Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:STAT4_HUMAN
Description:signal transducer and activator of transcription 4 [Source:HGNC Symbol;Acc:11365]
Location:chr2 q32.3
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y355LPELNyQVKVKSTAT_bindPhosphoSitePlus
S721DLLPMsPSVYAMAPK14HPRD
Y645DILRDyKVIMAPhosphoSitePlus
Y288STKMTyEGDPISTAT_alphaPhosphoSitePlus
Y693RGDKGyVPSVFJAK_groupphosphoELM; RegPhos
T284LEEQStKMTYESTAT_alphaPhosphoSitePlus
S396SNGSLsVEFRHSTAT_bindPhosphoSitePlus
T298IPMQRtHMLERSTAT_alphaPhosphoSitePlus
S721DLLPMsPSVYAPhosphoSitePlus; phosphoELM; RegPhos
Y693RGDKGyVPSVFJAK1RegPhos
Y693RGDKGyVPSVFPhosphoSitePlus; HPRD; RegPhos
T287QSTKMtYEGDPSTAT_alphaPhosphoSitePlus
S394ESSNGsLSVEFSTAT_bindPhosphoSitePlus
S721DLLPMsPSVYAMAP2K6HPRD; RegPhos
S721DLLPMsPSVYAp38aRegPhos
S386NVKAMsIEESSSTAT_bindPhosphoSitePlus

Dephosphorylation site
STAT4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000376134V103ACOSMICProstate Cancer20668451
ENSP00000351255E112QSjoblom2006, COSMIC, HPIBreast Cancer16959974, 18428421
ENSP00000376134S547LCOSMICMelanoma21499247
ENSP00000376134S615CCOSMICBreast Cancer20668451
ENSP00000351255V103ACOSMICProstate Cancer20668451
ENSP00000376134E112QSjoblom2006, COSMIC, HPIBreast Cancer16959974, 18428421
ENSP00000351255H401YCOSMICOvarian Cancer21720365
ENSP00000351255E520*COSMICLung Cancer20668451
ENSP00000351255S615CCOSMICBreast Cancer20668451
ENSP00000376134E520*COSMICLung Cancer20668451
ENSP00000376134H401YCOSMICOvarian Cancer21720365
ENSP00000351255S547LCOSMICMelanoma21499247

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000376134Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineUp4.515169874

Hyperphosphorylation site
STAT4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
JAK1_HUMANSTAT4_HUMANkinase -> substrateRegPhos
MK14_HUMANSTAT4_HUMANkinase -> substrateHPRD; NetPath
ZAGL2_HUMANSTAT4_HUMANkinase -> substrateRegPhos
MP2K6_HUMANSTAT4_HUMANkinase -> substrateHPRD; RegPhos
STAT4_HUMANPERF_HUMANTF -> target geneTRANSFAC
STAT4_HUMANPIM1_HUMANTF -> target geneTRANSFAC
STAT4_HUMANIRF1_HUMANTF -> target geneTRANSFAC
STAT4_HUMANMYC_HUMANTF -> target geneTRANSFAC
STAT4_HUMANIL2RA_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04630Jak-STAT signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIEAcellular_component
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0005509calcium ion bindingIEAmolecular_function
GO:0019221cytokine-mediated signaling pathwayIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0008283cell proliferationIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0071310cellular response to organic substanceIEAbiological_process
GO:0007259JAK-STAT cascadeTASbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function


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