Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IGF1R_HUMAN
Description:insulin-like growth factor 1 receptor [Source:HGNC Symbol;Acc:5465]
Location:chr15 q26.3
Node attribute:kinase; receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1364LPLPQsSHPRD
S1310LDPSAsSSSLPPhosphoSitePlus; HPRD
Y1280REVSFyYSEENIGF1RphosphoELM; RegPhos
S982NPEYFsAADVYPhosphoSitePlus
Y1161MTRDIyETDYYIGF1RphosphoELM; RegPhos; SysPTM
Y1166YETDYyRKGGKautocatalysisRegPhos
Y131KDIGLyNLRNIRecep_L_domainPhosphoSitePlus
Y1165IYETDyYRKGGIGF1RphosphoELM; RegPhos; SysPTM
S29SLWPTsGEICGPhosphoSitePlus
T468EEVTGtKGRQSHPRD
T123VIFEMtNLKDIRecep_L_domainPhosphoSitePlus
Y1166YETDYyRKGGKphosphoELM
Y1161MTRDIyETDYYPkinase_TyrPhosphoSitePlus; SysPTM
T11GGGSPtSLWGLPhosphoSitePlus
Y973GNGVLyASVNPPhosphoSitePlus
Y1166YETDYyRKGGKPkinase_TyrPhosphoSitePlus
S1278GFREVsFYYSEPhosphoSitePlus; HPRD
Y1166YETDYyRKGGKSRCHPRD; phosphoELM; RegPhos
T1163RDIYEtDYYRKPkinase_TyrPhosphoSitePlus
Y1165IYETDyYRKGGautocatalysisRegPhos; SysPTM
T1366LPQSStC____PhosphoSitePlus; SysPTM
S1308VPLDPsASSSSHPRD
S1193VFTTYsDVWSFPkinase_TyrPhosphoSitePlus
Y1166YETDYyRKGGKSrcRegPhos
Y1165IYETDyYRKGGSRCHPRD; phosphoELM; RegPhos; SysPTM
Y577KPWTQyAVYVKfn3PhosphoSitePlus
Y580TQYAVyVKAVTfn3PhosphoSitePlus
Y1161MTRDIyETDYYSRCHPRD; phosphoELM; RegPhos; SysPTM
Y980SVNPEyFSAADIGF1RphosphoELM; RegPhos
Y1161MTRDIyETDYYSrcRegPhos; SysPTM
S1312PSASSsSLPLPPhosphoSitePlus
Y1280REVSFyYSEENPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y973GNGVLyASVNPSRCHPRD; RegPhos
Y1346DERQPyAHMNGIGF1RphosphoELM; RegPhos
Y113GWKLFyNYALVRecep_L_domainPhosphoSitePlus
T28LSLWPtSGEICPhosphoSitePlus
Y973GNGVLyASVNPIGF1RphosphoELM; RegPhos
Y1165IYETDyYRKGGPkinase_TyrPhosphoSitePlus; SysPTM
Y1165IYETDyYRKGGSrcRegPhos; SysPTM
Y1014SFGMVyEGVAKPkinase_TyrPhosphoSitePlus
S1313SASSSsLPLPDPhosphoSitePlus
S1311DPSASsSSLPLPhosphoSitePlus
Y115KLFYNyALVIFRecep_L_domainPhosphoSitePlus
S9GSGGGsPTSLWPhosphoSitePlus
Y1166YETDYyRKGGKIGF1RphosphoELM; RegPhos
Y980SVNPEyFSAADPhosphoSitePlus; phosphoELM
S623LSASNsSSQLIfn3PhosphoSitePlus
Y1346DERQPyAHMNGPhosphoSitePlus; HPRD; RegPhos
Y980SVNPEyFSAADautocatalysisRegPhos
Y1165IYETDyYRKGGphosphoELM; SysPTM
S3___MKsGSGGGPhosphoSitePlus
S12GGSPTsLWGLLPhosphoSitePlus
S5_MKSGsGGGSPPhosphoSitePlus
T1366LPQSSHPRD; SysPTM
Y980SVNPEyFSAADSRCHPRD; RegPhos
Y1281EVSFYySEENKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y1281EVSFYySEENKIGF1RphosphoELM; RegPhos
S1321LPDRHsGHKAEPhosphoSitePlus
Y1161MTRDIyETDYYautocatalysisRegPhos; SysPTM
Y1161MTRDIyETDYYphosphoELM; SysPTM
S1339LVLRAsFDERQPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S624SASNSsSQLIVfn3PhosphoSitePlus

Dephosphorylation site
IGF1R_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000268035M1001LBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000268035Q1214*Greenman2007Renal Cancer17344846, 18428421
ENSP00000268035M1255IDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000268035Q351KBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000268035I364MDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000268035A1347VGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000268035A1206TBIOMARTchronic lymphocytic leukemia21930507, 21930502
ENSP00000268035A1209TBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000268035V105LGreenman2007Renal Cancer17344846, 18428421

Differential expressed protein
IGF1R_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IGF1R_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
IGF1_HUMANIGF1R_HUMANligand -> receptorHPMR
IGF1R_HUMANIRS1_HUMANkinase -> substrateHPRD; RegPhos
IGF1R_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
IGF1R_HUMANIGF1R_HUMANkinase -> substrateRegPhos
IGF1R_HUMANADRB2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
IGF1R_HUMANCRK_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
ZAGL2_HUMANIGF1R_HUMANkinase -> substrateRegPhos
IGF1R_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
IGF1R_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
SRC_HUMANIGF1R_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04144Endocytosis
hsa04730Long-term depression
hsa04520Adherens junction
hsa05215Prostate cancer
hsa05214Glioma
hsa05200Pathways in cancer
hsa05218Melanoma
hsa04510Focal adhesion
hsa05202Transcriptional misregulation in cancer
hsa04914Progesterone-mediated oocyte maturation
hsa04114Oocyte meiosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042802identical protein bindingIPImolecular_function
GO:0031017exocrine pancreas developmentIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0016020membraneIDAcellular_component
GO:0031994insulin-like growth factor I bindingIPImolecular_function
GO:0046328regulation of JNK cascadeIDAbiological_process
GO:0051389inactivation of MAPKK activityIDAbiological_process
GO:0043409negative regulation of MAPK cascadeIEAbiological_process
GO:0005887integral to plasma membraneICcellular_component
GO:0005158insulin receptor bindingIDAmolecular_function
GO:0001965G-protein alpha-subunit bindingIEAmolecular_function
GO:0043559insulin bindingIPImolecular_function
GO:0051291protein heterooligomerizationIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0045740positive regulation of DNA replicationIMPbiological_process
GO:0048009insulin-like growth factor receptor signaling pathIDAbiological_process
GO:0051897positive regulation of protein kinase B signaling IEAbiological_process
GO:0030335positive regulation of cell migrationIMPbiological_process
GO:0007409axonogenesisIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0051262protein tetramerizationIDAbiological_process
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0007420brain developmentIEAbiological_process
GO:0051054positive regulation of DNA metabolic processIEAbiological_process
GO:0005901caveolaIEAcellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0030010establishment of cell polarityIEAbiological_process
GO:0014065phosphatidylinositol 3-kinase cascadeICbiological_process
GO:0043560insulin receptor substrate bindingIPImolecular_function
GO:0046777protein autophosphorylationIDAbiological_process
GO:0031175neuron projection developmentIEAbiological_process
GO:0043410positive regulation of MAPK cascadeIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0004714transmembrane receptor protein tyrosine kinase actIEAmolecular_function
GO:0005520insulin-like growth factor bindingIDAmolecular_function
GO:0032467positive regulation of cytokinesisIEAbiological_process
GO:0006955immune responseIMPbiological_process
GO:0060740prostate gland epithelium morphogenesisIEAbiological_process
GO:0043548phosphatidylinositol 3-kinase bindingIPImolecular_function
GO:0090031positive regulation of steroid hormone biosynthetiIEAbiological_process
GO:0033197response to vitamin EIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0030238male sex determinationIEAbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0005010insulin-like growth factor-activated receptor actiIDAmolecular_function
GO:0004713protein tyrosine kinase activityIDAmolecular_function
GO:0008284positive regulation of cell proliferationTASbiological_process
GO:0030879mammary gland developmentIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0051898negative regulation of protein kinase B signaling IEAbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0048015phosphatidylinositol-mediated signalingIDAbiological_process
GO:0043005neuron projectionIEAcellular_component
GO:0009887organ morphogenesisIEAbiological_process
GO:0008286insulin receptor signaling pathwayTASbiological_process