Phosphorylation

You are querying signaling transduction network mediated by ADA2C_HUMAN in Hepatocellular Carcinoma.

Signaling Transduction Network:

NO.	Source	Target	Relation Attribute	Resource
1	DOPO_HUMAN	ADA2C_HUMAN	ligand -> receptor	HPMR
2	ADA2C_HUMAN	GNAI2_HUMAN	GPCR -> Gprotein	gpDB
3	ADA2C_HUMAN	GNAO_HUMAN	GPCR -> Gprotein	gpDB
4	ADA2C_HUMAN	GNAI3_HUMAN	GPCR -> Gprotein	gpDB
5	ADA2C_HUMAN	GNAI1_HUMAN	GPCR -> Gprotein	gpDB
6	GNAI2_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
7	GNAO_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
8	GNAI3_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
9	GNAI1_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
10	GNAI2_HUMAN	RAC1_HUMAN	Gprotein -> effector	gpDB
11	GNAI2_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
12	GNAI1_HUMAN	RAC1_HUMAN	Gprotein -> effector	gpDB
13	GNAO_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
14	GNAI1_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
15	GNAI3_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
16	GNAI3_HUMAN	RAC1_HUMAN	Gprotein -> effector	gpDB
17	CSK_HUMAN	FGR_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
18	CSK_HUMAN	KPCA_HUMAN	kinase -> substrate	Robert H Newman (2013)
19	SRC_HUMAN	DDR2_HUMAN	kinase -> substrate	RegPhos
20	SRC_HUMAN	ESR1_HUMAN	kinase -> substrate	HPRD; RegPhos
21	RAC1_HUMAN	MK08_HUMAN	kinase -> substrate; other	KEGG
22	SRC_HUMAN	AKT1_HUMAN	kinase -> substrate	RegPhos
23	SRC_HUMAN	HNRPK_HUMAN	kinase -> substrate	RegPhos
24	CSK_HUMAN	LYN_HUMAN	kinase -> substrate; other	HPRD; RegPhos; Robert H Newman (2013); KEGG
25	SRC_HUMAN	ABL1_HUMAN	kinase -> substrate	RegPhos
26	SRC_HUMAN	PDPK1_HUMAN	kinase -> substrate	RegPhos
27	SRC_HUMAN	KPCI_HUMAN	kinase -> substrate	RegPhos
28	SRC_HUMAN	IKKB_HUMAN	kinase -> substrate	NetPath
29	CSK_HUMAN	FYN_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
30	CSK_HUMAN	MK15_HUMAN	kinase -> substrate	RegPhos
31	SRC_HUMAN	GTF2I_HUMAN	kinase -> substrate	RegPhos
32	SRC_HUMAN	RHG35_HUMAN	kinase -> substrate	KEGG; HPRD; RegPhos
33	SRC_HUMAN	STAT3_HUMAN	kinase -> substrate	HPRD; RegPhos
34	CSK_HUMAN	ANDR_HUMAN	kinase -> substrate	RegPhos
35	SRC_HUMAN	CTNB1_HUMAN	kinase -> substrate	RegPhos
36	CSK_HUMAN	CTNB1_HUMAN	kinase -> substrate	RegPhos
37	SRC_HUMAN	RAF1_HUMAN	kinase -> substrate	HPRD; RegPhos
38	CSK_HUMAN	LCK_HUMAN	kinase -> substrate	HPRD; RegPhos
39	CSK_HUMAN	ETS1_HUMAN	kinase -> substrate	Robert H Newman (2013)
40	CSK_HUMAN	YES_HUMAN	kinase -> substrate	Robert H Newman (2013)
41	SRC_HUMAN	IGF1R_HUMAN	kinase -> substrate	RegPhos
42	SRC_HUMAN	IKKA_HUMAN	kinase -> substrate	NetPath
43	SRC_HUMAN	FAK1_HUMAN	kinase -> substrate	RegPhos; NetPath
44	SRC_HUMAN	KIT_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
45	CSK_HUMAN	PTPRC_HUMAN	kinase -> substrate	Robert H Newman (2013)
46	SRC_HUMAN	EGFR_HUMAN	kinase -> substrate	RegPhos
47	SRC_HUMAN	SHC1_HUMAN	kinase -> substrate	RegPhos
48	SRC_HUMAN	STA5B_HUMAN	kinase -> substrate	HPRD; RegPhos
49	FGR_HUMAN	CSK21_HUMAN	kinase -> substrate	Robert H Newman (2013)
50	KPCA_HUMAN	KLF1_HUMAN	kinase -> substrate	HPRD
51	FGR_HUMAN	ZAP70_HUMAN	kinase -> substrate	Robert H Newman (2013)
52	DDR2_HUMAN	KPCD_HUMAN	kinase -> substrate	Robert H Newman (2013)
53	ESR1_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
54	MK08_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
55	AKT1_HUMAN	FOXO1_HUMAN	kinase -> substrate	RegPhos; NetPath
56	HNRPK_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
57	MK08_HUMAN	FOXO4_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
58	AKT1_HUMAN	MTOR_HUMAN	kinase -> substrate	RegPhos
59	LYN_HUMAN	CSK21_HUMAN	kinase -> substrate	Robert H Newman (2013)
60	ABL1_HUMAN	P73_HUMAN	kinase -> substrate	HPRD; RegPhos
61	DDR2_HUMAN	RET_HUMAN	kinase -> substrate	Robert H Newman (2013)
62	PDPK1_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
63	KPCI_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
64	AKT1_HUMAN	GATA1_HUMAN	kinase -> substrate	HPRD; RegPhos
65	LYN_HUMAN	KPCD_HUMAN	kinase -> substrate	RegPhos
66	IKKB_HUMAN	NFKB1_HUMAN	kinase -> substrate	HPRD; NetPath; Robert H Newman (2013)
67	FYN_HUMAN	CDK5_HUMAN	kinase -> substrate	HPRD; RegPhos
68	FGR_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
69	KPCA_HUMAN	FOS_HUMAN	kinase -> substrate	HPRD
70	FGR_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
71	KPCA_HUMAN	GSK3A_HUMAN	kinase -> substrate	HPRD
72	MK08_HUMAN	NFAC2_HUMAN	kinase -> substrate	KEGG
73	KPCA_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
74	MK15_HUMAN	RET_HUMAN	kinase -> substrate	Robert H Newman (2013)
75	IKKB_HUMAN	TF65_HUMAN	kinase -> substrate	NetPath; Robert H Newman (2013)
76	RHG35_HUMAN	GCR_HUMAN	TF -> target gene	TRANSFAC
77	ABL1_HUMAN	CDK5_HUMAN	kinase -> substrate	HPRD; RegPhos
78	STAT3_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
79	AKT1_HUMAN	CREB1_HUMAN	kinase -> substrate	HPRD; RegPhos
80	KPCA_HUMAN	MYOD1_HUMAN	kinase -> substrate	HPRD
81	KPCA_HUMAN	NFKB1_HUMAN	kinase -> substrate	HPRD
82	FGR_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
83	MK08_HUMAN	ELK1_HUMAN	kinase -> substrate	KEGG; Robert H Newman (2013)
84	LYN_HUMAN	CDK1_HUMAN	kinase -> substrate	HPRD; RegPhos
85	GTF2I_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
86	KPCA_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
87	AKT1_HUMAN	GSK3B_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
88	MK08_HUMAN	NFAC4_HUMAN	kinase -> substrate	KEGG
89	KPCA_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
90	KPCA_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
91	AKT1_HUMAN	FOXO4_HUMAN	kinase -> substrate	RegPhos
92	AKT1_HUMAN	GATA2_HUMAN	kinase -> substrate	HPRD
93	KPCA_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
94	KPCA_HUMAN	ATF1_HUMAN	kinase -> substrate	HPRD
95	FGR_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
96	KPCI_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
97	AKT1_HUMAN	STAT6_HUMAN	kinase -> substrate	Robert H Newman (2013)
98	MK08_HUMAN	GCR_HUMAN	kinase -> substrate	HPRD; RegPhos
99	AKT1_HUMAN	KPCD_HUMAN	kinase -> substrate	Robert H Newman (2013)
100	RAF1_HUMAN	MP2K1_HUMAN	kinase -> substrate; other	RegPhos; Robert H Newman (2013); KEGG
101	AKT1_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
102	PDPK1_HUMAN	ZAP70_HUMAN	kinase -> substrate	Robert H Newman (2013)
103	LCK_HUMAN	VDR_HUMAN	kinase -> substrate	Robert H Newman (2013)
104	RAF1_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
105	MK08_HUMAN	DYR1B_HUMAN	kinase -> substrate	Robert H Newman (2013)
106	FYN_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
107	ETS1_HUMAN	AP2A_HUMAN	TF -> target gene	TRANSFAC
108	MK08_HUMAN	ATF2_HUMAN	kinase -> substrate	NetPath; Robert H Newman (2013)
109	YES_HUMAN	TF65_HUMAN	kinase -> substrate	Robert H Newman (2013)
110	MK08_HUMAN	JUN_HUMAN	kinase -> substrate; other	NetPath; Robert H Newman (2013); KEGG
111	PDPK1_HUMAN	KPCD_HUMAN	kinase -> substrate	HPRD; RegPhos
112	AKT1_HUMAN	M3K11_HUMAN	kinase -> substrate	HPRD; RegPhos
113	KPCA_HUMAN	ATF4_HUMAN	kinase -> substrate	KEGG
114	AKT1_HUMAN	EP300_HUMAN	kinase -> substrate	HPRD; RegPhos
115	MK08_HUMAN	FOS_HUMAN	kinase -> substrate	KEGG
116	PDPK1_HUMAN	PKN1_HUMAN	kinase -> substrate	RegPhos
117	KPCA_HUMAN	AHR_HUMAN	kinase -> substrate	Robert H Newman (2013)
118	KPCA_HUMAN	STK11_HUMAN	kinase -> substrate	HPRD
119	IGF1R_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
120	FYN_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
121	LCK_HUMAN	ZAP70_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)
122	AKT1_HUMAN	SOX9_HUMAN	kinase -> substrate	Robert H Newman (2013)
123	FYN_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
124	MK08_HUMAN	PPARA_HUMAN	kinase -> substrate	Robert H Newman (2013)
125	IKKA_HUMAN	TF65_HUMAN	kinase -> substrate	HPRD; NetPath
126	MK08_HUMAN	MYC_HUMAN	kinase -> substrate	RegPhos
127	FAK1_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
128	LCK_HUMAN	KPCD_HUMAN	kinase -> substrate	RegPhos
129	AKT1_HUMAN	NR4A1_HUMAN	kinase -> substrate	HPRD; RegPhos
130	AKT1_HUMAN	TEAD1_HUMAN	kinase -> substrate	Robert H Newman (2013)
131	MK08_HUMAN	ELK3_HUMAN	kinase -> substrate	HPRD; RegPhos
132	AKT1_HUMAN	GSK3A_HUMAN	kinase -> substrate	NetPath
133	FGR_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
134	MK08_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
135	KPCA_HUMAN	TF65_HUMAN	kinase -> substrate	HPRD
136	ABL1_HUMAN	JUN_HUMAN	kinase -> substrate	HPRD; RegPhos
137	PDPK1_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
138	KPCA_HUMAN	GSK3B_HUMAN	kinase -> substrate	KEGG; HPRD
139	PDPK1_HUMAN	KS6A1_HUMAN	kinase -> substrate	HPRD; RegPhos
140	ESR1_HUMAN	PRGR_HUMAN	TF -> target gene	TRANSFAC
141	LYN_HUMAN	MK03_HUMAN	kinase -> substrate	NetPath
142	YES_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
143	STAT3_HUMAN	IRF1_HUMAN	TF -> target gene	TRANSFAC
144	KIT_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
145	LCK_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
146	LCK_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos
147	PTPRC_HUMAN	JAK1_HUMAN	phosphatase -> substrate	HPRD
148	EGFR_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos
149	PDPK1_HUMAN	MP2K1_HUMAN	kinase -> substrate	RegPhos
150	MK08_HUMAN	MITF_HUMAN	kinase -> substrate	Robert H Newman (2013)
151	KPCA_HUMAN	CREM_HUMAN	kinase -> substrate	HPRD
152	ETS1_HUMAN	NFKB1_HUMAN	TF -> target gene	TRANSFAC
153	MK08_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
154	SHC1_HUMAN	ZAP70_HUMAN	kinase -> substrate	HPRD
155	MK08_HUMAN	JUND_HUMAN	kinase -> substrate	KEGG
156	KPCA_HUMAN	GLI1_HUMAN	kinase -> substrate	KEGG
157	FAK1_HUMAN	MITF_HUMAN	kinase -> substrate	Robert H Newman (2013)
158	AKT1_HUMAN	THA_HUMAN	kinase -> substrate	Robert H Newman (2013)
159	YES_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
160	KPCA_HUMAN	EP300_HUMAN	kinase -> substrate	Robert H Newman (2013)
161	IKKA_HUMAN	NFKB1_HUMAN	kinase -> substrate; other	HPRD; NetPath; KEGG
162	STAT3_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
163	KPCA_HUMAN	PTN7_HUMAN	kinase -> substrate	HPRD
164	IKKA_HUMAN	IRF7_HUMAN	kinase -> substrate	KEGG
165	MK08_HUMAN	HSF1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
166	MK08_HUMAN	PAX2_HUMAN	kinase -> substrate	NetPath
167	CSK21_HUMAN	APEX1_HUMAN	kinase -> substrate	HPRD
168	CSK21_HUMAN	NKX25_HUMAN	kinase -> substrate	HPRD
169	ZAP70_HUMAN	MK14_HUMAN	kinase -> substrate	KEGG; RegPhos; Robert H Newman (2013)
170	KPCD_HUMAN	TWST1_HUMAN	kinase -> substrate	Robert H Newman (2013)
171	FOXO1_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
172	MYC_HUMAN	CDK4_HUMAN	TF -> target gene	TRANSFAC
173	MTOR_HUMAN	HIF1A_HUMAN	kinase -> substrate	KEGG
174	RET_HUMAN	MK14_HUMAN	kinase -> substrate	HPRD; RegPhos
175	MK07_HUMAN	MEF2D_HUMAN	kinase -> substrate	HPRD
176	KPCD_HUMAN	NF2L2_HUMAN	kinase -> substrate	HPRD
177	CDK5_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
178	GSK3A_HUMAN	TF7L2_HUMAN	kinase -> substrate	Robert H Newman (2013)
179	RXRA_HUMAN	RARB_HUMAN	TF -> target gene	TRANSFAC
180	GCR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
181	CDK5_HUMAN	MEF2A_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
182	CREB1_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
183	ELK1_HUMAN	EGR2_HUMAN	TF -> target gene	TRANSFAC
184	SRF_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
185	CDK1_HUMAN	CDK7_HUMAN	kinase -> substrate	RegPhos
186	CDK5_HUMAN	MEF2D_HUMAN	kinase -> substrate	RegPhos
187	CSK21_HUMAN	MEF2A_HUMAN	kinase -> substrate	Robert H Newman (2013)
188	GSK3B_HUMAN	CDX2_HUMAN	kinase -> substrate	RegPhos
189	CSK21_HUMAN	MAZ_HUMAN	kinase -> substrate	HPRD
190	CSK21_HUMAN	TF7L2_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
191	FOXO4_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
192	MK07_HUMAN	MEF2A_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
193	MP2K1_HUMAN	KS6A4_HUMAN	kinase -> substrate	RegPhos
194	SRF_HUMAN	EGR2_HUMAN	TF -> target gene	TRANSFAC
195	CDK1_HUMAN	E2F1_HUMAN	kinase -> substrate	RegPhos
196	DYR1B_HUMAN	HNF1A_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
197	AP2A_HUMAN	REL_HUMAN	TF -> target gene	TRANSFAC
198	CSK21_HUMAN	MYF6_HUMAN	kinase -> substrate	Robert H Newman (2013)
199	CSK21_HUMAN	MYF5_HUMAN	kinase -> substrate	HPRD
200	M3K11_HUMAN	MP2K7_HUMAN	kinase -> substrate	KEGG
201	PKN1_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
202	STK11_HUMAN	SIK2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
203	STK11_HUMAN	SIK1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
204	CDK1_HUMAN	HMGA2_HUMAN	kinase -> substrate	RegPhos
205	CSK21_HUMAN	EGR1_HUMAN	kinase -> substrate	HPRD
206	STK11_HUMAN	TFE3_HUMAN	kinase -> substrate	Robert H Newman (2013)
207	STK11_HUMAN	SIK3_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
208	CDK1_HUMAN	HMGA1_HUMAN	kinase -> substrate	RegPhos
209	KS6A1_HUMAN	ESR2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
210	MK03_HUMAN	MAZ_HUMAN	kinase -> substrate	Robert H Newman (2013)
211	CSK21_HUMAN	HMGA1_HUMAN	kinase -> substrate	HPRD
212	CSK21_HUMAN	HIF1A_HUMAN	kinase -> substrate	HPRD
213	CDK1_HUMAN	CUX1_HUMAN	kinase -> substrate	RegPhos
214	JAK1_HUMAN	STAT4_HUMAN	kinase -> substrate	RegPhos
215	ATF1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
216	NR4A1_HUMAN	E2F1_HUMAN	TF -> target gene	TRANSFAC
217	PRGR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
218	DYR1B_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
219	CREB1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
220	PTN7_HUMAN	MK14_HUMAN	phosphatase -> substrate	KEGG
221	NFAC2_HUMAN	EGR3_HUMAN	TF -> target gene	TRANSFAC
222	CDK4_HUMAN	FOXN2_HUMAN	kinase -> substrate	Robert H Newman (2013)
223	PRDM1_HUMAN	PAX5_HUMAN	TF -> target gene	TRANSFAC
224	CDK7_HUMAN	PO2F1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
225	CDK4_HUMAN	PKNX1_HUMAN	kinase -> substrate	Robert H Newman (2013)
226	MEF2A_HUMAN	MYOG_HUMAN	TF -> target gene	TRANSFAC
227	KS6A4_HUMAN	PO6F1_HUMAN	kinase -> substrate	Robert H Newman (2013)
228	MP2K7_HUMAN	M3K7_HUMAN	kinase -> substrate	KEGG
229	SIK2_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
230	SIK1_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
231	SIK3_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
232	M3K7_HUMAN	NLK_HUMAN	kinase -> substrate	KEGG
233	M3K7_HUMAN	FUBP1_HUMAN	kinase -> substrate	Robert H Newman (2013)
234	NLK_HUMAN	LEF1_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)

⁺Protein attribute:

protein with cancer-related variations (CanProVar)

up expressed protein;

down expressed protein(dbDEPC)

protein with hyperphosphorylation site (PhosphoSitePlus)

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network