Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RAC1_HUMAN
Description:ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [Source:HGNC Symbol;Acc:9801]
Location:chr7 p22.1
Node attribute:PPI(source); substrate; kinase; effector; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y64AGQEDyDRLRPRasPhosphoSitePlus
S71RLRPLsYPQTDphosphoELM
S71RLRPLsYPQTDAKT_groupRegPhos
S71RLRPLsYPQTDRasPhosphoSitePlus
S89LVSPAsFENVRRasPhosphoSitePlus
S71RLRPLsYPQTDPKB_groupphosphoELM
T167QRGLKtVFDEAphosphoELM
T167QRGLKtVFDEARasPhosphoSitePlus
S71RLRPLsYPQTDAKT1HPRD; RegPhos
T161ECSALtQRGLKRasPhosphoSitePlus
S71RLRPLsYPQTVAKT1HPRD
Y32AFPGEyIPTVFRasPhosphoSitePlus

Dephosphorylation site
RAC1_HUMAN do not have dephosphorylation site.

Mutation site
RAC1_HUMAN do not have mutation site.

Differential expressed protein
RAC1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RAC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG11_HUMANRAC1_HUMANGprotein -> effectorgpDB
GBG3_HUMANRAC1_HUMANGprotein -> effectorgpDB
GNAI1_HUMANRAC1_HUMANGprotein -> effectorgpDB
GBG5_HUMANRAC1_HUMANGprotein -> effectorgpDB
GNAI3_HUMANRAC1_HUMANGprotein -> effectorgpDB
GBG12_HUMANRAC1_HUMANGprotein -> effectorgpDB
GBB3_HUMANRAC1_HUMANGprotein -> effectorgpDB
GBG13_HUMANRAC1_HUMANGprotein -> effectorgpDB
GBG1_HUMANRAC1_HUMANGprotein -> effectorgpDB
GBB1_HUMANRAC1_HUMANGprotein -> effectorgpDB
GBB5_HUMANRAC1_HUMANGprotein -> effectorgpDB
GBG10_HUMANRAC1_HUMANGprotein -> effectorgpDB
GBB2_HUMANRAC1_HUMANGprotein -> effectorgpDB
GBG8_HUMANRAC1_HUMANGprotein -> effectorgpDB
GNAI2_HUMANRAC1_HUMANGprotein -> effectorgpDB
GBG2_HUMANRAC1_HUMANGprotein -> effectorgpDB
RAC1_HUMANMK08_HUMANkinase -> substrateKEGG
AKT1_HUMANRAC1_HUMANkinase -> substrateHPRD; RegPhos
RAC1_HUMANMP2K7_HUMANotherKEGG
RAC1_HUMANMK08_HUMANotherKEGG
DVL1_HUMANRAC1_HUMANotherKEGG
PI3R5_HUMANRAC1_HUMANotherKEGG
ARHG7_HUMANRAC1_HUMANotherKEGG
RHOA_HUMANRAC1_HUMANotherKEGG
RAC1_HUMANACTG_HUMANotherKEGG
ARHG4_HUMANRAC1_HUMANotherKEGG
CDC42_HUMANRAC1_HUMANotherKEGG
GBG12_HUMANRAC1_HUMANotherKEGG
RAC1_HUMANCDC42_HUMANotherKEGG
RAC1_HUMANBAIP2_HUMANotherKEGG
ARHG6_HUMANRAC1_HUMANotherKEGG
TLR2_HUMANRAC1_HUMANotherKEGG
RAC1_HUMANMP2K3_HUMANotherKEGG
RAC1_HUMANPKN1_HUMANotherKEGG
DOCK1_HUMANRAC1_HUMANotherKEGG
DAPP1_HUMANRAC1_HUMANotherKEGG
RAC1_HUMANM3K1_HUMANotherKEGG
RAC1_HUMANRAC1_HUMANotherKEGG
RAC1_HUMANPI3R5_HUMANotherKEGG
VAV3_HUMANRAC1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04650Natural killer cell mediated cytotoxicity
hsa05100Bacterial invasion of epithelial cells
hsa05210Colorectal cancer
hsa04662B cell receptor signaling pathway
hsa04360Axon guidance
hsa04062Chemokine signaling pathway
hsa05416Viral myocarditis
hsa04664Fc epsilon RI signaling pathway
hsa05131Shigellosis
hsa05200Pathways in cancer
hsa05132Salmonella infection
hsa04666Fc gamma R-mediated phagocytosis
hsa04010MAPK signaling pathway
hsa04670Leukocyte transendothelial migration
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05212Pancreatic cancer
hsa04380Osteoclast differentiation
hsa04310Wnt signaling pathway
hsa05211Renal cell carcinoma
hsa05203Viral carcinogenesis
hsa04145Phagosome
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa04520Adherens junction
hsa04510Focal adhesion
hsa04972Pancreatic secretion
hsa04810Regulation of actin cytoskeleton
hsa04370VEGF signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa04722Neurotrophin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIEAcellular_component
GO:0008283cell proliferationIEAbiological_process
GO:0016032viral reproductionTASbiological_process
GO:0016023cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0006928cellular component movementIEAbiological_process
GO:0002551mast cell chemotaxisIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0005622intracellularIEAcellular_component
GO:0042470melanosomeIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0021799cerebral cortex radially oriented cell migrationIEAbiological_process
GO:0030041actin filament polymerizationTASbiological_process
GO:0045216cell-cell junction organizationIEAbiological_process
GO:0007160cell-matrix adhesionNASbiological_process
GO:0030334regulation of cell migrationIMPbiological_process
GO:0031529ruffle organizationIDAbiological_process
GO:0035025positive regulation of Rho protein signal transducTASbiological_process
GO:0043552positive regulation of phosphatidylinositol 3-kinaIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0001891phagocytic cupIEAcellular_component
GO:0034446substrate adhesion-dependent cell spreadingIEAbiological_process
GO:0060071Wnt receptor signaling pathway, planar cell polariIEAbiological_process
GO:0030032lamellipodium assemblyIMPbiological_process
GO:0003924GTPase activityIEAmolecular_function
GO:0003382epithelial cell morphogenesisIEAbiological_process
GO:0005525GTP bindingIDAmolecular_function
GO:0030036actin cytoskeleton organizationIEAbiological_process
GO:0007411axon guidanceIEAbiological_process
GO:0032707negative regulation of interleukin-23 productionIDAbiological_process
GO:0010310regulation of hydrogen peroxide metabolic processTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0006928cellular component movementTASbiological_process
GO:0031410cytoplasmic vesicleIEAcellular_component
GO:0006972hyperosmotic responseIEAbiological_process
GO:0006184GTP catabolic processIEAbiological_process
GO:0006935chemotaxisIEAbiological_process
GO:0002093auditory receptor cell morphogenesisIEAbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0010592positive regulation of lamellipodium assemblyIDAbiological_process
GO:0030742GTP-dependent protein bindingIEAmolecular_function
GO:0007264small GTPase mediated signal transductionIEAbiological_process
GO:0030036actin cytoskeleton organizationIGIbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0019897extrinsic to plasma membraneIEAcellular_component
GO:0043652engulfment of apoptotic cellIEAbiological_process
GO:0071542dopaminergic neuron differentiationIEAbiological_process
GO:0035556intracellular signal transductionTASbiological_process
GO:0006911phagocytosis, engulfmentIEAbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0007155cell adhesionTASbiological_process
GO:0090103cochlea morphogenesisIEAbiological_process
GO:0048813dendrite morphogenesisIEAbiological_process
GO:0016358dendrite developmentIEAbiological_process
GO:0006897endocytosisIEAbiological_process
GO:0005525GTP bindingIEAmolecular_function
GO:0000139Golgi membraneIEAcellular_component
GO:0005802trans-Golgi networkIDAcellular_component
GO:0042995cell projectionIEAcellular_component
GO:0097178ruffle assemblyIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0009611response to woundingTASbiological_process
GO:0007155cell adhesionIEAbiological_process
GO:0032587ruffle membraneIEAcellular_component
GO:0048870cell motilityIDAbiological_process
GO:0007015actin filament organizationIEAbiological_process
GO:0031996thioesterase bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0017137Rab GTPase bindingIEAmolecular_function
GO:0007010cytoskeleton organizationIEAbiological_process
GO:0045740positive regulation of DNA replicationIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0048532anatomical structure arrangementIEAbiological_process
GO:0051668localization within membraneIMPbiological_process
GO:0030838positive regulation of actin filament polymerizatiIEAbiological_process
GO:0021831embryonic olfactory bulb interneuron precursor migIEAbiological_process
GO:0003924GTPase activityTASmolecular_function
GO:0048261negative regulation of receptor-mediated endocytosTASbiological_process
GO:0016477cell migrationIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0009653anatomical structure morphogenesisTASbiological_process
GO:0060263regulation of respiratory burstIDAbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0030334regulation of cell migrationIEAbiological_process
GO:0015031protein transportIEAbiological_process
GO:0045453bone resorptionIEAbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0030168platelet activationTASbiological_process
GO:0030027lamellipodiumIEAcellular_component
GO:0050690regulation of defense response to virus by virusTASbiological_process