Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BCL2_HUMAN
Description:B-cell CLL/lymphoma 2 [Source:HGNC Symbol;Acc:990]
Location:chr18 q21.33
Node attribute:PPI(source); PPI(target); substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S87AGPALsPVPPVPhosphoSitePlus
T69DPVARtSPLQTMAPK8HPRD
S87AGPALsPVPPVJNK1(MAPK8RegPhos
S70PVARTsPLQTPPKC_group RegPhos
T69DPVARtSPLQTPhosphoSitePlus
Y235ITLGAyLGHK_PhosphoSitePlus
T56SQPGHtPHPAAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S87AGPALsPVPPVMAPK1HPRD
S87AGPALsPVPPVMAPK8HPRD; phosphoELM
S24IHYKLsQRGYEPKCaRegPhos
T69DPVARtSPLQTMAPK_groupphosphoELM; RegPhos
S70PVARTsPLQTPJNK1(MAPK8RegPhos
T69DPVARtSPLQTJNK1RegPhos
Y9AGRTGyDNREIBH4PhosphoSitePlus
S87AGPALsPVPPVJNK1RegPhos
S87AGPALsPVPPVErk2RegPhos
S70PVARTsPLQTPMAPK8HPRD; phosphoELM
T74TSPLQtPAAPGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S70PVARTsPLQTPPhosphoSitePlus; HPRD
S70PVARTsPLQTPJNK1RegPhos
S70PVARTsPLQTPMAPK_groupphosphoELM; RegPhos
S87AGPALsPVPPVMAPK_groupphosphoELM; RegPhos
S24IHYKLsQRGYEPRKCAHPRD

Dephosphorylation site
BCL2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000329623P59SHPILymphoma1339299
ENSP00000329623A85TCOSMICCentral Nervous System Neoplasms18772890
ENSP00000381185P59SHPILymphoma1339299
ENSP00000381185A85TCOSMICCentral Nervous System Neoplasms18772890
ENSP00000381185V93IHPILymphoma1339299
ENSP00000329623V93IHPILymphoma1339299

Differential expressed protein
BCL2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BCL2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANBCL2_HUMANkinase -> substrateRegPhos
MK01_HUMANBCL2_HUMANkinase -> substrateKEGG; HPRD
KPCA_HUMANBCL2_HUMANkinase -> substrateHPRD
MK08_HUMANBCL2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
TNFA_HUMANBCL2_HUMANphosphatase -> substrateHPRD
SODC_HUMANBCL2_HUMANotherKEGG
BAX_HUMANBCL2_HUMANotherKEGG
BCL2_HUMANCYC_HUMANotherKEGG
MITF_HUMANBCL2_HUMANTF -> target geneTRANSFAC
GLI2_HUMANBCL2_HUMANTF -> target geneTRANSFAC
GLI3_HUMANBCL2_HUMANTF -> target geneTRANSFAC
CDX2_HUMANBCL2_HUMANTF -> target geneTRANSFAC
GLI1_HUMANBCL2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04064NF-kappa B signaling pathway
hsa04725Cholinergic synapse
hsa04510Focal adhesion
hsa05210Colorectal cancer
hsa05222Small cell lung cancer
hsa05145Toxoplasmosis
hsa05215Prostate cancer
hsa05152Tuberculosis
hsa04722Neurotrophin signaling pathway
hsa04210Apoptosis
hsa05169Epstein-Barr virus infection
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05200Pathways in cancer
hsa04141Protein processing in endoplasmic reticulum

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030890positive regulation of B cell proliferationIMPbiological_process
GO:0043473pigmentationIEAbiological_process
GO:0006582melanin metabolic processIEAbiological_process
GO:0000209protein polyubiquitinationIDAbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0070059intrinsic apoptotic signaling pathway in response IDAbiological_process
GO:0009314response to radiationNASbiological_process
GO:0001503ossificationIEAbiological_process
GO:0043375CD8-positive, alpha-beta T cell lineage commitmentIEAbiological_process
GO:0046902regulation of mitochondrial membrane permeabilityISSbiological_process
GO:0043497regulation of protein heterodimerization activityIDAbiological_process
GO:0031647regulation of protein stabilityIEAbiological_process
GO:0042100B cell proliferationIDAbiological_process
GO:0035094response to nicotineIDAbiological_process
GO:0016049cell growthIEAbiological_process
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0009636response to toxinIDAbiological_process
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0008283cell proliferationIEAbiological_process
GO:0043209myelin sheathIEAcellular_component
GO:0002320lymphoid progenitor cell differentiationIEAbiological_process
GO:0051881regulation of mitochondrial membrane potentialIEAbiological_process
GO:0014042positive regulation of neuron maturationIEAbiological_process
GO:0010559regulation of glycoprotein biosynthetic processIEAbiological_process
GO:0022898regulation of transmembrane transporter activityIDAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0030307positive regulation of cell growthIDAbiological_process
GO:0046671negative regulation of retinal cell programmed celIEAbiological_process
GO:0048041focal adhesion assemblyIEAbiological_process
GO:0072593reactive oxygen species metabolic processIEAbiological_process
GO:0002020protease bindingIDAmolecular_function
GO:0030279negative regulation of ossificationIEAbiological_process
GO:0031965nuclear membraneIDAcellular_component
GO:0009605response to external stimulusIEAbiological_process
GO:0006808regulation of nitrogen utilizationIEAbiological_process
GO:0005741mitochondrial outer membraneIDAcellular_component
GO:2000811negative regulation of anoikisIMPbiological_process
GO:0010468regulation of gene expressionIEAbiological_process
GO:0031069hair follicle morphogenesisIEAbiological_process
GO:0045930negative regulation of mitotic cell cycleIEAbiological_process
GO:0040007growthIEAbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0014911positive regulation of smooth muscle cell migratioIEAbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0018107peptidyl-threonine phosphorylationIEAbiological_process
GO:0048536spleen developmentIEAbiological_process
GO:0001541ovarian follicle developmentIEAbiological_process
GO:0007015actin filament organizationIEAbiological_process
GO:0048599oocyte developmentIEAbiological_process
GO:0005739mitochondrionIDAcellular_component
GO:0035872nucleotide-binding domain, leucine rich repeat conTASbiological_process
GO:2001234negative regulation of apoptotic signaling pathwayIMPbiological_process
GO:0016337cell-cell adhesionIEAbiological_process
GO:0001836release of cytochrome c from mitochondriaIEAbiological_process
GO:0030308negative regulation of cell growthIEAbiological_process
GO:0030318melanocyte differentiationIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0001662behavioral fear responseIEAbiological_process
GO:0001658branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0006470protein dephosphorylationIEAbiological_process
GO:0051402neuron apoptotic processTASbiological_process
GO:0002360T cell lineage commitmentIEAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0031103axon regenerationIEAbiological_process
GO:0002260lymphocyte homeostasisIEAbiological_process
GO:0048070regulation of developmental pigmentationIEAbiological_process
GO:0005789endoplasmic reticulum membraneIEAcellular_component
GO:0051726regulation of cell cycleIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0007569cell agingIEAbiological_process
GO:0048743positive regulation of skeletal muscle fiber develIEAbiological_process
GO:0006979response to oxidative stressIEAbiological_process
GO:0045069regulation of viral genome replicationIEAbiological_process
GO:0010523negative regulation of calcium ion transport into IEAbiological_process
GO:0043029T cell homeostasisIEAbiological_process
GO:0051434BH3 domain bindingIPImolecular_function
GO:0043524negative regulation of neuron apoptotic processIDAbiological_process
GO:0001782B cell homeostasisIEAbiological_process
GO:0042221response to chemical stimulusIEAbiological_process
GO:0051902negative regulation of mitochondrial depolarizatioTASbiological_process
GO:0018105peptidyl-serine phosphorylationIEAbiological_process
GO:0019903protein phosphatase bindingIEAmolecular_function
GO:0010332response to gamma radiationIEAbiological_process
GO:0051402neuron apoptotic processIEAbiological_process
GO:0006959humoral immune responseTASbiological_process
GO:0010224response to UV-BIEAbiological_process
GO:0005783endoplasmic reticulumIDAcellular_component
GO:0042542response to hydrogen peroxideIEAbiological_process
GO:0045636positive regulation of melanocyte differentiationIEAbiological_process
GO:0048589developmental growthIEAbiological_process
GO:0033138positive regulation of peptidyl-serine phosphorylaIEAbiological_process
GO:0034097response to cytokine stimulusIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0051384response to glucocorticoid stimulusIEAbiological_process
GO:0031965nuclear membraneIEAcellular_component
GO:0050790regulation of catalytic activityIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0000082G1/S transition of mitotic cell cycleIEAbiological_process
GO:0048546digestive tract morphogenesisIEAbiological_process
GO:0010039response to iron ionIDAbiological_process
GO:0010507negative regulation of autophagyTASbiological_process
GO:0048753pigment granule organizationIEAbiological_process
GO:0007565female pregnancyNASbiological_process
GO:0043565sequence-specific DNA bindingIDAmolecular_function
GO:0043496regulation of protein homodimerization activityIDAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0006974response to DNA damage stimulusIMPbiological_process
GO:0008584male gonad developmentIEAbiological_process
GO:0051924regulation of calcium ion transportIDAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0007409axonogenesisIEAbiological_process
GO:0001776leukocyte homeostasisIEAbiological_process
GO:0030183B cell differentiationIEAbiological_process
GO:0001822kidney developmentIEAbiological_process
GO:0033077T cell differentiation in thymusIEAbiological_process
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0046930pore complexIDAcellular_component
GO:0006874cellular calcium ion homeostasisIEAbiological_process
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0002326B cell lineage commitmentIEAbiological_process
GO:0032835glomerulus developmentIEAbiological_process
GO:0030217T cell differentiationIEAbiological_process
GO:0003014renal system processIEAbiological_process
GO:0048538thymus developmentIEAbiological_process
GO:0032848negative regulation of cellular pH reductionIDAbiological_process
GO:0051881regulation of mitochondrial membrane potentialISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0048087positive regulation of developmental pigmentationIEAbiological_process
GO:0042493response to drugIMPbiological_process
GO:0016020membraneIDAcellular_component
GO:0001656metanephros developmentIEAbiological_process
GO:0043085positive regulation of catalytic activityIEAbiological_process
GO:0030336negative regulation of cell migrationIEAbiological_process
GO:0050853B cell receptor signaling pathwayIMPbiological_process
GO:0008134transcription factor bindingIEAmolecular_function
GO:0033033negative regulation of myeloid cell apoptotic procIEAbiological_process
GO:0071310cellular response to organic substanceIEAbiological_process
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0031966mitochondrial membraneIEAcellular_component
GO:0032469endoplasmic reticulum calcium ion homeostasisIEAbiological_process
GO:0035265organ growthIEAbiological_process
GO:0001101response to acidIEAbiological_process
GO:0001657ureteric bud developmentIEAbiological_process
GO:0001952regulation of cell-matrix adhesionIEAbiological_process
GO:0043583ear developmentIEAbiological_process
GO:0043067regulation of programmed cell deathIEAbiological_process
GO:0032880regulation of protein localizationIEAbiological_process
GO:0040018positive regulation of multicellular organism growIEAbiological_process
GO:0002520immune system developmentIEAbiological_process
GO:0046902regulation of mitochondrial membrane permeabilityIEAbiological_process
GO:0051721protein phosphatase 2A bindingIEAmolecular_function
GO:0048066developmental pigmentationIEAbiological_process
GO:0034097response to cytokine stimulusIEAbiological_process
GO:0014031mesenchymal cell developmentIEAbiological_process
GO:0048545response to steroid hormone stimulusIEAbiological_process
GO:0009791post-embryonic developmentIEAbiological_process
GO:0009887organ morphogenesisIEAbiological_process
GO:0008219cell deathIDAbiological_process
GO:0021747cochlear nucleus developmentIEAbiological_process
GO:0009636response to toxinIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0030097hemopoiesisIEAbiological_process
GO:0022612gland morphogenesisIEAbiological_process
GO:0001836release of cytochrome c from mitochondriaNASbiological_process
GO:0042803protein homodimerization activityIPImolecular_function
GO:0033689negative regulation of osteoblast proliferationIEAbiological_process
GO:0000902cell morphogenesisIEAbiological_process
GO:0015267channel activityIDAmolecular_function
GO:0048873homeostasis of number of cells within a tissueIEAbiological_process
GO:0051607defense response to virusIDAbiological_process