Phosphorylation

Protein information

UniProt/SwissProt ID:	5HT6R_HUMAN
Description:	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled [Source:HGNC Symbol;Acc:5301]
Location:	chr1 p36.13
Node attribute:	receptor; GPCR

Position	PhosphoPeptide	Catalytic kinase	Source
Y125	ISLDRyLLILS		HPRD; phosphoELM
Y125	ISLDRyLLILS	7tm_1	PhosphoSitePlus

5HT6R_HUMAN do not have dephosphorylation site.

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000289753	P362S	TCGA	Ovarian Cancer	21720365, 18772890
ENSP00000289753	P362S	COSMIC	Ovarian Cancer	21720365
ENSP00000289753	A157T	COSMIC	Head and Neck Cancer	21984974

5HT6R_HUMAN is not differential expressed protein.

5HT6R_HUMAN do not have hyperphosphorylation site.

Source	Target	Relationship	Resource
TPH1_HUMAN	5HT6R_HUMAN	ligand -> receptor	HPMR
5HT6R_HUMAN	GNAS2_HUMAN	GPCR -> Gprotein	gpDB
5HT6R_HUMAN	GNAS1_HUMAN	GPCR -> Gprotein	gpDB

KEGG Pathway

KEGG ID	Pathway
hsa04726	Serotonergic synapse
hsa04020	Calcium signaling pathway
hsa04080	Neuroactive ligand-receptor interaction

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0007420	brain development	IEA	biological_process
GO:0014058	negative regulation of acetylcholine secretion	IEA	biological_process
GO:0060291	long-term synaptic potentiation	IEA	biological_process
GO:0007612	learning	IEA	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0004969	histamine receptor activity	TAS	molecular_function
GO:0016021	integral to membrane	IEA	cellular_component
GO:0042493	response to drug	IEA	biological_process
GO:0007210	serotonin receptor signaling pathway	IEA	biological_process
GO:0014050	negative regulation of glutamate secretion	IEA	biological_process
GO:0005886	plasma membrane	TAS	cellular_component
GO:0014053	negative regulation of gamma-aminobutyric acid sec	IEA	biological_process
GO:0033603	positive regulation of dopamine secretion	IEA	biological_process
GO:0005887	integral to plasma membrane	TAS	cellular_component
GO:0014054	positive regulation of gamma-aminobutyric acid sec	IEA	biological_process
GO:0007268	synaptic transmission	TAS	biological_process
GO:0030425	dendrite	IEA	cellular_component
GO:0032355	response to estradiol stimulus	IEA	biological_process
GO:0005886	plasma membrane	IEA	cellular_component
GO:0007186	G-protein coupled receptor signaling pathway	IEA	biological_process
GO:0004993	serotonin receptor activity	IEA	molecular_function
GO:0004930	G-protein coupled receptor activity	IEA	molecular_function
GO:0007187	G-protein coupled receptor signaling pathway, coup	IEA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network