Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KIT_HUMAN
Description:v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog [Source:HGNC Symbol;Acc:6342]
Location:chr4 q12
Node attribute:PPI(target); substrate; kinase; receptor; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y570GNNYVyIDPTQKitphosphoELM; RegPhos
Y900APAEMyDIMKTSrc_groupRegPhos
S959SVRINsVGSTAPKCa(PKC alphaRegPhos
S741ADKRRsVRIGSPKC_alphaphosphoELM
Y721DSTNEyMDMKPHPRD; phosphoELM; RegPhos
S729MKPGVsYVVPTPkinase_TyrPhosphoSitePlus
S741ADKRRsVRIGSPkinase_TyrPhosphoSitePlus
T354IYMNRtFTDKWI-setPhosphoSitePlus
S741ADKRRsVRIGSPKCaRegPhos
Y553LQKPMyEVQWKPhosphoSitePlus; HPRD; RegPhos
S931KQISEsTNHIYPhosphoSitePlus
Y747VRIGSyIERDVHPRD; RegPhos
S891GFRMLsPEHAPPkinase_TyrPhosphoSitePlus
T354IYMNRtFTDKWHPRD
Y547ILTYKyLQKPMPhosphoSitePlus; HPRD; RegPhos
S741ADKRRsVRIGSPRKCAHPRD
Y362DKWEDyPKSENI-setPhosphoSitePlus
Y362DKWEDyPKSENHPRD
Y609VEATAyGLIKSPkinase_TyrPhosphoSitePlus
Y703AEAALyKNLLHPkinase_TyrPhosphoSitePlus
S746SVRIGsYIERDPkinase_TyrPhosphoSitePlus
S959SVRINsVGSTAPhosphoSitePlus
Y823KNDSNyVVKGNphosphoELM; RegPhos
Y568INGNNyVYIDPPhosphoSitePlus; RegPhos
Y730KPGVSyVVPTKPkinase_TyrPhosphoSitePlus
S959SVRINsVGSTAPRKCAHPRD
Y823KNDSNyVVKGNPkinase_TyrPhosphoSitePlus
S821DIKNDsNYVVKPRKCAHPRD
Y578PTQLPyDHKWEPhosphoSitePlus
S746SVRIGsYIERDPKCa(PKC alphaRegPhos
S746SVRIGsYIERDPKC_alphaphosphoELM
S821DIKNDsNYVVKPkinase_TyrPhosphoSitePlus
S821DIKNDsNYVVKPKCaRegPhos
S240IKDVSsSVYSTigPhosphoSitePlus
S746SVRIGsYIERDPRKCAHPRD
S937TNHIYsNLANCPhosphoSitePlus
Y936STNHIySNLANPhosphoSitePlus; phosphoELM; RegPhos
S821DIKNDsNYVVKPKCa(PKC alphaRegPhos
Y721DSTNEyMDMKPPkinase_TyrPhosphoSitePlus
Y932STNHIySNLANHPRD
Y900APAEMyDIMKTSRC_groupphosphoELM
Y747VRIGSyIERDVPkinase_TyrPhosphoSitePlus
S215AVPVVsVSKASPhosphoSitePlus
Y936STNHIySNLANKITHPRD; RegPhos
S943NLANCsPNRQKPhosphoSitePlus
Y545VMILTyKYLQKHPRD; RegPhos
Y568INGNNyVYIDPKITHPRD; RegPhos
Y936STNHIySNLANKitphosphoELM; RegPhos
Y703AEAALyKNLLHKITHPRD; RegPhos
Y900APAEMyDIMKTPkinase_TyrPhosphoSitePlus
S746SVRIGsYIERDPKCaRegPhos
S821DIKNDsNYVVKPKC_alphaphosphoELM
Y730KPGVSyVVPTKHPRD; RegPhos
Y703AEAALyKNLLHKitphosphoELM; RegPhos
S959SVRINsVGSTAPKCaRegPhos
S741ADKRRsVRIGSPKCa(PKC alphaRegPhos
Y703AEAALyKNLLHRegPhos
Y570GNNYVyIDPTQPhosphoSitePlus; RegPhos
Y900APAEMyDIMKTSRCHPRD; phosphoELM; RegPhos
Y900APAEMyDIMKTSrcRegPhos
T801RNILLtHGRITPkinase_TyrPhosphoSitePlus
Y823KNDSNyVVKGNautocatalysis RegPhos
T232EEFTVtCTIKDigPhosphoSitePlus
Y570GNNYVyIDPTQKITHPRD; RegPhos
T718SCSDStNEYMDPkinase_TyrPhosphoSitePlus
Y568INGNNyVYIDPKitphosphoELM; RegPhos
S241KDVSSsVYSTWigPhosphoSitePlus
S959SVRINsVGSTAPKC_alphaphosphoELM

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y570INGNNYVyIDPTQLPPTPN6HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000288135N822KGreenman2007Neoplasms by Histologic Type11719439, 12111653, 12379771, 14695343, 15685537, 15811621, 16175573, 16842259, 17344846, 17566038, 18385756, 18428421
ENSP00000288135G961STCGAOvarian Cancer21720365, 18772890
ENSP00000288135A829PGreenman2007, HPITesticular Cancer16175573, 17344846, 18428421, 16175573, 17344846, 16175573 17344846
ENSP00000288135D816YGreenman2007Neoplasms by Histologic Type10660321, 15150569, 15166264, 15167915, 15371947, 15650049, 15725473, 15902284, 16175573, 16254134, 16533529, 16572634, 16741248, 16741525, 17274819, 17344846, 18428421, 9657776, 9714703, 9990072
ENSP00000288135N566KTCGAOvarian Cancer21720365, 18772890
ENSP00000288135P31LTCGAOvarian Cancer21720365, 18772890
ENSP00000288135N822KGreenman2007, HPITesticular Cancer11719439, 12111653, 12379771, 14695343, 15685537, 15811621, 16175573, 16842259, 17344846, 17566038, 18385756, 18428421, 16175573, 17344846, 22233328, 22109829, 21867644, 21569090, 21394667, 21262832, 21237497, 21429396, 20140688, 20581458, 20227111, 18246046, 18623623, 18293383, 17914733, 18483300, 17768701, 17875504, 17699867, 15621809, 16175573 17344846 22233328 22109829 21867644 21569090 21394667 21262832 21237497 21429396 20140688 20581458 20227111 18246046 18623623 18293383 17914733 18483300 17768701 17875504 17699867 15621809
ENSP00000288135R956QTCGAOvarian Cancer21720365, 18772890
ENSP00000288135T594IDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000288135K550IOMIM, HPIGastric Cancer9438854
ENSP00000288135D816YGreenman2007Other Cancer(genital_tract cancer)10660321, 15150569, 15166264, 15167915, 15371947, 15650049, 15725473, 15902284, 16175573, 16254134, 16533529, 16572634, 16741248, 16741525, 17274819, 17344846, 18428421, 9657776, 9714703, 9990072
ENSP00000288135D737NGreenman2007Intestines Cancer17344846, 18428421
ENSP00000288135D816YGreenman2007Testicular Cancer10660321, 15150569, 15166264, 15167915, 15371947, 15650049, 15725473, 15902284, 16175573, 16254134, 16533529, 16572634, 16741248, 16741525, 17274819, 17344846, 18428421, 9657776, 9714703, 9990072
ENSP00000288135N822KGreenman2007Other Cancer(genital_tract cancer)11719439, 12111653, 12379771, 14695343, 15685537, 15811621, 16175573, 16842259, 17344846, 17566038, 18385756, 18428421
ENSP00000288135V559AOMIMGastric Cancer11505412
ENSP00000288135D816HHPITesticular Cancer19164557 10362788 21504297 20147452 20095048 19164557 19264228 17768701 17875504
ENSP00000288135A599TTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000288135R804WHPIColorectal Cancer17344846 20140688
ENSP00000288135V833LBIOMARTchronic lymphocytic leukemia21930507, 21930502
ENSP00000288135M541LBIOMARTGastric Cancer21930507, 21930502
ENSP00000288135R804WGreenman2007Intestines Cancer17344846, 18428421, 17344846, 20140688
ENSP00000288135V559DHPIGastric Cancer9438854 21953054 22114577 21689725 20633291 20095048 19084944 19047911 17699867 17259998
ENSP00000288135I957TTCGAOvarian Cancer21720365, 18772890
ENSP00000288135D737NHPIColorectal Cancer17344846
ENSP00000288135D816YGreenman2007Leukemia10660321, 15150569, 15166264, 15167915, 15371947, 15650049, 15725473, 15902284, 16175573, 16254134, 16533529, 16572634, 16741248, 16741525, 17274819, 17344846, 18428421, 9657776, 9714703, 9990072
ENSP00000288135D816YGreenman2007Ovarian Cancer10660321, 15150569, 15166264, 15167915, 15371947, 15650049, 15725473, 15902284, 16175573, 16254134, 16533529, 16572634, 16741248, 16741525, 17274819, 17344846, 18428421, 9657776, 9714703, 9990072
ENSP00000288135K642EOMIMGastric Cancer11073817
ENSP00000288135D816HOMIMNeoplasms by Histologic Type10362788

Differential expressed protein
KIT_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y721Pkinase_TyrCSDSTNEyMDMKPGVGIST15007386PhosphoSitePlus
Y703Pkinase_TyrDHAEAALyKNLLHSKGIST15007386PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
SCF_HUMANKIT_HUMANligand -> receptorHPMR
KIT_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
KIT_HUMANSTAT1_HUMANkinase -> substrateHPRD; RegPhos; NetPath
KIT_HUMANP85A_HUMANkinase -> substrateNetPath
KIT_HUMANSTA5B_HUMANkinase -> substrateNetPath
KIT_HUMANSTAP1_HUMANkinase -> substrateNetPath
KPCB_HUMANKIT_HUMANkinase -> substrateNetPath
KIT_HUMANKIT_HUMANkinase -> substrateRegPhos; NetPath
SRC_HUMANKIT_HUMANkinase -> substrateHPRD; RegPhos; NetPath
KIT_HUMANSTA5A_HUMANkinase -> substrateNetPath
KIT_HUMANSPRE1_HUMANkinase -> substrateNetPath
KIT_HUMANSPRE2_HUMANkinase -> substrateNetPath
FYN_HUMANKIT_HUMANkinase -> substrateNetPath
KIT_HUMANVAV_HUMANkinase -> substrateNetPath
KPCA_HUMANKIT_HUMANkinase -> substrateHPRD; NetPath; Robert H Newman (2013)
ZAGL2_HUMANKIT_HUMANkinase -> substrateRegPhos
PTN6_HUMANKIT_HUMANphosphatase -> substrateHPRD; NetPath
SCF_HUMANKIT_HUMANotherKEGG
MYB_HUMANKIT_HUMANTF -> target geneTRANSFAC
SP1_HUMANKIT_HUMANTF -> target geneTRANSFAC
AP2A_HUMANKIT_HUMANTF -> target geneTRANSFAC
ETS2_HUMANKIT_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04916Melanogenesis
hsa05200Pathways in cancer
hsa04640Hematopoietic cell lineage
hsa04144Endocytosis
hsa05221Acute myeloid leukemia
hsa04060Cytokine-cytokine receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042803protein homodimerization activityIPImolecular_function
GO:0060374mast cell differentiationIEAbiological_process
GO:0038093Fc receptor signaling pathwayIDAbiological_process
GO:0000187activation of MAPK activityIDAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0008584male gonad developmentIEPbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0043552positive regulation of phosphatidylinositol 3-kinaTASbiological_process
GO:0007283spermatogenesisISSbiological_process
GO:0050910detection of mechanical stimulus involved in sensoISSbiological_process
GO:0050910detection of mechanical stimulus involved in sensoIEAbiological_process
GO:0007286spermatid developmentIEAbiological_process
GO:0097067cellular response to thyroid hormone stimulusIEAbiological_process
GO:0046427positive regulation of JAK-STAT cascadeIMPbiological_process
GO:0070662mast cell proliferationTASbiological_process
GO:0005020stem cell factor receptor activityIEAmolecular_function
GO:0030218erythrocyte differentiationIEAbiological_process
GO:0035162embryonic hemopoiesisISSbiological_process
GO:0048863stem cell differentiationIEAbiological_process
GO:0048565digestive tract developmentIEAbiological_process
GO:0019221cytokine-mediated signaling pathwayIDAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0009986cell surfaceIEAcellular_component
GO:0042517positive regulation of tyrosine phosphorylation ofIMPbiological_process
GO:0007283spermatogenesisIEAbiological_process
GO:0048863stem cell differentiationISSbiological_process
GO:0048565digestive tract developmentISSbiological_process
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0043410positive regulation of MAPK cascadeIMPbiological_process
GO:0097326melanocyte adhesionISSbiological_process
GO:0002551mast cell chemotaxisIDAbiological_process
GO:0002371dendritic cell cytokine productionISSbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0043473pigmentationISSbiological_process
GO:0042127regulation of cell proliferationTASbiological_process
GO:0009314response to radiationIEAbiological_process
GO:0030318melanocyte differentiationISSbiological_process
GO:0043303mast cell degranulationIMPbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005634nucleusIDAcellular_component
GO:0046777protein autophosphorylationIDAbiological_process
GO:0006954inflammatory responseISSbiological_process
GO:0014068positive regulation of phosphatidylinositol 3-kinaTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0002327immature B cell differentiationIEAbiological_process
GO:0019955cytokine bindingIDAmolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0038162erythropoietin-mediated signaling pathwayIEAbiological_process
GO:0001541ovarian follicle developmentIEAbiological_process
GO:0002320lymphoid progenitor cell differentiationIEAbiological_process
GO:0006687glycosphingolipid metabolic processIEAbiological_process
GO:0030032lamellipodium assemblyISSbiological_process
GO:0043473pigmentationIEAbiological_process
GO:0004714transmembrane receptor protein tyrosine kinase actIDAmolecular_function
GO:0051091positive regulation of sequence-specific DNA bindiIMPbiological_process
GO:0032762mast cell cytokine productionIDAbiological_process
GO:0030218erythrocyte differentiationISSbiological_process
GO:0010863positive regulation of phospholipase C activityTASbiological_process
GO:0030097hemopoiesisTASbiological_process
GO:0060374mast cell differentiationISSbiological_process
GO:0023014signal transduction by phosphorylationTASbiological_process
GO:0038109Kit signaling pathwayIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0097324melanocyte migrationIEAbiological_process
GO:0019827stem cell maintenanceTASbiological_process
GO:0048070regulation of developmental pigmentationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0009897external side of plasma membraneIEAcellular_component
GO:0018108peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0043069negative regulation of programmed cell deathIEAbiological_process
GO:0001541ovarian follicle developmentISSbiological_process
GO:0002327immature B cell differentiationISSbiological_process
GO:0030097hemopoiesisIEAbiological_process
GO:0048066developmental pigmentationIEAbiological_process
GO:0008360regulation of cell shapeISSbiological_process
GO:0035855megakaryocyte developmentIEAbiological_process
GO:0002020protease bindingIEAmolecular_function
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0030217T cell differentiationISSbiological_process
GO:0007165signal transductionTASbiological_process
GO:0060326cell chemotaxisIDAbiological_process
GO:0043406positive regulation of MAP kinase activityIEAbiological_process
GO:0035234germ cell programmed cell deathIEAbiological_process
GO:0097324melanocyte migrationISSbiological_process
GO:0002573myeloid leukocyte differentiationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0097326melanocyte adhesionIEAbiological_process
GO:0004713protein tyrosine kinase activityTASmolecular_function
GO:0042511positive regulation of tyrosine phosphorylation ofIMPbiological_process
GO:0019221cytokine-mediated signaling pathwayIEAbiological_process
GO:0002318myeloid progenitor cell differentiationIEAbiological_process
GO:0035855megakaryocyte developmentISSbiological_process
GO:0002371dendritic cell cytokine productionIEAbiological_process
GO:0035162embryonic hemopoiesisIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0030217T cell differentiationIEAbiological_process
GO:0030318melanocyte differentiationIEAbiological_process
GO:0042523positive regulation of tyrosine phosphorylation ofIMPbiological_process
GO:0038162erythropoietin-mediated signaling pathwayISSbiological_process
GO:0031532actin cytoskeleton reorganizationIDAbiological_process
GO:0008360regulation of cell shapeIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0004716receptor signaling protein tyrosine kinase activitTASmolecular_function
GO:0030032lamellipodium assemblyIEAbiological_process