Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GSK3A_HUMAN
Description:glycogen synthase kinase 3 alpha [Source:HGNC Symbol;Acc:4616]
Location:chr19 q13.2
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T19SGRARtSSFAEPhosphoSitePlus; HPRD; phosphoELM
S2GGPSHPRD; SysPTM
T46SGPGGtGGGKAPhosphoSitePlus
S77SGGGGsGGPGAPhosphoSitePlus; HPRD
S21RARTSsFAEPGPRKCBHPRD
S21RARTSsFAEPGPRKCGHPRD
S21RARTSsFAEPGPRKCDHPRD
Y180LRYFFySSGEKPkinasePhosphoSitePlus
S63GGVGAsSSGGGHPRD
T84GPGAGtSFPPPHPRD
S21RARTSsFAEPGPKA_groupphosphoELM; RegPhos
S21RARTSsFAEPGPhosphoSitePlus; phosphoELM; RegPhos
S97KLGRDsGKVTTPhosphoSitePlus
T480ATPTLtNHPRD
S72GGPGGsGGGGSPhosphoSitePlus; HPRD; SysPTM
S278GEPNVsYICSRGSK3AHPRD
S2____MsGGGPSPhosphoSitePlus; SysPTM
Y279EPNVSyICSRYPkinasePhosphoSitePlus; SysPTM
S482PTLTNHPRD
T478TDATPtLTNHPRD
S41PGGSAsGPGGTPhosphoSitePlus
Y197NLVLEyVPETVPkinasePhosphoSitePlus
Y278GEPNVsYICSRHPRD
Y279EPNVSyICSRYHPRD; phosphoELM; RegPhos; SysPTM
S21RARTSsFAEPGPKACaRegPhos
S21RARTSsFAEPGPKCbRegPhos
S21RARTSsFAEPGPKCaRegPhos
S21RARTSsFAEPGPKCgRegPhos
S20GRARTsSFAEPPhosphoSitePlus; HPRD; phosphoELM
S21RARTSsFAEPGSGK3HPRD; RegPhos
S21RARTSsFAEPGSGK1HPRD; RegPhos
Y351EMNPNyTEFKFPkinasePhosphoSitePlus
Y226VKVYMyQLFRSPkinasePhosphoSitePlus
S7SGGGPsGGGPGPhosphoSitePlus
S278GEPNVsYICSRPkinasePhosphoSitePlus
S21RARTSsFAEPGPKD3RegPhos
S21RARTSsFAEPGPRKACAHPRD
Y177IVRLRyFFYSSPkinasePhosphoSitePlus
S64GVGASsSGGGPHPRD
S21RARTSsFAEPGPRKCAHPRD
S21RARTSsFAEPGPRKD3HPRD
Y134SFGVVyQARLAPkinasePhosphoSitePlus
Y220TIPILyVKVYMPkinasePhosphoSitePlus
Y285ICSRYyRAPELPkinasePhosphoSitePlus
S39GGPGGsASGPGPhosphoSitePlus; HPRD
T101DSGKVtTVVATHPRD
S21RARTSsFAEPGPKB_groupphosphoELM
T480ATPTLtNSS__PhosphoSitePlus
T340VLGTPtREQIRPkinasePhosphoSitePlus
S282VSYICsRYYRAHPRD
S21RARTSsFAEPGPKCdRegPhos
S282VSYICsRYYRAPkinasePhosphoSitePlus
Y279EPNVSyICSRYGSK3AHPRD; SysPTM
S21RARTSsFAEPGAKT1HPRD; RegPhos
S21RARTSsFAEPGPKC_groupphosphoELM; RegPhos
Y284YICSRyYRAPEPkinasePhosphoSitePlus
T338IKVLGtPTREQPkinasePhosphoSitePlus

Dephosphorylation site
GSK3A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000222330H400RDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000222330R230CDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
GSK3A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S21SGRARTSsFAEPGGGmelanoma skin cancer19996208PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
GSK3A_HUMANRXRA_HUMANkinase -> substrateRobert H Newman (2013)
KPCD3_HUMANGSK3A_HUMANkinase -> substrateHPRD
GSK3A_HUMANCDK9_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANGSK3A_HUMANkinase -> substrateNetPath
GSK3A_HUMANLARP1_HUMANkinase -> substrateRobert H Newman (2013)
SGK3_HUMANGSK3A_HUMANkinase -> substrateHPRD; RegPhos
GSK3A_HUMANHSF1_HUMANkinase -> substrateHPRD; RegPhos
GSK3A_HUMANRSBN1_HUMANkinase -> substrateRobert H Newman (2013)
GSK3A_HUMANEI2BE_HUMANkinase -> substrateRegPhos
GSK3A_HUMANMYC_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
GSK3A_HUMANTF7L2_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANGSK3A_HUMANkinase -> substrateRegPhos
GSK3A_HUMANBCL3_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANGSK3A_HUMANkinase -> substrateHPRD
GSK3A_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
GSK3A_HUMANROR2_HUMANkinase -> substrateNetPath
GSK3A_HUMANCCNE1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KPCG_HUMANGSK3A_HUMANkinase -> substrateHPRD
GSK3A_HUMANTAU_HUMANkinase -> substrateRegPhos
GSK3A_HUMANGSK3A_HUMANkinase -> substrateHPRD
GSK3A_HUMANANS1A_HUMANkinase -> substrateRobert H Newman (2013)
GSK3A_HUMANMCL1_HUMANkinase -> substrateRegPhos
GSK3A_HUMANJUN_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
GSK3A_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
GSK3A_HUMANLRP6_HUMANkinase -> substrateNetPath
KPCD_HUMANGSK3A_HUMANkinase -> substrateHPRD
GSK3A_HUMANMK67I_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
SGK1_HUMANGSK3A_HUMANkinase -> substrateHPRD; RegPhos
GSK3A_HUMANCREM_HUMANkinase -> substrateHPRD; RegPhos
KPCB_HUMANGSK3A_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04062Chemokine signaling pathway
hsa04728Dopaminergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045732positive regulation of protein catabolic processNASbiological_process
GO:0045719negative regulation of glycogen biosynthetic proceTASbiological_process
GO:0046627negative regulation of insulin receptor signaling IMPbiological_process
GO:0051348negative regulation of transferase activityIMPbiological_process
GO:0071879positive regulation of adrenergic receptor signaliISSbiological_process
GO:0008286insulin receptor signaling pathwayISSbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0030877beta-catenin destruction complexTAScellular_component
GO:0006987activation of signaling protein activity involved TASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0032869cellular response to insulin stimulusIMPbiological_process
GO:0045823positive regulation of heart contractionISSbiological_process
GO:0010905negative regulation of UDP-glucose catabolic proceICbiological_process
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0005977glycogen metabolic processIEAbiological_process
GO:0034236protein kinase A catalytic subunit bindingIPImolecular_function
GO:2000466negative regulation of glycogen (starch) synthase TASbiological_process
GO:0046325negative regulation of glucose importIMPbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0030819positive regulation of cAMP biosynthetic processISSbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0090090negative regulation of canonical Wnt receptor signTASbiological_process
GO:0050321tau-protein kinase activityTASmolecular_function
GO:2000467positive regulation of glycogen (starch) synthase ISSbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:2000077negative regulation of type B pancreatic cell deveTASbiological_process
GO:0032007negative regulation of TOR signaling cascadeISSbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0030968endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0003214cardiac left ventricle morphogenesisISSbiological_process
GO:0007399nervous system developmentIEAbiological_process
GO:0061052negative regulation of cell growth involved in carISSbiological_process
GO:0003073regulation of systemic arterial blood pressureISSbiological_process