Phosphorylation

You are querying signaling transduction network mediated by V2R_HUMAN in Thyroid Carcinoma.

Signaling Transduction Network:

NO.	Source	Target	Relation Attribute	Resource
1	NEU2_HUMAN	V2R_HUMAN	ligand -> receptor	HPMR
2	V2R_HUMAN	GNAS2_HUMAN	GPCR -> Gprotein	gpDB
3	V2R_HUMAN	GNAS1_HUMAN	GPCR -> Gprotein	gpDB
4	GNAS2_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
5	GNAS1_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
6	GNAS2_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
7	GNAS1_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
8	CSK_HUMAN	FGR_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
9	CSK_HUMAN	KPCA_HUMAN	kinase -> substrate	Robert H Newman (2013)
10	SRC_HUMAN	IGF1R_HUMAN	kinase -> substrate	RegPhos
11	SRC_HUMAN	RAF1_HUMAN	kinase -> substrate	HPRD; RegPhos
12	SRC_HUMAN	AKT1_HUMAN	kinase -> substrate	RegPhos
13	SRC_HUMAN	PDPK1_HUMAN	kinase -> substrate	RegPhos
14	CSK_HUMAN	ETS1_HUMAN	kinase -> substrate	Robert H Newman (2013)
15	CSK_HUMAN	LYN_HUMAN	kinase -> substrate; other	HPRD; RegPhos; Robert H Newman (2013); KEGG
16	CSK_HUMAN	FYN_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
17	CSK_HUMAN	YES_HUMAN	kinase -> substrate	Robert H Newman (2013)
18	SRC_HUMAN	FAK1_HUMAN	kinase -> substrate	RegPhos; NetPath
19	SRC_HUMAN	GTF2I_HUMAN	kinase -> substrate	RegPhos
20	SRC_HUMAN	ABL1_HUMAN	kinase -> substrate	RegPhos
21	SRC_HUMAN	IKKA_HUMAN	kinase -> substrate	NetPath
22	SRC_HUMAN	KIT_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
23	SRC_HUMAN	RHG35_HUMAN	kinase -> substrate	KEGG; HPRD; RegPhos
24	SRC_HUMAN	STAT3_HUMAN	kinase -> substrate	HPRD; RegPhos
25	SRC_HUMAN	STA5B_HUMAN	kinase -> substrate	HPRD; RegPhos
26	CSK_HUMAN	PTPRC_HUMAN	kinase -> substrate	Robert H Newman (2013)
27	CSK_HUMAN	MK15_HUMAN	kinase -> substrate	RegPhos
28	CSK_HUMAN	LCK_HUMAN	kinase -> substrate	HPRD; RegPhos
29	SRC_HUMAN	SHC1_HUMAN	kinase -> substrate	RegPhos
30	SRC_HUMAN	IKKB_HUMAN	kinase -> substrate	NetPath
31	SRC_HUMAN	HNRPK_HUMAN	kinase -> substrate	RegPhos
32	SRC_HUMAN	KPCI_HUMAN	kinase -> substrate	RegPhos
33	SRC_HUMAN	ESR1_HUMAN	kinase -> substrate	HPRD; RegPhos
34	SRC_HUMAN	DDR2_HUMAN	kinase -> substrate	RegPhos
35	CSK_HUMAN	ANDR_HUMAN	kinase -> substrate	RegPhos
36	SRC_HUMAN	EGFR_HUMAN	kinase -> substrate	RegPhos
37	CSK_HUMAN	CTNB1_HUMAN	kinase -> substrate	RegPhos
38	SRC_HUMAN	CTNB1_HUMAN	kinase -> substrate	RegPhos
39	FGR_HUMAN	CSK21_HUMAN	kinase -> substrate	Robert H Newman (2013)
40	KPCA_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
41	IGF1R_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
42	RAF1_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
43	AKT1_HUMAN	THA_HUMAN	kinase -> substrate	Robert H Newman (2013)
44	PDPK1_HUMAN	KPCD_HUMAN	kinase -> substrate	HPRD; RegPhos
45	ETS1_HUMAN	AP2A_HUMAN	TF -> target gene	TRANSFAC
46	KPCA_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
47	AKT1_HUMAN	FOXO1_HUMAN	kinase -> substrate	RegPhos; NetPath
48	LYN_HUMAN	CDK1_HUMAN	kinase -> substrate	HPRD; RegPhos
49	LYN_HUMAN	CSK21_HUMAN	kinase -> substrate	Robert H Newman (2013)
50	FYN_HUMAN	CDK5_HUMAN	kinase -> substrate	HPRD; RegPhos
51	YES_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
52	AKT1_HUMAN	CREB1_HUMAN	kinase -> substrate	HPRD; RegPhos
53	FAK1_HUMAN	MITF_HUMAN	kinase -> substrate	Robert H Newman (2013)
54	GTF2I_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
55	KPCA_HUMAN	ATF1_HUMAN	kinase -> substrate	HPRD
56	ABL1_HUMAN	CDK5_HUMAN	kinase -> substrate	HPRD; RegPhos
57	PDPK1_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
58	IKKA_HUMAN	NFKB1_HUMAN	kinase -> substrate; other	HPRD; NetPath; KEGG
59	KIT_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
60	KPCA_HUMAN	EP300_HUMAN	kinase -> substrate	Robert H Newman (2013)
61	AKT1_HUMAN	FOXO4_HUMAN	kinase -> substrate	RegPhos
62	KPCA_HUMAN	MYOD1_HUMAN	kinase -> substrate	HPRD
63	PDPK1_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
64	STAT3_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
65	PTPRC_HUMAN	JAK1_HUMAN	phosphatase -> substrate	HPRD
66	LYN_HUMAN	KPCD_HUMAN	kinase -> substrate	RegPhos
67	KPCA_HUMAN	ATF4_HUMAN	kinase -> substrate	KEGG
68	MK15_HUMAN	RET_HUMAN	kinase -> substrate	Robert H Newman (2013)
69	FAK1_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
70	KPCA_HUMAN	KLF1_HUMAN	kinase -> substrate	HPRD
71	IKKA_HUMAN	TF65_HUMAN	kinase -> substrate	HPRD; NetPath
72	AKT1_HUMAN	GATA2_HUMAN	kinase -> substrate	HPRD
73	AKT1_HUMAN	STAT6_HUMAN	kinase -> substrate	Robert H Newman (2013)
74	LCK_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos
75	SHC1_HUMAN	ZAP70_HUMAN	kinase -> substrate	HPRD
76	IKKB_HUMAN	NFKB1_HUMAN	kinase -> substrate	HPRD; NetPath; Robert H Newman (2013)
77	FYN_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
78	FYN_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
79	AKT1_HUMAN	GSK3B_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
80	HNRPK_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
81	AKT1_HUMAN	NR4A1_HUMAN	kinase -> substrate	HPRD; RegPhos
82	PDPK1_HUMAN	MP2K1_HUMAN	kinase -> substrate	RegPhos
83	FGR_HUMAN	ZAP70_HUMAN	kinase -> substrate	Robert H Newman (2013)
84	PDPK1_HUMAN	PKN1_HUMAN	kinase -> substrate	RegPhos
85	RHG35_HUMAN	GCR_HUMAN	TF -> target gene	TRANSFAC
86	KPCI_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
87	KPCA_HUMAN	PTN7_HUMAN	kinase -> substrate	HPRD
88	KPCA_HUMAN	FOS_HUMAN	kinase -> substrate	HPRD
89	FYN_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
90	RAF1_HUMAN	MP2K1_HUMAN	kinase -> substrate; other	RegPhos; Robert H Newman (2013); KEGG
91	AKT1_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
92	ABL1_HUMAN	JUN_HUMAN	kinase -> substrate	HPRD; RegPhos
93	AKT1_HUMAN	M3K11_HUMAN	kinase -> substrate	HPRD; RegPhos
94	AKT1_HUMAN	MTOR_HUMAN	kinase -> substrate	RegPhos
95	LYN_HUMAN	MK03_HUMAN	kinase -> substrate	NetPath
96	DDR2_HUMAN	KPCD_HUMAN	kinase -> substrate	Robert H Newman (2013)
97	KPCA_HUMAN	TF65_HUMAN	kinase -> substrate	HPRD
98	KPCA_HUMAN	CREM_HUMAN	kinase -> substrate	HPRD
99	ABL1_HUMAN	P73_HUMAN	kinase -> substrate	HPRD; RegPhos
100	LCK_HUMAN	ZAP70_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)
101	KPCI_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
102	FGR_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
103	FGR_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
104	PDPK1_HUMAN	ZAP70_HUMAN	kinase -> substrate	Robert H Newman (2013)
105	LCK_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
106	LCK_HUMAN	KPCD_HUMAN	kinase -> substrate	RegPhos
107	LCK_HUMAN	VDR_HUMAN	kinase -> substrate	Robert H Newman (2013)
108	AKT1_HUMAN	KPCD_HUMAN	kinase -> substrate	Robert H Newman (2013)
109	FGR_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
110	KPCA_HUMAN	STK11_HUMAN	kinase -> substrate	HPRD
111	STAT3_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
112	FGR_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
113	STAT3_HUMAN	IRF1_HUMAN	TF -> target gene	TRANSFAC
114	KPCA_HUMAN	AHR_HUMAN	kinase -> substrate	Robert H Newman (2013)
115	AKT1_HUMAN	GSK3A_HUMAN	kinase -> substrate	NetPath
116	DDR2_HUMAN	RET_HUMAN	kinase -> substrate	Robert H Newman (2013)
117	ESR1_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
118	KPCA_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
119	FGR_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
120	PDPK1_HUMAN	KS6A1_HUMAN	kinase -> substrate	HPRD; RegPhos
121	AKT1_HUMAN	EP300_HUMAN	kinase -> substrate	HPRD; RegPhos
122	KPCA_HUMAN	NFKB1_HUMAN	kinase -> substrate	HPRD
123	AKT1_HUMAN	GATA1_HUMAN	kinase -> substrate	HPRD; RegPhos
124	YES_HUMAN	TF65_HUMAN	kinase -> substrate	Robert H Newman (2013)
125	ETS1_HUMAN	NFKB1_HUMAN	TF -> target gene	TRANSFAC
126	KPCA_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
127	KPCA_HUMAN	GSK3B_HUMAN	kinase -> substrate	KEGG; HPRD
128	KPCA_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
129	IKKB_HUMAN	TF65_HUMAN	kinase -> substrate	NetPath; Robert H Newman (2013)
130	EGFR_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos
131	KPCA_HUMAN	GSK3A_HUMAN	kinase -> substrate	HPRD
132	ESR1_HUMAN	PRGR_HUMAN	TF -> target gene	TRANSFAC
133	KPCA_HUMAN	GLI1_HUMAN	kinase -> substrate	KEGG
134	IKKA_HUMAN	IRF7_HUMAN	kinase -> substrate	KEGG
135	YES_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
136	AKT1_HUMAN	SOX9_HUMAN	kinase -> substrate	Robert H Newman (2013)
137	AKT1_HUMAN	TEAD1_HUMAN	kinase -> substrate	Robert H Newman (2013)
138	CSK21_HUMAN	TF7L2_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
139	SRF_HUMAN	EGR2_HUMAN	TF -> target gene	TRANSFAC
140	KPCD_HUMAN	TWST1_HUMAN	kinase -> substrate	Robert H Newman (2013)
141	FOXO1_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
142	CDK1_HUMAN	HMGA2_HUMAN	kinase -> substrate	RegPhos
143	CSK21_HUMAN	MEF2A_HUMAN	kinase -> substrate	Robert H Newman (2013)
144	CDK5_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
145	CREB1_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
146	ATF1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
147	CDK1_HUMAN	E2F1_HUMAN	kinase -> substrate	RegPhos
148	CSK21_HUMAN	MAZ_HUMAN	kinase -> substrate	HPRD
149	MK07_HUMAN	MEF2A_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
150	JAK1_HUMAN	STAT4_HUMAN	kinase -> substrate	RegPhos
151	RET_HUMAN	MK14_HUMAN	kinase -> substrate	HPRD; RegPhos
152	CSK21_HUMAN	MYF6_HUMAN	kinase -> substrate	Robert H Newman (2013)
153	CDK1_HUMAN	HMGA1_HUMAN	kinase -> substrate	RegPhos
154	MK07_HUMAN	MEF2D_HUMAN	kinase -> substrate	HPRD
155	ZAP70_HUMAN	MK14_HUMAN	kinase -> substrate	KEGG; RegPhos; Robert H Newman (2013)
156	CDK5_HUMAN	MEF2D_HUMAN	kinase -> substrate	RegPhos
157	GSK3B_HUMAN	CDX2_HUMAN	kinase -> substrate	RegPhos
158	NR4A1_HUMAN	E2F1_HUMAN	TF -> target gene	TRANSFAC
159	MP2K1_HUMAN	KS6A4_HUMAN	kinase -> substrate	RegPhos
160	CSK21_HUMAN	NKX25_HUMAN	kinase -> substrate	HPRD
161	CDK5_HUMAN	MEF2A_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
162	PKN1_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
163	PTN7_HUMAN	MK14_HUMAN	phosphatase -> substrate	KEGG
164	SRF_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
165	CSK21_HUMAN	APEX1_HUMAN	kinase -> substrate	HPRD
166	RXRA_HUMAN	RARB_HUMAN	TF -> target gene	TRANSFAC
167	M3K11_HUMAN	MP2K7_HUMAN	kinase -> substrate	KEGG
168	MTOR_HUMAN	HIF1A_HUMAN	kinase -> substrate	KEGG
169	MK03_HUMAN	MAZ_HUMAN	kinase -> substrate	Robert H Newman (2013)
170	CDK1_HUMAN	CUX1_HUMAN	kinase -> substrate	RegPhos
171	KPCD_HUMAN	NF2L2_HUMAN	kinase -> substrate	HPRD
172	CREB1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
173	CSK21_HUMAN	MYF5_HUMAN	kinase -> substrate	HPRD
174	MYC_HUMAN	CDK4_HUMAN	TF -> target gene	TRANSFAC
175	FOXO4_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
176	STK11_HUMAN	SIK2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
177	AP2A_HUMAN	REL_HUMAN	TF -> target gene	TRANSFAC
178	CSK21_HUMAN	HIF1A_HUMAN	kinase -> substrate	HPRD
179	GSK3A_HUMAN	TF7L2_HUMAN	kinase -> substrate	Robert H Newman (2013)
180	CSK21_HUMAN	HMGA1_HUMAN	kinase -> substrate	HPRD
181	STK11_HUMAN	SIK1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
182	STK11_HUMAN	TFE3_HUMAN	kinase -> substrate	Robert H Newman (2013)
183	KS6A1_HUMAN	ESR2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
184	CSK21_HUMAN	EGR1_HUMAN	kinase -> substrate	HPRD
185	GCR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
186	STK11_HUMAN	SIK3_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
187	PRGR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
188	CDK1_HUMAN	CDK7_HUMAN	kinase -> substrate	RegPhos
189	PRDM1_HUMAN	PAX5_HUMAN	TF -> target gene	TRANSFAC
190	MEF2A_HUMAN	MYOG_HUMAN	TF -> target gene	TRANSFAC
191	KS6A4_HUMAN	PO6F1_HUMAN	kinase -> substrate	Robert H Newman (2013)
192	MP2K7_HUMAN	M3K7_HUMAN	kinase -> substrate	KEGG
193	CDK4_HUMAN	PKNX1_HUMAN	kinase -> substrate	Robert H Newman (2013)
194	SIK2_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
195	CDK4_HUMAN	FOXN2_HUMAN	kinase -> substrate	Robert H Newman (2013)
196	SIK1_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
197	SIK3_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
198	CDK7_HUMAN	PO2F1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
199	M3K7_HUMAN	FUBP1_HUMAN	kinase -> substrate	Robert H Newman (2013)
200	M3K7_HUMAN	NLK_HUMAN	kinase -> substrate	KEGG
201	NLK_HUMAN	LEF1_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)

⁺Protein attribute:

protein with cancer-related variations (CanProVar)

up expressed protein;

down expressed protein(dbDEPC)

protein with hyperphosphorylation site (PhosphoSitePlus)

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network