Phosphorylation

You are querying signaling transduction network mediated by AGTR2_HUMAN in Lung Cancer.

Signaling Transduction Network:

NO.	Source	Target	Relation Attribute	Resource
1	ANGT_HUMAN	AGTR2_HUMAN	ligand -> receptor	HPMR
2	AGTR2_HUMAN	GNAO_HUMAN	GPCR -> Gprotein	gpDB
3	AGTR2_HUMAN	GNAI2_HUMAN	GPCR -> Gprotein	gpDB
4	AGTR2_HUMAN	GNAI1_HUMAN	GPCR -> Gprotein	gpDB
5	AGTR2_HUMAN	GNAI3_HUMAN	GPCR -> Gprotein	gpDB
6	GNAO_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
7	GNAI2_HUMAN	RAC1_HUMAN	Gprotein -> effector	gpDB
8	GNAI1_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
9	GNAI3_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
10	GNAO_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
11	GNAI2_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
12	GNAI2_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
13	GNAI3_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
14	GNAI1_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
15	GNAI3_HUMAN	RAC1_HUMAN	Gprotein -> effector	gpDB
16	GNAI1_HUMAN	RAC1_HUMAN	Gprotein -> effector	gpDB
17	SRC_HUMAN	AKT1_HUMAN	kinase -> substrate	RegPhos
18	RAC1_HUMAN	MK08_HUMAN	kinase -> substrate; other	KEGG
19	CSK_HUMAN	KPCA_HUMAN	kinase -> substrate	Robert H Newman (2013)
20	SRC_HUMAN	PDPK1_HUMAN	kinase -> substrate	RegPhos
21	SRC_HUMAN	ABL1_HUMAN	kinase -> substrate	RegPhos
22	CSK_HUMAN	FYN_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
23	CSK_HUMAN	FGR_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
24	CSK_HUMAN	LCK_HUMAN	kinase -> substrate	HPRD; RegPhos
25	SRC_HUMAN	DDR2_HUMAN	kinase -> substrate	RegPhos
26	SRC_HUMAN	IKKA_HUMAN	kinase -> substrate	NetPath
27	CSK_HUMAN	LYN_HUMAN	kinase -> substrate; other	HPRD; RegPhos; Robert H Newman (2013); KEGG
28	SRC_HUMAN	KIT_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
29	SRC_HUMAN	STAT3_HUMAN	kinase -> substrate	HPRD; RegPhos
30	CSK_HUMAN	YES_HUMAN	kinase -> substrate	Robert H Newman (2013)
31	SRC_HUMAN	HNRPK_HUMAN	kinase -> substrate	RegPhos
32	SRC_HUMAN	CTNB1_HUMAN	kinase -> substrate	RegPhos
33	CSK_HUMAN	PTPRC_HUMAN	kinase -> substrate	Robert H Newman (2013)
34	SRC_HUMAN	STA5B_HUMAN	kinase -> substrate	HPRD; RegPhos
35	SRC_HUMAN	GTF2I_HUMAN	kinase -> substrate	RegPhos
36	CSK_HUMAN	CTNB1_HUMAN	kinase -> substrate	RegPhos
37	SRC_HUMAN	RHG35_HUMAN	kinase -> substrate	KEGG; HPRD; RegPhos
38	SRC_HUMAN	ESR1_HUMAN	kinase -> substrate	HPRD; RegPhos
39	CSK_HUMAN	MK15_HUMAN	kinase -> substrate	RegPhos
40	SRC_HUMAN	RAF1_HUMAN	kinase -> substrate	HPRD; RegPhos
41	CSK_HUMAN	ETS1_HUMAN	kinase -> substrate	Robert H Newman (2013)
42	SRC_HUMAN	SHC1_HUMAN	kinase -> substrate	RegPhos
43	SRC_HUMAN	EGFR_HUMAN	kinase -> substrate	RegPhos
44	SRC_HUMAN	FAK1_HUMAN	kinase -> substrate	RegPhos; NetPath
45	SRC_HUMAN	KPCI_HUMAN	kinase -> substrate	RegPhos
46	SRC_HUMAN	IKKB_HUMAN	kinase -> substrate	NetPath
47	SRC_HUMAN	IGF1R_HUMAN	kinase -> substrate	RegPhos
48	CSK_HUMAN	ANDR_HUMAN	kinase -> substrate	RegPhos
49	AKT1_HUMAN	STAT6_HUMAN	kinase -> substrate	Robert H Newman (2013)
50	MK08_HUMAN	GCR_HUMAN	kinase -> substrate	HPRD; RegPhos
51	KPCA_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
52	PDPK1_HUMAN	MP2K1_HUMAN	kinase -> substrate	RegPhos
53	ABL1_HUMAN	CDK5_HUMAN	kinase -> substrate	HPRD; RegPhos
54	FYN_HUMAN	CDK5_HUMAN	kinase -> substrate	HPRD; RegPhos
55	FGR_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
56	MK08_HUMAN	ATF2_HUMAN	kinase -> substrate	NetPath; Robert H Newman (2013)
57	KPCA_HUMAN	MYOD1_HUMAN	kinase -> substrate	HPRD
58	KPCA_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
59	AKT1_HUMAN	EP300_HUMAN	kinase -> substrate	HPRD; RegPhos
60	LCK_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
61	KPCA_HUMAN	EP300_HUMAN	kinase -> substrate	Robert H Newman (2013)
62	AKT1_HUMAN	CREB1_HUMAN	kinase -> substrate	HPRD; RegPhos
63	FGR_HUMAN	ZAP70_HUMAN	kinase -> substrate	Robert H Newman (2013)
64	DDR2_HUMAN	KPCD_HUMAN	kinase -> substrate	Robert H Newman (2013)
65	AKT1_HUMAN	GSK3B_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
66	IKKA_HUMAN	NFKB1_HUMAN	kinase -> substrate; other	HPRD; NetPath; KEGG
67	PDPK1_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
68	FYN_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
69	MK08_HUMAN	FOXO4_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
70	LYN_HUMAN	KPCD_HUMAN	kinase -> substrate	RegPhos
71	MK08_HUMAN	HSF1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
72	MK08_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
73	LYN_HUMAN	CSK21_HUMAN	kinase -> substrate	Robert H Newman (2013)
74	FGR_HUMAN	CSK21_HUMAN	kinase -> substrate	Robert H Newman (2013)
75	AKT1_HUMAN	FOXO4_HUMAN	kinase -> substrate	RegPhos
76	KIT_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
77	FGR_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
78	FGR_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
79	YES_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
80	MK08_HUMAN	NFAC4_HUMAN	kinase -> substrate	KEGG
81	KPCA_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
82	LYN_HUMAN	CDK1_HUMAN	kinase -> substrate	HPRD; RegPhos
83	PDPK1_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
84	FYN_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
85	KPCA_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
86	HNRPK_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
87	MK08_HUMAN	DYR1B_HUMAN	kinase -> substrate	Robert H Newman (2013)
88	KPCA_HUMAN	PTN7_HUMAN	kinase -> substrate	HPRD
89	PDPK1_HUMAN	KPCD_HUMAN	kinase -> substrate	HPRD; RegPhos
90	KPCA_HUMAN	ATF4_HUMAN	kinase -> substrate	KEGG
91	AKT1_HUMAN	GSK3A_HUMAN	kinase -> substrate	NetPath
92	MK08_HUMAN	FOS_HUMAN	kinase -> substrate	KEGG
93	PDPK1_HUMAN	PKN1_HUMAN	kinase -> substrate	RegPhos
94	KPCA_HUMAN	CREM_HUMAN	kinase -> substrate	HPRD
95	MK08_HUMAN	JUN_HUMAN	kinase -> substrate; other	NetPath; Robert H Newman (2013); KEGG
96	KPCA_HUMAN	STK11_HUMAN	kinase -> substrate	HPRD
97	AKT1_HUMAN	FOXO1_HUMAN	kinase -> substrate	RegPhos; NetPath
98	AKT1_HUMAN	M3K11_HUMAN	kinase -> substrate	HPRD; RegPhos
99	PTPRC_HUMAN	JAK1_HUMAN	phosphatase -> substrate	HPRD
100	LCK_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos
101	AKT1_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
102	RHG35_HUMAN	GCR_HUMAN	TF -> target gene	TRANSFAC
103	ABL1_HUMAN	P73_HUMAN	kinase -> substrate	HPRD; RegPhos
104	FGR_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
105	GTF2I_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
106	YES_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
107	IKKA_HUMAN	IRF7_HUMAN	kinase -> substrate	KEGG
108	KPCA_HUMAN	FOS_HUMAN	kinase -> substrate	HPRD
109	KPCA_HUMAN	KLF1_HUMAN	kinase -> substrate	HPRD
110	MK08_HUMAN	NFAC2_HUMAN	kinase -> substrate	KEGG
111	AKT1_HUMAN	TEAD1_HUMAN	kinase -> substrate	Robert H Newman (2013)
112	ESR1_HUMAN	PRGR_HUMAN	TF -> target gene	TRANSFAC
113	MK15_HUMAN	RET_HUMAN	kinase -> substrate	Robert H Newman (2013)
114	MK08_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
115	STAT3_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
116	KPCA_HUMAN	GLI1_HUMAN	kinase -> substrate	KEGG
117	RAF1_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
118	FGR_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
119	ETS1_HUMAN	AP2A_HUMAN	TF -> target gene	TRANSFAC
120	LCK_HUMAN	VDR_HUMAN	kinase -> substrate	Robert H Newman (2013)
121	ETS1_HUMAN	NFKB1_HUMAN	TF -> target gene	TRANSFAC
122	AKT1_HUMAN	NR4A1_HUMAN	kinase -> substrate	HPRD; RegPhos
123	MK08_HUMAN	PPARA_HUMAN	kinase -> substrate	Robert H Newman (2013)
124	MK08_HUMAN	MITF_HUMAN	kinase -> substrate	Robert H Newman (2013)
125	MK08_HUMAN	MYC_HUMAN	kinase -> substrate	RegPhos
126	SHC1_HUMAN	ZAP70_HUMAN	kinase -> substrate	HPRD
127	KPCA_HUMAN	TF65_HUMAN	kinase -> substrate	HPRD
128	KPCA_HUMAN	AHR_HUMAN	kinase -> substrate	Robert H Newman (2013)
129	MK08_HUMAN	PAX2_HUMAN	kinase -> substrate	NetPath
130	DDR2_HUMAN	RET_HUMAN	kinase -> substrate	Robert H Newman (2013)
131	EGFR_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos
132	PDPK1_HUMAN	KS6A1_HUMAN	kinase -> substrate	HPRD; RegPhos
133	LYN_HUMAN	MK03_HUMAN	kinase -> substrate	NetPath
134	AKT1_HUMAN	MTOR_HUMAN	kinase -> substrate	RegPhos
135	LCK_HUMAN	KPCD_HUMAN	kinase -> substrate	RegPhos
136	AKT1_HUMAN	GATA2_HUMAN	kinase -> substrate	HPRD
137	AKT1_HUMAN	SOX9_HUMAN	kinase -> substrate	Robert H Newman (2013)
138	STAT3_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
139	AKT1_HUMAN	KPCD_HUMAN	kinase -> substrate	Robert H Newman (2013)
140	ABL1_HUMAN	JUN_HUMAN	kinase -> substrate	HPRD; RegPhos
141	MK08_HUMAN	JUND_HUMAN	kinase -> substrate	KEGG
142	MK08_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
143	FAK1_HUMAN	MITF_HUMAN	kinase -> substrate	Robert H Newman (2013)
144	KPCI_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
145	KPCA_HUMAN	ATF1_HUMAN	kinase -> substrate	HPRD
146	MK08_HUMAN	ELK1_HUMAN	kinase -> substrate	KEGG; Robert H Newman (2013)
147	IKKB_HUMAN	NFKB1_HUMAN	kinase -> substrate	HPRD; NetPath; Robert H Newman (2013)
148	AKT1_HUMAN	GATA1_HUMAN	kinase -> substrate	HPRD; RegPhos
149	PDPK1_HUMAN	ZAP70_HUMAN	kinase -> substrate	Robert H Newman (2013)
150	YES_HUMAN	TF65_HUMAN	kinase -> substrate	Robert H Newman (2013)
151	RAF1_HUMAN	MP2K1_HUMAN	kinase -> substrate; other	RegPhos; Robert H Newman (2013); KEGG
152	IGF1R_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
153	MK08_HUMAN	ELK3_HUMAN	kinase -> substrate	HPRD; RegPhos
154	KPCA_HUMAN	GSK3A_HUMAN	kinase -> substrate	HPRD
155	ESR1_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
156	KPCA_HUMAN	NFKB1_HUMAN	kinase -> substrate	HPRD
157	FYN_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
158	FAK1_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
159	KPCI_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
160	STAT3_HUMAN	IRF1_HUMAN	TF -> target gene	TRANSFAC
161	AKT1_HUMAN	THA_HUMAN	kinase -> substrate	Robert H Newman (2013)
162	IKKB_HUMAN	TF65_HUMAN	kinase -> substrate	NetPath; Robert H Newman (2013)
163	IKKA_HUMAN	TF65_HUMAN	kinase -> substrate	HPRD; NetPath
164	KPCA_HUMAN	GSK3B_HUMAN	kinase -> substrate	KEGG; HPRD
165	LCK_HUMAN	ZAP70_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)
166	KPCA_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
167	RXRA_HUMAN	RARB_HUMAN	TF -> target gene	TRANSFAC
168	MP2K1_HUMAN	KS6A4_HUMAN	kinase -> substrate	RegPhos
169	CDK5_HUMAN	MEF2D_HUMAN	kinase -> substrate	RegPhos
170	SRF_HUMAN	EGR2_HUMAN	TF -> target gene	TRANSFAC
171	CDK5_HUMAN	MEF2A_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
172	CREB1_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
173	ZAP70_HUMAN	MK14_HUMAN	kinase -> substrate	KEGG; RegPhos; Robert H Newman (2013)
174	KPCD_HUMAN	TWST1_HUMAN	kinase -> substrate	Robert H Newman (2013)
175	GSK3B_HUMAN	CDX2_HUMAN	kinase -> substrate	RegPhos
176	SRF_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
177	CDK5_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
178	CSK21_HUMAN	TF7L2_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
179	CSK21_HUMAN	HMGA1_HUMAN	kinase -> substrate	HPRD
180	FOXO4_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
181	CDK1_HUMAN	CDK7_HUMAN	kinase -> substrate	RegPhos
182	MK07_HUMAN	MEF2D_HUMAN	kinase -> substrate	HPRD
183	MK07_HUMAN	MEF2A_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
184	MYC_HUMAN	CDK4_HUMAN	TF -> target gene	TRANSFAC
185	DYR1B_HUMAN	HNF1A_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
186	CREB1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
187	PTN7_HUMAN	MK14_HUMAN	phosphatase -> substrate	KEGG
188	KPCD_HUMAN	NF2L2_HUMAN	kinase -> substrate	HPRD
189	GSK3A_HUMAN	TF7L2_HUMAN	kinase -> substrate	Robert H Newman (2013)
190	CDK1_HUMAN	E2F1_HUMAN	kinase -> substrate	RegPhos
191	PKN1_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
192	CSK21_HUMAN	MEF2A_HUMAN	kinase -> substrate	Robert H Newman (2013)
193	STK11_HUMAN	SIK3_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
194	M3K11_HUMAN	MP2K7_HUMAN	kinase -> substrate	KEGG
195	JAK1_HUMAN	STAT4_HUMAN	kinase -> substrate	RegPhos
196	CDK1_HUMAN	CUX1_HUMAN	kinase -> substrate	RegPhos
197	CSK21_HUMAN	MYF6_HUMAN	kinase -> substrate	Robert H Newman (2013)
198	STK11_HUMAN	SIK2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
199	DYR1B_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
200	GCR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
201	RET_HUMAN	MK14_HUMAN	kinase -> substrate	HPRD; RegPhos
202	CSK21_HUMAN	NKX25_HUMAN	kinase -> substrate	HPRD
203	CSK21_HUMAN	HIF1A_HUMAN	kinase -> substrate	HPRD
204	NFAC2_HUMAN	EGR3_HUMAN	TF -> target gene	TRANSFAC
205	CSK21_HUMAN	MAZ_HUMAN	kinase -> substrate	HPRD
206	CSK21_HUMAN	MYF5_HUMAN	kinase -> substrate	HPRD
207	STK11_HUMAN	SIK1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
208	PRGR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
209	KS6A1_HUMAN	ESR2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
210	CSK21_HUMAN	APEX1_HUMAN	kinase -> substrate	HPRD
211	MK03_HUMAN	MAZ_HUMAN	kinase -> substrate	Robert H Newman (2013)
212	MTOR_HUMAN	HIF1A_HUMAN	kinase -> substrate	KEGG
213	CDK1_HUMAN	HMGA2_HUMAN	kinase -> substrate	RegPhos
214	CDK1_HUMAN	HMGA1_HUMAN	kinase -> substrate	RegPhos
215	CSK21_HUMAN	EGR1_HUMAN	kinase -> substrate	HPRD
216	FOXO1_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
217	STK11_HUMAN	TFE3_HUMAN	kinase -> substrate	Robert H Newman (2013)
218	ELK1_HUMAN	EGR2_HUMAN	TF -> target gene	TRANSFAC
219	ATF1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
220	AP2A_HUMAN	REL_HUMAN	TF -> target gene	TRANSFAC
221	NR4A1_HUMAN	E2F1_HUMAN	TF -> target gene	TRANSFAC
222	KS6A4_HUMAN	PO6F1_HUMAN	kinase -> substrate	Robert H Newman (2013)
223	MEF2A_HUMAN	MYOG_HUMAN	TF -> target gene	TRANSFAC
224	CDK7_HUMAN	PO2F1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
225	CDK4_HUMAN	PKNX1_HUMAN	kinase -> substrate	Robert H Newman (2013)
226	SIK3_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
227	MP2K7_HUMAN	M3K7_HUMAN	kinase -> substrate	KEGG
228	SIK2_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
229	PRDM1_HUMAN	PAX5_HUMAN	TF -> target gene	TRANSFAC
230	CDK4_HUMAN	FOXN2_HUMAN	kinase -> substrate	Robert H Newman (2013)
231	SIK1_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
232	M3K7_HUMAN	FUBP1_HUMAN	kinase -> substrate	Robert H Newman (2013)
233	M3K7_HUMAN	NLK_HUMAN	kinase -> substrate	KEGG
234	NLK_HUMAN	LEF1_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)

⁺Protein attribute:

protein with cancer-related variations (CanProVar)

up expressed protein;

down expressed protein(dbDEPC)

protein with hyperphosphorylation site (PhosphoSitePlus)

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network