Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:V2R_HUMAN
Description:arginine vasopressin receptor 2 [Source:HGNC Symbol;Acc:897]
Location:chrX q28
Node attribute:receptor; GPCR

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S363CTTASsSLAKDPhosphoSitePlus; phosphoELM
S255GRRTGsPGEGA7tm_1PhosphoSitePlus
S362SCTTAsSSLAKPhosphoSitePlus; phosphoELM
S364TTASSsLAKDTPhosphoSitePlus; phosphoELM
Y117CRAVKyLQMVGTM; 7tm_1PhosphoSitePlus
Y124QMVGMyASSYMTM; 7tm_1PhosphoSitePlus
Y325TNPWIyASFSSHPRD

Dephosphorylation site
V2R_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000338072R247HSjoblom2006Breast Cancer16959974
ENSP00000351805R247HSjoblom2006Breast Cancer16959974
ENSP00000359066*310SCOSMICOvarian Cancer21720365
ENSP00000351805R247HHPI, COSMICBreast Cancer16959974
ENSP00000338072R247HHPI, COSMICBreast Cancer16959974

Differential expressed protein
V2R_HUMAN is not differential expressed protein.

Hyperphosphorylation site
V2R_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NEU2_HUMANV2R_HUMANligand -> receptorHPMR
V2R_HUMANGNAS2_HUMANGPCR -> GproteingpDB
V2R_HUMANGNAS1_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04962Vasopressin-regulated water reabsorption
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007588excretionTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0034097response to cytokine stimulusIEAbiological_process
GO:0005794Golgi apparatusTAScellular_component
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0031398positive regulation of protein ubiquitinationNASbiological_process
GO:0055085transmembrane transportTASbiological_process
GO:0035811negative regulation of urine volumeIEAbiological_process
GO:0007188adenylate cyclase-modulating G-protein coupled recTASbiological_process
GO:0016021integral to membraneNAScellular_component
GO:0010628positive regulation of gene expressionISSbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0032609interferon-gamma productionIEAbiological_process
GO:0005783endoplasmic reticulumTAScellular_component
GO:0021537telencephalon developmentIEAbiological_process
GO:0035814negative regulation of renal sodium excretionIEAbiological_process
GO:0005000vasopressin receptor activityTASmolecular_function
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0007599hemostasisTASbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0005768endosomeTAScellular_component
GO:0007190activation of adenylate cyclase activityTASbiological_process
GO:0003084positive regulation of systemic arterial blood preIEAbiological_process
GO:0007249I-kappaB kinase/NF-kappaB cascadeIEAbiological_process
GO:0045777positive regulation of blood pressureIEAbiological_process
GO:0006833water transportTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process


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