Phosphorylation

You are querying signaling transduction network mediated by ADRB1_HUMAN in Lung Cancer.

Signaling Transduction Network:

NO.	Source	Target	Relation Attribute	Resource
1	DOPO_HUMAN	ADRB1_HUMAN	ligand -> receptor	HPMR
2	ADRB1_HUMAN	GNAS2_HUMAN	GPCR -> Gprotein	gpDB
3	ADRB1_HUMAN	GNAS1_HUMAN	GPCR -> Gprotein	gpDB
4	GNAS2_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
5	GNAS1_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
6	GNAS1_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
7	GNAS2_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
8	SRC_HUMAN	HNRPK_HUMAN	kinase -> substrate	RegPhos
9	CSK_HUMAN	FGR_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
10	CSK_HUMAN	KPCA_HUMAN	kinase -> substrate	Robert H Newman (2013)
11	SRC_HUMAN	ESR1_HUMAN	kinase -> substrate	HPRD; RegPhos
12	SRC_HUMAN	PDPK1_HUMAN	kinase -> substrate	RegPhos
13	CSK_HUMAN	YES_HUMAN	kinase -> substrate	Robert H Newman (2013)
14	SRC_HUMAN	RHG35_HUMAN	kinase -> substrate	KEGG; HPRD; RegPhos
15	SRC_HUMAN	AKT1_HUMAN	kinase -> substrate	RegPhos
16	CSK_HUMAN	LYN_HUMAN	kinase -> substrate; other	HPRD; RegPhos; Robert H Newman (2013); KEGG
17	CSK_HUMAN	FYN_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
18	SRC_HUMAN	IGF1R_HUMAN	kinase -> substrate	RegPhos
19	SRC_HUMAN	KPCI_HUMAN	kinase -> substrate	RegPhos
20	SRC_HUMAN	RAF1_HUMAN	kinase -> substrate	HPRD; RegPhos
21	SRC_HUMAN	GTF2I_HUMAN	kinase -> substrate	RegPhos
22	SRC_HUMAN	STAT3_HUMAN	kinase -> substrate	HPRD; RegPhos
23	CSK_HUMAN	LCK_HUMAN	kinase -> substrate	HPRD; RegPhos
24	SRC_HUMAN	FAK1_HUMAN	kinase -> substrate	RegPhos; NetPath
25	SRC_HUMAN	ABL1_HUMAN	kinase -> substrate	RegPhos
26	SRC_HUMAN	IKKA_HUMAN	kinase -> substrate	NetPath
27	CSK_HUMAN	ETS1_HUMAN	kinase -> substrate	Robert H Newman (2013)
28	SRC_HUMAN	IKKB_HUMAN	kinase -> substrate	NetPath
29	SRC_HUMAN	EGFR_HUMAN	kinase -> substrate	RegPhos
30	SRC_HUMAN	STA5B_HUMAN	kinase -> substrate	HPRD; RegPhos
31	SRC_HUMAN	SHC1_HUMAN	kinase -> substrate	RegPhos
32	SRC_HUMAN	DDR2_HUMAN	kinase -> substrate	RegPhos
33	CSK_HUMAN	ANDR_HUMAN	kinase -> substrate	RegPhos
34	SRC_HUMAN	CTNB1_HUMAN	kinase -> substrate	RegPhos
35	CSK_HUMAN	PTPRC_HUMAN	kinase -> substrate	Robert H Newman (2013)
36	CSK_HUMAN	MK15_HUMAN	kinase -> substrate	RegPhos
37	CSK_HUMAN	CTNB1_HUMAN	kinase -> substrate	RegPhos
38	SRC_HUMAN	KIT_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
39	HNRPK_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
40	FGR_HUMAN	CSK21_HUMAN	kinase -> substrate	Robert H Newman (2013)
41	KPCA_HUMAN	PTN7_HUMAN	kinase -> substrate	HPRD
42	ESR1_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
43	PDPK1_HUMAN	PKN1_HUMAN	kinase -> substrate	RegPhos
44	YES_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
45	RHG35_HUMAN	GCR_HUMAN	TF -> target gene	TRANSFAC
46	AKT1_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
47	LYN_HUMAN	CSK21_HUMAN	kinase -> substrate	Robert H Newman (2013)
48	FYN_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
49	KPCA_HUMAN	ATF1_HUMAN	kinase -> substrate	HPRD
50	IGF1R_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
51	KPCI_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
52	KPCA_HUMAN	GLI1_HUMAN	kinase -> substrate	KEGG
53	AKT1_HUMAN	FOXO4_HUMAN	kinase -> substrate	RegPhos
54	PDPK1_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
55	AKT1_HUMAN	M3K11_HUMAN	kinase -> substrate	HPRD; RegPhos
56	RAF1_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
57	KPCA_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
58	FYN_HUMAN	CDK5_HUMAN	kinase -> substrate	HPRD; RegPhos
59	KPCA_HUMAN	MYOD1_HUMAN	kinase -> substrate	HPRD
60	GTF2I_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
61	FYN_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
62	KPCA_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
63	AKT1_HUMAN	SOX9_HUMAN	kinase -> substrate	Robert H Newman (2013)
64	AKT1_HUMAN	CREB1_HUMAN	kinase -> substrate	HPRD; RegPhos
65	LCK_HUMAN	KPCD_HUMAN	kinase -> substrate	RegPhos
66	LYN_HUMAN	CDK1_HUMAN	kinase -> substrate	HPRD; RegPhos
67	STAT3_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
68	PDPK1_HUMAN	KPCD_HUMAN	kinase -> substrate	HPRD; RegPhos
69	KPCA_HUMAN	CREM_HUMAN	kinase -> substrate	HPRD
70	FAK1_HUMAN	MITF_HUMAN	kinase -> substrate	Robert H Newman (2013)
71	KPCA_HUMAN	STK11_HUMAN	kinase -> substrate	HPRD
72	STAT3_HUMAN	IRF1_HUMAN	TF -> target gene	TRANSFAC
73	ABL1_HUMAN	CDK5_HUMAN	kinase -> substrate	HPRD; RegPhos
74	IKKA_HUMAN	NFKB1_HUMAN	kinase -> substrate; other	HPRD; NetPath; KEGG
75	FGR_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
76	AKT1_HUMAN	KPCD_HUMAN	kinase -> substrate	Robert H Newman (2013)
77	STAT3_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
78	AKT1_HUMAN	TEAD1_HUMAN	kinase -> substrate	Robert H Newman (2013)
79	ETS1_HUMAN	AP2A_HUMAN	TF -> target gene	TRANSFAC
80	IKKA_HUMAN	IRF7_HUMAN	kinase -> substrate	KEGG
81	KPCA_HUMAN	EP300_HUMAN	kinase -> substrate	Robert H Newman (2013)
82	AKT1_HUMAN	FOXO1_HUMAN	kinase -> substrate	RegPhos; NetPath
83	LCK_HUMAN	VDR_HUMAN	kinase -> substrate	Robert H Newman (2013)
84	KPCI_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
85	KPCA_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
86	AKT1_HUMAN	GSK3A_HUMAN	kinase -> substrate	NetPath
87	KPCA_HUMAN	NFKB1_HUMAN	kinase -> substrate	HPRD
88	PDPK1_HUMAN	ZAP70_HUMAN	kinase -> substrate	Robert H Newman (2013)
89	LCK_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
90	KPCA_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
91	ABL1_HUMAN	JUN_HUMAN	kinase -> substrate	HPRD; RegPhos
92	YES_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
93	IKKA_HUMAN	TF65_HUMAN	kinase -> substrate	HPRD; NetPath
94	FGR_HUMAN	ZAP70_HUMAN	kinase -> substrate	Robert H Newman (2013)
95	IKKB_HUMAN	NFKB1_HUMAN	kinase -> substrate	HPRD; NetPath; Robert H Newman (2013)
96	KPCA_HUMAN	AHR_HUMAN	kinase -> substrate	Robert H Newman (2013)
97	YES_HUMAN	TF65_HUMAN	kinase -> substrate	Robert H Newman (2013)
98	LYN_HUMAN	MK03_HUMAN	kinase -> substrate	NetPath
99	AKT1_HUMAN	GSK3B_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
100	KPCA_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
101	AKT1_HUMAN	NR4A1_HUMAN	kinase -> substrate	HPRD; RegPhos
102	AKT1_HUMAN	GATA2_HUMAN	kinase -> substrate	HPRD
103	EGFR_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos
104	FGR_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
105	KPCA_HUMAN	ATF4_HUMAN	kinase -> substrate	KEGG
106	LYN_HUMAN	KPCD_HUMAN	kinase -> substrate	RegPhos
107	AKT1_HUMAN	THA_HUMAN	kinase -> substrate	Robert H Newman (2013)
108	ESR1_HUMAN	PRGR_HUMAN	TF -> target gene	TRANSFAC
109	SHC1_HUMAN	ZAP70_HUMAN	kinase -> substrate	HPRD
110	PDPK1_HUMAN	MP2K1_HUMAN	kinase -> substrate	RegPhos
111	FYN_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
112	KPCA_HUMAN	GSK3A_HUMAN	kinase -> substrate	HPRD
113	LCK_HUMAN	ZAP70_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)
114	ETS1_HUMAN	NFKB1_HUMAN	TF -> target gene	TRANSFAC
115	DDR2_HUMAN	KPCD_HUMAN	kinase -> substrate	Robert H Newman (2013)
116	KPCA_HUMAN	FOS_HUMAN	kinase -> substrate	HPRD
117	AKT1_HUMAN	GATA1_HUMAN	kinase -> substrate	HPRD; RegPhos
118	AKT1_HUMAN	MTOR_HUMAN	kinase -> substrate	RegPhos
119	DDR2_HUMAN	RET_HUMAN	kinase -> substrate	Robert H Newman (2013)
120	LCK_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos
121	PDPK1_HUMAN	KS6A1_HUMAN	kinase -> substrate	HPRD; RegPhos
122	PDPK1_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
123	PTPRC_HUMAN	JAK1_HUMAN	phosphatase -> substrate	HPRD
124	KPCA_HUMAN	KLF1_HUMAN	kinase -> substrate	HPRD
125	MK15_HUMAN	RET_HUMAN	kinase -> substrate	Robert H Newman (2013)
126	KPCA_HUMAN	GSK3B_HUMAN	kinase -> substrate	KEGG; HPRD
127	IKKB_HUMAN	TF65_HUMAN	kinase -> substrate	NetPath; Robert H Newman (2013)
128	AKT1_HUMAN	STAT6_HUMAN	kinase -> substrate	Robert H Newman (2013)
129	RAF1_HUMAN	MP2K1_HUMAN	kinase -> substrate; other	RegPhos; Robert H Newman (2013); KEGG
130	FGR_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
131	AKT1_HUMAN	EP300_HUMAN	kinase -> substrate	HPRD; RegPhos
132	FGR_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
133	KPCA_HUMAN	TF65_HUMAN	kinase -> substrate	HPRD
134	FAK1_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
135	ABL1_HUMAN	P73_HUMAN	kinase -> substrate	HPRD; RegPhos
136	FGR_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
137	KIT_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
138	MYC_HUMAN	CDK4_HUMAN	TF -> target gene	TRANSFAC
139	CSK21_HUMAN	HIF1A_HUMAN	kinase -> substrate	HPRD
140	PTN7_HUMAN	MK14_HUMAN	phosphatase -> substrate	KEGG
141	PKN1_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
142	CSK21_HUMAN	EGR1_HUMAN	kinase -> substrate	HPRD
143	FOXO4_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
144	MK07_HUMAN	MEF2A_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
145	M3K11_HUMAN	MP2K7_HUMAN	kinase -> substrate	KEGG
146	CSK21_HUMAN	MEF2A_HUMAN	kinase -> substrate	Robert H Newman (2013)
147	CDK5_HUMAN	MEF2A_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
148	CSK21_HUMAN	MYF6_HUMAN	kinase -> substrate	Robert H Newman (2013)
149	SRF_HUMAN	EGR2_HUMAN	TF -> target gene	TRANSFAC
150	CREB1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
151	CSK21_HUMAN	MAZ_HUMAN	kinase -> substrate	HPRD
152	KPCD_HUMAN	TWST1_HUMAN	kinase -> substrate	Robert H Newman (2013)
153	CDK1_HUMAN	HMGA2_HUMAN	kinase -> substrate	RegPhos
154	CSK21_HUMAN	HMGA1_HUMAN	kinase -> substrate	HPRD
155	STK11_HUMAN	SIK3_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
156	CDK5_HUMAN	MEF2D_HUMAN	kinase -> substrate	RegPhos
157	KPCD_HUMAN	NF2L2_HUMAN	kinase -> substrate	HPRD
158	MK07_HUMAN	MEF2D_HUMAN	kinase -> substrate	HPRD
159	RXRA_HUMAN	RARB_HUMAN	TF -> target gene	TRANSFAC
160	CSK21_HUMAN	APEX1_HUMAN	kinase -> substrate	HPRD
161	CDK1_HUMAN	CUX1_HUMAN	kinase -> substrate	RegPhos
162	FOXO1_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
163	CDK5_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
164	GSK3A_HUMAN	TF7L2_HUMAN	kinase -> substrate	Robert H Newman (2013)
165	CREB1_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
166	ZAP70_HUMAN	MK14_HUMAN	kinase -> substrate	KEGG; RegPhos; Robert H Newman (2013)
167	MK03_HUMAN	MAZ_HUMAN	kinase -> substrate	Robert H Newman (2013)
168	GSK3B_HUMAN	CDX2_HUMAN	kinase -> substrate	RegPhos
169	SRF_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
170	CSK21_HUMAN	NKX25_HUMAN	kinase -> substrate	HPRD
171	NR4A1_HUMAN	E2F1_HUMAN	TF -> target gene	TRANSFAC
172	AP2A_HUMAN	REL_HUMAN	TF -> target gene	TRANSFAC
173	STK11_HUMAN	TFE3_HUMAN	kinase -> substrate	Robert H Newman (2013)
174	MP2K1_HUMAN	KS6A4_HUMAN	kinase -> substrate	RegPhos
175	CDK1_HUMAN	E2F1_HUMAN	kinase -> substrate	RegPhos
176	STK11_HUMAN	SIK1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
177	CDK1_HUMAN	CDK7_HUMAN	kinase -> substrate	RegPhos
178	MTOR_HUMAN	HIF1A_HUMAN	kinase -> substrate	KEGG
179	RET_HUMAN	MK14_HUMAN	kinase -> substrate	HPRD; RegPhos
180	CSK21_HUMAN	TF7L2_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
181	KS6A1_HUMAN	ESR2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
182	ATF1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
183	CSK21_HUMAN	MYF5_HUMAN	kinase -> substrate	HPRD
184	JAK1_HUMAN	STAT4_HUMAN	kinase -> substrate	RegPhos
185	STK11_HUMAN	SIK2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
186	PRGR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
187	GCR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
188	CDK1_HUMAN	HMGA1_HUMAN	kinase -> substrate	RegPhos
189	CDK4_HUMAN	PKNX1_HUMAN	kinase -> substrate	Robert H Newman (2013)
190	MEF2A_HUMAN	MYOG_HUMAN	TF -> target gene	TRANSFAC
191	MP2K7_HUMAN	M3K7_HUMAN	kinase -> substrate	KEGG
192	SIK3_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
193	CDK4_HUMAN	FOXN2_HUMAN	kinase -> substrate	Robert H Newman (2013)
194	PRDM1_HUMAN	PAX5_HUMAN	TF -> target gene	TRANSFAC
195	KS6A4_HUMAN	PO6F1_HUMAN	kinase -> substrate	Robert H Newman (2013)
196	SIK1_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
197	CDK7_HUMAN	PO2F1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
198	SIK2_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
199	M3K7_HUMAN	NLK_HUMAN	kinase -> substrate	KEGG
200	M3K7_HUMAN	FUBP1_HUMAN	kinase -> substrate	Robert H Newman (2013)
201	NLK_HUMAN	LEF1_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)

⁺Protein attribute:

protein with cancer-related variations (CanProVar)

up expressed protein;

down expressed protein(dbDEPC)

protein with hyperphosphorylation site (PhosphoSitePlus)

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network