Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NKX25_HUMAN
Description:NK2 homeobox 5 [Source:HGNC Symbol;Acc:2488]
Location:chr5 q35.1
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S164QQRYLsAPERDCSNK2A1HPRD
S164QQRYLsAPERDHomeoboxPhosphoSitePlus
T180LKLTStQVKIWHomeoboxPhosphoSitePlus

Dephosphorylation site
NKX25_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000327758A108TCOSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
NKX25_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NKX25_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANNKX25_HUMANkinase -> substrateHPRD
NKX25_HUMANPLOD1_HUMANTF -> target geneTRANSFAC
NKX25_HUMANANF_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
NKX25_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0003148outflow tract septum morphogenesisIMPbiological_process
GO:0003162atrioventricular node developmentIEAbiological_process
GO:0060261positive regulation of transcription initiation frIEAbiological_process
GO:0005667transcription factor complexIEAcellular_component
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0055008cardiac muscle tissue morphogenesisIMPbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0060047heart contractionIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0003211cardiac ventricle formationIEAbiological_process
GO:0003221right ventricular cardiac muscle tissue morphogeneIMPbiological_process
GO:0003208cardiac ventricle morphogenesisIEAbiological_process
GO:0003007heart morphogenesisISSbiological_process
GO:0010667negative regulation of cardiac muscle cell apoptotIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0060070canonical Wnt receptor signaling pathwayIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0001190RNA polymerase II transcription factor binding traIEAmolecular_function
GO:0030878thyroid gland developmentIEAbiological_process
GO:0010736serum response element bindingISSmolecular_function
GO:0030097hemopoiesisIEAbiological_process
GO:0048738cardiac muscle tissue developmentIEAbiological_process
GO:0060037pharyngeal system developmentIEAbiological_process
GO:0010667negative regulation of cardiac muscle cell apoptotIMPbiological_process
GO:0055005ventricular cardiac myofibril developmentIEAbiological_process
GO:0001947heart loopingIEAbiological_process
GO:0060261positive regulation of transcription initiation frISSbiological_process
GO:0003285septum secundum developmentIMPbiological_process
GO:0035050embryonic heart tube developmentIEAbiological_process
GO:0003278apoptotic process involved in heart morphogenesisIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenISSbiological_process
GO:0060043regulation of cardiac muscle cell proliferationIEAbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0003161cardiac conduction system developmentIEAbiological_process
GO:0010735positive regulation of transcription via serum resISSbiological_process
GO:0003168Purkinje myocyte differentiationIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0003682chromatin bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0055007cardiac muscle cell differentiationISSbiological_process
GO:0007512adult heart developmentIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0060412ventricular septum morphogenesisIMPbiological_process
GO:0072358cardiovascular system developmentIEAbiological_process
GO:0030097hemopoiesisISSbiological_process
GO:0007512adult heart developmentIMPbiological_process
GO:0001570vasculogenesisIEAbiological_process
GO:0055007cardiac muscle cell differentiationIEAbiological_process
GO:0035050embryonic heart tube developmentISSbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIMPbiological_process
GO:0090090negative regulation of canonical Wnt receptor signIEAbiological_process
GO:0043565sequence-specific DNA bindingIDAmolecular_function
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIGIbiological_process
GO:0010765positive regulation of sodium ion transportIEAbiological_process
GO:0030878thyroid gland developmentIMPbiological_process
GO:0003007heart morphogenesisIEAbiological_process
GO:0010736serum response element bindingIEAmolecular_function
GO:0055015ventricular cardiac muscle cell developmentISSbiological_process
GO:1901387positive regulation of voltage-gated calcium channIEAbiological_process
GO:0003682chromatin bindingIDAmolecular_function
GO:0030509BMP signaling pathwayIEAbiological_process
GO:0003151outflow tract morphogenesisIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0060038cardiac muscle cell proliferationIEAbiological_process
GO:0001570vasculogenesisISSbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0005667transcription factor complexICcellular_component
GO:0003705RNA polymerase II distal enhancer sequence-specifiIEAmolecular_function
GO:0060347heart trabecula formationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045823positive regulation of heart contractionIEAbiological_process
GO:0010832negative regulation of myotube differentiationIMPbiological_process
GO:0090090negative regulation of canonical Wnt receptor signISSbiological_process
GO:0060413atrial septum morphogenesisIMPbiological_process
GO:0045823positive regulation of heart contractionISSbiological_process
GO:0055117regulation of cardiac muscle contractionISSbiological_process
GO:0060971embryonic heart tube left/right pattern formationIEAbiological_process
GO:0003222ventricular trabecula myocardium morphogenesisIEAbiological_process
GO:0048536spleen developmentISSbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0001104RNA polymerase II transcription cofactor activityIEAmolecular_function
GO:0003342proepicardium developmentIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0060037pharyngeal system developmentISSbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0030154cell differentiationISSbiological_process
GO:0010765positive regulation of sodium ion transportISSbiological_process
GO:0055117regulation of cardiac muscle contractionIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0045214sarcomere organizationIEAbiological_process
GO:0010735positive regulation of transcription via serum resIEAbiological_process
GO:0051891positive regulation of cardioblast differentiationISSbiological_process
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0001947heart loopingISSbiological_process
GO:0051891positive regulation of cardioblast differentiationIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0003350pulmonary myocardium developmentIEAbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0055014atrial cardiac muscle cell developmentISSbiological_process
GO:0060929atrioventricular node cell fate commitmentIEAbiological_process
GO:0003161cardiac conduction system developmentIMPbiological_process
GO:0045666positive regulation of neuron differentiationIMPbiological_process
GO:0060048cardiac muscle contractionIEAbiological_process
GO:1901387positive regulation of voltage-gated calcium channISSbiological_process
GO:0046982protein heterodimerization activityISSmolecular_function
GO:0008284positive regulation of cell proliferationISSbiological_process
GO:0060928atrioventricular node cell developmentIEAbiological_process
GO:0003166bundle of His developmentIEAbiological_process