2_HUMANkinase -> substrateKEGG
RAF1_HUMANSYSC_HUMANkinase -> substrateRobert H Newman (2013)
RAF1_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
RAF1_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
MPIP1_HUMANRAF1_HUMANphosphatase -> substrateHPRD
RRAS2_HUMANRAF1_HUMANotherKEGG
KPCA_HUMANRAF1_HUMANotherKEGG
RAF1_HUMANMP2K1_HUMANotherKEGG
RASH_HUMANRAF1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05212Pancreatic cancer
hsa04510Focal adhesion
hsa04664Fc epsilon RI signaling pathway
hsa04910Insulin signaling pathway
hsa05223Non-small cell lung cancer
hsa04540Gap junction
hsa05220Chronic myeloid leukemia
hsa04730Long-term depression
hsa05210Colorectal cancer
hsa04650Natural killer cell mediated cytotoxicity
hsa04914Progesterone-mediated oocyte maturation
hsa04810Regulation of actin cytoskeleton
hsa05152Tuberculosis
hsa05219Bladder cancer
hsa04916Melanogenesis
hsa05214Glioma
hsa04726Serotonergic synapse
hsa05034Alcoholism
hsa05218Melanoma
hsa04912GnRH signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04010MAPK signaling pathway
hsa04062Chemokine signaling pathway
hsa04720Long-term potentiation
hsa04370VEGF signaling pathway
hsa05213Endometrial cancer
hsa04660T cell receptor signaling pathway
hsa05215Prostate cancer
hsa04012ErbB signaling pathway
hsa05160Hepatitis C
hsa05200Pathways in cancer
hsa04722Neurotrophin signaling pathway
hsa04662B cell receptor signaling pathway
hsa05164Influenza A
hsa04666Fc gamma R-mediated phagocytosis
hsa05211Renal cell carcinoma
hsa05221Acute myeloid leukemia

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000186activation of MAPKK activityTASbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0008285negative regulation of cell proliferationIDAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:2000145regulation of cell motilityTASbiological_process
GO:0005737cytoplasmISScellular_component
GO:0004709MAP kinase kinase kinase activityIEAmolecular_function
GO:0033138positive regulation of peptidyl-serine phosphorylaIDAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0035556intracellular signal transductionIEAbiological_process
GO:0000165MAPK cascadeIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0043154negative regulation of cysteine-type endopeptidaseTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0030168platelet activationTASbiological_process
GO:0042981regulation of apoptotic processTASbiological_process
GO:0005057receptor signaling protein activityIEAmolecular_function
GO:0001666response to hypoxiaIEAbiological_process
GO:0000186activation of MAPKK activityIEAbiological_process
GO:0007010cytoskeleton organizationIEAbiological_process
GO:0004672protein kinase activityTASmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0000165MAPK cascadeTASbiological_process
GO:0031143pseudopodiumIEAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0042060wound healingTASbiological_process
GO:0035023regulation of Rho protein signal transductionTASbiological_process
GO:0031434mitogen-activated protein kinase kinase bindingIEAmolecular_function
GO:0008283cell proliferationTASbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006915apoptotic processIEAbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0031333negative regulation of protein complex assemblyIDAbiological_process
GO:0005741mitochondrial outer membraneTAScellular_component
GO:0006915apoptotic processTASbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0007190activation of adenylate cyclase activityNASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0007265Ras protein signal transductionTASbiological_process
GO:0017016Ras GTPase bindingIEAmolecular_function
GO:0045595regulation of cell differentiationTASbiological_process