UniProt/SwissProt ID: | GNAS1_HUMAN |
Description: | GNAS complex locus [Source:HGNC Symbol;Acc:4392] |
Location: | chr20 q13.32 |
Node attribute: | Gprotein |
Phosphorylation site |
Position | PhosphoPeptide | Catalytic kinase | Source |
---|---|---|---|
S992 | EFLRIsTASGD | HPRD | |
S327 | PVNMDsPPIAL | PhosphoSitePlus | |
Y378 | VPSPGyGSPAA | PhosphoSitePlus | |
S995 | RISTAsGDGRH | HPRD | |
S520 | SAAPAsGARRK | PhosphoSitePlus | |
Dephosphorylation site |
GNAS1_HUMAN do not have dephosphorylation site. |
Mutation site |
Ensembl ID | Variation | Source | Cancer name | Pubmed |
---|---|---|---|---|
ENSP00000360141 | N740S | COSMIC | Head and Neck Cancer | 21798893 |
ENSP00000360141 | G196R | COSMIC | Central Nervous System Neoplasms | |
ENSP00000360141 | Y806* | COSMIC | Ovarian Cancer | 21720365 |
ENSP00000360141 | F916L | COSMIC | Ovarian Cancer | 21720365 |
ENSP00000360141 | A548E | COSMIC | Lung Cancer | |
ENSP00000360141 | R844C | COSMIC | Head and Neck Cancer | 21798893 |
ENSP00000360143 | R265C | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 |
ENSP00000360143 | R830C | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
Differential expressed protein |
GNAS1_HUMAN is not differential expressed protein. |
Hyperphosphorylation site |
GNAS1_HUMAN do not have hyperphosphorylation site. |
Direct Interaction Pair |
Source | Target | Relationship | Resource |
---|---|---|---|
5HT4R_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
MC4R_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
PE2R3_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
SCTR_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
TAAR2_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
LSHR_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
DRD1_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
P2Y11_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
GLP2R_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
CRFR1_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
ACTHR_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
NK2R_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
VIPR1_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
PE2R4_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
GHRHR_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
CALCR_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
TAAR1_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
GLP1R_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
PD2R_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
HRH2_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
ADRB3_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
ADRB2_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
NK3R_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
GIPR_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
GLR_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
5HT6R_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
EDNRA_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
DRD5_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
TAAR8_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
ADA2A_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
LPAR4_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
ADRB1_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
GPR6_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
MSHR_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
GPR63_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
FSHR_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
CRFR2_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
PTH1R_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
V2R_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
5HT7R_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
VIPR2_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
PTH2R_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
MC3R_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
GPR12_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
TAAR6_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
PE2R2_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
GNAS1_HUMAN | TBB1_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | TBA8_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | ADCY1_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | TBB2B_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | TBB4B_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | TBA4A_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | TBG1_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | SRC_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | TBD_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | ADCY5_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | TBB8_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | TBA1A_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | TBB6_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | ADCY6_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | ADCY3_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | TBA4B_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | ADCY4_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | ADCY2_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | SNX13_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | CSK_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | TBE_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | TBA1C_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | TBA3C_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | ADCY8_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | TBB3_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | TBB4A_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | TBAL3_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | TBG2_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | TBA1B_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | TBA3E_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | TBB5_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | ADCY7_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | TBB2A_HUMAN | Gprotein -> effector | gpDB |
GNAS1_HUMAN | ADCY9_HUMAN | Gprotein -> effector | gpDB |
Function Annotation |
KEGG Pathway |
KEGG ID | Pathway |
---|---|
hsa04730 | Long-term depression |
hsa04270 | Vascular smooth muscle contraction |
hsa04962 | Vasopressin-regulated water reabsorption |
hsa04912 | GnRH signaling pathway |
hsa04742 | Taste transduction |
hsa04976 | Bile secretion |
hsa05032 | Morphine addiction |
hsa05414 | Dilated cardiomyopathy |
hsa04540 | Gap junction |
hsa04020 | Calcium signaling pathway |
hsa05030 | Cocaine addiction |
hsa04724 | Glutamatergic synapse |
hsa04728 | Dopaminergic synapse |
hsa05146 | Amoebiasis |
hsa05031 | Amphetamine addiction |
hsa04970 | Salivary secretion |
hsa04961 | Endocrine and other factor-regulated calcium reabs |
hsa05110 | Vibrio cholerae infection |
hsa05142 | Chagas disease (American trypanosomiasis) |
hsa04726 | Serotonergic synapse |
hsa05034 | Alcoholism |
hsa04972 | Pancreatic secretion |
hsa04916 | Melanogenesis |
hsa04971 | Gastric acid secretion |
Gene Ontology |
GO ID | GO_Term | Evidence | Ontology |
---|---|---|---|
GO:0009791 | post-embryonic development | IEA | biological_process |
GO:0030425 | dendrite | IEA | cellular_component |
GO:0048701 | embryonic cranial skeleton morphogenesis | IEA | biological_process |
GO:0016020 | membrane | IEA | cellular_component |
GO:0007610 | behavior | IEA | biological_process |
GO:0001501 | skeletal system development | IEA | biological_process |
GO:0006184 | GTP catabolic process | IBA | biological_process |
GO:0004871 | signal transducer activity | IBA | molecular_function |
GO:0007165 | signal transduction | IEA | biological_process |
GO:0031683 | G-protein beta/gamma-subunit complex binding | IBA | molecular_function |
GO:0042493 | response to drug | IEA | biological_process |
GO:0005525 | GTP binding | IEA | molecular_function |
GO:0005834 | heterotrimeric G-protein complex | IBA | cellular_component |
GO:0001894 | tissue homeostasis | IEA | biological_process |
GO:0005829 | cytosol | ISS | cellular_component |
GO:0006306 | DNA methylation | IEA | biological_process |
GO:0016020 | membrane | ISS | cellular_component |
GO:0043588 | skin development | IEA | biological_process |
GO:0031852 | mu-type opioid receptor binding | IBA | molecular_function |
GO:0045669 | positive regulation of osteoblast differentiation | IEA | biological_process |
GO:0040032 | post-embryonic body morphogenesis | IEA | biological_process |
GO:0019001 | guanyl nucleotide binding | IEA | molecular_function |
GO:0071514 | genetic imprinting | IEA | biological_process |
GO:0007606 | sensory perception of chemical stimulus | IBA | biological_process |
GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
GO:0045672 | positive regulation of osteoclast differentiation | IEA | biological_process |
GO:0006112 | energy reserve metabolic process | IEA | biological_process |
GO:0046872 | metal ion binding | IEA | molecular_function |
GO:0007191 | adenylate cyclase-activating dopamine receptor sig | IBA | biological_process |
GO:0001958 | endochondral ossification | IEA | biological_process |
GO:0007189 | adenylate cyclase-activating G-protein coupled rec | IEA | biological_process |
GO:0003924 | GTPase activity | IBA | molecular_function |
GO:0005515 | protein binding | IEA | molecular_function |
GO:0035264 | multicellular organism growth | IEA | biological_process |
GO:0035116 | embryonic hindlimb morphogenesis | IEA | biological_process |
GO:0031234 | extrinsic to internal side of plasma membrane | IBA | cellular_component |
GO:0007191 | adenylate cyclase-activating dopamine receptor sig | IEA | biological_process |
GO:0051216 | cartilage development | IEA | biological_process |
GO:0035255 | ionotropic glutamate receptor binding | IBA | molecular_function |