Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IKKB_HUMAN
Description:inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [Source:HGNC Symbol;Acc:5960]
Location:chr8 p11.21
Node attribute:substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S692LMSQPsTASNSautocatalysis RegPhos
Y609KVRVIyTQLSKPhosphoSitePlus
S740TALDWsWLQTEautocatalysis RegPhos
S750EEEEHsCLEQAPhosphoSitePlus
S695QPSTAsNSLPEIKK_groupphosphoELM; RegPhos
S181GSLCTsFVGTLPKCzRegPhos
S181GSLCTsFVGTLPKCtRegPhos
S740TALDWsWLQTEIKKbetaNEMObindPhosphoSitePlus
S740TALDWsWLQTEIKKbRegPhos
Y188VGTLQyLAPELPkinasePhosphoSitePlus
S181GSLCTsFVGTLPkinasePhosphoSitePlus
S682NASRLsQPGQLIKBKBHPRD
S697STASNsLPEPAIKKbRegPhos
S740TALDWsWLQTEIKK_groupphosphoELM; RegPhos
S679DSMNAsRLSQPPhosphoSitePlus
S181GSLCTsFVGTLTAK1RegPhos
S692LMSQPsTASNSPhosphoSitePlus
S697STASNsLPEPAautocatalysis RegPhos
S177ELDQGsLCTSFTAK1RegPhos
S672GPVSGsPDSMNIKBKBHPRD; SysPTM
S177ELDQGsLCTSFPRKCQHPRD
S177ELDQGsLCTSFPKCzRegPhos
S689PGQLMsQPSTAIKBKBHPRD
S733REQDQsFTALDIKK_groupphosphoELM; RegPhos
S750EEEEHsCLEQAautocatalysis RegPhos
S177ELDQGsLCTSFCHUKHPRD
S177ELDQGsLCTSFMAP3K7HPRD
S411QPESVsCILQEPhosphoSitePlus
S675SGSPDsMNASRIKK_groupphosphoELM; RegPhos
S705EPAKKsEELVAIKBKBHPRD
S600LQAIQsFEKKVPhosphoSitePlus
S733REQDQsFTALDIKBKBHPRD
S181GSLCTsFVGTLHPRD; RegPhos
S181GSLCTsFVGTLIKKaRegPhos
S672GPVSGsPDSMNPhosphoSitePlus; phosphoELM; SysPTM
S670VRGPVsGSPDSPhosphoSitePlus
S682NASRLsQPGQLIKK_groupphosphoELM; RegPhos
S177ELDQGsLCTSFPRKCZHPRD
S679DSMNAsRLSQPIKBKBHPRD
S695QPSTAsNSLPEIKKbRegPhos
S409RPQPEsVSCILPhosphoSitePlus
S697STASNsLPEPAIKK_groupphosphoELM; RegPhos
S689PGQLMsQPSTAIKKbRegPhos
S682NASRLsQPGQLIKKbRegPhos
Y199LEQQKyTVTVDPkinasePhosphoSitePlus
S705EPAKKsEELVAautocatalysis RegPhos
S675SGSPDsMNASRPhosphoSitePlus
C179DQGSLcTSFVGIKBKBHPRD
S670VRGPVsGSPDSIKKbRegPhos
S750EEEEHsCLEQAIKKbRegPhos
S672GPVSGsPDSMNIKK_groupphosphoELM; RegPhos; SysPTM
S177ELDQGsLCTSFIKK_groupphosphoELM; RegPhos
S679DSMNAsRLSQPIKKbRegPhos
S733REQDQsFTALDIKKbRegPhos
T23KERLGtGGFGNRegPhos
S177ELDQGsLCTSFPKCtRegPhos
S750EEEEHsCLEQIKK_groupphosphoELM
S177ELDQGsLCTSFNIKRegPhos
S740TALDWsWLQTEIKBKBHPRD
S695QPSTAsNSLPEIKBKBHPRD
S181GSLCTsFVGTLCHUKHPRD
S181GSLCTsFVGTLNIKRegPhos
S692LMSQPsTASNSIKK_groupphosphoELM; RegPhos
S733REQDQsFTALDautocatalysis RegPhos
S756CLEQIKBKBHPRD
S181GSLCTsFVGTLIKK_groupphosphoELM; RegPhos
S692LMSQPsTASNSIKBKBHPRD
S697STASNsLPEPAIKBKBHPRD
S181GSLCTsFVGTLPRKCQHPRD
S675SGSPDsMNASRIKBKBHPRD
S550VDLQRsPMGRKPhosphoSitePlus
S670VRGPVsGSPDSautocatalysis RegPhos
S675SGSPDsMNASRautocatalysis RegPhos
S675SGSPDsMNASRIKKbRegPhos
S689PGQLMsQPSTAautocatalysis RegPhos
S181GSLCTsFVGTLPRKCZHPRD
S177ELDQGsLCTSFHPRD; RegPhos
S692LMSQPsTASNSIKKbRegPhos
S695QPSTAsNSLPEautocatalysis RegPhos
S181GSLCTsFVGTLMAP3K14HPRD
S733REQDQsFTALDIKKbetaNEMObindPhosphoSitePlus
S750EEEEHsCLEQAIKK_groupRegPhos
S689PGQLMsQPSTAIKK_groupphosphoELM; RegPhos
S672GPVSGsPDSMNautocatalysis RegPhos; SysPTM
S670VRGPVsGSPDSIKK_groupphosphoELM; RegPhos
S682NASRLsQPGQLautocatalysis RegPhos
S689PGQLMsQPSTAPhosphoSitePlus
S177ELDQGsLCTSFMAP3K14HPRD
S705EPAKKsEELVAIKKbRegPhos
S705EPAKKsEELVAIKK_groupphosphoELM; RegPhos
S756CLEQAsIKKbRegPhos
S471SKMKNsMASMSPhosphoSitePlus
S181GSLCTsFVGTLMAP3K7HPRD
S750EEEEHsCLEQIKBKBHPRD
S177ELDQGsLCTSFIKKaRegPhos
S177ELDQGsLCTSFPkinasePhosphoSitePlus
S670VRGPVsGSPDSIKBKBHPRD
S672GPVSGsPDSMNIKKbRegPhos; SysPTM

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S181DQGSLCTsFVGTLQYPPM1BHPRD
S177AKELDQGsLCTSFVGPPM1BHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000430684N677DCOSMICGastric Cancer21097718
ENSP00000430868D637NTCGAOvarian Cancer21720365, 18772890
ENSP00000430684W58RCOSMICLung Cancer20668451
ENSP00000430684A360SBIOMARTBreast Cancer21930507, 21930502
ENSP00000430684G667CCOSMICLung Cancer20668451

Differential expressed protein
IKKB_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IKKB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
IKKB_HUMANTSC1_HUMANkinase -> substrateKEGG; NetPath
IKKB_HUMANT22D3_HUMANkinase -> substrateRobert H Newman (2013)
IKKB_HUMANNCOA3_HUMANkinase -> substrateHPRD
M4K4_HUMANIKKB_HUMANkinase -> substrateRegPhos
SRC_HUMANIKKB_HUMANkinase -> substrateNetPath
IKKB_HUMANFOXO3_HUMANkinase -> substrateRobert H Newman (2013)
IKKB_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
IKKB_HUMANIKBB_HUMANkinase -> substrateHPRD; NetPath
IKKB_HUMANNFKB1_HUMANkinase -> substrateHPRD; NetPath; Robert H Newman (2013)
M3K3_HUMANIKKB_HUMANkinase -> substrateNetPath
M3K7_HUMANIKKB_HUMANkinase -> substrateKEGG; HPRD; NetPath
IKKB_HUMANNEMO_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
IKKB_HUMANIKBA_HUMANkinase -> substrateNetPath
IKKB_HUMANIKKB_HUMANkinase -> substrateHPRD; NetPath
IKKB_HUMANTF65_HUMANkinase -> substrateNetPath; Robert H Newman (2013)
KPCZ_HUMANIKKB_HUMANkinase -> substrateHPRD
KPCB_HUMANIKKB_HUMANkinase -> substrateNetPath
NR2C2_HUMANIKKB_HUMANkinase -> substrateRegPhos
M3K14_HUMANIKKB_HUMANkinase -> substrateHPRD
ZAGL2_HUMANIKKB_HUMANkinase -> substrateRegPhos
IKKB_HUMANNAR4_HUMANkinase -> substrateNetPath
KPCT_HUMANIKKB_HUMANkinase -> substrateHPRD
IKKA_HUMANIKKB_HUMANkinase -> substrateHPRD
IKKB_HUMANIRS1_HUMANkinase -> substrateKEGG; HPRD
PPM1B_HUMANIKKB_HUMANphosphatase -> substrateHPRD
CASP7_HUMANIKKB_HUMANotherNetPath
CASP3_HUMANIKKB_HUMANotherNetPath
TNFA_HUMANIKKB_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04210Apoptosis
hsa04064NF-kappa B signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa05212Pancreatic cancer
hsa04622RIG-I-like receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa04660T cell receptor signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa05166HTLV-I infection
hsa05222Small cell lung cancer
hsa05145Toxoplasmosis
hsa05164Influenza A
hsa04150mTOR signaling pathway
hsa04722Neurotrophin signaling pathway
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa05221Acute myeloid leukemia
hsa04621NOD-like receptor signaling pathway
hsa05131Shigellosis
hsa04920Adipocytokine signaling pathway
hsa04010MAPK signaling pathway
hsa05160Hepatitis C
hsa05200Pathways in cancer
hsa04062Chemokine signaling pathway
hsa05220Chronic myeloid leukemia
hsa05215Prostate cancer
hsa04380Osteoclast differentiation
hsa04930Type II diabetes mellitus
hsa05168Herpes simplex infection
hsa04910Insulin signaling pathway
hsa05169Epstein-Barr virus infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051092positive regulation of NF-kappaB transcription facIDAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0070423nucleotide-binding oligomerization domain containiTASbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0009615response to virusTASbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0042802identical protein bindingIPImolecular_function
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0008384IkappaB kinase activityTASmolecular_function
GO:0035872nucleotide-binding domain, leucine rich repeat conTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0045893positive regulation of transcription, DNA-dependenNASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0004674protein serine/threonine kinase activityTASmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0006954inflammatory responseTASbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0010765positive regulation of sodium ion transportIEAbiological_process
GO:0009898internal side of plasma membraneISScellular_component
GO:0016020membraneIEAcellular_component
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0035631CD40 receptor complexISScellular_component
GO:0008063Toll signaling pathwayTASbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0007249I-kappaB kinase/NF-kappaB cascadeTASbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0045087innate immune responseTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0008384IkappaB kinase activityIEAmolecular_function
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:2001259positive regulation of cation channel activityIEAbiological_process
GO:0001782B cell homeostasisIEAbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0032481positive regulation of type I interferon productioTASbiological_process
GO:0007252I-kappaB phosphorylationTASbiological_process
GO:0008385IkappaB kinase complexTAScellular_component
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cTASbiological_process