Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IKKA_HUMAN
Description:conserved helix-loop-helix ubiquitous kinase [Source:HGNC Symbol;Acc:1974]
Location:chr10 q24.31
Node attribute:PPI(target); substrate; kinase; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S180GSLCTsFVGTLNIKRegPhos
T23RERLGtGGFGNAKT1(PKBRegPhos
S176DVDQGsLCTSFMAP3K14HPRD
T23RERLGtGGFGNAKT_groupRegPhos
Y500SEQMTyGISSEPhosphoSitePlus
S180GSLCTsFVGTLMAP3K14HPRD
T23RERLGtGGFGNPKB_groupphosphoELM
S176DVDQGsLCTSFPRKCQHPRD
T23RERLGtGGFGNAKT1HPRD; RegPhos
T23RERLGtGGFGNAKT2HPRD; RegPhos
S176DVDQGsLCTSFPkinasePhosphoSitePlus
S176DVDQGsLCTSFNIKRegPhos
T463YNANLtKMKNTPhosphoSitePlus
S176DVDQGsLCTSFNIK(MAP3K14RegPhos
S180GSLCTsFVGTLPRKCQHPRD
S180GSLCTsFVGTLPkinasePhosphoSitePlus
S176DVDQGsLCTSFPKCtRegPhos
T23RERLGtGGFGNPkinasePhosphoSitePlus
S180GSLCTsFVGTLPKCtRegPhos
S473TLISAsQQLKAPhosphoSitePlus

Dephosphorylation site
IKKA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000359424R133*Greenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000359424R143*Greenman2007Lung Cancer16140923, 17344846, 18428421
ENSP00000359424R133*Greenman2007Intestines Cancer16618716, 17344846, 18428421
ENSP00000359424R133*Greenman2007Neoplasms by Histologic Type16618716, 17344846, 18428421

Differential expressed protein
IKKA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IKKA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M3K7_HUMANIKKA_HUMANkinase -> substrateKEGG
M3K1_HUMANIKKA_HUMANkinase -> substrateKEGG
AKT1_HUMANIKKA_HUMANkinase -> substrateHPRD; RegPhos; NetPath
IKKA_HUMANIKBB_HUMANkinase -> substrateHPRD; NetPath
AKT2_HUMANIKKA_HUMANkinase -> substrateHPRD; RegPhos; NetPath
KPCT_HUMANIKKA_HUMANkinase -> substrateHPRD
IKKA_HUMANTAXB1_HUMANkinase -> substrateNetPath
IKKA_HUMANIKBA_HUMANkinase -> substrateNetPath
M4K4_HUMANIKKA_HUMANkinase -> substrateRegPhos
M3K14_HUMANIKKA_HUMANkinase -> substrateNetPath
SRC_HUMANIKKA_HUMANkinase -> substrateNetPath
IKKA_HUMANTF65_HUMANkinase -> substrateHPRD; NetPath
IKKA_HUMANIRS1_HUMANkinase -> substrateKEGG
IKKA_HUMANNCOA3_HUMANkinase -> substrateHPRD
IKKA_HUMANNFKB1_HUMANkinase -> substrateHPRD; NetPath
M3K8_HUMANIKKA_HUMANkinase -> substrateKEGG
IKKA_HUMANIKKB_HUMANkinase -> substrateHPRD
KPCB_HUMANIKKA_HUMANkinase -> substrateNetPath
IKKA_HUMANIRF7_HUMANkinase -> substrateKEGG
IKKA_HUMANPIAS1_HUMANkinase -> substrateHPRD; NetPath
IKKA_HUMANRGRF1_HUMANotherKEGG
IKKA_HUMANNFKB1_HUMANotherKEGG
KPCT_HUMANIKKA_HUMANotherKEGG
TRAF2_HUMANIKKA_HUMANotherKEGG
IKKA_HUMANGRP1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05162Measles
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa05215Prostate cancer
hsa05222Small cell lung cancer
hsa04620Toll-like receptor signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa04380Osteoclast differentiation
hsa04210Apoptosis
hsa04622RIG-I-like receptor signaling pathway
hsa05168Herpes simplex infection
hsa05220Chronic myeloid leukemia
hsa05160Hepatitis C
hsa04623Cytosolic DNA-sensing pathway
hsa05200Pathways in cancer
hsa05166HTLV-I infection
hsa04064NF-kappa B signaling pathway
hsa05212Pancreatic cancer
hsa05145Toxoplasmosis
hsa04062Chemokine signaling pathway
hsa04920Adipocytokine signaling pathway
hsa05131Shigellosis
hsa04010MAPK signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa05169Epstein-Barr virus infection
hsa05221Acute myeloid leukemia

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004672protein kinase activityIDAmolecular_function
GO:0035872nucleotide-binding domain, leucine rich repeat conTASbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0043231intracellular membrane-bounded organelleIEAcellular_component
GO:0032481positive regulation of type I interferon productioTASbiological_process
GO:0008385IkappaB kinase complexTAScellular_component
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0008063Toll signaling pathwayTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEAbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cTASbiological_process
GO:0001101response to acidIEAbiological_process
GO:0010033response to organic substanceIEAbiological_process
GO:0042475odontogenesis of dentin-containing toothIEAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0007252I-kappaB phosphorylationTASbiological_process
GO:0033194response to hydroperoxideIEAbiological_process
GO:0009898internal side of plasma membraneISScellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0007595lactationIEAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0007249I-kappaB kinase/NF-kappaB cascadeTASbiological_process
GO:0033598mammary gland epithelial cell proliferationIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0006955immune responseTASbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0008384IkappaB kinase activityTASmolecular_function
GO:0043200response to amino acid stimulusIEAbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0003009skeletal muscle contractionIEAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0009636response to toxinIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0051146striated muscle cell differentiationIEAbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0060749mammary gland alveolus developmentIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0002011morphogenesis of an epithelial sheetIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0030316osteoclast differentiationIEAbiological_process
GO:0007266Rho protein signal transductionIEAbiological_process
GO:0009615response to virusTASbiological_process
GO:0035631CD40 receptor complexISScellular_component
GO:0009653anatomical structure morphogenesisTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0051092positive regulation of NF-kappaB transcription facTASbiological_process
GO:0070423nucleotide-binding oligomerization domain containiTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045087innate immune responseTASbiological_process
GO:0008385IkappaB kinase complexIEAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function