Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AGTR2_HUMAN
Description:angiotensin II receptor, type 2 [Source:HGNC Symbol;Acc:338]
Location:chrX q23
Node attribute:receptor; GPCR

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S331QQKLRsVFRVPPhosphoSitePlus

Dephosphorylation site
AGTR2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000360973L218ITCGAOvarian Cancer21720365, 18772890
ENSP00000360973L300HBIOMARTBreast Cancer21930507, 21930502
ENSP00000360973K76EBIOMARTSmall cell lung carcinoma21930507, 21930502
ENSP00000360973R350QTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
AGTR2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
AGTR2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ANGT_HUMANAGTR2_HUMANligand -> receptorHPMR
AGTR2_HUMANGNAO_HUMANGPCR -> GproteingpDB
AGTR2_HUMANGNAI2_HUMANGPCR -> GproteingpDB
AGTR2_HUMANGNAI1_HUMANGPCR -> GproteingpDB
AGTR2_HUMANGNAI3_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04614Renin-angiotensin system
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007263nitric oxide mediated signal transductionICbiological_process
GO:0004945angiotensin type II receptor activityIEAmolecular_function
GO:0010700negative regulation of norepinephrine secretionIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0004945angiotensin type II receptor activityIPImolecular_function
GO:0045909positive regulation of vasodilationIEAbiological_process
GO:0050715positive regulation of cytokine secretionIEAbiological_process
GO:0061049cell growth involved in cardiac muscle cell develoIEAbiological_process
GO:0035566regulation of metanephros sizeIEAbiological_process
GO:0060993kidney morphogenesisIEAbiological_process
GO:0008134transcription factor bindingIEAmolecular_function
GO:0007243intracellular protein kinase cascadeISSbiological_process
GO:0002035brain renin-angiotensin systemIEAbiological_process
GO:0001991regulation of systemic arterial blood pressure by IEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayICbiological_process
GO:0002033vasodilation by angiotensin involved in regulationIEAbiological_process
GO:0048147negative regulation of fibroblast proliferationIEAbiological_process
GO:0032516positive regulation of phosphoprotein phosphatase IDAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0043065positive regulation of apoptotic processIMPbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0045429positive regulation of nitric oxide biosynthetic pICbiological_process
GO:0051000positive regulation of nitric-oxide synthase activIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0008217regulation of blood pressureTASbiological_process
GO:0007166cell surface receptor signaling pathwayIDAbiological_process
GO:0090190positive regulation of branching involved in ureteIEAbiological_process
GO:0007610behaviorISSbiological_process
GO:0006883cellular sodium ion homeostasisIEAbiological_process
GO:0001822kidney developmentIEAbiological_process
GO:0007199G-protein coupled receptor signaling pathway couplISSbiological_process
GO:0042416dopamine biosynthetic processIEAbiological_process
GO:0001991regulation of systemic arterial blood pressure by ISSbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0035815positive regulation of renal sodium excretionIEAbiological_process
GO:0010459negative regulation of heart rateISSbiological_process
GO:0010459negative regulation of heart rateIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0021695cerebellar cortex developmentIEAbiological_process
GO:0002018renin-angiotensin regulation of aldosterone producIEAbiological_process
GO:0051000positive regulation of nitric-oxide synthase activISSbiological_process
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0001974blood vessel remodelingTASbiological_process
GO:0043537negative regulation of blood vessel endothelial ceNASbiological_process
GO:0048019receptor antagonist activityTASmolecular_function
GO:0072300positive regulation of metanephric glomerulus deveIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0017046peptide hormone bindingIEAmolecular_function
GO:0051387negative regulation of nerve growth factor receptoIMPbiological_process
GO:0007420brain developmentNASbiological_process
GO:0042990regulation of transcription factor import into nucIEAbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0007610behaviorIEAbiological_process
GO:1900116extracellular negative regulation of signal transdTASbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0030308negative regulation of cell growthTASbiological_process
GO:0007199G-protein coupled receptor signaling pathway couplIEAbiological_process
GO:0005887integral to plasma membraneICcellular_component
GO:0071549cellular response to dexamethasone stimulusIEAbiological_process
GO:0035932aldosterone secretionIEAbiological_process
GO:0010243response to organic nitrogenIEAbiological_process
GO:0045909positive regulation of vasodilationIDAbiological_process