Phosphorylation

You are querying signaling transduction network mediated by 5HT4R_HUMAN in Lung Cancer.

Signaling Transduction Network:

NO.	Source	Target	Relation Attribute	Resource
1	TPH1_HUMAN	5HT4R_HUMAN	ligand -> receptor	HPMR
2	5HT4R_HUMAN	GNAS1_HUMAN	GPCR -> Gprotein	gpDB
3	5HT4R_HUMAN	GNAS2_HUMAN	GPCR -> Gprotein	gpDB
4	5HT4R_HUMAN	GNA13_HUMAN	GPCR -> Gprotein	gpDB
5	GNAS1_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
6	GNAS2_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
7	GNAS1_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
8	GNAS2_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
9	GNA13_HUMAN	KPCD1_HUMAN	Gprotein -> effector	gpDB
10	CSK_HUMAN	FGR_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
11	CSK_HUMAN	LCK_HUMAN	kinase -> substrate	HPRD; RegPhos
12	CSK_HUMAN	LYN_HUMAN	kinase -> substrate; other	HPRD; RegPhos; Robert H Newman (2013); KEGG
13	CSK_HUMAN	ETS1_HUMAN	kinase -> substrate	Robert H Newman (2013)
14	SRC_HUMAN	AKT1_HUMAN	kinase -> substrate	RegPhos
15	CSK_HUMAN	KPCA_HUMAN	kinase -> substrate	Robert H Newman (2013)
16	CSK_HUMAN	PTPRC_HUMAN	kinase -> substrate	Robert H Newman (2013)
17	SRC_HUMAN	ABL1_HUMAN	kinase -> substrate	RegPhos
18	CSK_HUMAN	FYN_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
19	SRC_HUMAN	IKKB_HUMAN	kinase -> substrate	NetPath
20	CSK_HUMAN	YES_HUMAN	kinase -> substrate	Robert H Newman (2013)
21	SRC_HUMAN	PDPK1_HUMAN	kinase -> substrate	RegPhos
22	SRC_HUMAN	CTNB1_HUMAN	kinase -> substrate	RegPhos
23	SRC_HUMAN	FAK1_HUMAN	kinase -> substrate	RegPhos; NetPath
24	SRC_HUMAN	STA5B_HUMAN	kinase -> substrate	HPRD; RegPhos
25	SRC_HUMAN	RHG35_HUMAN	kinase -> substrate	KEGG; HPRD; RegPhos
26	SRC_HUMAN	DDR2_HUMAN	kinase -> substrate	RegPhos
27	SRC_HUMAN	ESR1_HUMAN	kinase -> substrate	HPRD; RegPhos
28	SRC_HUMAN	STAT3_HUMAN	kinase -> substrate	HPRD; RegPhos
29	SRC_HUMAN	GTF2I_HUMAN	kinase -> substrate	RegPhos
30	SRC_HUMAN	HNRPK_HUMAN	kinase -> substrate	RegPhos
31	CSK_HUMAN	MK15_HUMAN	kinase -> substrate	RegPhos
32	SRC_HUMAN	SHC1_HUMAN	kinase -> substrate	RegPhos
33	SRC_HUMAN	KPCI_HUMAN	kinase -> substrate	RegPhos
34	SRC_HUMAN	IKKA_HUMAN	kinase -> substrate	NetPath
35	SRC_HUMAN	IGF1R_HUMAN	kinase -> substrate	RegPhos
36	SRC_HUMAN	EGFR_HUMAN	kinase -> substrate	RegPhos
37	SRC_HUMAN	KIT_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
38	KPCD1_HUMAN	KSYK_HUMAN	kinase -> substrate	NetPath
39	SRC_HUMAN	RAF1_HUMAN	kinase -> substrate	HPRD; RegPhos
40	CSK_HUMAN	CTNB1_HUMAN	kinase -> substrate	RegPhos
41	CSK_HUMAN	ANDR_HUMAN	kinase -> substrate	RegPhos
42	FGR_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
43	LCK_HUMAN	VDR_HUMAN	kinase -> substrate	Robert H Newman (2013)
44	FGR_HUMAN	CSK21_HUMAN	kinase -> substrate	Robert H Newman (2013)
45	FGR_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
46	LYN_HUMAN	CSK21_HUMAN	kinase -> substrate	Robert H Newman (2013)
47	AKT1_HUMAN	GATA1_HUMAN	kinase -> substrate	HPRD; RegPhos
48	AKT1_HUMAN	M3K11_HUMAN	kinase -> substrate	HPRD; RegPhos
49	KPCA_HUMAN	NFKB1_HUMAN	kinase -> substrate	HPRD
50	PTPRC_HUMAN	JAK1_HUMAN	phosphatase -> substrate	HPRD
51	ABL1_HUMAN	CDK5_HUMAN	kinase -> substrate	HPRD; RegPhos
52	FYN_HUMAN	CDK5_HUMAN	kinase -> substrate	HPRD; RegPhos
53	IKKB_HUMAN	NFKB1_HUMAN	kinase -> substrate	HPRD; NetPath; Robert H Newman (2013)
54	FGR_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
55	YES_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
56	PDPK1_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
57	AKT1_HUMAN	FOXO1_HUMAN	kinase -> substrate	RegPhos; NetPath
58	FAK1_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
59	FYN_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
60	KPCA_HUMAN	ATF1_HUMAN	kinase -> substrate	HPRD
61	LYN_HUMAN	CDK1_HUMAN	kinase -> substrate	HPRD; RegPhos
62	DDR2_HUMAN	KPCD_HUMAN	kinase -> substrate	Robert H Newman (2013)
63	KPCA_HUMAN	AHR_HUMAN	kinase -> substrate	Robert H Newman (2013)
64	AKT1_HUMAN	GATA2_HUMAN	kinase -> substrate	HPRD
65	PDPK1_HUMAN	ZAP70_HUMAN	kinase -> substrate	Robert H Newman (2013)
66	ESR1_HUMAN	PRGR_HUMAN	TF -> target gene	TRANSFAC
67	FYN_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
68	ESR1_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
69	STAT3_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
70	RHG35_HUMAN	GCR_HUMAN	TF -> target gene	TRANSFAC
71	KPCA_HUMAN	GLI1_HUMAN	kinase -> substrate	KEGG
72	LCK_HUMAN	ZAP70_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)
73	KPCA_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
74	FYN_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
75	HNRPK_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
76	KPCA_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
77	KPCA_HUMAN	STK11_HUMAN	kinase -> substrate	HPRD
78	KPCA_HUMAN	FOS_HUMAN	kinase -> substrate	HPRD
79	ABL1_HUMAN	JUN_HUMAN	kinase -> substrate	HPRD; RegPhos
80	KPCA_HUMAN	EP300_HUMAN	kinase -> substrate	Robert H Newman (2013)
81	FGR_HUMAN	ZAP70_HUMAN	kinase -> substrate	Robert H Newman (2013)
82	KPCA_HUMAN	MYOD1_HUMAN	kinase -> substrate	HPRD
83	STAT3_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
84	LYN_HUMAN	KPCD_HUMAN	kinase -> substrate	RegPhos
85	MK15_HUMAN	RET_HUMAN	kinase -> substrate	Robert H Newman (2013)
86	LCK_HUMAN	KPCD_HUMAN	kinase -> substrate	RegPhos
87	KPCA_HUMAN	GSK3B_HUMAN	kinase -> substrate	KEGG; HPRD
88	ETS1_HUMAN	AP2A_HUMAN	TF -> target gene	TRANSFAC
89	AKT1_HUMAN	SOX9_HUMAN	kinase -> substrate	Robert H Newman (2013)
90	KPCA_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
91	SHC1_HUMAN	ZAP70_HUMAN	kinase -> substrate	HPRD
92	KPCI_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
93	FGR_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
94	AKT1_HUMAN	CREB1_HUMAN	kinase -> substrate	HPRD; RegPhos
95	AKT1_HUMAN	KPCD_HUMAN	kinase -> substrate	Robert H Newman (2013)
96	KPCA_HUMAN	ATF4_HUMAN	kinase -> substrate	KEGG
97	KPCA_HUMAN	GSK3A_HUMAN	kinase -> substrate	HPRD
98	KPCA_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
99	AKT1_HUMAN	FOXO4_HUMAN	kinase -> substrate	RegPhos
100	IKKA_HUMAN	IRF7_HUMAN	kinase -> substrate	KEGG
101	IGF1R_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
102	GTF2I_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
103	IKKB_HUMAN	TF65_HUMAN	kinase -> substrate	NetPath; Robert H Newman (2013)
104	AKT1_HUMAN	STAT6_HUMAN	kinase -> substrate	Robert H Newman (2013)
105	PDPK1_HUMAN	MP2K1_HUMAN	kinase -> substrate	RegPhos
106	IKKA_HUMAN	NFKB1_HUMAN	kinase -> substrate; other	HPRD; NetPath; KEGG
107	AKT1_HUMAN	MTOR_HUMAN	kinase -> substrate	RegPhos
108	EGFR_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos
109	KIT_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
110	LCK_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos
111	PDPK1_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
112	IKKA_HUMAN	TF65_HUMAN	kinase -> substrate	HPRD; NetPath
113	PDPK1_HUMAN	PKN1_HUMAN	kinase -> substrate	RegPhos
114	FGR_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
115	KPCI_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
116	KPCA_HUMAN	KLF1_HUMAN	kinase -> substrate	HPRD
117	KPCA_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
118	AKT1_HUMAN	GSK3A_HUMAN	kinase -> substrate	NetPath
119	KPCA_HUMAN	PTN7_HUMAN	kinase -> substrate	HPRD
120	ETS1_HUMAN	NFKB1_HUMAN	TF -> target gene	TRANSFAC
121	ABL1_HUMAN	P73_HUMAN	kinase -> substrate	HPRD; RegPhos
122	LYN_HUMAN	MK03_HUMAN	kinase -> substrate	NetPath
123	LCK_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
124	AKT1_HUMAN	TEAD1_HUMAN	kinase -> substrate	Robert H Newman (2013)
125	KSYK_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
126	AKT1_HUMAN	NR4A1_HUMAN	kinase -> substrate	HPRD; RegPhos
127	RAF1_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
128	YES_HUMAN	TF65_HUMAN	kinase -> substrate	Robert H Newman (2013)
129	KSYK_HUMAN	KS6A1_HUMAN	kinase -> substrate	NetPath
130	FAK1_HUMAN	MITF_HUMAN	kinase -> substrate	Robert H Newman (2013)
131	KPCA_HUMAN	TF65_HUMAN	kinase -> substrate	HPRD
132	AKT1_HUMAN	THA_HUMAN	kinase -> substrate	Robert H Newman (2013)
133	AKT1_HUMAN	GSK3B_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
134	AKT1_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
135	PDPK1_HUMAN	KPCD_HUMAN	kinase -> substrate	HPRD; RegPhos
136	STAT3_HUMAN	IRF1_HUMAN	TF -> target gene	TRANSFAC
137	RAF1_HUMAN	MP2K1_HUMAN	kinase -> substrate; other	RegPhos; Robert H Newman (2013); KEGG
138	AKT1_HUMAN	EP300_HUMAN	kinase -> substrate	HPRD; RegPhos
139	YES_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
140	KPCA_HUMAN	CREM_HUMAN	kinase -> substrate	HPRD
141	DDR2_HUMAN	RET_HUMAN	kinase -> substrate	Robert H Newman (2013)
142	PDPK1_HUMAN	KS6A1_HUMAN	kinase -> substrate	HPRD; RegPhos
143	KSYK_HUMAN	MK03_HUMAN	kinase -> substrate	NetPath
144	RXRA_HUMAN	RARB_HUMAN	TF -> target gene	TRANSFAC
145	CSK21_HUMAN	MYF6_HUMAN	kinase -> substrate	Robert H Newman (2013)
146	SRF_HUMAN	EGR2_HUMAN	TF -> target gene	TRANSFAC
147	CSK21_HUMAN	MAZ_HUMAN	kinase -> substrate	HPRD
148	M3K11_HUMAN	MP2K7_HUMAN	kinase -> substrate	KEGG
149	JAK1_HUMAN	STAT4_HUMAN	kinase -> substrate	RegPhos
150	CDK5_HUMAN	MEF2A_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
151	CDK5_HUMAN	MEF2D_HUMAN	kinase -> substrate	RegPhos
152	MK07_HUMAN	MEF2D_HUMAN	kinase -> substrate	HPRD
153	FOXO1_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
154	CDK1_HUMAN	CUX1_HUMAN	kinase -> substrate	RegPhos
155	KPCD_HUMAN	TWST1_HUMAN	kinase -> substrate	Robert H Newman (2013)
156	ZAP70_HUMAN	MK14_HUMAN	kinase -> substrate	KEGG; RegPhos; Robert H Newman (2013)
157	CSK21_HUMAN	NKX25_HUMAN	kinase -> substrate	HPRD
158	CSK21_HUMAN	MEF2A_HUMAN	kinase -> substrate	Robert H Newman (2013)
159	GCR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
160	SRF_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
161	MYC_HUMAN	CDK4_HUMAN	TF -> target gene	TRANSFAC
162	STK11_HUMAN	SIK3_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
163	CDK5_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
164	MK07_HUMAN	MEF2A_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
165	RET_HUMAN	MK14_HUMAN	kinase -> substrate	HPRD; RegPhos
166	CDK1_HUMAN	HMGA2_HUMAN	kinase -> substrate	RegPhos
167	KPCD_HUMAN	NF2L2_HUMAN	kinase -> substrate	HPRD
168	GSK3B_HUMAN	CDX2_HUMAN	kinase -> substrate	RegPhos
169	AP2A_HUMAN	REL_HUMAN	TF -> target gene	TRANSFAC
170	CDK1_HUMAN	CDK7_HUMAN	kinase -> substrate	RegPhos
171	CSK21_HUMAN	EGR1_HUMAN	kinase -> substrate	HPRD
172	PRGR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
173	CREB1_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
174	CSK21_HUMAN	HIF1A_HUMAN	kinase -> substrate	HPRD
175	STK11_HUMAN	SIK2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
176	GSK3A_HUMAN	TF7L2_HUMAN	kinase -> substrate	Robert H Newman (2013)
177	FOXO4_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
178	CSK21_HUMAN	HMGA1_HUMAN	kinase -> substrate	HPRD
179	CSK21_HUMAN	TF7L2_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
180	CSK21_HUMAN	MYF5_HUMAN	kinase -> substrate	HPRD
181	CDK1_HUMAN	E2F1_HUMAN	kinase -> substrate	RegPhos
182	MP2K1_HUMAN	KS6A4_HUMAN	kinase -> substrate	RegPhos
183	MTOR_HUMAN	HIF1A_HUMAN	kinase -> substrate	KEGG
184	CREB1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
185	CSK21_HUMAN	APEX1_HUMAN	kinase -> substrate	HPRD
186	ATF1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
187	PKN1_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
188	STK11_HUMAN	SIK1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
189	PTN7_HUMAN	MK14_HUMAN	phosphatase -> substrate	KEGG
190	CDK1_HUMAN	HMGA1_HUMAN	kinase -> substrate	RegPhos
191	MK03_HUMAN	MAZ_HUMAN	kinase -> substrate	Robert H Newman (2013)
192	NR4A1_HUMAN	E2F1_HUMAN	TF -> target gene	TRANSFAC
193	STK11_HUMAN	TFE3_HUMAN	kinase -> substrate	Robert H Newman (2013)
194	KS6A1_HUMAN	ESR2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
195	MP2K7_HUMAN	M3K7_HUMAN	kinase -> substrate	KEGG
196	MEF2A_HUMAN	MYOG_HUMAN	TF -> target gene	TRANSFAC
197	CDK4_HUMAN	PKNX1_HUMAN	kinase -> substrate	Robert H Newman (2013)
198	SIK3_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
199	PRDM1_HUMAN	PAX5_HUMAN	TF -> target gene	TRANSFAC
200	CDK7_HUMAN	PO2F1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
201	SIK2_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
202	CDK4_HUMAN	FOXN2_HUMAN	kinase -> substrate	Robert H Newman (2013)
203	KS6A4_HUMAN	PO6F1_HUMAN	kinase -> substrate	Robert H Newman (2013)
204	SIK1_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
205	M3K7_HUMAN	NLK_HUMAN	kinase -> substrate	KEGG
206	M3K7_HUMAN	FUBP1_HUMAN	kinase -> substrate	Robert H Newman (2013)
207	NLK_HUMAN	LEF1_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)
208	5HT4R_HUMAN	GNA12_HUMAN	GPCR -> Gprotein	gpDB

⁺Protein attribute:

protein with cancer-related variations (CanProVar)

up expressed protein;

down expressed protein(dbDEPC)

protein with hyperphosphorylation site (PhosphoSitePlus)

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network