Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KPCD1_HUMAN
Description:protein kinase D1 [Source:HGNC Symbol;Acc:9407]
Location:chr14 q12
Node attribute:kinase; effector; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S249EKRSNsQSYIGPhosphoSitePlus; HPRD; RegPhos
Y95PECGFyGMYDKPhosphoSitePlus
S738IIGEKsFRRSVPKD1RegPhos
S742KSFRRsVVGTPPKC_deltaphosphoELM
S738IIGEKsFRRSVPKC_deltaphosphoELM
S205RRRRLsNVSLTPKD1phosphoELM; RegPhos
S249EKRSNsQSYIGPKC_groupphosphoELM; RegPhos
Y463TGSRYyKEIPLAblphosphoELM
S379ECQNDsGEMQDPhosphoSitePlus
Y95PECGFyGMYDKSRCphosphoELM
S549IPKGSsVGTGTPhosphoSitePlus
S223SSAELsTSAPDPhosphoSitePlus; phosphoELM; RegPhos
S397ANRTIsPSTSNPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S910LGERVsILautocatalysis RegPhos
S742KSFRRsVVGTPphosphoELM
S401ISPSTsNNIPLPhosphoSitePlus; HPRD; phosphoELM
S910LGERVsphosphoELM
Y502ANVVYyVGENVSRCHPRD; RegPhos
S738IIGEKsFRRSVPKCh(PKC etaRegPhos
T746RSVVGtPAYLAHPRD; phosphoELM
S742KSFRRsVVGTPPKCh(PKC etaRegPhos
Y463TGSRYyKEIPLABL1HPRD; RegPhos
Y749VGTPAyLAPEVPkinasePhosphoSitePlus
S742KSFRRsVVGTPPKC_etaphosphoELM
S910LGERVsILPKD1RegPhos
S738IIGEKsFRRSVPkinasePhosphoSitePlus
Y502ANVVYyVGENVABL1RegPhos
S345VMEEGsDDNDSPhosphoSitePlus
Y502ANVVYyVGENVAblphosphoELM
S448YWRLDsKCITLPHPhosphoSitePlus
S738IIGEKsFRRSVPKC_etaphosphoELM
Y443LRKRHyWRLDSPHPhosphoSitePlus
Y432GWMVHyTSKDTPHPhosphoSitePlus
S205RRRRLsNVSLTPhosphoSitePlus; RegPhos
Y432GWMVHyTSKDTABL1HPRD; RegPhos
S742KSFRRsVVGTPPRKD1HPRD
S742KSFRRsVVGTPPkinasePhosphoSitePlus
Y463TGSRYyKEIPLSRCHPRD; RegPhos
S738IIGEKsFRRSVPKCd(PKC deltaRegPhos
S910LGERVsPRKD1HPRD
S205RRRRLsNVSLTPRKD1HPRD
S421TKRKSsTVMKEPhosphoSitePlus
Y463TGSRYyKEIPLPHPhosphoSitePlus
S738IIGEKsFRRSVPKCa(PKC alphaRegPhos
S742KSFRRsVVGTPPKCa(PKC alphaRegPhos
Y432GWMVHyTSKDTSRCHPRD; RegPhos
S235PLLQKsPSESFPhosphoSitePlus
S738IIGEKsFRRSVphosphoELM
Y432GWMVHyTSKDTAblphosphoELM
T224SAELStSAPDEPhosphoSitePlus
S738IIGEKsFRRSVPRKCHHPRD
S738IIGEKsFRRSVPKC_alphaphosphoELM
T395EDANRtISPSTPhosphoSitePlus
T210SNVSLtGVSTIPhosphoSitePlus; RegPhos
S237LQKSPsESFIGPhosphoSitePlus; HPRD
S738IIGEKsFRRSVPKChRegPhos
S742KSFRRsVVGTPPKD1RegPhos
T217VSTIRtSSAELPhosphoSitePlus; HPRD
S910LGERVsIL___PhosphoSitePlus
S742KSFRRsVVGTPPKCd(PKC deltaRegPhos
S208RLSNVsLTGVSPhosphoSitePlus; phosphoELM; RegPhos
S473LSEILsLEPVKPHPhosphoSitePlus
S219TIRTSsAELSTPhosphoSitePlus; phosphoELM; RegPhos
Y502ANVVYyVGENVHPRD; RegPhos
S412MRVVQsVKHTKPhosphoSitePlus
Y502ANVVYyVGENVPHPhosphoSitePlus
S890INPSAsHSDTPPhosphoSitePlus
S460QNDTGsRYYKEPHPhosphoSitePlus
S910LGERVsPKD1phosphoELM
S742KSFRRsVVGTPPKC_alphaphosphoELM
S738IIGEKsFRRSVPRKD1HPRD

Dephosphorylation site
KPCD1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000333568H152YCOSMICBreast Cancer20668451
ENSP00000333568H152YHPIColorectal Cancer16959974
ENSP00000333568L175VBIOMARTBreast Cancer21930507, 21930502
ENSP00000333568P585SGreenman2007Skin Cancer17344846, 18428421
ENSP00000333568E857KBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974
ENSP00000333568V477ICOSMICOvarian Cancer21720365
ENSP00000333568N516SCOSMICPancreatic Cancer
ENSP00000333568P270LCOSMICOvarian Cancer21720365
ENSP00000333568R677MGreenman2007, HPILung Cancer17344846, 18428421
ENSP00000333568Y760*COSMICGastric Cancer21097718
ENSP00000333568G779ACOSMICSkin Cancer21984974

Differential expressed protein
KPCD1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KPCD1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBB2_HUMANKPCD1_HUMANGprotein -> effectorgpDB
GBG11_HUMANKPCD1_HUMANGprotein -> effectorgpDB
GBG5_HUMANKPCD1_HUMANGprotein -> effectorgpDB
GBB1_HUMANKPCD1_HUMANGprotein -> effectorgpDB
GBB5_HUMANKPCD1_HUMANGprotein -> effectorgpDB
GBG10_HUMANKPCD1_HUMANGprotein -> effectorgpDB
GNA13_HUMANKPCD1_HUMANGprotein -> effectorgpDB
GBG1_HUMANKPCD1_HUMANGprotein -> effectorgpDB
GBB3_HUMANKPCD1_HUMANGprotein -> effectorgpDB
GBG8_HUMANKPCD1_HUMANGprotein -> effectorgpDB
GBG13_HUMANKPCD1_HUMANGprotein -> effectorgpDB
GNAQ_HUMANKPCD1_HUMANGprotein -> effectorgpDB
GBG2_HUMANKPCD1_HUMANGprotein -> effectorgpDB
GBG3_HUMANKPCD1_HUMANGprotein -> effectorgpDB
GBG12_HUMANKPCD1_HUMANGprotein -> effectorgpDB
KPCA_HUMANKPCD1_HUMANkinase -> substrateRobert H Newman (2013)
KPCD1_HUMANKPCD1_HUMANkinase -> substrateHPRD; NetPath
PKD1_HUMANKPCD1_HUMANkinase -> substrateRegPhos
KPCD_HUMANKPCD1_HUMANkinase -> substrateRobert H Newman (2013)
SRC_HUMANKPCD1_HUMANkinase -> substrateRegPhos
KPCL_HUMANKPCD1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCD1_HUMANHDAC5_HUMANkinase -> substrateHPRD
KPCD1_HUMANKSYK_HUMANkinase -> substrateNetPath
KPCD1_HUMANRIN1_HUMANkinase -> substrateRegPhos
KPCD1_HUMANKDIS_HUMANkinase -> substrateHPRD
KPCD1_HUMANPLCG1_HUMANkinase -> substrateHPRD; NetPath
KPCD1_HUMANEPAS1_HUMANkinase -> substrateHPRD
KPCD1_HUMANPP14A_HUMANkinase -> substrateHPRD
KPCD1_HUMANHDAC9_HUMANkinase -> substrateHPRD
ABL1_HUMANKPCD1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANKPCD1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KPCD1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006468protein phosphorylationIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0006644phospholipid metabolic processTASbiological_process
GO:0005938cell cortexIEAcellular_component
GO:0043536positive regulation of blood vessel endothelial ceIMPbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0010837regulation of keratinocyte proliferationISSbiological_process
GO:0010595positive regulation of endothelial cell migrationIMPbiological_process
GO:0045806negative regulation of endocytosisTASbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0060548negative regulation of cell deathIMPbiological_process
GO:0048193Golgi vesicle transportISSbiological_process
GO:0007030Golgi organizationIMPbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0007165signal transductionTASbiological_process
GO:0045087innate immune responseIEAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005543phospholipid bindingIEAmolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0034599cellular response to oxidative stressIDAbiological_process
GO:0005802trans-Golgi networkIEAcellular_component
GO:0006665sphingolipid metabolic processTASbiological_process
GO:0007243intracellular protein kinase cascadeIMPbiological_process
GO:0008283cell proliferationTASbiological_process
GO:1901727positive regulation of histone deacetylase activitIGIbiological_process
GO:0048010vascular endothelial growth factor receptor signalIMPbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0048193Golgi vesicle transportIEAbiological_process
GO:0005829cytosolISScellular_component
GO:0010837regulation of keratinocyte proliferationIEAbiological_process
GO:0030148sphingolipid biosynthetic processTASbiological_process
GO:0035924cellular response to vascular endothelial growth fIMPbiological_process
GO:2001044regulation of integrin-mediated signaling pathwayTASbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0010976positive regulation of neuron projection developmeIMPbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIMPbiological_process
GO:0005802trans-Golgi networkIDAcellular_component
GO:0035556intracellular signal transductionIEAbiological_process
GO:0045669positive regulation of osteoblast differentiationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0001525angiogenesisIEAbiological_process
GO:0032793positive regulation of CREB transcription factor aIGIbiological_process
GO:0033138positive regulation of peptidyl-serine phosphorylaIGIbiological_process
GO:0038033positive regulation of endothelial cell chemotaxisIMPbiological_process
GO:0046777protein autophosphorylationTASbiological_process
GO:0045669positive regulation of osteoblast differentiationISSbiological_process
GO:0005794Golgi apparatusIEAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0007229integrin-mediated signaling pathwayTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0005829cytosolIEAcellular_component
GO:0001938positive regulation of endothelial cell proliferatIGIbiological_process
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:2001028positive regulation of endothelial cell chemotaxisIMPbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0004697protein kinase C activityIEAmolecular_function
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIMPbiological_process
GO:0005911cell-cell junctionIEAcellular_component
GO:0045766positive regulation of angiogenesisIMPbiological_process