Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:APEX1_HUMAN
Description:APEX nuclease (multifunctional DNA repair enzyme) 1 [Source:HGNC Symbol;Acc:587]
Location:chr14 q11.2
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y184LVRLEyRQRWDExo_endo_phosPhosphoSitePlus
S290FLLSHsLLPALCK2_groupphosphoELM; RegPhos
Y128SDKEGySGVGLExo_endo_phosPhosphoSitePlus
T233KNAGFtPQERQExo_endo_phosPhosphoSitePlus
Y262YPNTPyAYTFWHPRD; RegPhos
Y171VLVTAyVPNAGExo_endo_phosPhosphoSitePlus
S123YWSAPsDKEGYCSNK2A1HPRD
S123YWSAPsDKEGYCK2a1-rsRegPhos
Y262YPNTPyAYTFWExo_endo_phosPhosphoSitePlus
Y184LVRLEyRQRWDHPRD
S123YWSAPsDKEGYCK2a1RegPhos
Y45EGPALyEDPPDPhosphoSitePlus

Dephosphorylation site
APEX1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000451979R274*COSMICBreast Cancer20668451
ENSP00000381111R193HCOSMICOvarian Cancer21720365
ENSP00000216714E242*TCGAOvarian Cancer21720365, 18772890
ENSP00000381111E242*COSMICOvarian Cancer21720365
ENSP00000451979E242*COSMICOvarian Cancer21720365
ENSP00000216714R274*COSMICBreast Cancer20668451
ENSP00000216714R193HTCGAOvarian Cancer21720365, 18772890
ENSP00000381111R274*COSMICBreast Cancer20668451
ENSP00000451979R193HCOSMICOvarian Cancer21720365
ENSP00000216714R193HCOSMICOvarian Cancer21720365
ENSP00000216714E242*COSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000381111Renal CancerNormal vs. CancertissueDown0.4119610612
ENSP00000381111Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
APEX1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANAPEX1_HUMANkinase -> substrateHPRD
ZAGL2_HUMANAPEX1_HUMANkinase -> substrateRegPhos
APEX1_HUMANPTHY_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03410Base excision repair

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005813centrosomeIDAcellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0005654nucleoplasmIDAcellular_component
GO:0071375cellular response to peptide hormone stimulusIEAbiological_process
GO:0071320cellular response to cAMPIEAbiological_process
GO:0032403protein complex bindingIEAmolecular_function
GO:0016890site-specific endodeoxyribonuclease activity, specIDAmolecular_function
GO:0046872metal ion bindingIDAmolecular_function
GO:0055114oxidation-reduction processIDAbiological_process
GO:0003713transcription coactivator activityIDAmolecular_function
GO:0004528phosphodiesterase I activityTASmolecular_function
GO:0006284base-excision repairTASbiological_process
GO:0003714transcription corepressor activityTASmolecular_function
GO:0051059NF-kappaB bindingIEAmolecular_function
GO:0004521endoribonuclease activityIEAmolecular_function
GO:0004518nuclease activityIEAmolecular_function
GO:0003906DNA-(apurinic or apyrimidinic site) lyase activityIDAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0003684damaged DNA bindingIDAmolecular_function
GO:0071417cellular response to organic nitrogenIEAbiological_process
GO:0043488regulation of mRNA stabilityIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0045750positive regulation of S phase of mitotic cell cycIEAbiological_process
GO:0005840ribosomeTAScellular_component
GO:00084083'-5' exonuclease activityTASmolecular_function
GO:0045739positive regulation of DNA repairIDAbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0003723RNA bindingIEAmolecular_function
GO:0005667transcription factor complexIEAcellular_component
GO:0005783endoplasmic reticulumTAScellular_component
GO:0016491oxidoreductase activityIDAmolecular_function
GO:0080111DNA demethylationIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0004844uracil DNA N-glycosylase activityTASmolecular_function
GO:0007568agingIEAbiological_process
GO:0070301cellular response to hydrogen peroxideIEAbiological_process
GO:0006310DNA recombinationIEAbiological_process
GO:0014912negative regulation of smooth muscle cell migratioIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0016607nuclear speckIDAcellular_component
GO:0045454cell redox homeostasisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0004523ribonuclease H activityTASmolecular_function
GO:0031490chromatin DNA bindingIDAmolecular_function
GO:0004520endodeoxyribonuclease activityTASmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0005739mitochondrionIEAcellular_component
GO:0010243response to organic nitrogenIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0004519endonuclease activityIDAmolecular_function
GO:0006281DNA repairIEAbiological_process
GO:0008081phosphoric diester hydrolase activityIDAmolecular_function
GO:0042493response to drugIEAbiological_process
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0003677DNA bindingIEAmolecular_function


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