Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DOPO_HUMAN
Description:dopamine beta-hydroxylase (dopamine beta-monooxygenase) [Source:HGNC Symbol;Acc:2689]
Location:chr9 q34.2
Node attribute:ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y353GIRLYyTAKLRPhosphoSitePlus
Y334RLEVHyHNPLVPhosphoSitePlus
T588PKVIStLEEPTPhosphoSitePlus
Y310GAKAFyYPEEAPhosphoSitePlus
S603TSQGRsPAGPTPhosphoSitePlus
T422GRKVVtVLVRDPhosphoSitePlus; SysPTM
Y327PGSSRyLRLEVPhosphoSitePlus
S587LPKVIsTLEEPPhosphoSitePlus

Dephosphorylation site
DOPO_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000376776N344HCOSMICOvarian Cancer21720365
ENSP00000376776Y494CCOSMICHepatocellular Carcinoma21822264
ENSP00000376776R79WCOSMICOvarian Cancer21720365
ENSP00000376776V276IBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000376776G480SCOSMICSkin Cancer21984974
ENSP00000376776I183MTCGAOvarian Cancer21720365, 18772890
ENSP00000376776I183MCOSMICOvarian Cancer21720365

Differential expressed protein
DOPO_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DOPO_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DOPO_HUMANADA1D_HUMANligand -> receptorHPMR
DOPO_HUMANGP161_HUMANligand -> receptorHPMR
DOPO_HUMANADRB3_HUMANligand -> receptorHPMR
DOPO_HUMANADRB1_HUMANligand -> receptorHPMR
DOPO_HUMANADA2A_HUMANligand -> receptorHPMR
DOPO_HUMANADA2B_HUMANligand -> receptorHPMR
DOPO_HUMANADA2C_HUMANligand -> receptorHPMR
DOPO_HUMANADA1B_HUMANligand -> receptorHPMR
DOPO_HUMANADRB2_HUMANligand -> receptorHPMR
CREB1_HUMANDOPO_HUMANTF -> target geneTRANSFAC
TYY1_HUMANDOPO_HUMANTF -> target geneTRANSFAC
PHX2A_HUMANDOPO_HUMANTF -> target geneTRANSFAC
SP1_HUMANDOPO_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa01100Metabolic pathways
hsa00350Tyrosine metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004497monooxygenase activityIEAmolecular_function
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0034641cellular nitrogen compound metabolic processTASbiological_process
GO:0034466chromaffin granule lumenIEAcellular_component
GO:0031418L-ascorbic acid bindingIEAmolecular_function
GO:0048149behavioral response to ethanolIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0016020membraneTAScellular_component
GO:0048265response to painIEAbiological_process
GO:0030658transport vesicle membraneIEAcellular_component
GO:0007613memoryIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0016715oxidoreductase activity, acting on paired donors, IEAmolecular_function
GO:0008542visual learningIEAbiological_process
GO:0001975response to amphetamineIEAbiological_process
GO:0003824catalytic activityTASmolecular_function
GO:0007268synaptic transmissionTASbiological_process
GO:0042596fear responseIEAbiological_process
GO:0042584chromaffin granule membraneIEAcellular_component
GO:0055114oxidation-reduction processIEAbiological_process
GO:0030141secretory granuleTAScellular_component
GO:0002443leukocyte mediated immunityIEAbiological_process
GO:0005507copper ion bindingIEAmolecular_function
GO:0042420dopamine catabolic processIEAbiological_process
GO:0042423catecholamine biosynthetic processTASbiological_process
GO:0042421norepinephrine biosynthetic processIEAbiological_process
GO:0042593glucose homeostasisIEAbiological_process
GO:0001974blood vessel remodelingIEAbiological_process
GO:0007626locomotory behaviorIEAbiological_process
GO:0008306associative learningIEAbiological_process
GO:0001816cytokine productionIEAbiological_process
GO:0050900leukocyte migrationIEAbiological_process
GO:0042711maternal behaviorIEAbiological_process
GO:0004500dopamine beta-monooxygenase activityTASmolecular_function
GO:0005576extracellular regionNAScellular_component
GO:0045907positive regulation of vasoconstrictionIEAbiological_process
GO:0042309homoiothermyIEAbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0042583chromaffin granuleNAScellular_component


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