Phosphorylation

You are querying signaling transduction network mediated by 5HT7R_HUMAN in Hepatocellular Carcinoma.

Signaling Transduction Network:

NO.	Source	Target	Relation Attribute	Resource
1	TPH1_HUMAN	5HT7R_HUMAN	ligand -> receptor	HPMR
2	5HT7R_HUMAN	GNAS2_HUMAN	GPCR -> Gprotein	gpDB
3	5HT7R_HUMAN	GNAS1_HUMAN	GPCR -> Gprotein	gpDB
4	GNAS2_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
5	GNAS2_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
6	GNAS1_HUMAN	CSK_HUMAN	Gprotein -> effector	gpDB
7	GNAS1_HUMAN	SRC_HUMAN	Gprotein -> effector	gpDB
8	CSK_HUMAN	KPCA_HUMAN	kinase -> substrate	Robert H Newman (2013)
9	SRC_HUMAN	HNRPK_HUMAN	kinase -> substrate	RegPhos
10	CSK_HUMAN	LYN_HUMAN	kinase -> substrate; other	HPRD; RegPhos; Robert H Newman (2013); KEGG
11	CSK_HUMAN	FGR_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
12	CSK_HUMAN	FYN_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
13	SRC_HUMAN	ABL1_HUMAN	kinase -> substrate	RegPhos
14	CSK_HUMAN	LCK_HUMAN	kinase -> substrate	HPRD; RegPhos
15	CSK_HUMAN	PTPRC_HUMAN	kinase -> substrate	Robert H Newman (2013)
16	SRC_HUMAN	PDPK1_HUMAN	kinase -> substrate	RegPhos
17	SRC_HUMAN	AKT1_HUMAN	kinase -> substrate	RegPhos
18	CSK_HUMAN	YES_HUMAN	kinase -> substrate	Robert H Newman (2013)
19	SRC_HUMAN	STAT3_HUMAN	kinase -> substrate	HPRD; RegPhos
20	SRC_HUMAN	RHG35_HUMAN	kinase -> substrate	KEGG; HPRD; RegPhos
21	CSK_HUMAN	ETS1_HUMAN	kinase -> substrate	Robert H Newman (2013)
22	SRC_HUMAN	IKKB_HUMAN	kinase -> substrate	NetPath
23	SRC_HUMAN	SHC1_HUMAN	kinase -> substrate	RegPhos
24	SRC_HUMAN	RAF1_HUMAN	kinase -> substrate	HPRD; RegPhos
25	SRC_HUMAN	FAK1_HUMAN	kinase -> substrate	RegPhos; NetPath
26	SRC_HUMAN	IGF1R_HUMAN	kinase -> substrate	RegPhos
27	SRC_HUMAN	GTF2I_HUMAN	kinase -> substrate	RegPhos
28	SRC_HUMAN	IKKA_HUMAN	kinase -> substrate	NetPath
29	CSK_HUMAN	ANDR_HUMAN	kinase -> substrate	RegPhos
30	SRC_HUMAN	ESR1_HUMAN	kinase -> substrate	HPRD; RegPhos
31	SRC_HUMAN	DDR2_HUMAN	kinase -> substrate	RegPhos
32	CSK_HUMAN	CTNB1_HUMAN	kinase -> substrate	RegPhos
33	SRC_HUMAN	STA5B_HUMAN	kinase -> substrate	HPRD; RegPhos
34	SRC_HUMAN	KPCI_HUMAN	kinase -> substrate	RegPhos
35	SRC_HUMAN	EGFR_HUMAN	kinase -> substrate	RegPhos
36	SRC_HUMAN	CTNB1_HUMAN	kinase -> substrate	RegPhos
37	SRC_HUMAN	KIT_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
38	CSK_HUMAN	MK15_HUMAN	kinase -> substrate	RegPhos
39	KPCA_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
40	LYN_HUMAN	CDK1_HUMAN	kinase -> substrate	HPRD; RegPhos
41	FGR_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
42	KPCA_HUMAN	FOS_HUMAN	kinase -> substrate	HPRD
43	FYN_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
44	ABL1_HUMAN	JUN_HUMAN	kinase -> substrate	HPRD; RegPhos
45	KPCA_HUMAN	NFKB1_HUMAN	kinase -> substrate	HPRD
46	KPCA_HUMAN	ATF4_HUMAN	kinase -> substrate	KEGG
47	LCK_HUMAN	KPCD_HUMAN	kinase -> substrate	RegPhos
48	PTPRC_HUMAN	JAK1_HUMAN	phosphatase -> substrate	HPRD
49	PDPK1_HUMAN	PKN1_HUMAN	kinase -> substrate	RegPhos
50	FGR_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
51	AKT1_HUMAN	M3K11_HUMAN	kinase -> substrate	HPRD; RegPhos
52	YES_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
53	FGR_HUMAN	CSK21_HUMAN	kinase -> substrate	Robert H Newman (2013)
54	STAT3_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
55	LYN_HUMAN	CSK21_HUMAN	kinase -> substrate	Robert H Newman (2013)
56	KPCA_HUMAN	STK11_HUMAN	kinase -> substrate	HPRD
57	ABL1_HUMAN	P73_HUMAN	kinase -> substrate	HPRD; RegPhos
58	LYN_HUMAN	KPCD_HUMAN	kinase -> substrate	RegPhos
59	KPCA_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
60	FYN_HUMAN	CDK5_HUMAN	kinase -> substrate	HPRD; RegPhos
61	KPCA_HUMAN	ATF1_HUMAN	kinase -> substrate	HPRD
62	KPCA_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
63	PDPK1_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
64	RHG35_HUMAN	GCR_HUMAN	TF -> target gene	TRANSFAC
65	ETS1_HUMAN	AP2A_HUMAN	TF -> target gene	TRANSFAC
66	IKKB_HUMAN	TF65_HUMAN	kinase -> substrate	NetPath; Robert H Newman (2013)
67	SHC1_HUMAN	ZAP70_HUMAN	kinase -> substrate	HPRD
68	PDPK1_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
69	AKT1_HUMAN	THA_HUMAN	kinase -> substrate	Robert H Newman (2013)
70	PDPK1_HUMAN	KPCD_HUMAN	kinase -> substrate	HPRD; RegPhos
71	RAF1_HUMAN	MP2K1_HUMAN	kinase -> substrate; other	RegPhos; Robert H Newman (2013); KEGG
72	KPCA_HUMAN	AHR_HUMAN	kinase -> substrate	Robert H Newman (2013)
73	FAK1_HUMAN	MITF_HUMAN	kinase -> substrate	Robert H Newman (2013)
74	LCK_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
75	FGR_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
76	AKT1_HUMAN	NR4A1_HUMAN	kinase -> substrate	HPRD; RegPhos
77	KPCA_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
78	IGF1R_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
79	YES_HUMAN	TF65_HUMAN	kinase -> substrate	Robert H Newman (2013)
80	IKKA_HUMAN	NFKB1_HUMAN	kinase -> substrate; other	HPRD; NetPath; KEGG
81	AKT1_HUMAN	TEAD1_HUMAN	kinase -> substrate	Robert H Newman (2013)
82	FAK1_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
83	FGR_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
84	FYN_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
85	AKT1_HUMAN	FOXO4_HUMAN	kinase -> substrate	RegPhos
86	AKT1_HUMAN	SOX9_HUMAN	kinase -> substrate	Robert H Newman (2013)
87	RAF1_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
88	KPCA_HUMAN	PTN7_HUMAN	kinase -> substrate	HPRD
89	AKT1_HUMAN	FOXO1_HUMAN	kinase -> substrate	RegPhos; NetPath
90	ESR1_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
91	FGR_HUMAN	ZAP70_HUMAN	kinase -> substrate	Robert H Newman (2013)
92	ETS1_HUMAN	NFKB1_HUMAN	TF -> target gene	TRANSFAC
93	STAT3_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
94	IKKA_HUMAN	IRF7_HUMAN	kinase -> substrate	KEGG
95	ESR1_HUMAN	PRGR_HUMAN	TF -> target gene	TRANSFAC
96	YES_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
97	DDR2_HUMAN	KPCD_HUMAN	kinase -> substrate	Robert H Newman (2013)
98	LCK_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos
99	ABL1_HUMAN	CDK5_HUMAN	kinase -> substrate	HPRD; RegPhos
100	FYN_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
101	AKT1_HUMAN	MTOR_HUMAN	kinase -> substrate	RegPhos
102	KPCA_HUMAN	MYOD1_HUMAN	kinase -> substrate	HPRD
103	LYN_HUMAN	MK03_HUMAN	kinase -> substrate	NetPath
104	AKT1_HUMAN	GATA1_HUMAN	kinase -> substrate	HPRD; RegPhos
105	STAT3_HUMAN	IRF1_HUMAN	TF -> target gene	TRANSFAC
106	KPCA_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
107	AKT1_HUMAN	KPCD_HUMAN	kinase -> substrate	Robert H Newman (2013)
108	AKT1_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
109	DDR2_HUMAN	RET_HUMAN	kinase -> substrate	Robert H Newman (2013)
110	KPCA_HUMAN	GSK3B_HUMAN	kinase -> substrate	KEGG; HPRD
111	AKT1_HUMAN	EP300_HUMAN	kinase -> substrate	HPRD; RegPhos
112	KPCA_HUMAN	KLF1_HUMAN	kinase -> substrate	HPRD
113	KPCI_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
114	EGFR_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos
115	AKT1_HUMAN	STAT6_HUMAN	kinase -> substrate	Robert H Newman (2013)
116	AKT1_HUMAN	CREB1_HUMAN	kinase -> substrate	HPRD; RegPhos
117	KPCI_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
118	IKKA_HUMAN	TF65_HUMAN	kinase -> substrate	HPRD; NetPath
119	IKKB_HUMAN	NFKB1_HUMAN	kinase -> substrate	HPRD; NetPath; Robert H Newman (2013)
120	KPCA_HUMAN	TF65_HUMAN	kinase -> substrate	HPRD
121	PDPK1_HUMAN	ZAP70_HUMAN	kinase -> substrate	Robert H Newman (2013)
122	FGR_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
123	LCK_HUMAN	VDR_HUMAN	kinase -> substrate	Robert H Newman (2013)
124	HNRPK_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
125	GTF2I_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
126	KIT_HUMAN	STAT1_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
127	AKT1_HUMAN	GSK3A_HUMAN	kinase -> substrate	NetPath
128	KPCA_HUMAN	EP300_HUMAN	kinase -> substrate	Robert H Newman (2013)
129	AKT1_HUMAN	GSK3B_HUMAN	kinase -> substrate	HPRD; RegPhos; NetPath
130	KPCA_HUMAN	CREM_HUMAN	kinase -> substrate	HPRD
131	MK15_HUMAN	RET_HUMAN	kinase -> substrate	Robert H Newman (2013)
132	LCK_HUMAN	ZAP70_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)
133	KPCA_HUMAN	GLI1_HUMAN	kinase -> substrate	KEGG
134	PDPK1_HUMAN	MP2K1_HUMAN	kinase -> substrate	RegPhos
135	AKT1_HUMAN	GATA2_HUMAN	kinase -> substrate	HPRD
136	PDPK1_HUMAN	KS6A1_HUMAN	kinase -> substrate	HPRD; RegPhos
137	KPCA_HUMAN	GSK3A_HUMAN	kinase -> substrate	HPRD
138	CDK1_HUMAN	HMGA1_HUMAN	kinase -> substrate	RegPhos
139	SRF_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
140	MK07_HUMAN	MEF2D_HUMAN	kinase -> substrate	HPRD
141	CDK1_HUMAN	HMGA2_HUMAN	kinase -> substrate	RegPhos
142	KPCD_HUMAN	NF2L2_HUMAN	kinase -> substrate	HPRD
143	JAK1_HUMAN	STAT4_HUMAN	kinase -> substrate	RegPhos
144	PKN1_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
145	M3K11_HUMAN	MP2K7_HUMAN	kinase -> substrate	KEGG
146	CSK21_HUMAN	MAZ_HUMAN	kinase -> substrate	HPRD
147	CSK21_HUMAN	MYF5_HUMAN	kinase -> substrate	HPRD
148	STK11_HUMAN	SIK2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
149	STK11_HUMAN	SIK3_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
150	RXRA_HUMAN	RARB_HUMAN	TF -> target gene	TRANSFAC
151	CDK5_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
152	CSK21_HUMAN	APEX1_HUMAN	kinase -> substrate	HPRD
153	SRF_HUMAN	EGR2_HUMAN	TF -> target gene	TRANSFAC
154	GCR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
155	ZAP70_HUMAN	MK14_HUMAN	kinase -> substrate	KEGG; RegPhos; Robert H Newman (2013)
156	MK07_HUMAN	MEF2A_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
157	MP2K1_HUMAN	KS6A4_HUMAN	kinase -> substrate	RegPhos
158	CSK21_HUMAN	MEF2A_HUMAN	kinase -> substrate	Robert H Newman (2013)
159	CSK21_HUMAN	MYF6_HUMAN	kinase -> substrate	Robert H Newman (2013)
160	FOXO4_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
161	PTN7_HUMAN	MK14_HUMAN	phosphatase -> substrate	KEGG
162	FOXO1_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
163	CSK21_HUMAN	HMGA1_HUMAN	kinase -> substrate	HPRD
164	CDK1_HUMAN	E2F1_HUMAN	kinase -> substrate	RegPhos
165	CSK21_HUMAN	EGR1_HUMAN	kinase -> substrate	HPRD
166	MYC_HUMAN	CDK4_HUMAN	TF -> target gene	TRANSFAC
167	KPCD_HUMAN	TWST1_HUMAN	kinase -> substrate	Robert H Newman (2013)
168	CDK5_HUMAN	MEF2A_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
169	CSK21_HUMAN	HIF1A_HUMAN	kinase -> substrate	HPRD
170	CDK1_HUMAN	CDK7_HUMAN	kinase -> substrate	RegPhos
171	MTOR_HUMAN	HIF1A_HUMAN	kinase -> substrate	KEGG
172	MK03_HUMAN	MAZ_HUMAN	kinase -> substrate	Robert H Newman (2013)
173	RET_HUMAN	MK14_HUMAN	kinase -> substrate	HPRD; RegPhos
174	GSK3B_HUMAN	CDX2_HUMAN	kinase -> substrate	RegPhos
175	CDK5_HUMAN	MEF2D_HUMAN	kinase -> substrate	RegPhos
176	AP2A_HUMAN	REL_HUMAN	TF -> target gene	TRANSFAC
177	NR4A1_HUMAN	E2F1_HUMAN	TF -> target gene	TRANSFAC
178	CSK21_HUMAN	NKX25_HUMAN	kinase -> substrate	HPRD
179	CSK21_HUMAN	TF7L2_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
180	STK11_HUMAN	TFE3_HUMAN	kinase -> substrate	Robert H Newman (2013)
181	CREB1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
182	CDK1_HUMAN	CUX1_HUMAN	kinase -> substrate	RegPhos
183	GSK3A_HUMAN	TF7L2_HUMAN	kinase -> substrate	Robert H Newman (2013)
184	STK11_HUMAN	SIK1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
185	ATF1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
186	PRGR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
187	CREB1_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
188	KS6A1_HUMAN	ESR2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
189	PRDM1_HUMAN	PAX5_HUMAN	TF -> target gene	TRANSFAC
190	MP2K7_HUMAN	M3K7_HUMAN	kinase -> substrate	KEGG
191	SIK2_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
192	SIK3_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
193	KS6A4_HUMAN	PO6F1_HUMAN	kinase -> substrate	Robert H Newman (2013)
194	MEF2A_HUMAN	MYOG_HUMAN	TF -> target gene	TRANSFAC
195	CDK4_HUMAN	PKNX1_HUMAN	kinase -> substrate	Robert H Newman (2013)
196	CDK7_HUMAN	PO2F1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
197	CDK4_HUMAN	FOXN2_HUMAN	kinase -> substrate	Robert H Newman (2013)
198	SIK1_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
199	M3K7_HUMAN	FUBP1_HUMAN	kinase -> substrate	Robert H Newman (2013)
200	M3K7_HUMAN	NLK_HUMAN	kinase -> substrate	KEGG
201	NLK_HUMAN	LEF1_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)

⁺Protein attribute:

protein with cancer-related variations (CanProVar)

up expressed protein;

down expressed protein(dbDEPC)

protein with hyperphosphorylation site (PhosphoSitePlus)

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network