Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GTF2I_HUMAN
Description:general transcription factor IIi [Source:HGNC Symbol;Acc:4659]
Location:chr7 q11.23
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S656PRSPGsNSKVPHPRD
Y879FKAPSyLEISSHPRD
S820IKESTsSKSPPPhosphoSitePlus
S689TQTNGsNVPFKHPRD
Y318IEDDDySPPSKSrcRegPhos
S690TQTNGsNVPFKHPRD
S784PFRRPsTFGIPPRKG1HPRD
S207TDADRsILSPGPhosphoSitePlus; HPRD; phosphoELM
Y611ELVISyLPPGMSRCHPRD
T836SPNVNtTASGVPhosphoSitePlus
S620GIPFRsPTWFGGTF2IPhosphoSitePlus
S803STSSKsPPRKIHPRD
Y318IEDDDySPPSKphosphoELM
Y249EDPDYyQYNIQPhosphoSitePlus
S638SPGSNsKVPEIHPRD
S391PFRRPsTYGIPPRKG1HPRD
S763PFRRPsTFGIPPRKG1HPRD
Y652ELVISyLPPGMSRCHPRD; RegPhos
S210DRSILsPGGSCPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S884YLEISsMRRILHPRD
T646PEIEVtVEGPNHPRD
S904YLEISsMRRILHPRD
S476PFRSPsWYGIPHPRD
T809NIIQVtIPDDDHPRD
S743PFRRPsTFGIPPRKG1HPRD
Y462HPNDLyVEGLPBTKHPRD
Y378HVEDLyVEGLPBTKHPRD
T413FRRPStYGIPRGTF2IPhosphoSitePlus
S669TQTNGsNVPFKHPRD
T667PEIEVtVEGPNHPRD
T677NNNPQtSAVRTHPRD
S674PKRPRsPGSNSPhosphoSitePlus; HPRD; RegPhos
S699NNPQTsAVRTPPhosphoSitePlus; HPRD; phosphoELM
S810PRKINsSPNVNHPRD
S392YPLFQsHVEDLPKG1RegPhos
S925YLEISsMRRILGTF2IPhosphoSitePlus
Y503HPNDLyVEGLPBTKHPRD; phosphoELM; RegPhos
S515NIPFRsPSWYGGTF2IPhosphoSitePlus
T537QPRTNtPVKEDHPRD
Y920FKAPSyLEISSHPRD
Y398HVEDLyVEGLPGTF2IPhosphoSitePlus
S790RKINSsPNVNTHPRD
T785FRRPStFGIPRGTF2IPhosphoSitePlus
S856VNDLFsRKFGEHPRD
S764PFRRPsTFGIPPRKG1HPRD
S412PFRRPsTYGIPPKG1RegPhos
T796PNVNTtASGVEHPRD
T817PNVNTtASGVEHPRD
T850NIIQVtIPDDDHPRD; phosphoELM
S710TQTNGsNVPFKHPRD
S659PPGMAsKINTKPhosphoSitePlus
S877VNDLFsRKFGEGTF2IPhosphoSitePlus
S782STSSKsPPRKIHPRD
T687PEIEVtVEGPNPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S798VNTTAsGVEDLHPRD
T829NIIQVtIPDDDHPRD
S857VNDLFsRKFGEHPRD
T538QPRTNtPVKEDHPRD
S95MHKMKsTTQANHPRD
Y519RSPSWyGIPRLGTF2IPhosphoSitePlus
S784PFRRPsTFGIPGTF2IPhosphoSitePlus
S830PRKINsSPNVNPhosphoSitePlus; HPRD; phosphoELM
Y248SEDPDyYQYNIJAK2HPRD; RegPhos
S839VNTTAsGVEDLPhosphoSitePlus; HPRD; phosphoELM
Y248SEDPDyYQYNIPhosphoSitePlus; phosphoELM
Y460VKEEWyARITKPhosphoSitePlus
S678NNPQTsAVRTPHPRD
S809PRKINsSPNVNHPRD
S654PKRPRsPGSNSHPRD
T657NNNPQtSAVRTHPRD
S823STSSKsPPRKIPhosphoSitePlus; HPRD; RegPhos
Y357HVEDLyVEGLPBTKHPRD
S764FALFEsFPEDFPKG1RegPhos
S811RKINSsPNVNTHPRD
S474NIPFRsPSWYGHPRD
S818TAIKEsTSSKSPhosphoSitePlus
Y770FPEDFyVEGLPGTF2IPhosphoSitePlus
S818VNTTAsGVEDLHPRD
T837PNVNTtASGVEPhosphoSitePlus; HPRD
S668TKALQsPKRPRPhosphoSitePlus; HPRD; RegPhos
Y503HPNDLyVEGLPGTF2IPhosphoSitePlus
Y920FKAPSyLEISSGTF2IPhosphoSitePlus
Y398HVEDLyVEGLPBTKHPRD; phosphoELM; RegPhos
T556VTQPRtNTPVKPhosphoSitePlus; HPRD; phosphoELM
S103QANRMsVDAVEPhosphoSitePlus; HPRD; phosphoELM
S802STSSKsPPRKIHPRD
Y482HPNDLyVEGLPBTKHPRD
S925YLEISsMRRILHPRD
T517QPRTNtPVKEDHPRD
S659SPGSNsKVPEIHPRD
S494NIPFRsPSWYGHPRD
T238EMAAVtVKEESPhosphoSitePlus
S636PRSPGsNSKVPHPRD
S648TKALQsPKRPRHPRD
S722RGREFsFEAWNPhosphoSitePlus
Y248SEDPDyYQYNISRCHPRD; RegPhos
S214LSPGGsCGPIKPhosphoSitePlus
T705AVRTPtQTNGSPhosphoSitePlus
S657PRSPGsNSKVPHPRD
S412PFRRPsTYGIPGTF2IPhosphoSitePlus
S517PFRSPsWYGIPHPRD; phosphoELM; RegPhos
S784PFRRPsTFGIPPKG1RegPhos
S677PRSPGsNSKVPPhosphoSitePlus; HPRD; phosphoELM
T515VTQPRtNTPVKHPRD
Y900FKAPSyLEISSHPRD
T536VTQPRtNTPVKHPRD
S905YLEISsMRRILHPRD
S497PFRSPsWYGIPHPRD
T111AVEIEtLRKTVHPRD
S679NNPQTsAVRTPHPRD
S821KESTSsKSPPRPhosphoSitePlus
T816PNVNTtASGVEHPRD
S278EDDDYsPPSKRHPRD
Y318IEDDDySPPSKBTKRegPhos
S496PFRSPsWYGIPHPRD
T535VTQPRtNTPVKHPRD
T558QPRTNtPVKEDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S627TKALQsPKRPRHPRD
T663ASKINtKALQSPhosphoSitePlus
Y377HVEDLyVEGLPBTKHPRD
T678NNNPQtSAVRTHPRD
S819VNTTAsGVEDLHPRD
S495NIPFRsPSWYGHPRD
T703TSAVRtPTQTNPhosphoSitePlus
S658NNPQTsAVRTPHPRD
S836VNDLFsRKFGEHPRD
Y632ELVISyLPPGMSRCHPRD
S647TKALQsPKRPRHPRD
S658SPGSNsKVPEIHPRD
T830NIIQVtIPDDDHPRD
Y248SEDPDyYQYNIBTKHPRD; phosphoELM; RegPhos
S831RKINSsPNVNTPhosphoSitePlus; HPRD; phosphoELM
S810RKINSsPNVNTHPRD
S371PFRRPsTYGIPPRKG1HPRD
S517PFRSPsWYGIPGTF2IPhosphoSitePlus
T666PEIEVtVEGPNHPRD
Y899FKAPSyLEISSHPRD
Y483HPNDLyVEGLPBTKHPRD
S789PRKINsSPNVNHPRD
Y631ELVISyLPPGMSRCHPRD
S877VNDLFsRKFGEHPRD
S633PKRPRsPGSNSHPRD
S392PFRRPsTYGIPPRKG1HPRD
T202GRVMVtDADRSPhosphoSitePlus; HPRD
S412PFRRPsTYGIPPRKG1HPRD
T698NNNPQtSAVRTHPRD; phosphoELM
S679SPGSNsKVPEIPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S653PKRPRsPGSNSHPRD
S515NIPFRsPSWYGHPRD; phosphoELM

Dephosphorylation site
GTF2I_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000322599S207*BIOMARTBreast Cancer21930507, 21930502
ENSP00000322542S207*BIOMARTBreast Cancer21930507, 21930502
ENSP00000387651S207*BIOMARTBreast Cancer21930507, 21930502
ENSP00000322542M33TCOSMICHead and Neck Cancer21798893
ENSP00000322671S207*BIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000322542Breast CancerNormal vs. CancertissueDown0.4820739354
ENSP00000322542Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
GTF2I_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KGP1_HUMANGTF2I_HUMANkinase -> substrateHPRD
SRC_HUMANGTF2I_HUMANkinase -> substrateRegPhos
BTK_HUMANGTF2I_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
FRK_HUMANGTF2I_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANGTF2I_HUMANkinase -> substrateRegPhos
JAK2_HUMANGTF2I_HUMANkinase -> substrateHPRD; RegPhos
GTF2I_HUMANFOS_HUMANTF -> target geneTRANSFAC
GTF2I_HUMANTRBC1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05168Herpes simplex infection
hsa03022Basal transcription factors

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0009790embryo developmentIEAbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0051019mitogen-activated protein kinase bindingIEAmolecular_function
GO:0051481reduction of cytosolic calcium ion concentrationIEAbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0016525negative regulation of angiogenesisIDAbiological_process
GO:0042995cell projectionIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0003700sequence-specific DNA binding transcription factorNASmolecular_function


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