| UniProt/SwissProt ID: | MK15_HUMAN |
| Description: | mitogen-activated protein kinase 15 [Source:HGNC Symbol;Acc:24667] |
| Location: | chr8 q24.3 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y177 | QAVTEyVATRW | CSK | HPRD; RegPhos |
| Y177 | QAVTEyVATRW | Pkinase | PhosphoSitePlus |
| T175 | EDQAVtEYVAT | Erk7 | RegPhos |
| S192 | EVLLSsHRYTL | Pkinase | PhosphoSitePlus |
| T175 | EDQAVtEYVAT | MAPK15 | HPRD |
| S362 | GPEGVsPSQAH | PhosphoSitePlus | |
| T175 | EDQAVtEYVAT | Pkinase | PhosphoSitePlus |
| Y340 | YRSRVyQMILE | PhosphoSitePlus | |
| S415 | VPRQNsAPLLQ | PhosphoSitePlus | |
| T352 | GGSSGtSREKG | PhosphoSitePlus | |
| Y177 | QAVTEyVATRW | RegPhos | |
| S379 | DPQLPsRTPVQ | PhosphoSitePlus | |
| T175 | EDQAVtEYVAT | RegPhos | |
| S331 | EGVQLsVPEYR | PhosphoSitePlus | |
| Y177 | QAVTEyVATRW | Erk7 | RegPhos |
| Y177 | QAVTEyVATRW | MAPK15 | HPRD |
| T381 | QLPSRtPVQGP | PhosphoSitePlus | |
| T175 | EDQAVtEYVAT | CSK | HPRD; RegPhos |
| Dephosphorylation site |
| MK15_HUMAN do not have dephosphorylation site. |
| Mutation site |
| MK15_HUMAN do not have mutation site. |
| Differential expressed protein |
| MK15_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MK15_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | MK15_HUMAN | kinase -> substrate | RegPhos |
| CSK_HUMAN | MK15_HUMAN | kinase -> substrate | RegPhos |
| MK15_HUMAN | FGR_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK15_HUMAN | ETS1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK15_HUMAN | RET_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK15_HUMAN | MK15_HUMAN | kinase -> substrate | HPRD |
| MK15_HUMAN | CBL_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK15_HUMAN | CSN6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| MK15_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA poly | IEA | biological_process |
| GO:0000165 | MAPK cascade | IDA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0032355 | response to estradiol stimulus | IEA | biological_process |
| GO:0008156 | negative regulation of DNA replication | IEA | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0001934 | positive regulation of protein phosphorylation | IEA | biological_process |
| GO:0046777 | protein autophosphorylation | IDA | biological_process |
| GO:0031398 | positive regulation of protein ubiquitination | IEA | biological_process |
| GO:0017124 | SH3 domain binding | NAS | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005622 | intracellular | NAS | cellular_component |
| GO:0005576 | extracellular region | NAS | cellular_component |
| GO:0004707 | MAP kinase activity | IDA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0045732 | positive regulation of protein catabolic process | IEA | biological_process |