Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ANGT_HUMAN
Description:angiotensinogen (serpin peptidase inhibitor, clade A, member 8) [Source:HGNC Symbol;Acc:333]
Location:chr1 q42.2
Node attribute:ligand; gene

Phosphorylation site
ANGT_HUMAN do not have phosphorylation site.

Dephosphorylation site
ANGT_HUMAN do not have dephosphorylation site.

Mutation site
ANGT_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000355627Non-small cell lung carcinomaNormal vs. CancertissueUp18465169

Hyperphosphorylation site
ANGT_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ANGT_HUMANAGTR2_HUMANligand -> receptorHPMR
ANGT_HUMANAGTR1_HUMANligand -> receptorHPMR
ANGT_HUMANMAS_HUMANligand -> receptorHPMR
ANGT_HUMANLRP2_HUMANligand -> receptorHPMR
COT1_HUMANANGT_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04614Renin-angiotensin system

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045742positive regulation of epidermal growth factor recIDAbiological_process
GO:0007568agingIEAbiological_process
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIDAbiological_process
GO:0048146positive regulation of fibroblast proliferationIEAbiological_process
GO:0035813regulation of renal sodium excretionIEAbiological_process
GO:0005179hormone activityISSmolecular_function
GO:0002019regulation of renal output by angiotensinNASbiological_process
GO:0002034regulation of blood vessel size by renin-angiotensTASbiological_process
GO:0007267cell-cell signalingTASbiological_process
GO:0005576extracellular regionNAScellular_component
GO:0001999renal response to blood flow involved in circulatoIEAbiological_process
GO:0044255cellular lipid metabolic processTASbiological_process
GO:0048169regulation of long-term neuronal synaptic plasticiIEAbiological_process
GO:0014068positive regulation of phosphatidylinositol 3-kinaIDAbiological_process
GO:0007588excretionIEAbiological_process
GO:0034374low-density lipoprotein particle remodelingNASbiological_process
GO:0032270positive regulation of cellular protein metabolic IDAbiological_process
GO:0002035brain renin-angiotensin systemIEAbiological_process
GO:0002019regulation of renal output by angiotensinIEAbiological_process
GO:0007202activation of phospholipase C activityIEAbiological_process
GO:0002016regulation of blood volume by renin-angiotensinNASbiological_process
GO:0014824artery smooth muscle contractionIEAbiological_process
GO:0048144fibroblast proliferationIEAbiological_process
GO:0048143astrocyte activationIEAbiological_process
GO:0048146positive regulation of fibroblast proliferationISSbiological_process
GO:0031703type 2 angiotensin receptor bindingIEAmolecular_function
GO:0031702type 1 angiotensin receptor bindingIPImolecular_function
GO:0005179hormone activityIEAmolecular_function
GO:0001819positive regulation of cytokine productionTASbiological_process
GO:0043085positive regulation of catalytic activityIEAbiological_process
GO:0007199G-protein coupled receptor signaling pathway couplTASbiological_process
GO:0035813regulation of renal sodium excretionNASbiological_process
GO:0042445hormone metabolic processIEAbiological_process
GO:0010468regulation of gene expressionIEAbiological_process
GO:0001991regulation of systemic arterial blood pressure by IEAbiological_process
GO:0001658branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0048659smooth muscle cell proliferationIEAbiological_process
GO:0030198extracellular matrix organizationIEAbiological_process
GO:0045723positive regulation of fatty acid biosynthetic proIEAbiological_process
GO:0035815positive regulation of renal sodium excretionIEAbiological_process
GO:0010951negative regulation of endopeptidase activityIBAbiological_process
GO:0003051angiotensin-mediated drinking behaviorIEAbiological_process
GO:0043410positive regulation of MAPK cascadeIEAbiological_process
GO:0007160cell-matrix adhesionIEAbiological_process
GO:0035411catenin import into nucleusIEAbiological_process
GO:0014873response to muscle activity involved in regulationISSbiological_process
GO:0090190positive regulation of branching involved in ureteIDAbiological_process
GO:0006917induction of apoptosisIEAbiological_process
GO:0040018positive regulation of multicellular organism growIEAbiological_process
GO:0033864positive regulation of NAD(P)H oxidase activityTASbiological_process
GO:0001543ovarian follicle ruptureIEAbiological_process
GO:0034104negative regulation of tissue remodelingIEAbiological_process
GO:0010535positive regulation of activation of JAK2 kinase aIMPbiological_process
GO:0010595positive regulation of endothelial cell migrationIDAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0009409response to coldIEAbiological_process
GO:0002018renin-angiotensin regulation of aldosterone producNASbiological_process
GO:0007263nitric oxide mediated signal transductionTASbiological_process
GO:0042127regulation of cell proliferationNASbiological_process
GO:0030162regulation of proteolysisIBAbiological_process
GO:0031703type 2 angiotensin receptor bindingIPImolecular_function
GO:0007200phospholipase C-activating G-protein coupled recepNASbiological_process
GO:0044444cytoplasmic partIEAcellular_component
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0071260cellular response to mechanical stimulusIEAbiological_process
GO:0001568blood vessel developmentIEAbiological_process
GO:0061049cell growth involved in cardiac muscle cell develoIEAbiological_process
GO:0031701angiotensin receptor bindingIEAmolecular_function
GO:0007250activation of NF-kappaB-inducing kinase activityIEAbiological_process
GO:0050727regulation of inflammatory responseIEAbiological_process
GO:0019229regulation of vasoconstrictionNASbiological_process
GO:0009651response to salt stressIEAbiological_process
GO:0001822kidney developmentIEAbiological_process
GO:0070371ERK1 and ERK2 cascadeIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0051387negative regulation of nerve growth factor receptoIDAbiological_process
GO:0051924regulation of calcium ion transportIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0003331positive regulation of extracellular matrix constiIEAbiological_process
GO:0004867serine-type endopeptidase inhibitor activityIBAmolecular_function
GO:0001998angiotensin mediated vasoconstriction involved in IEAbiological_process
GO:0001974blood vessel remodelingTASbiological_process
GO:0008065establishment of blood-nerve barrierIEAbiological_process
GO:0030308negative regulation of cell growthIEAbiological_process
GO:0014873response to muscle activity involved in regulationIEAbiological_process
GO:0010744positive regulation of macrophage derived foam celICbiological_process
GO:0010613positive regulation of cardiac muscle hypertrophyISSbiological_process
GO:0043065positive regulation of apoptotic processIDAbiological_process
GO:0010873positive regulation of cholesterol esterificationIDAbiological_process
GO:0031702type 1 angiotensin receptor bindingIEAmolecular_function
GO:2000379positive regulation of reactive oxygen species metTASbiological_process
GO:0051092positive regulation of NF-kappaB transcription facTASbiological_process
GO:0030432peristalsisIEAbiological_process
GO:0005615extracellular spaceISScellular_component
GO:0008217regulation of blood pressureIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0050663cytokine secretionIEAbiological_process
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0032930positive regulation of superoxide anion generationIEAbiological_process
GO:0010698acetyltransferase activator activityIDAmolecular_function
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0042310vasoconstrictionIEAbiological_process
GO:0042756drinking behaviorIEAbiological_process
GO:0001558regulation of cell growthNASbiological_process
GO:0051145smooth muscle cell differentiationIEAbiological_process
GO:0045777positive regulation of blood pressureIEAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0008083growth factor activityTASmolecular_function
GO:0050729positive regulation of inflammatory responseTASbiological_process
GO:0001822kidney developmentIMPbiological_process
GO:0006883cellular sodium ion homeostasisIEAbiological_process
GO:0002018renin-angiotensin regulation of aldosterone producIEAbiological_process
GO:0046622positive regulation of organ growthIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0014061regulation of norepinephrine secretionIEAbiological_process
GO:0010613positive regulation of cardiac muscle hypertrophyIEAbiological_process
GO:0051403stress-activated MAPK cascadeIEAbiological_process
GO:0061098positive regulation of protein tyrosine kinase actIMPbiological_process
GO:0042311vasodilationIEAbiological_process