Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LYN_HUMAN
Description:v-yes-1 Yamaguchi sarcoma viral related oncogene homolog [Source:HGNC Symbol;Acc:6735]
Location:chr8 q12.1
Node attribute:PPI(target); cleavage(target); ubiquitination(target); substrate; kinase; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y193LDNGGyYISPRSH2PhosphoSitePlus
Y508ATEGQyQQphosphoELM; SysPTM
S228EKACIsPKPQKPhosphoSitePlus; HPRD; SysPTM
S149LAPGNsAGAFLSH2PhosphoSitePlus
Y460ALSQGyRMPRVPkinase_TyrPhosphoSitePlus
Y193LDNGGyYISPRHPRD; phosphoELM; RegPhos
T58GQRFQtKDPEEPhosphoSitePlus
Y194DNGGYyISPRIHPRD; phosphoELM; RegPhos; SysPTM
Y492RPTFDyLQSVLHPRD
S158FLIREsETLKGSH2PhosphoSitePlus
S164ETLKGsFSLSVSH2PhosphoSitePlus
T438LYEIVtYGKIPPkinase_TyrPhosphoSitePlus
Y508ATEGQyQQQP_PhosphoSitePlus; SysPTM
Y397IEDNEyTAREGLYNHPRD; RegPhos; SysPTM
T448PYPGRtNADVMPkinase_TyrPhosphoSitePlus
Y397IEDNEyTAREGLynphosphoELM; RegPhos; SysPTM
Y508ATEGQyQQMATKHPRD; SysPTM
Y508ATEGQyQQQPRegPhos; SysPTM
Y397IEDNEyTAREGPkinase_TyrPhosphoSitePlus; SysPTM
Y194DNGGYyISPRISH2PhosphoSitePlus; SysPTM
T502LDDFYtATEGQPhosphoSitePlus
Y501VLDDFyTATEGPhosphoSitePlus; HPRD; SysPTM
Y508ATEGQyQQQPCTKRegPhos; SysPTM
S246EIPREsIKLVKPhosphoSitePlus; HPRD
Y117FIPSNyVAKLNPhosphoSitePlus
Y397IEDNEyTAREGphosphoELM; SysPTM
Y508ATEGQyQQCSKHPRD; SysPTM
S11SKGKDsLSDDGPhosphoSitePlus; HPRD; RegPhos; SysPTM
Y316REEPIyIITEYHPRD
Y473CPDELyDIMKMHPRD; phosphoELM; SysPTM
Y508ATEGQyQQCskphosphoELM; SysPTM
Y306KLVRLyAVVTRHPRD; phosphoELM
Y397IEDNEyTAREGautocatalysis RegPhos; SysPTM
Y439YEIVTyGKIPYPkinase_TyrPhosphoSitePlus
Y321YIITEyMAKGSPkinase_TyrPhosphoSitePlus
Y316REEPIyIITEYPkinase_TyrPhosphoSitePlus
T319PIYIItEYMAKPkinase_TyrPhosphoSitePlus
Y265EVWMGyYNNSTPkinase_TyrPhosphoSitePlus
Y508ATEGQyQQQPCSKRegPhos; SysPTM
Y32TERTIyVRDPTPhosphoSitePlus; HPRD; SysPTM
Y266VWMGYyNNSTKPkinase_TyrPhosphoSitePlus
T398EDNEYtAREGAPkinase_TyrPhosphoSitePlus
T489AEERPtFDYLQHPRD
Y508ATEGQyQQQPCskRegPhos; SysPTM
Y473CPDELyDIMKMPkinase_TyrPhosphoSitePlus; SysPTM
Y306KLVRLyAVVTRPkinase_TyrPhosphoSitePlus
T504DFYTAtEGQYQPhosphoSitePlus; HPRD
S269GYYNNsTKVAVPkinase_TyrPhosphoSitePlus
S13GKDSLsDDGVDPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y508YTATEGQyQQQPPTPRCHPRD
Y397RVIEDNEyTAREGAKPTPN6HPRD
Y397RVIEDNEyTAREGAKPTPRCHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000428424A98VTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000428924D385YHPIBreast Cancer17344846

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000428924Uterine CancerNormal vs. Cancercell lineUp22015838902

Hyperphosphorylation site
LYN_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
LYN_HUMANTRPV4_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
LYN_HUMANHCLS1_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
LYN_HUMANCLNK_HUMANkinase -> substrateRegPhos
LYN_HUMANFCERB_HUMANkinase -> substrateKEGG
LYN_HUMANKPYM_HUMANkinase -> substrateRobert H Newman (2013)
LYN_HUMANCDK1_HUMANkinase -> substrateHPRD; RegPhos
LYN_HUMANTEC_HUMANkinase -> substrateNetPath
LYN_HUMANGAB2_HUMANkinase -> substrateNetPath
LYN_HUMANHSP72_HUMANkinase -> substrateRobert H Newman (2013)
LYN_HUMANKSYK_HUMANkinase -> substrateRegPhos; NetPath
LYN_HUMANKPCD_HUMANkinase -> substrateRegPhos
LYN_HUMANFCG2A_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
LYN_HUMANLIME1_HUMANkinase -> substrateNetPath
LYN_HUMANCDN1B_HUMANkinase -> substrateHPRD; RegPhos
LYN_HUMAN1433Z_HUMANkinase -> substrateRobert H Newman (2013)
LYN_HUMANNAR4_HUMANkinase -> substrateNetPath
LYN_HUMANBANK1_HUMANkinase -> substrateNetPath
LYN_HUMANCD79A_HUMANkinase -> substrateKEGG; HPRD; RegPhos; NetPath; Robert H Newman (201
LYN_HUMANMAP2_HUMANkinase -> substrateRobert H Newman (2013)
LYN_HUMANCD79B_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
LYN_HUMANITPR1_HUMANkinase -> substrateNetPath
LYN_HUMANNDUB4_HUMANkinase -> substrateRobert H Newman (2013)
LYN_HUMANSYUA_HUMANkinase -> substrateHPRD; RegPhos
LYN_HUMANFCG2C_HUMANkinase -> substrateRobert H Newman (2013)
LYN_HUMANFCG2B_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
LYN_HUMANCD72_HUMANkinase -> substrateNetPath
LYN_HUMANPLCG1_HUMANkinase -> substrateRegPhos
LYN_HUMANTB10B_HUMANkinase -> substrateRobert H Newman (2013)
LYN_HUMANMK03_HUMANkinase -> substrateNetPath
MATK_HUMANLYN_HUMANkinase -> substrateHPRD; RegPhos
LYN_HUMANRM18_HUMANkinase -> substrateRobert H Newman (2013)
LYN_HUMANCD19_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
LYN_HUMANCSK21_HUMANkinase -> substrateRobert H Newman (2013)
LYN_HUMANSTA5A_HUMANkinase -> substrateRobert H Newman (2013)
LYN_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANLYN_HUMANkinase -> substrateRegPhos
LYN_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
LYN_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
LYN_HUMANPLCG2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
LYN_HUMANBTK_HUMANkinase -> substrateKEGG; HPRD; RegPhos; NetPath; Robert H Newman (201
LYN_HUMANSLAF1_HUMANkinase -> substrateRobert H Newman (2013)
LYN_HUMANB3AT_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
LYN_HUMANM4K1_HUMANkinase -> substrateHPRD; RegPhos
LYN_HUMANNMT1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
LYN_HUMANPP1R8_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
LYN_HUMANDOK2_HUMANkinase -> substrateHPRD
LYN_HUMANRGS16_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
LYN_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
LYN_HUMANHCD2_HUMANkinase -> substrateRobert H Newman (2013)
LYN_HUMANPTN6_HUMANkinase -> substrateHPRD; RegPhos
LYN_HUMANCD22_HUMANkinase -> substrateNetPath
LYN_HUMANBCAR1_HUMANkinase -> substrateNetPath
CSK_HUMANLYN_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
LYN_HUMANLYN_HUMANkinase -> substrateNetPath
LYN_HUMANDAPP1_HUMANkinase -> substrateKEGG; HPRD; RegPhos
LYN_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
LYN_HUMANFCERG_HUMANkinase -> substrateKEGG
LYN_HUMANEPOR_HUMANkinase -> substrateRobert H Newman (2013)
PTN6_HUMANLYN_HUMANphosphatase -> substrateHPRD
PTPRC_HUMANLYN_HUMANphosphatase -> substrateHPRD
CBL_HUMANLYN_HUMANubiquitinationNetPath
CASP7_HUMANLYN_HUMANcleavageNetPath
CASP9_HUMANLYN_HUMANcleavageNetPath
SHIP1_HUMANLYN_HUMANotherKEGG
CSK_HUMANLYN_HUMANotherKEGG
ELF2_HUMANLYN_HUMANTF -> target geneTRANSFAC
ETV7_HUMANLYN_HUMANTF -> target geneTRANSFAC
PO2F1_HUMANLYN_HUMANTF -> target geneTRANSFAC
PO2F2_HUMANLYN_HUMANTF -> target geneTRANSFAC
ELF1_HUMANLYN_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04664Fc epsilon RI signaling pathway
hsa04064NF-kappa B signaling pathway
hsa04662B cell receptor signaling pathway
hsa04062Chemokine signaling pathway
hsa05203Viral carcinogenesis
hsa05169Epstein-Barr virus infection
hsa04730Long-term depression
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa04666Fc gamma R-mediated phagocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0009725response to hormone stimulusISSbiological_process
GO:0045121membrane raftIDAcellular_component
GO:0005161platelet-derived growth factor receptor bindingIEAmolecular_function
GO:0048678response to axon injuryIEAbiological_process
GO:0005178integrin bindingIEAmolecular_function
GO:0019899enzyme bindingIEAmolecular_function
GO:0002576platelet degranulationISSbiological_process
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0001782B cell homeostasisIEAbiological_process
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0031663lipopolysaccharide-mediated signaling pathwayISSbiological_process
GO:0005829cytosolTAScellular_component
GO:0060369positive regulation of Fc receptor mediated stimulIEAbiological_process
GO:0006991response to sterol depletionIEAbiological_process
GO:0010976positive regulation of neuron projection developmeIMPbiological_process
GO:0005634nucleusIEAcellular_component
GO:0010741negative regulation of intracellular protein kinasIEAbiological_process
GO:0002513tolerance induction to self antigenISSbiological_process
GO:0030097hemopoiesisIEAbiological_process
GO:0002902regulation of B cell apoptotic processIEAbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0070304positive regulation of stress-activated protein kiIDAbiological_process
GO:0002774Fc receptor mediated inhibitory signaling pathwayISSbiological_process
GO:0014069postsynaptic densityIEAcellular_component
GO:0009725response to hormone stimulusIEAbiological_process
GO:0002553histamine secretion by mast cellIEAbiological_process
GO:2000670positive regulation of dendritic cell apoptotic prIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0002431Fc receptor mediated stimulatory signaling pathwayIEAbiological_process
GO:0045646regulation of erythrocyte differentiationISSbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0090025regulation of monocyte chemotaxisIMPbiological_process
GO:2000670positive regulation of dendritic cell apoptotic prISSbiological_process
GO:0097028dendritic cell differentiationIEAbiological_process
GO:0034666alpha2-beta1 integrin complexIEAcellular_component
GO:0046777protein autophosphorylationIDAbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0043304regulation of mast cell degranulationISSbiological_process
GO:0032868response to insulin stimulusIEAbiological_process
GO:0001933negative regulation of protein phosphorylationISSbiological_process
GO:0002431Fc receptor mediated stimulatory signaling pathwayISSbiological_process
GO:0002768immune response-regulating cell surface receptor sISSbiological_process
GO:0005102receptor bindingIEAmolecular_function
GO:0045121membrane raftIEAcellular_component
GO:0002762negative regulation of myeloid leukocyte differentIEAbiological_process
GO:0043407negative regulation of MAP kinase activityISSbiological_process
GO:0001782B cell homeostasisISSbiological_process
GO:0043407negative regulation of MAP kinase activityIEAbiological_process
GO:0050663cytokine secretionIEAbiological_process
GO:0004715non-membrane spanning protein tyrosine kinase actiTASmolecular_function
GO:0050853B cell receptor signaling pathwayIEAbiological_process
GO:0001817regulation of cytokine productionISSbiological_process
GO:0070668positive regulation of mast cell proliferationIMPbiological_process
GO:0070447positive regulation of oligodendrocyte progenitor IEAbiological_process
GO:0009743response to carbohydrate stimulusIEAbiological_process
GO:0030218erythrocyte differentiationIEAbiological_process
GO:0070667negative regulation of mast cell proliferationIEAbiological_process
GO:0032403protein complex bindingIEAmolecular_function
GO:0042531positive regulation of tyrosine phosphorylation ofISSbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0002576platelet degranulationIEAbiological_process
GO:0001933negative regulation of protein phosphorylationIEAbiological_process
GO:0043552positive regulation of phosphatidylinositol 3-kinaIEAbiological_process
GO:0031625ubiquitin protein ligase bindingIEAmolecular_function
GO:0043208glycosphingolipid bindingIEAmolecular_function
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0034136negative regulation of toll-like receptor 2 signalISSbiological_process
GO:0008284positive regulation of cell proliferationISSbiological_process
GO:0004713protein tyrosine kinase activityIDAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0090330regulation of platelet aggregationISSbiological_process
GO:0002513tolerance induction to self antigenIEAbiological_process
GO:0031668cellular response to extracellular stimulusIEAbiological_process
GO:0008285negative regulation of cell proliferationIMPbiological_process
GO:0060252positive regulation of glial cell proliferationIEAbiological_process
GO:0023014signal transduction by phosphorylationTASbiological_process
GO:0034136negative regulation of toll-like receptor 2 signalIEAbiological_process
GO:0043304regulation of mast cell degranulationIEAbiological_process
GO:0002774Fc receptor mediated inhibitory signaling pathwayIEAbiological_process
GO:0043200response to amino acid stimulusIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0009636response to toxinIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0034605cellular response to heatIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigIMPbiological_process
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0005737cytoplasmISScellular_component
GO:0070373negative regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0033628regulation of cell adhesion mediated by integrinIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0004716receptor signaling protein tyrosine kinase activitTASmolecular_function
GO:0034144negative regulation of toll-like receptor 4 signalISSbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0031966mitochondrial membraneIEAcellular_component
GO:0031175neuron projection developmentIEAbiological_process
GO:0051272positive regulation of cellular component movementIDAbiological_process
GO:0030889negative regulation of B cell proliferationIEAbiological_process
GO:0050707regulation of cytokine secretionIEAbiological_process
GO:0001932regulation of protein phosphorylationTASbiological_process
GO:0044325ion channel bindingIPImolecular_function
GO:0035556intracellular signal transductionIEAbiological_process
GO:0031663lipopolysaccharide-mediated signaling pathwayIEAbiological_process
GO:0050855regulation of B cell receptor signaling pathwayIEAbiological_process
GO:0010741negative regulation of intracellular protein kinasISSbiological_process
GO:0043434response to peptide hormone stimulusIEAbiological_process
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIEAbiological_process
GO:0071300cellular response to retinoic acidIMPbiological_process
GO:0030061mitochondrial cristaIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0030218erythrocyte differentiationISSbiological_process
GO:0016020membraneIEAcellular_component
GO:0050777negative regulation of immune responseTASbiological_process
GO:0006974response to DNA damage stimulusIDAbiological_process
GO:0070667negative regulation of mast cell proliferationISSbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0051219phosphoprotein bindingIEAmolecular_function
GO:0005758mitochondrial intermembrane spaceIEAcellular_component
GO:0060397JAK-STAT cascade involved in growth hormone signalTASbiological_process
GO:0014003oligodendrocyte developmentIEAbiological_process
GO:0042327positive regulation of phosphorylationIEAbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0050855regulation of B cell receptor signaling pathwayISSbiological_process
GO:0090330regulation of platelet aggregationIEAbiological_process
GO:0001817regulation of cytokine productionIEAbiological_process
GO:0042981regulation of apoptotic processIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0046777protein autophosphorylationIEAbiological_process
GO:0005634nucleusISScellular_component
GO:0070373negative regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:0050727regulation of inflammatory responseIEAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0034144negative regulation of toll-like receptor 4 signalIEAbiological_process
GO:0033003regulation of mast cell activationISSbiological_process
GO:0070372regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0002768immune response-regulating cell surface receptor sIEAbiological_process
GO:0051279regulation of release of sequestered calcium ion iIEAbiological_process
GO:0045087innate immune responseIEAbiological_process
GO:0042531positive regulation of tyrosine phosphorylation ofIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0045646regulation of erythrocyte differentiationIEAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0097028dendritic cell differentiationISSbiological_process
GO:0033003regulation of mast cell activationIEAbiological_process
GO:0070372regulation of ERK1 and ERK2 cascadeISSbiological_process