Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TPH1_HUMAN
Description:tryptophan hydroxylase 1 [Source:HGNC Symbol;Acc:12008]
Location:chr11 p15.1
Node attribute:ligand; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T225FLKERtGFSIRBiopterin_HPhosphoSitePlus
S58SKRRNsEFEIFPKACaRegPhos
S228ERTGFsIRPVABiopterin_HPhosphoSitePlus
Y373TFQDVyFVSESBiopterin_HPhosphoSitePlus
S58SKRRNsEFEIFPKA_groupphosphoELM; RegPhos
S58SKRRNsEFEIFPKA_group RegPhos
S58SKRRNsEFEIFPRKACAHPRD
Y404VKYNPyTRSIQBiopterin_HPhosphoSitePlus
Y401PFGVKyNPYTRBiopterin_HPhosphoSitePlus

Dephosphorylation site
TPH1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000343550K415NBIOMARTBreast Cancer21930507, 21930502
ENSP00000250018K415NBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
TPH1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TPH1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TPH1_HUMAN5HT2A_HUMANligand -> receptorHPMR
TPH1_HUMAN5HT4R_HUMANligand -> receptorHPMR
TPH1_HUMAN5HT1B_HUMANligand -> receptorHPMR
TPH1_HUMAN5HT1F_HUMANligand -> receptorHPMR
TPH1_HUMAN5HT5A_HUMANligand -> receptorHPMR
TPH1_HUMAN5HT6R_HUMANligand -> receptorHPMR
TPH1_HUMAN5HT2C_HUMANligand -> receptorHPMR
TPH1_HUMAN5HT1A_HUMANligand -> receptorHPMR
TPH1_HUMANGPR26_HUMANligand -> receptorHPMR
TPH1_HUMAN5HT7R_HUMANligand -> receptorHPMR
TPH1_HUMAN5HT1E_HUMANligand -> receptorHPMR
TPH1_HUMAN5HT2B_HUMANligand -> receptorHPMR
TPH1_HUMANGP119_HUMANligand -> receptorHPMR
TPH1_HUMAN5HT1D_HUMANligand -> receptorHPMR
KPCA_HUMANTPH1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa01100Metabolic pathways
hsa04726Serotonergic synapse
hsa00380Tryptophan metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0034641cellular nitrogen compound metabolic processTASbiological_process
GO:0046849bone remodelingIEAbiological_process
GO:0007623circadian rhythmIEAbiological_process
GO:0035902response to immobilization stressIEAbiological_process
GO:0004510tryptophan 5-monooxygenase activityIEAmolecular_function
GO:0060749mammary gland alveolus developmentIEAbiological_process
GO:0030279negative regulation of ossificationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0016597amino acid bindingIEAmolecular_function
GO:0009072aromatic amino acid family metabolic processIEAbiological_process
GO:0043005neuron projectionIEAcellular_component
GO:0046219indolalkylamine biosynthetic processTASbiological_process
GO:0008152metabolic processIEAbiological_process
GO:0005506iron ion bindingIEAmolecular_function
GO:0042427serotonin biosynthetic processIEAbiological_process
GO:0016714oxidoreductase activity, acting on paired donors, IEAmolecular_function
GO:0055114oxidation-reduction processIEAbiological_process


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