Phosphorylation

You are querying signaling transduction network mediated by ACM4_HUMAN in Lymphoma.

Signaling Transduction Network:

NO.	Source	Target	Relation Attribute	Resource
1	CLAT_HUMAN	ACM4_HUMAN	ligand -> receptor	HPMR
2	ACM4_HUMAN	GNAI1_HUMAN	GPCR -> Gprotein	gpDB
3	ACM4_HUMAN	GNAO_HUMAN	GPCR -> Gprotein	gpDB
4	ACM4_HUMAN	GNAI3_HUMAN	GPCR -> Gprotein	gpDB
5	ACM4_HUMAN	GNAI2_HUMAN	GPCR -> Gprotein	gpDB
6	GNAI1_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
7	GNAI1_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
8	GNAO_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
9	GNAI3_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
10	GNAO_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
11	GNAI3_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
12	GNAI2_HUMAN	RAC1_HUMAN	Gprotein -> effector	gpDB
13	GNAI2_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
14	GNAI2_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
15	GNAI1_HUMAN	RAC1_HUMAN	Gprotein -> effector	gpDB
16	GNAI3_HUMAN	RAC1_HUMAN	Gprotein -> effector	gpDB
17	CSK_HUMAN	LCK_HUMAN	kinase -> substrate	HPRD; RegPhos
18	SRC_HUMAN	STA5B_HUMAN	kinase -> substrate	HPRD; RegPhos
19	SRC_HUMAN	ABL1_HUMAN	kinase -> substrate	RegPhos
20	SRC_HUMAN	PDPK1_HUMAN	kinase -> substrate	RegPhos
21	CSK_HUMAN	YES_HUMAN	kinase -> substrate	Robert H Newman (2013)
22	CSK_HUMAN	FGR_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
23	SRC_HUMAN	AKT1_HUMAN	kinase -> substrate	RegPhos
24	CSK_HUMAN	FYN_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
25	CSK_HUMAN	KPCA_HUMAN	kinase -> substrate	Robert H Newman (2013)
26	RAC1_HUMAN	MK08_HUMAN	kinase -> substrate; other	KEGG
27	CSK_HUMAN	MK15_HUMAN	kinase -> substrate	RegPhos
28	SRC_HUMAN	DDR2_HUMAN	kinase -> substrate	RegPhos
29	CSK_HUMAN	LYN_HUMAN	kinase -> substrate; other	HPRD; RegPhos; Robert H Newman (2013); KEGG
30	CSK_HUMAN	ANDR_HUMAN	kinase -> substrate	RegPhos
31	SRC_HUMAN	FAK1_HUMAN	kinase -> substrate	RegPhos; NetPath
32	SRC_HUMAN	ESR1_HUMAN	kinase -> substrate	HPRD; RegPhos
33	SRC_HUMAN	STAT3_HUMAN	kinase -> substrate	HPRD; RegPhos
34	CSK_HUMAN	ETS1_HUMAN	kinase -> substrate	Robert H Newman (2013)
35	SRC_HUMAN	IKKA_HUMAN	kinase -> substrate	NetPath
36	SRC_HUMAN	HNRPK_HUMAN	kinase -> substrate	RegPhos
37	SRC_HUMAN	IKKB_HUMAN	kinase -> substrate	NetPath
38	SRC_HUMAN	CTNB1_HUMAN	kinase -> substrate	RegPhos
39	SRC_HUMAN	IGF1R_HUMAN	kinase -> substrate	RegPhos
40	CSK_HUMAN	CTNB1_HUMAN	kinase -> substrate	RegPhos
41	SRC_HUMAN	RHG35_HUMAN	kinase -> substrate	KEGG; HPRD; RegPhos
42	SRC_HUMAN	KPCI_HUMAN	kinase -> substrate	RegPhos
43	SRC_HUMAN	RAF1_HUMAN	kinase -> substrate	HPRD; RegPhos
44	CSK_HUMAN	PTPRC_HUMAN	kinase -> substrate	Robert H Newman (2013)
45	SRC_HUMAN	GTF2I_HUMAN	kinase -> substrate	RegPhos
46	SRC_HUMAN	SHC1_HUMAN	kinase -> substrate	RegPhos
47	SRC_HUMAN	EGFR_HUMAN	kinase -> substrate	RegPhos
48	SRC_HUMAN	KIT_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
49	LCK_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos
50	ABL1_HUMAN	CDK5_HUMAN	kinase -> substrate	HPRD; RegPhos
51	PDPK1_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
52	YES_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
53	FGR_HUMAN	CSK21_HUMAN	kinase -> substrate	Robert H Newman (2013)
54	AKT1_HUMAN	EP300_HUMAN	kinase -> substrate	HPRD; RegPhos
55	LCK_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
56	FYN_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
57	KPCA_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
58	MK08_HUMAN	MYC_HUMAN	kinase -> substrate	RegPhos
59	MK15_HUMAN	RET_HUMAN	kinase -> substrate	Robert H Newman (2013)
60	KPCA_HUMAN	CREM_HUMAN	kinase -> substrate	HPRD
61	KPCA_HUMAN	STK11_HUMAN	kinase -> substrate	HPRD
62	FGR_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
63	KPCA_HUMAN	NFKB1_HUMAN	kinase -> substrate	HPRD
64	DDR2_HUMAN	KPCD_HUMAN	kinase -> substrate	Robert H Newman (2013)
65	LYN_HUMAN	CSK21_HUMAN	kinase -> substrate	Robert H Newman (2013)
66	LYN_HUMAN	CDK1_HUMAN	kinase -> substrate	HPRD; RegPhos
67	AKT1_HUMAN	FOXO1_HUMAN	kinase -> substrate	RegPhos; NetPath
68	PDPK1_HUMAN	ZAP70_HUMAN	kinase -> substrate	Robert H Newman (2013)
69	FYN_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
70	AKT1_HUMAN	SOX9_HUMAN	kinase -> substrate	Robert H Newman (2013)
71	KPCA_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
72	FGR_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
73	FAK1_HUMAN	MITF_HUMAN	kinase -> substrate	Robert H Newman (2013)
74	KPCA_HUMAN	GSK3A_HUMAN	kinase -> substrate	HPRD
75	AKT1_HUMAN	STAT6_HUMAN	kinase -> substrate	Robert H Newman (2013)
76	MK08_HUMAN	JUN_HUMAN	kinase -> substrate; other	NetPath; Robert H Newman (2013); KEGG
77	PDPK1_HUMAN	PKN1_HUMAN	kinase -> substrate	RegPhos
78	MK08_HUMAN	HSF1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
79	AKT1_HUMAN	THA_HUMAN	kinase -> substrate	Robert H Newman (2013)
80	KPCA_HUMAN	PTN7_HUMAN	kinase -> substrate	HPRD
81	FGR_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
82	ABL1_HUMAN	P73_HUMAN	kinase -> substrate	HPRD; RegPhos
83	MK08_HUMAN	PPARA_HUMAN	kinase -> substrate	Robert H Newman (2013)
84	FYN_HUMAN	CDK5_HUMAN	kinase -> substrate	HPRD; RegPhos
85	FYN_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
86	KPCA_HUMAN	ATF1_HUMAN	kinase -> substrate	HPRD
87	MK08_HUMAN	JUND_HUMAN	kinase -> substrate	KEGG
88	PDPK1_HUMAN	KS6A1_HUMAN	kinase -> substrate	HPRD; RegPhos
89	ETS1_HUMAN	NFKB1_HUMAN	TF -> target gene	TRANSFAC
90	KPCA_HUMAN	ATF4_HUMAN	kinase -> substrate	KEGG
91	IKKA_HUMAN	NFKB1_HUMAN	kinase -> substrate; other	HPRD; NetPath; KEGG
92	AKT1_HUMAN	GSK3A_HUMAN	kinase -> substrate	NetPath
93	MK08_HUMAN	GCR_HUMAN	kinase -> substrate	HPRD; RegPhos
94	ESR1_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
95	HNRPK_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
96	PDPK1_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
97	IKKB_HUMAN	NFKB1_HUMAN	kinase -> substrate	HPRD; NetPath; Robert H Newman (2013)
98	FGR_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
99	MK08_HUMAN	FOXO4_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
100	LYN_HUMAN	KPCD_HUMAN	kinase -> substrate	RegPhos
101	LCK_HUMAN	KPCD_HUMAN	kinase -> substrate	RegPhos
102	AKT1_HUMAN	FOXO4_HUMAN	kinase -> substrate	RegPhos
103	PDPK1_HUMAN	KPCD_HUMAN	kinase -> substrate	HPRD; RegPhos
104	YES_HUMAN	TF65_HUMAN	kinase -> substrate	Robert H Newman (2013)
105	KPCA_HUMAN	GLI1_HUMAN	kinase -> substrate	KEGG
106	KPCA_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
107	MK08_HUMAN	DYR1B_HUMAN	kinase -> substrate	Robert H Newman (2013)
108	DDR2_HUMAN	RET_HUMAN	kinase -> substrate	Robert H Newman (2013)
109	AKT1_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
110	MK08_HUMAN	FOS_HUMAN	kinase -> substrate	KEGG
111	ESR1_HUMAN	PRGR_HUMAN	TF -> target gene	TRANSFAC
112	MK08_HUMAN	ELK1_HUMAN	kinase -> substrate	KEGG; Robert H Newman (2013)
113	AKT1_HUMAN	GSK3B_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
114	AKT1_HUMAN	GATA1_HUMAN	kinase -> substrate	HPRD; RegPhos
115	IGF1R_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
116	STAT3_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
117	KPCA_HUMAN	TF65_HUMAN	kinase -> substrate	HPRD
118	FAK1_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
119	KPCA_HUMAN	FOS_HUMAN	kinase -> substrate	HPRD
120	MK08_HUMAN	NFAC2_HUMAN	kinase -> substrate	KEGG
121	KPCA_HUMAN	GSK3B_HUMAN	kinase -> substrate	KEGG; HPRD
122	MK08_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
123	MK08_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
124	AKT1_HUMAN	CREB1_HUMAN	kinase -> substrate	HPRD; RegPhos
125	FGR_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
126	RHG35_HUMAN	GCR_HUMAN	TF -> target gene	TRANSFAC
127	KPCI_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
128	RAF1_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
129	MK08_HUMAN	ATF2_HUMAN	kinase -> substrate	NetPath; Robert H Newman (2013)
130	PTPRC_HUMAN	JAK1_HUMAN	phosphatase -> substrate	HPRD
131	ETS1_HUMAN	AP2A_HUMAN	TF -> target gene	TRANSFAC
132	STAT3_HUMAN	IRF1_HUMAN	TF -> target gene	TRANSFAC
133	AKT1_HUMAN	GATA2_HUMAN	kinase -> substrate	HPRD
134	KPCI_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
135	MK08_HUMAN	MITF_HUMAN	kinase -> substrate	Robert H Newman (2013)
136	AKT1_HUMAN	KPCD_HUMAN	kinase -> substrate	Robert H Newman (2013)
137	SHC1_HUMAN	ZAP70_HUMAN	kinase -> substrate	HPRD
138	AKT1_HUMAN	MTOR_HUMAN	kinase -> substrate	RegPhos
139	FGR_HUMAN	ZAP70_HUMAN	kinase -> substrate	Robert H Newman (2013)
140	EGFR_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos
141	LCK_HUMAN	ZAP70_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)
142	AKT1_HUMAN	M3K11_HUMAN	kinase -> substrate	HPRD; RegPhos
143	IKKB_HUMAN	TF65_HUMAN	kinase -> substrate	NetPath; Robert H Newman (2013)
144	KPCA_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
145	RAF1_HUMAN	MP2K1_HUMAN	kinase -> substrate; other	RegPhos; Robert H Newman (2013); KEGG
146	AKT1_HUMAN	NR4A1_HUMAN	kinase -> substrate	HPRD; RegPhos
147	KPCA_HUMAN	AHR_HUMAN	kinase -> substrate	Robert H Newman (2013)
148	KPCA_HUMAN	MYOD1_HUMAN	kinase -> substrate	HPRD
149	STAT3_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
150	LYN_HUMAN	MK03_HUMAN	kinase -> substrate	NetPath
151	GTF2I_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
152	YES_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
153	MK08_HUMAN	PAX2_HUMAN	kinase -> substrate	NetPath
154	IKKA_HUMAN	IRF7_HUMAN	kinase -> substrate	KEGG
155	LCK_HUMAN	VDR_HUMAN	kinase -> substrate	Robert H Newman (2013)
156	ABL1_HUMAN	JUN_HUMAN	kinase -> substrate	HPRD; RegPhos
157	KIT_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
158	MK08_HUMAN	ELK3_HUMAN	kinase -> substrate	HPRD; RegPhos
159	IKKA_HUMAN	TF65_HUMAN	kinase -> substrate	HPRD; NetPath
160	AKT1_HUMAN	TEAD1_HUMAN	kinase -> substrate	Robert H Newman (2013)
161	MK08_HUMAN	NFAC4_HUMAN	kinase -> substrate	KEGG
162	KPCA_HUMAN	EP300_HUMAN	kinase -> substrate	Robert H Newman (2013)
163	KPCA_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
164	KPCA_HUMAN	KLF1_HUMAN	kinase -> substrate	HPRD
165	MK08_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
166	PDPK1_HUMAN	MP2K1_HUMAN	kinase -> substrate	RegPhos
167	CDK5_HUMAN	MEF2A_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
168	MK07_HUMAN	MEF2A_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
169	CSK21_HUMAN	EGR1_HUMAN	kinase -> substrate	HPRD
170	CDK5_HUMAN	MEF2D_HUMAN	kinase -> substrate	RegPhos
171	MYC_HUMAN	CDK4_HUMAN	TF -> target gene	TRANSFAC
172	RET_HUMAN	MK14_HUMAN	kinase -> substrate	HPRD; RegPhos
173	STK11_HUMAN	SIK3_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
174	KPCD_HUMAN	NF2L2_HUMAN	kinase -> substrate	HPRD
175	CSK21_HUMAN	MYF5_HUMAN	kinase -> substrate	HPRD
176	CDK1_HUMAN	E2F1_HUMAN	kinase -> substrate	RegPhos
177	FOXO1_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
178	ZAP70_HUMAN	MK14_HUMAN	kinase -> substrate	KEGG; RegPhos; Robert H Newman (2013)
179	SRF_HUMAN	EGR2_HUMAN	TF -> target gene	TRANSFAC
180	GSK3A_HUMAN	TF7L2_HUMAN	kinase -> substrate	Robert H Newman (2013)
181	CSK21_HUMAN	HMGA1_HUMAN	kinase -> substrate	HPRD
182	CSK21_HUMAN	APEX1_HUMAN	kinase -> substrate	HPRD
183	PKN1_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
184	STK11_HUMAN	SIK1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
185	PTN7_HUMAN	MK14_HUMAN	phosphatase -> substrate	KEGG
186	CDK5_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
187	CDK1_HUMAN	HMGA2_HUMAN	kinase -> substrate	RegPhos
188	CDK1_HUMAN	CUX1_HUMAN	kinase -> substrate	RegPhos
189	ATF1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
190	KS6A1_HUMAN	ESR2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
191	SRF_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
192	FOXO4_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
193	KPCD_HUMAN	TWST1_HUMAN	kinase -> substrate	Robert H Newman (2013)
194	RXRA_HUMAN	RARB_HUMAN	TF -> target gene	TRANSFAC
195	DYR1B_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
196	CSK21_HUMAN	TF7L2_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
197	CSK21_HUMAN	HIF1A_HUMAN	kinase -> substrate	HPRD
198	CSK21_HUMAN	MEF2A_HUMAN	kinase -> substrate	Robert H Newman (2013)
199	GSK3B_HUMAN	CDX2_HUMAN	kinase -> substrate	RegPhos
200	CSK21_HUMAN	MYF6_HUMAN	kinase -> substrate	Robert H Newman (2013)
201	PRGR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
202	CREB1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
203	CSK21_HUMAN	NKX25_HUMAN	kinase -> substrate	HPRD
204	MK07_HUMAN	MEF2D_HUMAN	kinase -> substrate	HPRD
205	JAK1_HUMAN	STAT4_HUMAN	kinase -> substrate	RegPhos
206	CDK1_HUMAN	HMGA1_HUMAN	kinase -> substrate	RegPhos
207	MTOR_HUMAN	HIF1A_HUMAN	kinase -> substrate	KEGG
208	M3K11_HUMAN	MP2K7_HUMAN	kinase -> substrate	KEGG
209	GCR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
210	MP2K1_HUMAN	KS6A4_HUMAN	kinase -> substrate	RegPhos
211	NR4A1_HUMAN	E2F1_HUMAN	TF -> target gene	TRANSFAC
212	STK11_HUMAN	TFE3_HUMAN	kinase -> substrate	Robert H Newman (2013)
213	DYR1B_HUMAN	HNF1A_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
214	CSK21_HUMAN	MAZ_HUMAN	kinase -> substrate	HPRD
215	MK03_HUMAN	MAZ_HUMAN	kinase -> substrate	Robert H Newman (2013)
216	ELK1_HUMAN	EGR2_HUMAN	TF -> target gene	TRANSFAC
217	AP2A_HUMAN	REL_HUMAN	TF -> target gene	TRANSFAC
218	NFAC2_HUMAN	EGR3_HUMAN	TF -> target gene	TRANSFAC
219	STK11_HUMAN	SIK2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
220	CDK1_HUMAN	CDK7_HUMAN	kinase -> substrate	RegPhos
221	CREB1_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
222	MEF2A_HUMAN	MYOG_HUMAN	TF -> target gene	TRANSFAC
223	CDK4_HUMAN	PKNX1_HUMAN	kinase -> substrate	Robert H Newman (2013)
224	SIK3_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
225	SIK1_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
226	PRDM1_HUMAN	PAX5_HUMAN	TF -> target gene	TRANSFAC
227	CDK4_HUMAN	FOXN2_HUMAN	kinase -> substrate	Robert H Newman (2013)
228	MP2K7_HUMAN	M3K7_HUMAN	kinase -> substrate	KEGG
229	KS6A4_HUMAN	PO6F1_HUMAN	kinase -> substrate	Robert H Newman (2013)
230	SIK2_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
231	CDK7_HUMAN	PO2F1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
232	M3K7_HUMAN	FUBP1_HUMAN	kinase -> substrate	Robert H Newman (2013)
233	M3K7_HUMAN	NLK_HUMAN	kinase -> substrate	KEGG
234	NLK_HUMAN	LEF1_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)

⁺Protein attribute:

protein with cancer-related variations (CanProVar)

up expressed protein;

down expressed protein(dbDEPC)

protein with hyperphosphorylation site (PhosphoSitePlus)

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network