Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:5HT6R_HUMAN
Description:5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled [Source:HGNC Symbol;Acc:5301]
Location:chr1 p36.13
Node attribute:receptor; GPCR

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y125ISLDRyLLILSHPRD; phosphoELM
Y125ISLDRyLLILS7tm_1PhosphoSitePlus

Dephosphorylation site
5HT6R_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000289753P362STCGAOvarian Cancer21720365, 18772890
ENSP00000289753P362SCOSMICOvarian Cancer21720365
ENSP00000289753A157TCOSMICHead and Neck Cancer21984974

Differential expressed protein
5HT6R_HUMAN is not differential expressed protein.

Hyperphosphorylation site
5HT6R_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TPH1_HUMAN5HT6R_HUMANligand -> receptorHPMR
5HT6R_HUMANGNAS2_HUMANGPCR -> GproteingpDB
5HT6R_HUMANGNAS1_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04726Serotonergic synapse
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007420brain developmentIEAbiological_process
GO:0014058negative regulation of acetylcholine secretionIEAbiological_process
GO:0060291long-term synaptic potentiationIEAbiological_process
GO:0007612learningIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0004969histamine receptor activityTASmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0042493response to drugIEAbiological_process
GO:0007210serotonin receptor signaling pathwayIEAbiological_process
GO:0014050negative regulation of glutamate secretionIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0014053negative regulation of gamma-aminobutyric acid secIEAbiological_process
GO:0033603positive regulation of dopamine secretionIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0014054positive regulation of gamma-aminobutyric acid secIEAbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0030425dendriteIEAcellular_component
GO:0032355response to estradiol stimulusIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0004993serotonin receptor activityIEAmolecular_function
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0007187G-protein coupled receptor signaling pathway, coupIEAbiological_process


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