Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MP2K1_HUMAN
Description:mitogen-activated protein kinase kinase 1 [Source:HGNC Symbol;Acc:6840]
Location:chr15 q22.31
Node attribute:substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T226NSFVGtRSYMSPkinasePhosphoSitePlus
T292PPRPRtPGRPLErk2(MAPK1RegPhos
S222DSMANsFVGTRARAFHPRD; RegPhos
S222DSMANsFVGTRMAP3K_groupphosphoELM; RegPhos
T386LNQPStPTHAAErk2(MAPK1RegPhos; SysPTM
S385GLNQPsTPTHAPhosphoSitePlus; HPRD
T292PPRPRtPGRPLErk2RegPhos
S298PGRPLsSYGMDMAP2K_groupphosphoELM; RegPhos
T286GDAAEtPPRPRCDK1phosphoELM; SysPTM
S212CDFGVsGQLIDPkinasePhosphoSitePlus
S231TRSYMsPERLQPkinasePhosphoSitePlus; SysPTM
S222DSMANsFVGTRRAF_groupRegPhos
S222DSMANsFVGTRPkinasePhosphoSitePlus
S25VNGTSsAETNLMAP2K_groupphosphoELM; RegPhos
S222DSMANsFVGTRRAF1HPRD; phosphoELM; RegPhos
S218GQLIDsMANSFRAF1HPRD; phosphoELM; RegPhos
S194RDVKPsNILVNPkinasePhosphoSitePlus
T386LNQPStPTHAAPhosphoSitePlus; SysPTM
S218GQLIDsMANSFMAP3K_groupphosphoELM; RegPhos
T388QPSTPtHAAGVPhosphoSitePlus
S298PGRPLsSYGMDPkinasePhosphoSitePlus
T292PPRPRtPGRPLRAF1HPRD; RegPhos
T286GDAAEtPPRPRPkinasePhosphoSitePlus; SysPTM
S218GQLIDsMANSFBRAFHPRD; RegPhos
S304SYGMDsRPPMAMAP2K1HPRD; RegPhos
S222DSMANsFVGTRPDK1RegPhos
S222DSMANsFVGTRMAP3K8phosphoELM; RegPhos
S24AVNGTsSAETNMAP2K_groupphosphoELM; RegPhos
S212CDFGVsGQLIDphosphoELM; RegPhos
S218GQLIDsMANSFRAF_groupRegPhos
S218GQLIDsMANSFPkinasePhosphoSitePlus
S218GQLIDsMANSFMAP3K8phosphoELM; RegPhos
T292PPRPRtPGRPLphosphoELM
T286GDAAEtPPRPRRAF1HPRD; RegPhos; SysPTM
S218GQLIDsMANSFARAFHPRD; RegPhos
S298PGRPLsSYGMDPAK1HPRD; phosphoELM; RegPhos
T23SAVNGtSSAETMAP2K_groupphosphoELM; RegPhos
T386LNQPStPTHAARAF1HPRD; RegPhos; SysPTM
S231TRSYMsPERLQHPRD; SysPTM
S218GQLIDsMANSFHPRD; phosphoELM
S222DSMANsFVGTRPDK-1phosphoELM
T386LNQPStPTHAAMAPK1phosphoELM; SysPTM
T286GDAAEtPPRPRphosphoELM; SysPTM
T286GDAAEtPPRPRCDK_groupphosphoELM; RegPhos; SysPTM
S222DSMANsFVGTRBRAFHPRD; RegPhos
S218GQLIDsMANSFMAP2K_groupphosphoELM; RegPhos
T292PPRPRtPGRPLMAPK1HPRD; phosphoELM
T292PPRPRtPGRPLPkinasePhosphoSitePlus
S222DSMANsFVGTRHPRD; phosphoELM
T286GDAAEtPPRPRCDK5HPRD; RegPhos; SysPTM

Dephosphorylation site
MP2K1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000302486Y134CCOSMICGastric Cancer21097718

Differential expressed protein
MP2K1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S222PkinaseLIDSMANsFVGTRSYAlzheimer's disease17064357PhosphoSitePlus
S218PkinaseVSGQLIDsMANSFVGAlzheimer's disease17064357PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
RAF1_HUMANMP2K1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
M3K8_HUMANMP2K1_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
MOS_HUMANMP2K1_HUMANkinase -> substrateKEGG
PKN1_HUMANMP2K1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
ZAGL2_HUMANMP2K1_HUMANkinase -> substrateRegPhos
ZHX2_HUMANMP2K1_HUMANkinase -> substrateRegPhos
MP2K1_HUMANPARVA_HUMANkinase -> substrateHPRD
BRAF_HUMANMP2K1_HUMANkinase -> substrateRegPhos
MP2K1_HUMANGSK3B_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ARAF_HUMANMP2K1_HUMANkinase -> substrateRegPhos
MK01_HUMANMP2K1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MP2K1_HUMANBAD_HUMANkinase -> substrateKEGG
MP2K1_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
MP2K1_HUMANMP2K1_HUMANkinase -> substrateHPRD; RegPhos
PDPK1_HUMANMP2K1_HUMANkinase -> substrateRegPhos
M3K1_HUMANMP2K1_HUMANkinase -> substrateKEGG
MP2K1_HUMANMK01_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
MP2K1_HUMANNEK3_HUMANkinase -> substrateRobert H Newman (2013)
MP2K1_HUMANCASP9_HUMANkinase -> substrateHPRD; RegPhos
MP2K1_HUMANRAF1_HUMANkinase -> substrateNetPath
MP2K1_HUMANKS6A4_HUMANkinase -> substrateRegPhos
CDK5_HUMANMP2K1_HUMANkinase -> substrateHPRD; RegPhos
MP2K1_HUMANMK03_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
RAF1_HUMANMP2K1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05219Bladder cancer
hsa04012ErbB signaling pathway
hsa04722Neurotrophin signaling pathway
hsa05211Renal cell carcinoma
hsa04664Fc epsilon RI signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04725Cholinergic synapse
hsa05034Alcoholism
hsa05164Influenza A
hsa04320Dorso-ventral axis formation
hsa04010MAPK signaling pathway
hsa05223Non-small cell lung cancer
hsa04726Serotonergic synapse
hsa04666Fc gamma R-mediated phagocytosis
hsa04380Osteoclast differentiation
hsa05210Colorectal cancer
hsa05215Prostate cancer
hsa05220Chronic myeloid leukemia
hsa04370VEGF signaling pathway
hsa04910Insulin signaling pathway
hsa04912GnRH signaling pathway
hsa05213Endometrial cancer
hsa04730Long-term depression
hsa04660T cell receptor signaling pathway
hsa04114Oocyte meiosis
hsa04914Progesterone-mediated oocyte maturation
hsa05020Prion diseases
hsa04620Toll-like receptor signaling pathway
hsa04270Vascular smooth muscle contraction
hsa05200Pathways in cancer
hsa05218Melanoma
hsa04540Gap junction
hsa04810Regulation of actin cytoskeleton
hsa04720Long-term potentiation
hsa05212Pancreatic cancer
hsa05214Glioma
hsa05221Acute myeloid leukemia
hsa04062Chemokine signaling pathway
hsa05216Thyroid cancer
hsa04916Melanogenesis
hsa04662B cell receptor signaling pathway
hsa04510Focal adhesion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0000187activation of MAPK activityIEAbiological_process
GO:0004672protein kinase activityTASmolecular_function
GO:0005829cytosolTAScellular_component
GO:0031435mitogen-activated protein kinase kinase kinase binIEAmolecular_function
GO:0004728receptor signaling protein tyrosine phosphatase acIEAmolecular_function
GO:0032968positive regulation of transcription elongation frIEAbiological_process
GO:0005739mitochondrionTAScellular_component
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0005770late endosomeTAScellular_component
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0043204perikaryonIEAcellular_component
GO:0045597positive regulation of cell differentiationIEAbiological_process
GO:0030425dendriteIEAcellular_component
GO:0006935chemotaxisTASbiological_process
GO:0046579positive regulation of Ras protein signal transducIEAbiological_process
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0004708MAP kinase kinase activityIDAmolecular_function
GO:0033267axon partIEAcellular_component
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0048870cell motilityIEAbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0000165MAPK cascadeTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:2000641regulation of early endosome to late endosome tranTASbiological_process
GO:0032402melanosome transportIEAbiological_process
GO:0030182neuron differentiationIEAbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0008283cell proliferationIEAbiological_process
GO:0004712protein serine/threonine/tyrosine kinase activityTASmolecular_function
GO:0017016Ras GTPase bindingIEAmolecular_function
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0008285negative regulation of cell proliferationIDAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0000187activation of MAPK activityTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0032320positive regulation of Ras GTPase activityIEAbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0006928cellular component movementTASbiological_process
GO:0051291protein heterooligomerizationIEAbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0004708MAP kinase kinase activityIEAmolecular_function
GO:0090170regulation of Golgi inheritanceTASbiological_process
GO:0000165MAPK cascadeIEAbiological_process
GO:0005794Golgi apparatusTAScellular_component
GO:0048313Golgi inheritanceIEAbiological_process
GO:0005816spindle pole bodyIEAcellular_component
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0005794Golgi apparatusIEAcellular_component
GO:0005925focal adhesionTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0006979response to oxidative stressIEAbiological_process
GO:0003056regulation of vascular smooth muscle contractionIEAbiological_process
GO:0034111negative regulation of homotypic cell-cell adhesioIEAbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0032872regulation of stress-activated MAPK cascadeTASbiological_process
GO:0047496vesicle transport along microtubuleIEAbiological_process
GO:0005634nucleusTAScellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0007265Ras protein signal transductionTASbiological_process
GO:0032839dendrite cytoplasmIEAcellular_component
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0000186activation of MAPKK activityTASbiological_process
GO:0071902positive regulation of protein serine/threonine kiIDAbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0090398cellular senescenceIMPbiological_process
GO:0005938cell cortexIEAcellular_component
GO:0060674placenta blood vessel developmentIEAbiological_process
GO:0060711labyrinthine layer developmentIEAbiological_process
GO:0051384response to glucocorticoid stimulusIEAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0023014signal transduction by phosphorylationIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0005769early endosomeTAScellular_component
GO:0007067mitosisIEAbiological_process
GO:0048678response to axon injuryIEAbiological_process
GO:0043539protein serine/threonine kinase activator activityIDAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0045087innate immune responseTASbiological_process
GO:0004674protein serine/threonine kinase activityTASmolecular_function
GO:0007050cell cycle arrestIMPbiological_process
GO:0030216keratinocyte differentiationIEAbiological_process
GO:0048812neuron projection morphogenesisIEAbiological_process
GO:0007411axon guidanceTASbiological_process