Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SRC_HUMAN
Description:v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [Source:HGNC Symbol;Acc:11283]
Location:chr20 q11.23
Node attribute:PPI(target); PPI(source); substrate; kinase; effector; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S75SDTVTsPQRAGCDK5HPRD; phosphoELM; RegPhos
S75SDTVTsPQRAGCDK_groupphosphoELM; RegPhos
Y338SEEPIyIVTEYSrcRegPhos
S17SQRRRsLEPAEPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
Y530STEPQyQPGEphosphoELM
S306KPGTMsPEAFLHPRD
S12KPKDAsQRRRSPRKCAHPRD
S17SQRRRsLEPAEPKA_groupphosphoELM; RegPhos; SysPTM
S97LYDYEsRTETDHPRD; phosphoELM; RegPhos
S35GAFPAsQTPSKPhosphoSitePlus
S39ASQTPsKPASAPhosphoSitePlus
Y419IEDNEyTARQGphosphoELM; SysPTM
T72FNSSDtVTSPQPhosphoSitePlus
T37FPASQtPSKPAPhosphoSitePlus
S525EDYFTsTEPQYPhosphoSitePlus; SysPTM
Y419IEDNEyTARQGPkinase_TyrPhosphoSitePlus; SysPTM
T182VRESEtTKGAYSH2PhosphoSitePlus
Y530STEPQyQPGEFGRHPRD
T250TTVCPtSKPQTPhosphoSitePlus
T420EDNEYtARQGAPkinase_TyrPhosphoSitePlus
Y530STEPQyQPGENPhosphoSitePlus
Y419IEDNEyTARQGautocatalysisRegPhos; SysPTM
Y530STEPQyQPGENFGRRegPhos
S75SDTVTsPQRAGPhosphoSitePlus; phosphoELM; RegPhos
T246CHRLTtVCPTSPhosphoSitePlus
Y216DSGGFyITSRTHPRD; RegPhos
S17SQRRRsLEPAEPKACaRegPhos; SysPTM
Y530STEPQyQPGECskphosphoELM
Y530STEPQyQPGECSKHPRD
Y216DSGGFyITSRTSrcRegPhos
S70GGFNSsDTVTSPhosphoSitePlus
Y216DSGGFyITSRTSRCphosphoELM
T304TLKPGtMSPEAPkinase_TyrPhosphoSitePlus
T526DYFTStEPQYQPhosphoSitePlus
S97LYDYEsRTETDSH3_1PhosphoSitePlus
T74SSDTVtSPQRAPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T183RESETtKGAYCSH2PhosphoSitePlus
Y216DSGGFyITSRTSH2PhosphoSitePlus
S12KPKDAsQRRRSPhosphoSitePlus; phosphoELM; RegPhos
Y338SEEPIyIVTEYSRCphosphoELM
S306KPGTMsPEAFLPkinase_TyrPhosphoSitePlus
Y187TTKGAyCLSVSRegPhos
Y530STEPQyQPGENCSKRegPhos
Y439PEAALyGRFTIphosphoELM
Y530STEPQyQPGENCskRegPhos
Y338SEEPIyIVTEYPkinase_TyrPhosphoSitePlus
S17SQRRRsLEPAEPRKACAHPRD; SysPTM
Y187TTKGAyCLSVSSH2PhosphoSitePlus
Y419IEDNEyTARQGSrcRegPhos; SysPTM
Y522AFLEDyFTSTEPhosphoSitePlus
Y439PEAALyGRFTIPkinase_TyrPhosphoSitePlus
Y419IEDNEyTARQGSRCHPRD; phosphoELM; RegPhos; SysPTM
S12KPKDAsQRRRSPKCaRegPhos
S69FGGFNsSDTVTPhosphoSitePlus; phosphoELM; RegPhos

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y530FTSTEPQyQPGENLPTPN1HPRD
Y530FTSTEPQyQPGENLPTPN6HPRD
Y530FTSTEPQyQPGENLPTPREHPRD
Y530FTSTEPQyQPGENLPTPRAHPRD
Y419RLIEDNEyTARQGAKPTPN1HPRD
Y419RLIEDNEyTARQGAKPTPN2HPRD
Y419RLIEDNEyTARQGAKPTPN6HPRD
Y338VVSEEPIyIVTEYMSPTPN6HPRD
Y419RLIEDNEyTARQGAKPTPN18HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000362680D407HTCGAOvarian Cancer21720365, 18772890
ENSP00000350941D407HTCGAOvarian Cancer21720365, 18772890
ENSP00000408503D407HTCGAOvarian Cancer21720365, 18772890
ENSP00000362668D407HTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
SRC_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y419Pkinase_TyrRLIEDNEyTARQGAKcolorectal carcinoma17148760PhosphoSitePlus
Y419Pkinase_TyrRLIEDNEyTARQGAKprostate cancer17045208PhosphoSitePlus
Y530FTSTEPQyQPGENL_colorectal carcinoma17974954PhosphoSitePlus
Y530FTSTEPQyQPGENL_cholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
GNAS1_HUMANSRC_HUMANGprotein -> effectorgpDB
GNAI3_HUMANSRC_HUMANGprotein -> effectorgpDB
GNAS2_HUMANSRC_HUMANGprotein -> effectorgpDB
GNAI2_HUMANSRC_HUMANGprotein -> effectorgpDB
GNAI1_HUMANSRC_HUMANGprotein -> effectorgpDB
GNAO_HUMANSRC_HUMANGprotein -> effectorgpDB
SRC_HUMANCDCP1_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMAN1B82_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANFHIT_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANSPTN1_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANDYN1_HUMANkinase -> substrateRegPhos
SRC_HUMANCTND1_HUMANkinase -> substrateRegPhos
SRC_HUMANFAK1_HUMANkinase -> substrateRegPhos; NetPath
SRC_HUMANBMX_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANCDN1B_HUMANkinase -> substrateHPRD
SRC_HUMANWWOX_HUMANkinase -> substrateHPRD
SRC_HUMAN1A80_HUMANkinase -> substrateHPRD
SRC_HUMANDDR2_HUMANkinase -> substrateRegPhos
SRC_HUMANGRB2_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANAT2B4_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANPLCG1_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANIKKB_HUMANkinase -> substrateNetPath
SRC_HUMANITB3_HUMANkinase -> substrateRegPhos
SRC_HUMANCAV1_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANSTAT3_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANIKBA_HUMANkinase -> substrateHPRD; RegPhos; NetPath
SRC_HUMANSHIP2_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANCD33_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANDOK2_HUMANkinase -> substrateHPRD
SRC_HUMANAKT1_HUMANkinase -> substrateRegPhos
SRC_HUMANSTAP2_HUMANkinase -> substrateRegPhos
SRC_HUMANSHC1_HUMANkinase -> substrateRegPhos
SRC_HUMANCTNB1_HUMANkinase -> substrateRegPhos
SRC_HUMANKCNB1_HUMANkinase -> substrateHPRD; RegPhos
FAK1_HUMANSRC_HUMANkinase -> substrateKEGG
SRC_HUMANKPCD1_HUMANkinase -> substrateRegPhos
SRC_HUMANAFAP1_HUMANkinase -> substrateHPRD
CDK5_HUMANSRC_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
SRC_HUMANPDPK1_HUMANkinase -> substrateRegPhos
SRC_HUMANMUC1_HUMANkinase -> substrateRegPhos
SRC_HUMANTERT_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANSTA5B_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANERBB2_HUMANkinase -> substrateNetPath
SRC_HUMANCADH5_HUMANkinase -> substrateHPRD
SRC_HUMANNMDE2_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANPLAK_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANGTF2I_HUMANkinase -> substrateRegPhos
SRC_HUMANIKKA_HUMANkinase -> substrateNetPath
SRC_HUMANTXK_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANSRC_HUMANkinase -> substrateRegPhos
SRC_HUMANDAPP1_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANESR1_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANANXA1_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANVILI_HUMANkinase -> substrateRegPhos
SRC_HUMANRGS16_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANKIT_HUMANkinase -> substrateHPRD; RegPhos; NetPath
SRC_HUMANABL1_HUMANkinase -> substrateRegPhos
SRC_HUMANKPCI_HUMANkinase -> substrateRegPhos
SRC_HUMANMPZL1_HUMANkinase -> substrateRegPhos
SRC_HUMANGNAT1_HUMANkinase -> substrateRegPhos
FGR_HUMANSRC_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANEGFR_HUMANkinase -> substrateRegPhos
SRC_HUMANANXA2_HUMANkinase -> substrateRegPhos
SRC_HUMANPAK2_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANPDC6I_HUMANkinase -> substrateHPRD
SRC_HUMANRAF1_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANLRP1_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANDAG1_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANVINC_HUMANkinase -> substrateRegPhos
SRC_HUMANDAB1_HUMANkinase -> substrateRegPhos
SRC_HUMANSRC_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANCAV2_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANHNRPK_HUMANkinase -> substrateRegPhos
CSK_HUMANSRC_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
SRC_HUMANGELS_HUMANkinase -> substrateRegPhos
SRC_HUMANNMDE1_HUMANkinase -> substrateRegPhos
SRC_HUMANGRB10_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANBCAR1_HUMANkinase -> substrateRegPhos
SRC_HUMANLIMK1_HUMANkinase -> substrateKEGG
KPCA_HUMANSRC_HUMANkinase -> substrateHPRD
SRC_HUMANCXA1_HUMANkinase -> substrateRegPhos
SRC_HUMANIGF1R_HUMANkinase -> substrateRegPhos
SRC_HUMANCEAM1_HUMANkinase -> substrateRegPhos
SRC_HUMANSRC8_HUMANkinase -> substrateRegPhos
SRC_HUMANPTPRA_HUMANkinase -> substrateHPRD; RegPhos
SRC_HUMANRHG35_HUMANkinase -> substrateKEGG; HPRD; RegPhos
PTPRE_HUMANSRC_HUMANphosphatase -> substrateHPRD
PTN6_HUMANSRC_HUMANphosphatase -> substrateHPRD
PTN1_HUMANSRC_HUMANphosphatase -> substrateHPRD
PTN2_HUMANSRC_HUMANphosphatase -> substrateHPRD
PTN18_HUMANSRC_HUMANphosphatase -> substrateHPRD
PTPRA_HUMANSRC_HUMANphosphatase -> substrateHPRD
SRC_HUMANCDC42_HUMANotherKEGG
ITA11_HUMANSRC_HUMANotherKEGG
SRC_HUMANRASH_HUMANotherKEGG
VGFR2_HUMANSRC_HUMANotherKEGG
EGFR_HUMANSRC_HUMANotherKEGG
ITB1_HUMANSRC_HUMANotherKEGG
KPCA_HUMANSRC_HUMANotherKEGG
SRC_HUMANPI3R5_HUMANotherKEGG
HNF1A_HUMANSRC_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04540Gap junction
hsa04370VEGF signaling pathway
hsa05152Tuberculosis
hsa04912GnRH signaling pathway
hsa05203Viral carcinogenesis
hsa04012ErbB signaling pathway
hsa04520Adherens junction
hsa05131Shigellosis
hsa04530Tight junction
hsa04727GABAergic synapse
hsa04510Focal adhesion
hsa04810Regulation of actin cytoskeleton
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa04144Endocytosis
hsa05100Bacterial invasion of epithelial cells
hsa04062Chemokine signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051895negative regulation of focal adhesion assemblyISSbiological_process
GO:0060444branching involved in mammary gland duct morphogenIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0016301kinase activityIEAmolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0005178integrin bindingTASmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0045453bone resorptionIEAbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0004715non-membrane spanning protein tyrosine kinase actiTASmolecular_function
GO:0045124regulation of bone resorptionTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0019048virus-host interactionIEAbiological_process
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0007155cell adhesionIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0007049cell cycleIEAbiological_process
GO:0033625positive regulation of integrin activationTASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0005070SH3/SH2 adaptor activityTASmolecular_function
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0033146regulation of intracellular estrogen receptor signIEAbiological_process
GO:0048477oogenesisIEAbiological_process
GO:0016044cellular membrane organizationTASbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0042802identical protein bindingIPImolecular_function
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0050847progesterone receptor signaling pathwayISSbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0071803positive regulation of podosome assemblyIEAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0016477cell migrationIEAbiological_process
GO:0051897positive regulation of protein kinase B signaling IMPbiological_process
GO:0016301kinase activityTASmolecular_function
GO:0005743mitochondrial inner membraneIDAcellular_component
GO:0090263positive regulation of canonical Wnt receptor signIEAbiological_process
GO:0070555response to interleukin-1IMPbiological_process
GO:0020037heme bindingIDAmolecular_function
GO:0007172signal complex assemblyTASbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0046875ephrin receptor bindingIPImolecular_function
GO:2001243negative regulation of intrinsic apoptotic signaliIMPbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0046875ephrin receptor bindingIEAmolecular_function
GO:0005764lysosomeIDAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0043114regulation of vascular permeabilityTASbiological_process
GO:0071393cellular response to progesterone stimulusISSbiological_process
GO:0005102receptor bindingIPImolecular_function
GO:0044325ion channel bindingIPImolecular_function
GO:0032463negative regulation of protein homooligomerizationIMPbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005856cytoskeletonIEAcellular_component
GO:0043154negative regulation of cysteine-type endopeptidaseIMPbiological_process
GO:0060065uterus developmentIEAbiological_process
GO:2000811negative regulation of anoikisIMPbiological_process
GO:0005829cytosolTAScellular_component
GO:0042169SH2 domain bindingIPImolecular_function
GO:0005770late endosomeIDAcellular_component
GO:0007265Ras protein signal transductionTASbiological_process
GO:0004713protein tyrosine kinase activityTASmolecular_function
GO:0030168platelet activationTASbiological_process
GO:0045453bone resorptionISSbiological_process
GO:0005901caveolaIDAcellular_component
GO:2001237negative regulation of extrinsic apoptotic signaliIMPbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process