Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PDPK1_HUMAN
Description:3-phosphoinositide dependent protein kinase-1 [Source:HGNC Symbol;Acc:8816]
Location:chr16 p13.3
Node attribute:PPI(target); substrate; kinase; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T513AKNFKtFFVHTPDK-1phosphoELM
Y9TTSQLyDAVPISrcRegPhos
S374GEIPWsQELRPHPRD
Y9TTSQLyDAVPISRCHPRD; phosphoELM; RegPhos
S160LYFGLsYAKNGPkinase; YukCPhosphoSitePlus
T386AKNFKtFFVHTPDPK1HPRD
S25LCSCPsPSMVRPDK1RegPhos
S241QARANsFVGTAPDK1RegPhos
Y9TTSQLyDAVPIRETphosphoELM
S114ATRANsFVGTAPDPK1HPRD
Y485EGPHLyYVDPVPhosphoSitePlus
Y161YFGLSyAKNGEPkinase; YukCPhosphoSitePlus
T513AKNFKtFFVHTPDPK1HPRD
Y486GPHLYyVDPVNPhosphoSitePlus
S394SSSSSsHSLSAPhosphoSitePlus
T245NSFVGtAQYVSHPRD; phosphoELM; RegPhos
T37QTESStPPGIPPhosphoSitePlus; HPRD; phosphoELM
T245NSFVGtAQYVSPkinasePhosphoSitePlus
S234VLSPEsKQARAPkinase; YukCPhosphoSitePlus
T33MVRTQtESSTPPDK1RegPhos
S410PQRSGsNIEQYPDK1RegPhos
T118NSFVGtAQYVSHPRD
S396SSSSHsLSASDPDK-1phosphoELM
S241QARANsFVGTAPkinase; YukCPhosphoSitePlus
T148VKLYFtFQDDEPkinase; YukCPhosphoSitePlus
S501GEIPWsQELRPPhosphoSitePlus; HPRD
Y126ENKVPyVTRERPkinase; YukCPhosphoSitePlus
S231TAKVLsPESKQPkinase; YukCPhosphoSitePlus
S266VSSSSsSHSLSHPRD
S241QARANsFVGTAautocatalysisRegPhos
S114ATRANsFVGTAHPRD
Y485EGPHLyYVDPVSRCHPRD; RegPhos
T513AKNFKtFFVHTPDK1RegPhos
S269SSSSHsLSASDHPRD
S283PQRSGsNIEQYHPRD
S241QARANsFVGTAPDPK1HPRD
Y358EGPHLyYVDPVSRCHPRD
Y248VGTAQyVSPELPkinasePhosphoSitePlus
Y376DCYGNyDNLLSSRCphosphoELM
S393VSSSSsSHSLSPDK1RegPhos
S396SSSSHsLSASDPDK1RegPhos
S22SVVLCsCPSPSPhosphoSitePlus
Y376DCYGNyDNLLSSrcRegPhos
Y373DDEDCyGNYDNSRCHPRD; phosphoELM; RegPhos
S410PQRSGsNIEQYPhosphoSitePlus; HPRD; RegPhos
S398SSHSLsASDTGPhosphoSitePlus
Y373DDEDCyGNYDNPhosphoSitePlus; phosphoELM; RegPhos
S25LCSCPsPSMVRPDK-1phosphoELM
S241QARANsFVGTAHPRD; phosphoELM; RegPhos
T513AKNFKtFFVHTPhosphoSitePlus
S393VSSSSsSHSLSPhosphoSitePlus; HPRD; RegPhos
Y376DCYGNyDNLLSPhosphoSitePlus; phosphoELM; RegPhos
S366YLPAMsEDDEDPhosphoSitePlus
S393VSSSSsSHSLSPDK-1phosphoELM
T255SPELLtEKSACPkinasePhosphoSitePlus
S410PQRSGsNIEQYPDK-1phosphoELM
S396SSSSHsLSASDPhosphoSitePlus; HPRD; RegPhos
S241QARANsFVGTAPDK-1phosphoELM
Y246DDEDCyGNYDNSRCHPRD
S25LCSCPsPSMVRPhosphoSitePlus; HPRD; RegPhos
S176IRKIGsFDETCPkinase; YukCPhosphoSitePlus
Y373DDEDCyGNYDNSrcRegPhos
Y9TTSQLyDAVPIRetRegPhos
T354NLHQQtPPKLTPhosphoSitePlus
T33MVRTQtESSTPPDPK1HPRD
Y288RAGNEyLIFQKPkinasePhosphoSitePlus
Y9TTSQLyDAVPIPhosphoSitePlus; phosphoELM; RegPhos

Dephosphorylation site
PDPK1_HUMAN do not have dephosphorylation site.

Mutation site
PDPK1_HUMAN do not have mutation site.

Differential expressed protein
PDPK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PDPK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PDPK1_HUMANZBT16_HUMANkinase -> substrateRegPhos
PDPK1_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANPDPK1_HUMANkinase -> substrateRegPhos
PDPK1_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANPDLI5_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANVIGLN_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANPDPK1_HUMANkinase -> substrateRegPhos
PDPK1_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANEF1D_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANIF4H_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANVGFR1_HUMANkinase -> substrateRobert H Newman (2013)
ILK_HUMANPDPK1_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANAKT3_HUMANkinase -> substrateKEGG; HPRD; RegPhos
PDPK1_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANAKT1_HUMANkinase -> substrateRegPhos; NetPath
PDPK1_HUMANMLX_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANSGK3_HUMANkinase -> substrateRegPhos
PDPK1_HUMANKPCZ_HUMANkinase -> substrateHPRD; RegPhos
PDPK1_HUMANPKN2_HUMANkinase -> substrateRegPhos
PDPK1_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANSGK1_HUMANkinase -> substrateRegPhos
PDPK1_HUMANM3K5_HUMANkinase -> substrateRegPhos
SRC_HUMANPDPK1_HUMANkinase -> substrateRegPhos
PDPK1_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANTB22A_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANMP2K1_HUMANkinase -> substrateRegPhos
PDPK1_HUMANSMAD7_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANNIPBL_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANKPCD_HUMANkinase -> substrateHPRD; RegPhos
PDPK1_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
RET_HUMANPDPK1_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANPKN1_HUMANkinase -> substrateRegPhos
PDPK1_HUMANKPCE_HUMANkinase -> substrateHPRD; RegPhos
PDPK1_HUMANASCC1_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANRFA1_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANAKT2_HUMANkinase -> substrateRegPhos
PDPK1_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANBMX_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANSGK2_HUMANkinase -> substrateRegPhos
PDPK1_HUMANODPA_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
PDK1_HUMANPDPK1_HUMANkinase -> substrateRegPhos
PDPK1_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANMP2K2_HUMANkinase -> substrateRegPhos
PDPK1_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANKS6B2_HUMANkinase -> substrateRegPhos
PDPK1_HUMANITB3_HUMANkinase -> substrateRegPhos
PDPK1_HUMANMK07_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANKS6B1_HUMANkinase -> substrateRegPhos
PDPK1_HUMANTAU_HUMANkinase -> substrateRegPhos
PDPK1_HUMANNOC2L_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANKS6A1_HUMANkinase -> substrateHPRD; RegPhos
PI3R5_HUMANPDPK1_HUMANotherKEGG
PDPK1_HUMANAKT3_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05213Endometrial cancer
hsa04960Aldosterone-regulated sodium reabsorption
hsa04510Focal adhesion
hsa04910Insulin signaling pathway
hsa05223Non-small cell lung cancer
hsa05215Prostate cancer
hsa03320PPAR signaling pathway
hsa04150mTOR signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006468protein phosphorylationIDAbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0016301kinase activityEXPmolecular_function
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0032148activation of protein kinase B activityIDAbiological_process
GO:0030036actin cytoskeleton organizationTASbiological_process
GO:0043304regulation of mast cell degranulationIEAbiological_process
GO:0006972hyperosmotic responseIEAbiological_process
GO:0034122negative regulation of toll-like receptor signalinIEAbiological_process
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0010594regulation of endothelial cell migrationIEAbiological_process
GO:0035556intracellular signal transductionIDAbiological_process
GO:0042981regulation of apoptotic processIMPbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0090004positive regulation of establishment of protein loIMPbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0048041focal adhesion assemblyIEAbiological_process
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:00046763-phosphoinositide-dependent protein kinase activiIDAmolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0016023cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0043122regulation of I-kappaB kinase/NF-kappaB cascadeIMPbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0003323type B pancreatic cell developmentIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0010667negative regulation of cardiac muscle cell apoptotIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0032869cellular response to insulin stimulusIMPbiological_process
GO:0018107peptidyl-threonine phosphorylationIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0030168platelet activationTASbiological_process
GO:0005829cytosolIEAcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0046777protein autophosphorylationTASbiological_process
GO:00046763-phosphoinositide-dependent protein kinase activiIEAmolecular_function
GO:0005158insulin receptor bindingIEAmolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0030512negative regulation of transforming growth factor IDAbiological_process
GO:0006469negative regulation of protein kinase activityIDAbiological_process
GO:0005925focal adhesionIEAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function