Phosphorylation

You are querying signaling transduction network mediated by 5HT1B_HUMAN in Lymphoma.

Signaling Transduction Network:

NO.	Source	Target	Relation Attribute	Resource
1	TPH1_HUMAN	5HT1B_HUMAN	ligand -> receptor	HPMR
2	5HT1B_HUMAN	GNAI1_HUMAN	GPCR -> Gprotein	gpDB
3	5HT1B_HUMAN	GNAO_HUMAN	GPCR -> Gprotein	gpDB
4	5HT1B_HUMAN	GNAI3_HUMAN	GPCR -> Gprotein	gpDB
5	5HT1B_HUMAN	GNAI2_HUMAN	GPCR -> Gprotein	gpDB
6	GNAI1_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
7	GNAO_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
8	GNAI1_HUMAN	RAC1_HUMAN	Gprotein -> effector	gpDB
9	GNAI1_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
10	GNAI3_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
11	GNAO_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
12	GNAI3_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
13	GNAI2_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
14	GNAI2_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
15	GNAI2_HUMAN	RAC1_HUMAN	Gprotein -> effector	gpDB
16	GNAI3_HUMAN	RAC1_HUMAN	Gprotein -> effector	gpDB
17	CSK_HUMAN	LCK_HUMAN	kinase -> substrate	HPRD; RegPhos
18	SRC_HUMAN	PDPK1_HUMAN	kinase -> substrate	RegPhos
19	RAC1_HUMAN	MK08_HUMAN	kinase -> substrate; other	KEGG
20	SRC_HUMAN	IKKA_HUMAN	kinase -> substrate	NetPath
21	CSK_HUMAN	ANDR_HUMAN	kinase -> substrate	RegPhos
22	SRC_HUMAN	AKT1_HUMAN	kinase -> substrate	RegPhos
23	CSK_HUMAN	LYN_HUMAN	kinase -> substrate; other	HPRD; RegPhos; Robert H Newman (2013); KEGG
24	CSK_HUMAN	FGR_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
25	SRC_HUMAN	ABL1_HUMAN	kinase -> substrate	RegPhos
26	CSK_HUMAN	KPCA_HUMAN	kinase -> substrate	Robert H Newman (2013)
27	SRC_HUMAN	IKKB_HUMAN	kinase -> substrate	NetPath
28	SRC_HUMAN	RHG35_HUMAN	kinase -> substrate	KEGG; HPRD; RegPhos
29	SRC_HUMAN	STAT3_HUMAN	kinase -> substrate	HPRD; RegPhos
30	SRC_HUMAN	RAF1_HUMAN	kinase -> substrate	HPRD; RegPhos
31	CSK_HUMAN	ETS1_HUMAN	kinase -> substrate	Robert H Newman (2013)
32	SRC_HUMAN	HNRPK_HUMAN	kinase -> substrate	RegPhos
33	CSK_HUMAN	MK15_HUMAN	kinase -> substrate	RegPhos
34	CSK_HUMAN	FYN_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
35	SRC_HUMAN	ESR1_HUMAN	kinase -> substrate	HPRD; RegPhos
36	SRC_HUMAN	IGF1R_HUMAN	kinase -> substrate	RegPhos
37	SRC_HUMAN	EGFR_HUMAN	kinase -> substrate	RegPhos
38	SRC_HUMAN	KPCI_HUMAN	kinase -> substrate	RegPhos
39	SRC_HUMAN	STA5B_HUMAN	kinase -> substrate	HPRD; RegPhos
40	SRC_HUMAN	GTF2I_HUMAN	kinase -> substrate	RegPhos
41	SRC_HUMAN	DDR2_HUMAN	kinase -> substrate	RegPhos
42	SRC_HUMAN	CTNB1_HUMAN	kinase -> substrate	RegPhos
43	SRC_HUMAN	FAK1_HUMAN	kinase -> substrate	RegPhos; NetPath
44	CSK_HUMAN	YES_HUMAN	kinase -> substrate	Robert H Newman (2013)
45	CSK_HUMAN	CTNB1_HUMAN	kinase -> substrate	RegPhos
46	CSK_HUMAN	PTPRC_HUMAN	kinase -> substrate	Robert H Newman (2013)
47	SRC_HUMAN	KIT_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
48	SRC_HUMAN	SHC1_HUMAN	kinase -> substrate	RegPhos
49	LCK_HUMAN	VDR_HUMAN	kinase -> substrate	Robert H Newman (2013)
50	PDPK1_HUMAN	KPCD_HUMAN	kinase -> substrate	HPRD; RegPhos
51	MK08_HUMAN	DYR1B_HUMAN	kinase -> substrate	Robert H Newman (2013)
52	IKKA_HUMAN	NFKB1_HUMAN	kinase -> substrate; other	HPRD; NetPath; KEGG
53	MK08_HUMAN	GCR_HUMAN	kinase -> substrate	HPRD; RegPhos
54	AKT1_HUMAN	M3K11_HUMAN	kinase -> substrate	HPRD; RegPhos
55	LYN_HUMAN	MK03_HUMAN	kinase -> substrate	NetPath
56	FGR_HUMAN	CSK21_HUMAN	kinase -> substrate	Robert H Newman (2013)
57	ABL1_HUMAN	CDK5_HUMAN	kinase -> substrate	HPRD; RegPhos
58	KPCA_HUMAN	KLF1_HUMAN	kinase -> substrate	HPRD
59	FGR_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
60	IKKB_HUMAN	TF65_HUMAN	kinase -> substrate	NetPath; Robert H Newman (2013)
61	RHG35_HUMAN	GCR_HUMAN	TF -> target gene	TRANSFAC
62	AKT1_HUMAN	EP300_HUMAN	kinase -> substrate	HPRD; RegPhos
63	AKT1_HUMAN	FOXO1_HUMAN	kinase -> substrate	RegPhos; NetPath
64	KPCA_HUMAN	STK11_HUMAN	kinase -> substrate	HPRD
65	MK08_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
66	STAT3_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
67	LYN_HUMAN	CDK1_HUMAN	kinase -> substrate	HPRD; RegPhos
68	LYN_HUMAN	CSK21_HUMAN	kinase -> substrate	Robert H Newman (2013)
69	AKT1_HUMAN	CREB1_HUMAN	kinase -> substrate	HPRD; RegPhos
70	RAF1_HUMAN	MP2K1_HUMAN	kinase -> substrate; other	RegPhos; Robert H Newman (2013); KEGG
71	ETS1_HUMAN	AP2A_HUMAN	TF -> target gene	TRANSFAC
72	MK08_HUMAN	ATF2_HUMAN	kinase -> substrate	NetPath; Robert H Newman (2013)
73	MK08_HUMAN	FOXO4_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
74	KPCA_HUMAN	PTN7_HUMAN	kinase -> substrate	HPRD
75	PDPK1_HUMAN	PKN1_HUMAN	kinase -> substrate	RegPhos
76	MK15_HUMAN	RET_HUMAN	kinase -> substrate	Robert H Newman (2013)
77	FYN_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
78	FYN_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
79	ABL1_HUMAN	P73_HUMAN	kinase -> substrate	HPRD; RegPhos
80	KPCA_HUMAN	NFKB1_HUMAN	kinase -> substrate	HPRD
81	HNRPK_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
82	AKT1_HUMAN	STAT6_HUMAN	kinase -> substrate	Robert H Newman (2013)
83	LCK_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos
84	KPCA_HUMAN	GSK3A_HUMAN	kinase -> substrate	HPRD
85	KPCA_HUMAN	ATF1_HUMAN	kinase -> substrate	HPRD
86	MK08_HUMAN	MYC_HUMAN	kinase -> substrate	RegPhos
87	FYN_HUMAN	CDK5_HUMAN	kinase -> substrate	HPRD; RegPhos
88	MK08_HUMAN	HSF1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
89	IGF1R_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
90	EGFR_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos
91	KPCI_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
92	KPCA_HUMAN	MYOD1_HUMAN	kinase -> substrate	HPRD
93	AKT1_HUMAN	NR4A1_HUMAN	kinase -> substrate	HPRD; RegPhos
94	MK08_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
95	LCK_HUMAN	KPCD_HUMAN	kinase -> substrate	RegPhos
96	FGR_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
97	GTF2I_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
98	DDR2_HUMAN	KPCD_HUMAN	kinase -> substrate	Robert H Newman (2013)
99	MK08_HUMAN	JUN_HUMAN	kinase -> substrate; other	NetPath; Robert H Newman (2013); KEGG
100	MK08_HUMAN	ELK1_HUMAN	kinase -> substrate	KEGG; Robert H Newman (2013)
101	AKT1_HUMAN	SOX9_HUMAN	kinase -> substrate	Robert H Newman (2013)
102	KPCA_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
103	KPCA_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
104	FGR_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
105	KPCA_HUMAN	TF65_HUMAN	kinase -> substrate	HPRD
106	KPCA_HUMAN	AHR_HUMAN	kinase -> substrate	Robert H Newman (2013)
107	KPCA_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
108	AKT1_HUMAN	GSK3B_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
109	AKT1_HUMAN	FOXO4_HUMAN	kinase -> substrate	RegPhos
110	FAK1_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
111	AKT1_HUMAN	TEAD1_HUMAN	kinase -> substrate	Robert H Newman (2013)
112	PDPK1_HUMAN	KS6A1_HUMAN	kinase -> substrate	HPRD; RegPhos
113	FGR_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
114	LYN_HUMAN	KPCD_HUMAN	kinase -> substrate	RegPhos
115	KPCA_HUMAN	CREM_HUMAN	kinase -> substrate	HPRD
116	YES_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
117	KPCA_HUMAN	ATF4_HUMAN	kinase -> substrate	KEGG
118	IKKA_HUMAN	TF65_HUMAN	kinase -> substrate	HPRD; NetPath
119	LCK_HUMAN	ZAP70_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)
120	MK08_HUMAN	NFAC2_HUMAN	kinase -> substrate	KEGG
121	MK08_HUMAN	PPARA_HUMAN	kinase -> substrate	Robert H Newman (2013)
122	MK08_HUMAN	MITF_HUMAN	kinase -> substrate	Robert H Newman (2013)
123	MK08_HUMAN	JUND_HUMAN	kinase -> substrate	KEGG
124	YES_HUMAN	TF65_HUMAN	kinase -> substrate	Robert H Newman (2013)
125	STAT3_HUMAN	IRF1_HUMAN	TF -> target gene	TRANSFAC
126	MK08_HUMAN	PAX2_HUMAN	kinase -> substrate	NetPath
127	PTPRC_HUMAN	JAK1_HUMAN	phosphatase -> substrate	HPRD
128	AKT1_HUMAN	THA_HUMAN	kinase -> substrate	Robert H Newman (2013)
129	IKKA_HUMAN	IRF7_HUMAN	kinase -> substrate	KEGG
130	KIT_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
131	ESR1_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
132	PDPK1_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
133	LCK_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
134	PDPK1_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
135	ESR1_HUMAN	PRGR_HUMAN	TF -> target gene	TRANSFAC
136	ETS1_HUMAN	NFKB1_HUMAN	TF -> target gene	TRANSFAC
137	SHC1_HUMAN	ZAP70_HUMAN	kinase -> substrate	HPRD
138	AKT1_HUMAN	KPCD_HUMAN	kinase -> substrate	Robert H Newman (2013)
139	AKT1_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
140	KPCA_HUMAN	GLI1_HUMAN	kinase -> substrate	KEGG
141	FGR_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
142	AKT1_HUMAN	MTOR_HUMAN	kinase -> substrate	RegPhos
143	AKT1_HUMAN	GATA1_HUMAN	kinase -> substrate	HPRD; RegPhos
144	DDR2_HUMAN	RET_HUMAN	kinase -> substrate	Robert H Newman (2013)
145	MK08_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
146	RAF1_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
147	FYN_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
148	KPCA_HUMAN	GSK3B_HUMAN	kinase -> substrate	KEGG; HPRD
149	STAT3_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
150	AKT1_HUMAN	GSK3A_HUMAN	kinase -> substrate	NetPath
151	AKT1_HUMAN	GATA2_HUMAN	kinase -> substrate	HPRD
152	KPCA_HUMAN	FOS_HUMAN	kinase -> substrate	HPRD
153	ABL1_HUMAN	JUN_HUMAN	kinase -> substrate	HPRD; RegPhos
154	MK08_HUMAN	FOS_HUMAN	kinase -> substrate	KEGG
155	KPCI_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
156	KPCA_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
157	YES_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
158	FAK1_HUMAN	MITF_HUMAN	kinase -> substrate	Robert H Newman (2013)
159	PDPK1_HUMAN	MP2K1_HUMAN	kinase -> substrate	RegPhos
160	KPCA_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
161	FGR_HUMAN	ZAP70_HUMAN	kinase -> substrate	Robert H Newman (2013)
162	MK08_HUMAN	ELK3_HUMAN	kinase -> substrate	HPRD; RegPhos
163	IKKB_HUMAN	NFKB1_HUMAN	kinase -> substrate	HPRD; NetPath; Robert H Newman (2013)
164	KPCA_HUMAN	EP300_HUMAN	kinase -> substrate	Robert H Newman (2013)
165	MK08_HUMAN	NFAC4_HUMAN	kinase -> substrate	KEGG
166	PDPK1_HUMAN	ZAP70_HUMAN	kinase -> substrate	Robert H Newman (2013)
167	KPCD_HUMAN	TWST1_HUMAN	kinase -> substrate	Robert H Newman (2013)
168	DYR1B_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
169	GCR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
170	M3K11_HUMAN	MP2K7_HUMAN	kinase -> substrate	KEGG
171	MK03_HUMAN	MAZ_HUMAN	kinase -> substrate	Robert H Newman (2013)
172	CSK21_HUMAN	APEX1_HUMAN	kinase -> substrate	HPRD
173	CDK5_HUMAN	MEF2D_HUMAN	kinase -> substrate	RegPhos
174	FOXO1_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
175	STK11_HUMAN	SIK2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
176	MYC_HUMAN	CDK4_HUMAN	TF -> target gene	TRANSFAC
177	CDK1_HUMAN	CDK7_HUMAN	kinase -> substrate	RegPhos
178	CSK21_HUMAN	HIF1A_HUMAN	kinase -> substrate	HPRD
179	CREB1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
180	CSK21_HUMAN	MAZ_HUMAN	kinase -> substrate	HPRD
181	MP2K1_HUMAN	KS6A4_HUMAN	kinase -> substrate	RegPhos
182	CSK21_HUMAN	TF7L2_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
183	FOXO4_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
184	PTN7_HUMAN	MK14_HUMAN	phosphatase -> substrate	KEGG
185	PKN1_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
186	CSK21_HUMAN	MYF5_HUMAN	kinase -> substrate	HPRD
187	CDK1_HUMAN	E2F1_HUMAN	kinase -> substrate	RegPhos
188	RET_HUMAN	MK14_HUMAN	kinase -> substrate	HPRD; RegPhos
189	MK07_HUMAN	MEF2D_HUMAN	kinase -> substrate	HPRD
190	MK07_HUMAN	MEF2A_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
191	GSK3A_HUMAN	TF7L2_HUMAN	kinase -> substrate	Robert H Newman (2013)
192	CDK5_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
193	CSK21_HUMAN	HMGA1_HUMAN	kinase -> substrate	HPRD
194	SRF_HUMAN	EGR2_HUMAN	TF -> target gene	TRANSFAC
195	SRF_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
196	CSK21_HUMAN	MEF2A_HUMAN	kinase -> substrate	Robert H Newman (2013)
197	KPCD_HUMAN	NF2L2_HUMAN	kinase -> substrate	HPRD
198	NR4A1_HUMAN	E2F1_HUMAN	TF -> target gene	TRANSFAC
199	RXRA_HUMAN	RARB_HUMAN	TF -> target gene	TRANSFAC
200	GSK3B_HUMAN	CDX2_HUMAN	kinase -> substrate	RegPhos
201	CDK5_HUMAN	MEF2A_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
202	KS6A1_HUMAN	ESR2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
203	CSK21_HUMAN	EGR1_HUMAN	kinase -> substrate	HPRD
204	STK11_HUMAN	SIK1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
205	CSK21_HUMAN	NKX25_HUMAN	kinase -> substrate	HPRD
206	CSK21_HUMAN	MYF6_HUMAN	kinase -> substrate	Robert H Newman (2013)
207	ZAP70_HUMAN	MK14_HUMAN	kinase -> substrate	KEGG; RegPhos; Robert H Newman (2013)
208	NFAC2_HUMAN	EGR3_HUMAN	TF -> target gene	TRANSFAC
209	ELK1_HUMAN	EGR2_HUMAN	TF -> target gene	TRANSFAC
210	JAK1_HUMAN	STAT4_HUMAN	kinase -> substrate	RegPhos
211	STK11_HUMAN	SIK3_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
212	AP2A_HUMAN	REL_HUMAN	TF -> target gene	TRANSFAC
213	CDK1_HUMAN	HMGA2_HUMAN	kinase -> substrate	RegPhos
214	CDK1_HUMAN	CUX1_HUMAN	kinase -> substrate	RegPhos
215	STK11_HUMAN	TFE3_HUMAN	kinase -> substrate	Robert H Newman (2013)
216	CDK1_HUMAN	HMGA1_HUMAN	kinase -> substrate	RegPhos
217	MTOR_HUMAN	HIF1A_HUMAN	kinase -> substrate	KEGG
218	ATF1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
219	CREB1_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
220	PRGR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
221	DYR1B_HUMAN	HNF1A_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
222	MP2K7_HUMAN	M3K7_HUMAN	kinase -> substrate	KEGG
223	SIK2_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
224	CDK4_HUMAN	PKNX1_HUMAN	kinase -> substrate	Robert H Newman (2013)
225	CDK7_HUMAN	PO2F1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
226	KS6A4_HUMAN	PO6F1_HUMAN	kinase -> substrate	Robert H Newman (2013)
227	PRDM1_HUMAN	PAX5_HUMAN	TF -> target gene	TRANSFAC
228	MEF2A_HUMAN	MYOG_HUMAN	TF -> target gene	TRANSFAC
229	CDK4_HUMAN	FOXN2_HUMAN	kinase -> substrate	Robert H Newman (2013)
230	SIK1_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
231	SIK3_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
232	M3K7_HUMAN	FUBP1_HUMAN	kinase -> substrate	Robert H Newman (2013)
233	M3K7_HUMAN	NLK_HUMAN	kinase -> substrate	KEGG
234	NLK_HUMAN	LEF1_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)

⁺Protein attribute:

protein with cancer-related variations (CanProVar)

up expressed protein;

down expressed protein(dbDEPC)

protein with hyperphosphorylation site (PhosphoSitePlus)

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network