Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GLI1_HUMAN
Description:GLI family zinc finger 1 [Source:HGNC Symbol;Acc:4317]
Location:chr12 q13.3
Node attribute:TF; PPI(target); substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S640VTRRAsDPAQAPhosphoSitePlus
S544LERRSsSSSSIPhosphoSitePlus
S545ERRSSsSSSISPhosphoSitePlus
S84KKRALsISPLSPhosphoSitePlus
T374CTKRYtDPSSLzf-C2H2PhosphoSitePlus
T527LSHTGtTVSRRPhosphoSitePlus
S538VGPPVsLERRSPhosphoSitePlus
S560VSRRSsLASPFPhosphoSitePlus
S521GLKLPsLSHTGPhosphoSitePlus
S622MPPWRsRAEYPPhosphoSitePlus
S602RGGGTsPTAASPhosphoSitePlus

Dephosphorylation site
GLI1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000228682T514ISjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000228682E817QSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000228682N632KCOSMICOvarian Cancer21720365
ENSP00000228682R113QCOSMICPancreatic Cancer
ENSP00000228682S1094FCOSMICMelanoma20016485
ENSP00000228682P210ASjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000228682R72QBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000228682G263RCOSMICSkin Cancer21984974
ENSP00000228682R1093SCOSMICOvarian Cancer21720365
ENSP00000228682T115ICOSMICOvarian Cancer21720365
ENSP00000228682T601NBIOMARTBreast Cancer21930507, 21930502
ENSP00000228682S875LCOSMICHead and Neck Cancer21798893
ENSP00000228682D647ECOSMICOvarian Cancer21720365
ENSP00000228682L252MCOSMICOther Cancer
ENSP00000434408T560NBIOMARTBreast Cancer21930507, 21930502
ENSP00000228682A1051VCOSMICCentral Nervous System Neoplasms18772890
ENSP00000228682R637QCOSMICOvarian Cancer21720365

Differential expressed protein
GLI1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GLI1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANGLI1_HUMANkinase -> substrateKEGG
KC1AL_HUMANGLI1_HUMANkinase -> substrateKEGG
GSK3B_HUMANGLI1_HUMANkinase -> substrateKEGG
FBW1B_HUMANGLI1_HUMANotherKEGG
GLI1_HUMANPTC1_HUMANTF -> target geneKEGG
GLI1_HUMANPTCRA_HUMANTF -> target geneKEGG
SP1_HUMANGLI1_HUMANTF -> target geneTRANSFAC
GLI1_HUMANPTC1_HUMANTF -> target geneTRANSFAC
GLI1_HUMANCCND2_HUMANTF -> target geneTRANSFAC
GLI1_HUMANIBP6_HUMANTF -> target geneTRANSFAC
USF2_HUMANGLI1_HUMANTF -> target geneTRANSFAC
GLI2_HUMANGLI1_HUMANTF -> target geneTRANSFAC
TFE2_HUMANGLI1_HUMANTF -> target geneTRANSFAC
GLI1_HUMANGLI1_HUMANTF -> target geneTRANSFAC
GLI3_HUMANGLI1_HUMANTF -> target geneTRANSFAC
TWST1_HUMANGLI1_HUMANTF -> target geneTRANSFAC
GLI1_HUMANPLAK_HUMANTF -> target geneTRANSFAC
GLI1_HUMANBCL2_HUMANTF -> target geneTRANSFAC
USF1_HUMANGLI1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04340Hedgehog signaling pathway
hsa05200Pathways in cancer
hsa05217Basal cell carcinoma

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008017microtubule bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0003682chromatin bindingIEAmolecular_function
GO:0009953dorsal/ventral pattern formationIEAbiological_process
GO:0008589regulation of smoothened signaling pathwayTASbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0007224smoothened signaling pathwayIEAbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiIEAmolecular_function
GO:0048546digestive tract morphogenesisTASbiological_process
GO:0045740positive regulation of DNA replicationIDAbiological_process
GO:0005929ciliumIEAcellular_component
GO:0030324lung developmentIEAbiological_process
GO:0060032notochord regressionIEAbiological_process
GO:0045880positive regulation of smoothened signaling pathwaIDAbiological_process
GO:0009913epidermal cell differentiationIDAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0021938smoothened signaling pathway involved in regulatioIEAbiological_process
GO:0021696cerebellar cortex morphogenesisIEAbiological_process
GO:0007224smoothened signaling pathwayTASbiological_process
GO:0009954proximal/distal pattern formationIEAbiological_process
GO:0008284positive regulation of cell proliferationIMPbiological_process
GO:0021983pituitary gland developmentIEAbiological_process
GO:0005829cytosolIDAcellular_component
GO:0007418ventral midline developmentIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0007283spermatogenesisIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0001649osteoblast differentiationIDAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0090090negative regulation of canonical Wnt receptor signIMPbiological_process


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