Phosphorylation

You are querying signaling transduction network mediated by 5HT6R_HUMAN in Lymphoma.

Signaling Transduction Network:

NO.	Source	Target	Relation Attribute	Resource
1	TPH1_HUMAN	5HT6R_HUMAN	ligand -> receptor	HPMR
2	5HT6R_HUMAN	GNAS2_HUMAN	GPCR -> Gprotein	gpDB
3	5HT6R_HUMAN	GNAS1_HUMAN	GPCR -> Gprotein	gpDB
4	GNAS2_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
5	GNAS1_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
6	GNAS1_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
7	GNAS2_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
8	CSK_HUMAN	LYN_HUMAN	kinase -> substrate; other	HPRD; RegPhos; Robert H Newman (2013); KEGG
9	CSK_HUMAN	ETS1_HUMAN	kinase -> substrate	Robert H Newman (2013)
10	CSK_HUMAN	FYN_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
11	SRC_HUMAN	RHG35_HUMAN	kinase -> substrate	KEGG; HPRD; RegPhos
12	SRC_HUMAN	ABL1_HUMAN	kinase -> substrate	RegPhos
13	CSK_HUMAN	KPCA_HUMAN	kinase -> substrate	Robert H Newman (2013)
14	CSK_HUMAN	LCK_HUMAN	kinase -> substrate	HPRD; RegPhos
15	SRC_HUMAN	AKT1_HUMAN	kinase -> substrate	RegPhos
16	SRC_HUMAN	KPCI_HUMAN	kinase -> substrate	RegPhos
17	SRC_HUMAN	CTNB1_HUMAN	kinase -> substrate	RegPhos
18	CSK_HUMAN	FGR_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
19	SRC_HUMAN	KIT_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
20	SRC_HUMAN	GTF2I_HUMAN	kinase -> substrate	RegPhos
21	SRC_HUMAN	ESR1_HUMAN	kinase -> substrate	HPRD; RegPhos
22	SRC_HUMAN	SHC1_HUMAN	kinase -> substrate	RegPhos
23	SRC_HUMAN	PDPK1_HUMAN	kinase -> substrate	RegPhos
24	SRC_HUMAN	EGFR_HUMAN	kinase -> substrate	RegPhos
25	SRC_HUMAN	FAK1_HUMAN	kinase -> substrate	RegPhos; NetPath
26	SRC_HUMAN	IKKB_HUMAN	kinase -> substrate	NetPath
27	SRC_HUMAN	STAT3_HUMAN	kinase -> substrate	HPRD; RegPhos
28	CSK_HUMAN	MK15_HUMAN	kinase -> substrate	RegPhos
29	SRC_HUMAN	HNRPK_HUMAN	kinase -> substrate	RegPhos
30	SRC_HUMAN	DDR2_HUMAN	kinase -> substrate	RegPhos
31	CSK_HUMAN	PTPRC_HUMAN	kinase -> substrate	Robert H Newman (2013)
32	SRC_HUMAN	RAF1_HUMAN	kinase -> substrate	HPRD; RegPhos
33	CSK_HUMAN	CTNB1_HUMAN	kinase -> substrate	RegPhos
34	SRC_HUMAN	IKKA_HUMAN	kinase -> substrate	NetPath
35	CSK_HUMAN	YES_HUMAN	kinase -> substrate	Robert H Newman (2013)
36	CSK_HUMAN	ANDR_HUMAN	kinase -> substrate	RegPhos
37	SRC_HUMAN	STA5B_HUMAN	kinase -> substrate	HPRD; RegPhos
38	SRC_HUMAN	IGF1R_HUMAN	kinase -> substrate	RegPhos
39	LYN_HUMAN	KPCD_HUMAN	kinase -> substrate	RegPhos
40	ETS1_HUMAN	AP2A_HUMAN	TF -> target gene	TRANSFAC
41	FYN_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
42	RHG35_HUMAN	GCR_HUMAN	TF -> target gene	TRANSFAC
43	ABL1_HUMAN	CDK5_HUMAN	kinase -> substrate	HPRD; RegPhos
44	KPCA_HUMAN	STK11_HUMAN	kinase -> substrate	HPRD
45	LCK_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
46	AKT1_HUMAN	FOXO4_HUMAN	kinase -> substrate	RegPhos
47	AKT1_HUMAN	KPCD_HUMAN	kinase -> substrate	Robert H Newman (2013)
48	KPCI_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
49	KPCA_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
50	FGR_HUMAN	CSK21_HUMAN	kinase -> substrate	Robert H Newman (2013)
51	KPCA_HUMAN	CREM_HUMAN	kinase -> substrate	HPRD
52	KPCA_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
53	KIT_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
54	AKT1_HUMAN	EP300_HUMAN	kinase -> substrate	HPRD; RegPhos
55	AKT1_HUMAN	NR4A1_HUMAN	kinase -> substrate	HPRD; RegPhos
56	FYN_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
57	AKT1_HUMAN	FOXO1_HUMAN	kinase -> substrate	RegPhos; NetPath
58	GTF2I_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
59	LYN_HUMAN	CSK21_HUMAN	kinase -> substrate	Robert H Newman (2013)
60	LCK_HUMAN	KPCD_HUMAN	kinase -> substrate	RegPhos
61	SHC1_HUMAN	ZAP70_HUMAN	kinase -> substrate	HPRD
62	PDPK1_HUMAN	KPCD_HUMAN	kinase -> substrate	HPRD; RegPhos
63	EGFR_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos
64	FAK1_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
65	ESR1_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
66	AKT1_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
67	ABL1_HUMAN	JUN_HUMAN	kinase -> substrate	HPRD; RegPhos
68	KPCA_HUMAN	EP300_HUMAN	kinase -> substrate	Robert H Newman (2013)
69	AKT1_HUMAN	GSK3A_HUMAN	kinase -> substrate	NetPath
70	IKKB_HUMAN	TF65_HUMAN	kinase -> substrate	NetPath; Robert H Newman (2013)
71	FYN_HUMAN	CDK5_HUMAN	kinase -> substrate	HPRD; RegPhos
72	AKT1_HUMAN	CREB1_HUMAN	kinase -> substrate	HPRD; RegPhos
73	KPCA_HUMAN	ATF1_HUMAN	kinase -> substrate	HPRD
74	KPCA_HUMAN	MYOD1_HUMAN	kinase -> substrate	HPRD
75	KPCA_HUMAN	TF65_HUMAN	kinase -> substrate	HPRD
76	KPCA_HUMAN	GLI1_HUMAN	kinase -> substrate	KEGG
77	ESR1_HUMAN	PRGR_HUMAN	TF -> target gene	TRANSFAC
78	AKT1_HUMAN	GSK3B_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
79	PDPK1_HUMAN	PKN1_HUMAN	kinase -> substrate	RegPhos
80	AKT1_HUMAN	TEAD1_HUMAN	kinase -> substrate	Robert H Newman (2013)
81	KPCA_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
82	KPCI_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
83	KPCA_HUMAN	NFKB1_HUMAN	kinase -> substrate	HPRD
84	LYN_HUMAN	CDK1_HUMAN	kinase -> substrate	HPRD; RegPhos
85	MK15_HUMAN	RET_HUMAN	kinase -> substrate	Robert H Newman (2013)
86	FGR_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
87	LYN_HUMAN	MK03_HUMAN	kinase -> substrate	NetPath
88	KPCA_HUMAN	GSK3B_HUMAN	kinase -> substrate	KEGG; HPRD
89	LCK_HUMAN	VDR_HUMAN	kinase -> substrate	Robert H Newman (2013)
90	HNRPK_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
91	FGR_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
92	DDR2_HUMAN	RET_HUMAN	kinase -> substrate	Robert H Newman (2013)
93	AKT1_HUMAN	M3K11_HUMAN	kinase -> substrate	HPRD; RegPhos
94	PDPK1_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
95	PTPRC_HUMAN	JAK1_HUMAN	phosphatase -> substrate	HPRD
96	PDPK1_HUMAN	ZAP70_HUMAN	kinase -> substrate	Robert H Newman (2013)
97	LCK_HUMAN	ZAP70_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)
98	RAF1_HUMAN	MP2K1_HUMAN	kinase -> substrate; other	RegPhos; Robert H Newman (2013); KEGG
99	IKKA_HUMAN	IRF7_HUMAN	kinase -> substrate	KEGG
100	FGR_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
101	LCK_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos
102	IKKB_HUMAN	NFKB1_HUMAN	kinase -> substrate	HPRD; NetPath; Robert H Newman (2013)
103	YES_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
104	KPCA_HUMAN	PTN7_HUMAN	kinase -> substrate	HPRD
105	STAT3_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
106	AKT1_HUMAN	MTOR_HUMAN	kinase -> substrate	RegPhos
107	KPCA_HUMAN	FOS_HUMAN	kinase -> substrate	HPRD
108	AKT1_HUMAN	GATA2_HUMAN	kinase -> substrate	HPRD
109	STAT3_HUMAN	IRF1_HUMAN	TF -> target gene	TRANSFAC
110	KPCA_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
111	FAK1_HUMAN	MITF_HUMAN	kinase -> substrate	Robert H Newman (2013)
112	DDR2_HUMAN	KPCD_HUMAN	kinase -> substrate	Robert H Newman (2013)
113	KPCA_HUMAN	GSK3A_HUMAN	kinase -> substrate	HPRD
114	PDPK1_HUMAN	KS6A1_HUMAN	kinase -> substrate	HPRD; RegPhos
115	AKT1_HUMAN	SOX9_HUMAN	kinase -> substrate	Robert H Newman (2013)
116	STAT3_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
117	FGR_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
118	AKT1_HUMAN	GATA1_HUMAN	kinase -> substrate	HPRD; RegPhos
119	FYN_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
120	PDPK1_HUMAN	MP2K1_HUMAN	kinase -> substrate	RegPhos
121	KPCA_HUMAN	KLF1_HUMAN	kinase -> substrate	HPRD
122	IKKA_HUMAN	NFKB1_HUMAN	kinase -> substrate; other	HPRD; NetPath; KEGG
123	PDPK1_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
124	IGF1R_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
125	ETS1_HUMAN	NFKB1_HUMAN	TF -> target gene	TRANSFAC
126	ABL1_HUMAN	P73_HUMAN	kinase -> substrate	HPRD; RegPhos
127	KPCA_HUMAN	ATF4_HUMAN	kinase -> substrate	KEGG
128	RAF1_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
129	FGR_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
130	AKT1_HUMAN	STAT6_HUMAN	kinase -> substrate	Robert H Newman (2013)
131	AKT1_HUMAN	THA_HUMAN	kinase -> substrate	Robert H Newman (2013)
132	FGR_HUMAN	ZAP70_HUMAN	kinase -> substrate	Robert H Newman (2013)
133	KPCA_HUMAN	AHR_HUMAN	kinase -> substrate	Robert H Newman (2013)
134	IKKA_HUMAN	TF65_HUMAN	kinase -> substrate	HPRD; NetPath
135	YES_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
136	YES_HUMAN	TF65_HUMAN	kinase -> substrate	Robert H Newman (2013)
137	KPCA_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
138	KPCD_HUMAN	TWST1_HUMAN	kinase -> substrate	Robert H Newman (2013)
139	MK07_HUMAN	MEF2D_HUMAN	kinase -> substrate	HPRD
140	GCR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
141	CDK5_HUMAN	MEF2A_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
142	STK11_HUMAN	TFE3_HUMAN	kinase -> substrate	Robert H Newman (2013)
143	FOXO4_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
144	SRF_HUMAN	EGR2_HUMAN	TF -> target gene	TRANSFAC
145	CSK21_HUMAN	MEF2A_HUMAN	kinase -> substrate	Robert H Newman (2013)
146	CSK21_HUMAN	TF7L2_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
147	AP2A_HUMAN	REL_HUMAN	TF -> target gene	TRANSFAC
148	ZAP70_HUMAN	MK14_HUMAN	kinase -> substrate	KEGG; RegPhos; Robert H Newman (2013)
149	KPCD_HUMAN	NF2L2_HUMAN	kinase -> substrate	HPRD
150	RXRA_HUMAN	RARB_HUMAN	TF -> target gene	TRANSFAC
151	CSK21_HUMAN	NKX25_HUMAN	kinase -> substrate	HPRD
152	GSK3A_HUMAN	TF7L2_HUMAN	kinase -> substrate	Robert H Newman (2013)
153	CREB1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
154	PRGR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
155	CDK5_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
156	GSK3B_HUMAN	CDX2_HUMAN	kinase -> substrate	RegPhos
157	MK07_HUMAN	MEF2A_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
158	CDK5_HUMAN	MEF2D_HUMAN	kinase -> substrate	RegPhos
159	PKN1_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
160	CDK1_HUMAN	HMGA1_HUMAN	kinase -> substrate	RegPhos
161	CSK21_HUMAN	MAZ_HUMAN	kinase -> substrate	HPRD
162	SRF_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
163	RET_HUMAN	MK14_HUMAN	kinase -> substrate	HPRD; RegPhos
164	MK03_HUMAN	MAZ_HUMAN	kinase -> substrate	Robert H Newman (2013)
165	CSK21_HUMAN	APEX1_HUMAN	kinase -> substrate	HPRD
166	M3K11_HUMAN	MP2K7_HUMAN	kinase -> substrate	KEGG
167	CSK21_HUMAN	EGR1_HUMAN	kinase -> substrate	HPRD
168	CDK1_HUMAN	CDK7_HUMAN	kinase -> substrate	RegPhos
169	STK11_HUMAN	SIK3_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
170	JAK1_HUMAN	STAT4_HUMAN	kinase -> substrate	RegPhos
171	CDK1_HUMAN	CUX1_HUMAN	kinase -> substrate	RegPhos
172	MP2K1_HUMAN	KS6A4_HUMAN	kinase -> substrate	RegPhos
173	MYC_HUMAN	CDK4_HUMAN	TF -> target gene	TRANSFAC
174	CDK1_HUMAN	HMGA2_HUMAN	kinase -> substrate	RegPhos
175	NR4A1_HUMAN	E2F1_HUMAN	TF -> target gene	TRANSFAC
176	STK11_HUMAN	SIK2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
177	PTN7_HUMAN	MK14_HUMAN	phosphatase -> substrate	KEGG
178	MTOR_HUMAN	HIF1A_HUMAN	kinase -> substrate	KEGG
179	CSK21_HUMAN	MYF6_HUMAN	kinase -> substrate	Robert H Newman (2013)
180	CSK21_HUMAN	MYF5_HUMAN	kinase -> substrate	HPRD
181	CREB1_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
182	STK11_HUMAN	SIK1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
183	KS6A1_HUMAN	ESR2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
184	CSK21_HUMAN	HIF1A_HUMAN	kinase -> substrate	HPRD
185	CDK1_HUMAN	E2F1_HUMAN	kinase -> substrate	RegPhos
186	CSK21_HUMAN	HMGA1_HUMAN	kinase -> substrate	HPRD
187	ATF1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
188	FOXO1_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
189	MEF2A_HUMAN	MYOG_HUMAN	TF -> target gene	TRANSFAC
190	PRDM1_HUMAN	PAX5_HUMAN	TF -> target gene	TRANSFAC
191	MP2K7_HUMAN	M3K7_HUMAN	kinase -> substrate	KEGG
192	CDK7_HUMAN	PO2F1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
193	SIK3_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
194	KS6A4_HUMAN	PO6F1_HUMAN	kinase -> substrate	Robert H Newman (2013)
195	CDK4_HUMAN	PKNX1_HUMAN	kinase -> substrate	Robert H Newman (2013)
196	SIK2_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
197	SIK1_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
198	CDK4_HUMAN	FOXN2_HUMAN	kinase -> substrate	Robert H Newman (2013)
199	M3K7_HUMAN	FUBP1_HUMAN	kinase -> substrate	Robert H Newman (2013)
200	M3K7_HUMAN	NLK_HUMAN	kinase -> substrate	KEGG
201	NLK_HUMAN	LEF1_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)

⁺Protein attribute:

protein with cancer-related variations (CanProVar)

up expressed protein;

down expressed protein(dbDEPC)

protein with hyperphosphorylation site (PhosphoSitePlus)

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network