Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DDR2_HUMAN
Description:discoidin domain receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:2731]
Location:chr1 q23.3
Node attribute:kinase; receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y481PLRPDyQEPSRHerpes_gE; ShisaPhosphoSitePlus; SysPTM
S675EPPNSsSSDVRHPRD; SysPTM
Y471GSNSTyDRIFPphosphoELM; RegPhos
S485DYQEPsRLIRKHerpes_gE; ShisaPhosphoSitePlus
Y736MSRNLySGDYYPkinase_TyrPhosphoSitePlus
S467PSEQGsNSTYDHerpes_gE; ShisaPhosphoSitePlus
Y740LYSGDyYRIQGPkinase_TyrPhosphoSitePlus
Y736MSRNLySGDYYHPRD; phosphoELM; RegPhos
Y740LYSGDyYRIQGautocatalysis RegPhos
S461NNRSSsPSEQGHPRD; phosphoELM
Y741YSGDYyRIQGRphosphoELM; RegPhos
Y741YSGDYyRIQGRSRCHPRD; RegPhos
Y481PLRPDyQEPSRHPRD; SysPTM
S737SRNLYsGDYYRPkinase_TyrPhosphoSitePlus
Y740LYSGDyYRIQGHPRD; phosphoELM; RegPhos
S461NNRSSsPSEQGHerpes_gE; ShisaPhosphoSitePlus
Y813QGRQTyLPQPAPkinase_TyrPhosphoSitePlus
S501PGEEEsGCSGVHPRD
S459FNNNRsSSPSEHerpes_gE; ShisaPhosphoSitePlus
Y741YSGDYyRIQGRPkinase_TyrPhosphoSitePlus
Y471GSNSTyDRIFPHerpes_gE; ShisaPhosphoSitePlus
S675EPPNSsSSDVRPkinase_TyrPhosphoSitePlus; SysPTM
S37YPLGMsGGQIPPhosphoSitePlus
Y740LYSGDyYRIQGSRCHPRD; RegPhos

Dephosphorylation site
DDR2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000356898R105SHPINon-small cell lung carcinoma16140923 17344846
ENSP00000356898P815LTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000356899R834IBIOMARTBreast Cancer21930507, 21930502
ENSP00000356899R105SGreenman2007Lung Cancer16140923, 17344846, 18428421, 16140923, 17344846
ENSP00000356899N456SDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000356898R839HTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000356898R105SGreenman2007Lung Cancer16140923, 17344846, 18428421, 16140923, 17344846
ENSP00000356898R834IBIOMARTBreast Cancer21930507, 21930502
ENSP00000356899Q231KCOSMICSkin Cancer21984974
ENSP00000356899L595VCOSMICBreast Cancer20668451
ENSP00000356899L704VBIOMARTBreast Cancer21930507, 21930502
ENSP00000356899R709*COSMICHead and Neck Cancer21798893
ENSP00000356899R105SHPINon-small cell lung carcinoma16140923 17344846
ENSP00000356898L704VBIOMARTBreast Cancer21930507, 21930502
ENSP00000356899P815LTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000356899T533KCOSMICSkin Cancer21984974
ENSP00000356899R839HTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000356898N456SDing2008Lung Cancer18948947

Differential expressed protein
DDR2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y740Pkinase_TyrRNLYSGDyYRIQGRAcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
CO1A1_HUMANDDR2_HUMANligand -> receptorHPMR
DDR2_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
SRC_HUMANDDR2_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANDDR2_HUMANkinase -> substrateRegPhos
DDR2_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
DDR2_HUMANRET_HUMANkinase -> substrateRobert H Newman (2013)
DDR2_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
DDR2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0045669positive regulation of osteoblast differentiationIMPbiological_process
GO:0001503ossificationIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0048146positive regulation of fibroblast proliferationIEAbiological_process
GO:0090091positive regulation of extracellular matrix disassIEAbiological_process
GO:0004714transmembrane receptor protein tyrosine kinase actIDAmolecular_function
GO:0030500regulation of bone mineralizationIMPbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0038063collagen-activated tyrosine kinase receptor signalIDAbiological_process
GO:0005518collagen bindingIDAmolecular_function
GO:0046777protein autophosphorylationIDAbiological_process
GO:0030199collagen fibril organizationIEAbiological_process
GO:0003416endochondral bone growthIEAbiological_process
GO:0038062protein tyrosine kinase collagen receptor activityIEAmolecular_function
GO:0005887integral to plasma membraneTAScellular_component
GO:0010763positive regulation of fibroblast migrationIEAbiological_process
GO:0035988chondrocyte proliferationIEAbiological_process
GO:0038063collagen-activated tyrosine kinase receptor signalIEAbiological_process
GO:0051091positive regulation of sequence-specific DNA bindiIMPbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0007155cell adhesionIEAbiological_process
GO:0010715regulation of extracellular matrix disassemblyTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0045860positive regulation of protein kinase activityIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0031214biomineral tissue developmentIEAbiological_process


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