Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CSK_HUMAN
Description:c-src tyrosine kinase [Source:HGNC Symbol;Acc:2444]
Location:chr15 q24.1
Node attribute:substrate; kinase; effector; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S364REKKFsTKSDVPRKACAHPRD
Y64IIPANyVQKREPhosphoSitePlus
Y263EKGGLyIVTEYPkinase_TyrPhosphoSitePlus
Y416CPPAVyEVMKNautocatalysis RegPhos
Y97AERLLyPPETGSH2PhosphoSitePlus
Y416CPPAVyEVMKNPkinase_TyrPhosphoSitePlus
S284RSRGRsVLGGDPkinase_TyrPhosphoSitePlus
S186DEFYRsGWALNPhosphoSitePlus
S364REKKFsTKSDVPKACaRegPhos
S364REKKFsTKSDVPkinase_TyrPhosphoSitePlus
Y184AQDEFyRSGWAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y277GSLVDyLRSRGPkinase_TyrPhosphoSitePlus
Y304CEAMEyLEGNNCSKHPRD; RegPhos
Y304CEAMEyLEGNNautocatalysisRegPhos

Dephosphorylation site
CSK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000220003S2*Greenman2007Lung Cancer16140923, 17344846, 18428421

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000414764Hepatocellular CarcinomaTreatment (none vs resveratrol-treatment)cell lineUp19996131

Hyperphosphorylation site
CSK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNAS2_HUMANCSK_HUMANGprotein -> effectorgpDB
GNAO_HUMANCSK_HUMANGprotein -> effectorgpDB
GNAS1_HUMANCSK_HUMANGprotein -> effectorgpDB
GNAI1_HUMANCSK_HUMANGprotein -> effectorgpDB
GNAI2_HUMANCSK_HUMANGprotein -> effectorgpDB
GNAI3_HUMANCSK_HUMANGprotein -> effectorgpDB
CSK_HUMANMK15_HUMANkinase -> substrateRegPhos
CSK_HUMANYES_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMANCSK_HUMANkinase -> substrateRobert H Newman (2013)
CSK_HUMANPAXI_HUMANkinase -> substrateRegPhos
CSK_HUMANCSK_HUMANkinase -> substrateHPRD; RegPhos
CSK_HUMANMUC1_HUMANkinase -> substrateRegPhos
CSK_HUMANCTNB1_HUMANkinase -> substrateRegPhos
CSK_HUMANFGR_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
CSK_HUMANANDR_HUMANkinase -> substrateRegPhos
KPCA_HUMANCSK_HUMANkinase -> substrateHPRD
CSK_HUMANHCK_HUMANkinase -> substrateHPRD; RegPhos
CSK_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
CSK_HUMANLCK_HUMANkinase -> substrateHPRD; RegPhos
CSK_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
CSK_HUMANMO4L1_HUMANkinase -> substrateRobert H Newman (2013)
CSK_HUMANPTPRC_HUMANkinase -> substrateRobert H Newman (2013)
CSK_HUMANRGS16_HUMANkinase -> substrateHPRD; RegPhos
CSK_HUMANSRC_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
CSK_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
CSK_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
CSK_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
CSK_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
CSK_HUMANGELS_HUMANkinase -> substrateRegPhos
CSK_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
CSK_HUMANLYN_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
CSK_HUMANETS1_HUMANkinase -> substrateRobert H Newman (2013)
CSK_HUMANPI51C_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANCSK_HUMANkinase -> substrateRegPhos
CSK_HUMANFYN_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
CSK_HUMANLYN_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05120Epithelial cell signaling in Helicobacter pylori i

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005911cell-cell junctionIEAcellular_component
GO:0006468protein phosphorylationTASbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0007596blood coagulationTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0031295T cell costimulationTASbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0060368regulation of Fc receptor mediated stimulatory sigIEAbiological_process
GO:0043406positive regulation of MAP kinase activityIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005813centrosomeIDAcellular_component
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0050765negative regulation of phagocytosisIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0048709oligodendrocyte differentiationIEAbiological_process
GO:0008022protein C-terminus bindingTASmolecular_function
GO:0034332adherens junction organizationIEAbiological_process
GO:0070373negative regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0010989negative regulation of low-density lipoprotein parIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0070064proline-rich region bindingIEAmolecular_function
GO:0007420brain developmentIEAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0005886plasma membraneIPIcellular_component
GO:0042997negative regulation of Golgi to plasma membrane prIDAbiological_process
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0019903protein phosphatase bindingIEAmolecular_function
GO:0032715negative regulation of interleukin-6 productionIEAbiological_process
GO:0045779negative regulation of bone resorptionIEAbiological_process
GO:0033673negative regulation of kinase activityIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0004715non-membrane spanning protein tyrosine kinase actiIEAmolecular_function
GO:0071375cellular response to peptide hormone stimulusIEAbiological_process


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