Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NEK2_HUMAN
Description:NIMA-related kinase 2 [Source:HGNC Symbol;Acc:7745]
Location:chr1 q32.3
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S428RAQALsDIEKNPhosphoSitePlus
S356LLKNYsLLKERPhosphoSitePlus
S378LNLPSsVIKKKPhosphoSitePlus
S299EKSQDsSPVLSHPRD
S241IPYRYsDELNEPkinasePhosphoSitePlus
T179KTFVGtPYYMSPkinasePhosphoSitePlus
S184TPYYMsPEQMNHPRD; phosphoELM; SysPTM
S184TPYYMsPEQMNPkinasePhosphoSitePlus; SysPTM
T175TSFAKtFVGTPPkinasePhosphoSitePlus
S171LNHDTsFAKTFPkinasePhosphoSitePlus
S438NYQLKsRQILGPhosphoSitePlus
S400MRSENsESQLTPhosphoSitePlus
T170ILNHDtSFAKTPkinasePhosphoSitePlus
S365ERKFLsLASNPPhosphoSitePlus; phosphoELM
S402SENSEsQLTSKPhosphoSitePlus
S300KSQDSsPVLSEPhosphoSitePlus; HPRD; SysPTM
S304SSPVLsELKLKPhosphoSitePlus
S397ENIMRsENSESPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S406ESQLTsKSKCKPhosphoSitePlus
S296GEPEKsQDSSPPhosphoSitePlus; HPRD; SysPTM
T170ILNHDtSFAKTHPRD

Dephosphorylation site
NEK2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000355966P215ABIOMARTBreast Cancer21930507, 21930502
ENSP00000355965P215ABIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
NEK2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NEK2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NEK2_HUMANBCL3_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANETS1_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANNDC80_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
NEK2_HUMANSAFB2_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANPCM1_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANSTIP1_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANPRS6A_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANCSDC2_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANSRXN1_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANPAIRB_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANSMPX_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANKS6A2_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANMP2K7_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMAN1433F_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANUBB_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANPP1G_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
NEK2_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
NEK2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006468protein phosphorylationIEAbiological_process
GO:0005874microtubuleIEAcellular_component
GO:0051225spindle assemblyTASbiological_process
GO:0007059chromosome segregationIDAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0051301cell divisionIEAbiological_process
GO:0046602regulation of mitotic centrosome separationTASbiological_process
GO:0019903protein phosphatase bindingIPImolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005813centrosomeIDAcellular_component
GO:0043392negative regulation of DNA bindingIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0046777protein autophosphorylationIMPbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0030496midbodyIEAcellular_component
GO:0007067mitosisTASbiological_process
GO:0000070mitotic sister chromatid segregationIEAbiological_process
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000776kinetochoreIDAcellular_component
GO:0090307spindle assembly involved in mitosisIEAbiological_process
GO:0043234protein complexIMPcellular_component
GO:0007126meiosisIEAbiological_process
GO:0000794condensed nuclear chromosomeIEAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0004674protein serine/threonine kinase activityTASmolecular_function
GO:0000777condensed chromosome kinetochoreIEAcellular_component
GO:0007088regulation of mitosisTASbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0000922spindle poleIEAcellular_component
GO:0005730nucleolusIEAcellular_component
GO:0051988regulation of attachment of spindle microtubules tIMPbiological_process
GO:0001824blastocyst developmentIEAbiological_process
GO:0051299centrosome separationIDAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0005829cytosolTAScellular_component
GO:0007059chromosome segregationIEAbiological_process


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