Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KPCD_HUMAN
Description:protein kinase C, delta [Source:HGNC Symbol;Acc:9399]
Location:chr3 p21.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y313EPVGIyQGFEKLCKHPRD; RegPhos; SysPTM
Y646KARLSySDKNLHPRD
Y64FDAHIyEGRVIPhosphoSitePlus; phosphoELM; RegPhos
T507ESRAStFCGTPHPRD; phosphoELM; RegPhos
Y187LNKQGyKCRQCphosphoELM; RegPhos
T511STFCGtPDYIAHPRD
T218ANSRDtIFQKEProk-RING_1PhosphoSitePlus
Y514CGTPDyIAPEILCKHPRD; RegPhos
S647ARLSYsDKNLIHPRD; SysPTM
S631SPRDYsNFDQEPkinase_CPhosphoSitePlus
S306RSDSAsSEPVGPhosphoSitePlus; HPRD
S341KIWEGsSKCNIPhosphoSitePlus
S503NIFGEsRASTFHPRD; SysPTM
S654KNLIDsMDQSAPkinase_CPhosphoSitePlus
Y187LNKQGyKCRQCLYNHPRD; RegPhos
Y187LNKQGyKCRQCC1_1; DUF4206; Prok-RING_PhosphoSitePlus
Y630KSPRDySNFDQPkinase_CPhosphoSitePlus
T141EAKFPtMNRRGDUF4206PhosphoSitePlus
S307SDSASsEPVGIPhosphoSitePlus; HPRD
S503NIFGEsRASTFPkinasePhosphoSitePlus; SysPTM
T511STFCGtPDYIAPkinasePhosphoSitePlus
Y453YRATFyAAEIMPkinasePhosphoSitePlus
S506GESRAsTFCGTHPRD
Y52KKPTMyPEWKSLYNHPRD; RegPhos
S506GESRAsTFCGTPkinasePhosphoSitePlus
Y567VDTPHyPRWITLYNHPRD; RegPhos
S130VDCKQsMRSEDHPRD; SysPTM
T609KTINWtLLEKRPhosphoSitePlus
S331DMQDNsGTYGKPhosphoSitePlus; HPRD
S658DSMDQsAFAGFPkinase_CPhosphoSitePlus
S654KNLIDsMDQSAHPRD
Y155QAKIHyIKNHEphosphoELM; RegPhos
T507ESRAStFCGTPPDK1RegPhos
T507ESRAStFCGTPPDPK1HPRD
S664AFAGFsFVNPKPRKCZHPRD; SysPTM
Y155QAKIHyIKNHELYNHPRD; RegPhos
S342IWEGSsKCNINPhosphoSitePlus
S664AFAGFsFVNPKPkinase_CPhosphoSitePlus; SysPTM
Y155QAKIHyIKNHEDUF4206PhosphoSitePlus
T594KRLGVtGNIKIPkinasePhosphoSitePlus; SysPTM
Y374KGRGEyFAIKAPkinasePhosphoSitePlus
S645EKARLsYSDKNHPRD; phosphoELM; RegPhos; SysPTM
Y334DNSGTyGKIWELCKHPRD; RegPhos; SysPTM
Y646KARLSySDKNLPkinase_CPhosphoSitePlus
S304SRRSDsASSEPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S645EKARLsYSDKNPkinase_CPhosphoSitePlus; SysPTM
T507ESRAStFCGTPPDK-1phosphoELM
Y313EPVGIyQGFEKPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y52KKPTMyPEWKSPhosphoSitePlus; phosphoELM; RegPhos
S664AFAGFsFVNPKHPRD; phosphoELM; RegPhos; SysPTM
T451ELYRAtFYAAEPkinasePhosphoSitePlus
Y64FDAHIyEGRVILYNHPRD; RegPhos
T295ALNQVtQRASRPhosphoSitePlus; HPRD
T43TERGKtLVQKKPhosphoSitePlus; HPRD; SysPTM
S37MKEALsTERGKHPRD
Y448GRFELyRATFYPkinasePhosphoSitePlus
Y334DNSGTyGKIWEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y471SKGIIyRDLKLPkinasePhosphoSitePlus
T605HPFFKtINWTLPhosphoSitePlus
T50VQKKPtMYPEWPhosphoSitePlus; HPRD; SysPTM
S658DSMDQsAFAGFHPRD
T507ESRAStFCGTPPkinasePhosphoSitePlus
S299VTQRAsRRSDSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S645EKARLsYSDKNPKCdRegPhos; SysPTM
T333QDNSGtYGKIWPhosphoSitePlus; HPRD
Y567VDTPHyPRWITPkinasePhosphoSitePlus
S302RASRRsDSASSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S130VDCKQsMRSEDDUF4206PhosphoSitePlus; SysPTM
S645EKARLsYSDKNPRKCDHPRD; SysPTM
Y374KGRGEyFAIKAHPRD
S664AFAGFsFVNPKPKCzRegPhos; SysPTM
S647ARLSYsDKNLIPkinase_CPhosphoSitePlus; SysPTM
Y120LMSVQyFLEDVHPRD
Y525LQGLKyTFSVDPkinasePhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S664QSAFAGFsFVNPKFEPPP2CAHPRD
T507FGESRAStFCGTPDYPPM1AHPRD
T507FGESRAStFCGTPDYPPP2CAHPRD
S664QSAFAGFsFVNPKFEPPP1CAHPRD
S645LNEKARLsYSDKNLIPPP1CAHPRD
S664QSAFAGFsFVNPKFEPPM1AHPRD
S645LNEKARLsYSDKNLIPPM1AHPRD
S645LNEKARLsYSDKNLIPPP2CAHPRD
T507FGESRAStFCGTPDYPPP1CAHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000331602E289*BIOMARTBreast Cancer21930507, 21930502
ENSP00000378217E289*BIOMARTBreast Cancer21930507, 21930502
ENSP00000378217R6LDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000331602R6LDing2008Lung Cancer18948947

Differential expressed protein
KPCD_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y313SSEPVGIyQGFEKKTcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KPCD_HUMANIF2A_HUMANkinase -> substrateHPRD
KPCD_HUMANMUC1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
LCK_HUMANKPCD_HUMANkinase -> substrateRegPhos
KPCD_HUMANKKCC1_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANHNRPK_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCD_HUMANARI3A_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANPEBP1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCD_HUMANEP300_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
EPHB3_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANLIMK2_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANGRM5_HUMANkinase -> substrateHPRD
LYN_HUMANKPCD_HUMANkinase -> substrateRegPhos
KPCD_HUMANCYH1_HUMANkinase -> substrateHPRD
M3K7_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANCBP_HUMANkinase -> substrateHPRD
KPCD_HUMANEF1A1_HUMANkinase -> substrateHPRD
KS6A5_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANNCF4_HUMANkinase -> substrateHPRD
KPCD_HUMANERF_HUMANkinase -> substrateRobert H Newman (2013)
TYRO3_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANLRRF1_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANIRK1_HUMANkinase -> substrateHPRD
CDKL5_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
TRIB3_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANIL6RB_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCD_HUMANADDA_HUMANkinase -> substrateHPRD
KPCD_HUMANUBE2B_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANADRB2_HUMANkinase -> substrateHPRD
NEK2_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANKPCD1_HUMANkinase -> substrateRobert H Newman (2013)
KCC2D_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANPLCB1_HUMANkinase -> substrateHPRD
HIPK1_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANPTN22_HUMANkinase -> substrateHPRD
KPCD_HUMANK2C8_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
RIPK2_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANITB7_HUMANkinase -> substrateHPRD
STK25_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANFSCN1_HUMANkinase -> substrateHPRD
KPCD_HUMANNCF1_HUMANkinase -> substrateNetPath
NTRK3_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANTAGL_HUMANkinase -> substrateHPRD
KPCD_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANADDB_HUMANkinase -> substrateHPRD
GRK6_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANPTPRA_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCD_HUMANKPCD_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCD_HUMANITB2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MP2K1_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANIRK4_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANHABP4_HUMANkinase -> substrateHPRD
KPCD_HUMANWWTR1_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANKPCD_HUMANkinase -> substrateHPRD; RegPhos
KPCD_HUMANSTAT3_HUMANkinase -> substrateHPRD; NetPath
ST38L_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANADA2A_HUMANkinase -> substrateHPRD
KPCD_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMAN1433B_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANOPRD_HUMANkinase -> substrateHPRD
KPCD_HUMANTRAF2_HUMANkinase -> substrateNetPath
E2AK2_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANT22D4_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANKS6B2_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANKPCD_HUMANkinase -> substrateHPRD
KPCD_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANSRXN1_HUMANkinase -> substrateRobert H Newman (2013)
PI3R4_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
DDR2_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMAN1433Z_HUMANkinase -> substrateHPRD
KPCD_HUMANTAU_HUMANkinase -> substrateHPRD
KPCD_HUMANTWST1_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANMEP1B_HUMANkinase -> substrateHPRD
KPCD_HUMANNPM_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANSDC4_HUMANkinase -> substrateHPRD
KPCD_HUMANCDK9_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANGSK3A_HUMANkinase -> substrateHPRD
WNK1_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANDAB2_HUMANkinase -> substrateHPRD
KCC2A_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANIRS1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KPCD_HUMANSLTM_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANRS6_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANAKT3_HUMANkinase -> substrateHPRD
BMR1A_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANITB4_HUMANkinase -> substrateNetPath
KPCD_HUMANGNAZ_HUMANkinase -> substrateHPRD
MP2K6_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
CLK3_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANPLS1_HUMANkinase -> substrateHPRD
KPCD_HUMANBKRB2_HUMANkinase -> substrateHPRD
LIMK2_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANCLAT_HUMANkinase -> substrateHPRD
KPCD_HUMANEGFR_HUMANkinase -> substrateHPRD
KPCD_HUMANSMPX_HUMANkinase -> substrateRobert H Newman (2013)
KPCD_HUMANSTAT1_HUMANkinase -> substrateHPRD
ZAGL2_HUMANKPCD_HUMANkinase -> substrateRegPhos
KPCD_HUMANKLF5_HUMANkinase -> substrateHPRD
KPCD_HUMANITA6_HUMANkinase -> substrateNetPath
KPCD_HUMANARBK1_HUMANkinase -> substrateHPRD
KPCD_HUMANNF2L2_HUMANkinase -> substrateHPRD
PP1A_HUMANKPCD_HUMANphosphatase -> substrateHPRD
PP2AA_HUMANKPCD_HUMANphosphatase -> substrateHPRD
PPM1A_HUMANKPCD_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04722Neurotrophin signaling pathway
hsa04062Chemokine signaling pathway
hsa04912GnRH signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04270Vascular smooth muscle contraction
hsa04930Type II diabetes mellitus
hsa04664Fc epsilon RI signaling pathway
hsa04530Tight junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0043407negative regulation of MAP kinase activityIMPbiological_process
GO:2000755positive regulation of sphingomyelin catabolic proIMPbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0051490negative regulation of filopodium assemblyIEAbiological_process
GO:0009612response to mechanical stimulusIEAbiological_process
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0006979response to oxidative stressIEAbiological_process
GO:0035307positive regulation of protein dephosphorylationIMPbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0005783endoplasmic reticulumIDAcellular_component
GO:0043410positive regulation of MAPK cascadeIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0034351negative regulation of glial cell apoptotic procesIMPbiological_process
GO:0090398cellular senescenceIMPbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0004715non-membrane spanning protein tyrosine kinase actiIEAmolecular_function
GO:0032613interleukin-10 productionIEAbiological_process
GO:0009749response to glucose stimulusIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0042100B cell proliferationIEAbiological_process
GO:0016363nuclear matrixIEAcellular_component
GO:0043200response to amino acid stimulusIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0006921cellular component disassembly involved in executiTASbiological_process
GO:0008022protein C-terminus bindingIPImolecular_function
GO:0035556intracellular signal transductionIEAbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0046326positive regulation of glucose importIEAbiological_process
GO:0016071mRNA metabolic processTASbiological_process
GO:0070976TIR domain bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0043406positive regulation of MAP kinase activityIEAbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0004697protein kinase C activityIEAmolecular_function
GO:0042742defense response to bacteriumIEAbiological_process
GO:0042542response to hydrogen peroxideIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:2000304positive regulation of ceramide biosynthetic proceIMPbiological_process
GO:0010469regulation of receptor activityTASbiological_process
GO:0005911cell-cell junctionIEAcellular_component
GO:0007568agingIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0090331negative regulation of platelet aggregationIEAbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0009408response to heatIEAbiological_process
GO:0010243response to organic nitrogenIEAbiological_process
GO:0018107peptidyl-threonine phosphorylationIDAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:1900163positive regulation of phospholipid scramblase actIMPbiological_process
GO:0050821protein stabilizationNASbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0032091negative regulation of protein bindingTASbiological_process
GO:0006917induction of apoptosisIEAbiological_process
GO:2000753positive regulation of glucosylceramide catabolic IMPbiological_process
GO:0032869cellular response to insulin stimulusIEAbiological_process
GO:0008047enzyme activator activityIDAmolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006915apoptotic processIDAbiological_process
GO:0032930positive regulation of superoxide anion generationIMPbiological_process
GO:0023021termination of signal transductionIMPbiological_process
GO:0042119neutrophil activationIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0005829cytosolIEAcellular_component
GO:0007049cell cycleIEAbiological_process
GO:0030168platelet activationTASbiological_process
GO:2001022positive regulation of response to DNA damage stimIMPbiological_process
GO:0050728negative regulation of inflammatory responseICbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0042149cellular response to glucose starvationIEAbiological_process
GO:0004699calcium-independent protein kinase C activityIEAmolecular_function
GO:0016064immunoglobulin mediated immune responseIEAbiological_process
GO:0043560insulin receptor substrate bindingIEAmolecular_function
GO:0030837negative regulation of actin filament polymerizatiIEAbiological_process
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0010467gene expressionTASbiological_process
GO:0050732negative regulation of peptidyl-tyrosine phosphoryIEAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0032615interleukin-12 productionIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0046627negative regulation of insulin receptor signaling IEAbiological_process
GO:0004697protein kinase C activityISSmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0060333interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0045471response to ethanolIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0015810aspartate transportIEAbiological_process
GO:0032963collagen metabolic processIEAbiological_process