Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RHG35_HUMAN
Description:Rho GTPase activating protein 35 [Source:HGNC Symbol;Acc:4591]
Location:chr19 q13.32
Node attribute:PPI(source); substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1057TKGDLsYLDQGPhosphoSitePlus
T1173FASYRtSFSVGPhosphoSitePlus; HPRD; phosphoELM
Y1104NEEENiYSVPHHPRD
S1491QPLLPsQLQAEHPRD
S1153KVSIVsKPVLYPhosphoSitePlus
T771NLVSStASIKDPhosphoSitePlus
S1179SFSVGsDDELGPhosphoSitePlus; HPRD; phosphoELM
S667LCLYNsKESLSPhosphoSitePlus
S1150RGRKVsIVSKPPhosphoSitePlus; HPRD; phosphoELM
S1085DGFDPsDYAEPPhosphoSitePlus
T1226SLRRNtKKPKPPhosphoSitePlus
Y1105EEENIySVPHDSRCHPRD; phosphoELM
T1140DSEMDtSSLERPhosphoSitePlus; HPRD; phosphoELM
Y1087FDPSDyAEPMDPhosphoSitePlus; HPRD; phosphoELM
S1221RNILRsLRRNTPhosphoSitePlus
S1134GSGNGsDSEMDPhosphoSitePlus; HPRD; phosphoELM
T963AEACStTEEVFPhosphoSitePlus; HPRD; phosphoELM
S575IEHLIsSRFIRPhosphoSitePlus
S1074KSVSSsPWLPQPhosphoSitePlus; HPRD; phosphoELM
S1072QRKSVsSSPWLPhosphoSitePlus; HPRD; phosphoELM
S773VSSTAsIKDLAPhosphoSitePlus
S1106EENIYsVPHDSPhosphoSitePlus
T1480QSPPPtPQSPMHPRD
S1141SEMDTsSLERGHPRD; phosphoELM
S591QKNSLsDPNIDHPRD
Y1207NAVIPyETDEDPhosphoSitePlus
S46RFVRPsADEFHPhosphoSitePlus
S1111SVPHDsTQGKIPhosphoSitePlus
S1001FREDTsLPSLSPhosphoSitePlus
S589RNQKNsLSDPNPhosphoSitePlus; HPRD; phosphoELM
S1236PKPRPsITKATPhosphoSitePlus
S980SPLCNsNLQDSHPRD; phosphoELM
S1476PSPPQsPPPTPHPRD
S985SNLQDsEEDIEPhosphoSitePlus; HPRD; phosphoELM
S1174ASYRTsFSVGSPhosphoSitePlus
S970EEVFNsPRAGSPhosphoSitePlus; HPRD; phosphoELM
S1073RKSVSsSPWLPHPRD; phosphoELM
Y209EGVERyIRDAHRasPhosphoSitePlus
S1195EEDQAsQGYKGPhosphoSitePlus; HPRD; phosphoELM
S1130AQSNGsGNGSDPhosphoSitePlus
S182QLKFVsNLYNQHPRD
S576EHLISsRFIRPPhosphoSitePlus
S1127INKAQsNGSGNPhosphoSitePlus; HPRD; phosphoELM
S1070DGQRKsVSSSPPhosphoSitePlus; HPRD; phosphoELM
S975SPRAGsPLCNSPhosphoSitePlus; HPRD; phosphoELM
Y855RLVHGyIVFYSPhosphoSitePlus
S1450PGARPsSPSAVHPRD
S1142EMDTSsLERGRPhosphoSitePlus
T685KSREStLGRRDHPRD; phosphoELM
Y1198QASQGyKGDNAPhosphoSitePlus
T1112VPHDStQGKIIPhosphoSitePlus
Y1105EEENIySVPHDPhosphoSitePlus; phosphoELM
Y1158SKPVLyRTRCTHPRD

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1105RNEEENIySVPHDSTPTPRZ1HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000385720W452*TCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000385720L671QTCGAOvarian Cancer21720365, 18772890
ENSP00000385720S752ITCGAOvarian Cancer21720365, 18772890
ENSP00000385720E1102QBIOMARTBreast Cancer21930507, 21930502
ENSP00000385720I210VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000385720*1500WCOSMICHepatocellular Carcinoma
ENSP00000385720Q586*TCGAOvarian Cancer21720365, 18772890
ENSP00000385720S985*TCGAOvarian Cancer21720365, 18772890

Differential expressed protein
RHG35_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RHG35_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANRHG35_HUMANkinase -> substrateRegPhos
SRC_HUMANRHG35_HUMANkinase -> substrateKEGG; HPRD; RegPhos
PTPRZ_HUMANRHG35_HUMANphosphatase -> substrateHPRD
RHG35_HUMANRHOA_HUMANotherKEGG
RHG35_HUMANGCR_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa04510Focal adhesion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043116negative regulation of vascular permeabilityIEAbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0015629actin cytoskeletonIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0005634nucleusICcellular_component
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0032321positive regulation of Rho GTPase activityTASbiological_process
GO:0043010camera-type eye developmentIEAbiological_process
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0003714transcription corepressor activityTASmolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0030900forebrain developmentIEAbiological_process
GO:0001843neural tube closureIEAbiological_process
GO:0008360regulation of cell shapeIEAbiological_process
GO:0005100Rho GTPase activator activityTASmolecular_function
GO:0005829cytosolTAScellular_component
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0005622intracellularIEAcellular_component


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