Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RET_HUMAN
Description:ret proto-oncogene [Source:HGNC Symbol;Acc:9967]
Location:chr10 q11.21
Node attribute:substrate; kinase; receptor; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1062IENKLyGMSDPPhosphoSitePlus; phosphoELM
T753GRAGYtTVAVKHPRD
Y687AFPVSySSSGAPhosphoSitePlus
Y1096PNDSVyANWMLautocatalysisRegPhos
Y905YEEDSyVKRSQautocatalysisRegPhos
Y1090TGFPRyPNDSVRetRegPhos
T675SSAEMtFRRPAPhosphoSitePlus
Y900LSRDVyEEDSYRetRegPhos
Y1090TGFPRyPNDSVRETHPRD; phosphoELM; RegPhos
Y864SQGMQyLAEMKPkinase_TyrPhosphoSitePlus
S705MENQVsVDAFKPhosphoSitePlus
S891RKMKIsDFGLSphosphoELM; RegPhos
Y806LLIVEyAKYGSPkinase_TyrPhosphoSitePlus
Y809VEYAKyGSLRGPkinase_TyrPhosphoSitePlus
Y1062IENKLyGMSDPautocatalysisRegPhos
Y687AFPVSySSSGARETHPRD; phosphoELM; RegPhos
S686QAFPVsYSSSGPhosphoSitePlus
Y806LLIVEyAKYGSautocatalysisRegPhos
Y1029SDSLIyDDGLSPhosphoSitePlus; phosphoELM
Y981CSEEMyRLMLQRetRegPhos
Y900LSRDVyEEDSYRETHPRD; phosphoELM; RegPhos
Y905YEEDSyVKRSQRETHPRD; phosphoELM; RegPhos
Y981CSEEMyRLMLQRETHPRD; phosphoELM; RegPhos
Y809VEYAKyGSLRGRetRegPhos
Y809VEYAKyGSLRGRETHPRD; phosphoELM; RegPhos
Y752KGRAGyTTVAVPkinase_TyrPhosphoSitePlus
Y791HVIKLyGACSQPkinase_TyrPhosphoSitePlus
S159FPACSsLKPREPhosphoSitePlus
Y905YEEDSyVKRSQRetRegPhos
S891RKMKIsDFGLSPkinase_TyrPhosphoSitePlus
Y1029SDSLIyDDGLSRETHPRD; phosphoELM; RegPhos
Y1015VKRRDyLDLAAPhosphoSitePlus; phosphoELM
Y905YEEDSyVKRSQPkinase_TyrPhosphoSitePlus
Y1029SDSLIyDDGLSRetRegPhos
Y1015VKRRDyLDLAARETHPRD; phosphoELM; RegPhos
S696GARRPsLDSMEPhosphoSitePlus; phosphoELM; RegPhos
Y928LFDHIyTTQSDPkinase_TyrPhosphoSitePlus
Y1096PNDSVyANWMLRETHPRD; phosphoELM; RegPhos
Y1015VKRRDyLDLAARetRegPhos
Y1096PNDSVyANWMLPhosphoSitePlus; phosphoELM
Y1096PNDSVyANWMLRetRegPhos
Y806LLIVEyAKYGSRETHPRD; phosphoELM; RegPhos
Y826KVGPGyLGSGGphosphoELM
Y981CSEEMyRLMLQPkinase_TyrPhosphoSitePlus
Y1090TGFPRyPNDSVPhosphoSitePlus
Y806LLIVEyAKYGSRetRegPhos
S1065KLYGMsDPNWPPhosphoSitePlus
Y1062IENKLyGMSDPRetRegPhos
Y791HVIKLyGACSQphosphoELM; RegPhos
Y1062IENKLyGMSDPRETHPRD; phosphoELM; RegPhos
Y952LGGNPyPGIPPPkinase_TyrPhosphoSitePlus
Y1062IENKLyGRISHRETHPRD
Y809VEYAKyGSLRGautocatalysisRegPhos
Y1015VKRRDyLDLAAautocatalysisRegPhos
Y900LSRDVyEEDSYPkinase_TyrPhosphoSitePlus
Y826KVGPGyLGSGGRETHPRD; phosphoELM; RegPhos
Y900LSRDVyEEDSYautocatalysisRegPhos
Y826KVGPGyLGSGGRetRegPhos
Y981CSEEMyRLMLQautocatalysisRegPhos
S904VYEEDsYVKRSPkinase_TyrPhosphoSitePlus
Y1090TGFPRyPNDSVautocatalysisRegPhos
T754RAGYTtVAVKMHPRD
Y687AFPVSySSSGARetRegPhos
Y826KVGPGyLGSGGPkinase_TyrPhosphoSitePlus

Dephosphorylation site
RET_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000347942G593EBIOMART, HPIColorectal Cancer21930507, 21930502, 9359036 9067749 16959974
ENSP00000347942C634FOMIMThyroid Carcinoma7915165 12000816
ENSP00000347942F1112YHPIUrinary Bladder Cancer9359036 9067749 17344846
ENSP00000347942A639GHPIThyroid Carcinoma9359036 9067749 11692159
ENSP00000347942V145GBIOMART, HPIColorectal Cancer21930507, 21930502, 9359036 9067749 16959974 22131258
ENSP00000347942C620FHPIThyroid Carcinoma9359036 9067749 7915165 19826964 16705552 11187163
ENSP00000347942L790FOMIMOther Cancer9506724
ENSP00000344798F555LBIOMARTLung Cancer21930507, 21930502
ENSP00000347942M918TOMIM, HPIThyroid Carcinoma7906866 7977365 7911697 3078962 2660074 7906417 7536460 8825918, 9359036 9067749 7911697 7906866 7906417 8595427 8807338 18252215 22233172 22162469 22199277 22109971 21862994 21810974 21422803 21422198 21460789 21253810 21186952 21165219 20943719 19226610 19186126 19897677 19826964 18248620 19041016 18984779
ENSP00000347942A641GHPIThyroid Carcinoma9359036 9067749 11692159
ENSP00000347942S922FHPIThyroid Carcinoma9359036 9067749 11692159
ENSP00000347942C609ROMIMThyroid Carcinoma10982477
ENSP00000347942S891AOMIMOther Cancer15292360 9398735 10024437
ENSP00000347942D631GHPIThyroid Carcinoma9359036 9067749
ENSP00000347942R844LHPIThyroid Carcinoma9359036 9067749 10826520 17344846
ENSP00000347942C634WHPIThyroid Carcinoma9359036 9067749 12000816 21325074 22156466 22109971 21422803 20943719 20672905 19897677 18794325 18322301 18075281 17573899 17663821 17623957 17260470 16865647 15588376 15240784 12788868 11673360 9467562
ENSP00000347942C611GHPIThyroid Carcinoma9359036 9067749 9677065
ENSP00000347942L790FOMIM, HPIThyroid Carcinoma9506724, 9359036 9067749 9506724 21810974 21626080 20516206 18062802 12409662 15455293
ENSP00000347942M918TOMIMNeoplasms by Histologic Type7906866 7977365 7911697 3078962 2660074 7906417 7536460 8825918
ENSP00000347942C618YHPIThyroid Carcinoma9359036 9067749 18062802 18063059
ENSP00000347942R163QHPIColorectal Cancer9359036 9067749 17344846
ENSP00000347942V804LOMIMThyroid Carcinoma3697657 7784092 11932300 11589684 12694233 15741265
ENSP00000347942C634FOMIMNeoplasms by Histologic Type7915165 12000816
ENSP00000344798L923VBIOMARTLung Cancer21930507, 21930502
ENSP00000347942C618ROMIMThyroid Carcinoma7915165
ENSP00000347942C630YHPIThyroid Carcinoma9359036 9067749 17527003
ENSP00000344798T636MTCGAOvarian Cancer21720365, 18772890
ENSP00000347942V804MHPIThyroid Carcinoma9359036 9067749 9452077 10826520 21875731 21810974 21711375 21134561 20943719 20516206 20494215 20369307 19958926 19445625 19169500 18062802 18299477 17316110 18209889 17970769 17664273 17466010 16469774 17047083
ENSP00000347942R330WBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000347942M918TOMIMOther Cancer7906866 7977365 7911697 3078962 2660074 7906417 7536460 8825918
ENSP00000347942R360WBIOMARTColorectal Cancer21930507, 21930502
ENSP00000347942Y791FOMIM, HPIThyroid Carcinoma9506724 12000816 16118333 15870131, 9359036 9067749 9090527 9506724 12000816 21311890 21810974 20516206 20080836 19906784 19826964 18984779 18062802 18058472 17610518 17483988 17209045 17021738 16715139 16705552 16388093 16356097 16118333 15870131 15753368
ENSP00000347942C609YHPIThyroid Carcinoma9359036 9067749 7849720 7633441 9384613 19472011 18984779 18206480 18058472 17021738 16715139 16865647 15699703 15991157 15858153
ENSP00000344798R878*BIOMARTLung Cancer21930507, 21930502
ENSP00000344798E178KTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000347942S891AOMIM, HPIThyroid Carcinoma15292360 9398735 10024437, 9359036 9067749 9398735 21626080 20554711 20516206 18062802 18058472 17209045 16469774 15947103 15753368 11849247 11552438 10024437 10445857
ENSP00000347942G533COMIMThyroid Carcinoma14602786
ENSP00000347942C620SOMIMThyroid Carcinoma10777380
ENSP00000347942Y791FOMIMNeoplasms by Histologic Type9506724 12000816 16118333 15870131
ENSP00000347942C634FOMIMOther Cancer7915165 12000816
ENSP00000347942E768DOMIM, HPIThyroid Carcinoma9111992 7845675 7784092 12116277, 9359036 9067749 7845675 7784092 8807338 18062802 17097365 16736292 15875728 15855933 10445857 9242375 8732460
ENSP00000347942T946MHPIThyroid Carcinoma9359036 9067749

Differential expressed protein
RET_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RET_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GDNF_HUMANRET_HUMANligand -> receptorHPMR
ACK1_HUMANRET_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANRET_HUMANkinase -> substrateRobert H Newman (2013)
RET_HUMANMK01_HUMANkinase -> substrateHPRD; RegPhos
RET_HUMANFAK1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANRET_HUMANkinase -> substrateRegPhos
RET_HUMANPLCG1_HUMANkinase -> substrateHPRD; RegPhos
RET_HUMANSUMO4_HUMANkinase -> substrateRobert H Newman (2013)
RET_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
RET_HUMANMK09_HUMANkinase -> substrateHPRD; RegPhos
RET_HUMANETS1_HUMANkinase -> substrateRobert H Newman (2013)
RET_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
RET_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
RET_HUMANMTG16_HUMANkinase -> substrateRobert H Newman (2013)
RET_HUMANMK14_HUMANkinase -> substrateHPRD; RegPhos
RET_HUMANMK08_HUMANkinase -> substrateHPRD; RegPhos
RET_HUMANPDPK1_HUMANkinase -> substrateRobert H Newman (2013)
MK15_HUMANRET_HUMANkinase -> substrateRobert H Newman (2013)
RET_HUMANSHC3_HUMANkinase -> substrateRobert H Newman (2013)
DDR2_HUMANRET_HUMANkinase -> substrateRobert H Newman (2013)
RET_HUMANNAR4_HUMANkinase -> substrateHPRD; RegPhos
FGFR4_HUMANRET_HUMANkinase -> substrateRobert H Newman (2013)
RET_HUMANSTAT3_HUMANkinase -> substrateRobert H Newman (2013)
RET_HUMANRET_HUMANkinase -> substrateRegPhos
EGR1_HUMANRET_HUMANTF -> target geneTRANSFAC
SP3_HUMANRET_HUMANTF -> target geneTRANSFAC
SP1_HUMANRET_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04144Endocytosis
hsa05216Thyroid cancer
hsa05200Pathways in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005524ATP bindingIEAmolecular_function
GO:0071300cellular response to retinoic acidIMPbiological_process
GO:0072300positive regulation of metanephric glomerulus deveIEAbiological_process
GO:0097021lymphocyte migration into lymphoid organsISSbiological_process
GO:0072300positive regulation of metanephric glomerulus deveISSbiological_process
GO:0001755neural crest cell migrationIEAbiological_process
GO:0030155regulation of cell adhesionIDAbiological_process
GO:2001241positive regulation of extrinsic apoptotic signaliTASbiological_process
GO:0048265response to painIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0007497posterior midgut developmentTASbiological_process
GO:0005509calcium ion bindingIDAmolecular_function
GO:0007158neuron cell-cell adhesionIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0007156homophilic cell adhesionIEAbiological_process
GO:0007158neuron cell-cell adhesionIMPbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0033619membrane protein proteolysisIDAbiological_process
GO:0042551neuron maturationIEAbiological_process
GO:0007399nervous system developmentIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenISSbiological_process
GO:0004714transmembrane receptor protein tyrosine kinase actIEAmolecular_function
GO:0005887integral to plasma membraneIDAcellular_component
GO:0001838embryonic epithelial tube formationIEAbiological_process
GO:0004872receptor activityTASmolecular_function
GO:0000165MAPK cascadeIEAbiological_process
GO:0035799ureter maturationIEAbiological_process
GO:0030335positive regulation of cell migrationIDAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0033630positive regulation of cell adhesion mediated by iIDAbiological_process
GO:0061146Peyer's patch morphogenesisISSbiological_process
GO:0061146Peyer's patch morphogenesisIEAbiological_process
GO:0048265response to painISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0010976positive regulation of neuron projection developmeIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0001657ureteric bud developmentIEAbiological_process
GO:0010008endosome membraneIDAcellular_component
GO:0004713protein tyrosine kinase activityTASmolecular_function
GO:0048484enteric nervous system developmentIEAbiological_process