Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ITB4_HUMAN
Description:integrin, beta 4 [Source:HGNC Symbol;Acc:6158]
Location:chr17 q25.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T1297QPYRYtVKARNfn3PhosphoSitePlus
T1721VQARTtEGFGPfn3PhosphoSitePlus
Y1207QGEGPySSLVSHPRD; phosphoELM; RegPhos
S1084FHVQLsNPKFGCalx-betaPhosphoSitePlus
Y1199MKVCAyGAQGEfn3PhosphoSitePlus
T1401AAAYGtHLSPHHPRD
S1360RSPSGsQRPSVPhosphoSitePlus
T973PAGTAtLGRRLPhosphoSitePlus
T681EDDDCtYSYTMIntegrin_B_tailPhosphoSitePlus
S1360RSPSGsQRPSVPKCa(PKC alphaRegPhos
S1707TVPGLsENVPYfn3PhosphoSitePlus
T1766SSITTtHTSATPhosphoSitePlus
Y1564GYSVEyQLLNGphosphoELM; RegPhos
Y920KVAPGyYTLTAPhosphoSitePlus
S1511LPRDYsTLTSVPhosphoSitePlus
Y1760PLQSEySSITTPhosphoSitePlus
Y1469TSAAAyGTHLSPhosphoSitePlus; HPRD; SysPTM
S1758QHPLQsEYSSIPhosphoSitePlus
Y1207QGEGPySSLVSfn3PhosphoSitePlus
S7AGPRPsPWARLPhosphoSitePlus
S1208GEGPYsSLVSCfn3PhosphoSitePlus
Y1189TNLYPyCDYEMfn3PhosphoSitePlus
T1512PRDYStLTSVSPhosphoSitePlus
T1246AEPAEtNGEITfn3PhosphoSitePlus
S1762QSEYSsITTTHPhosphoSitePlus
Y1492TLTRDyNSLTRPhosphoSitePlus
T1460AGVPDtPTRLVHPRD
T1806VSRTLtTSGTLPhosphoSitePlus
S1503SEHSHsTTLPRPhosphoSitePlus
S1364GSQRPsVSDDTPKCa(PKC alphaRegPhos
S1653VFTALsPDSLQfn3PhosphoSitePlus
Y1349DSFLMySDDVLPhosphoSitePlus
S1364GSQRPsVSDDTPhosphoSitePlus
S1518LTSVSsHDSRLPhosphoSitePlus
S1498NSLTRsEHSHSPhosphoSitePlus
Y1399TSAAAyGTHLSHPRD
Y1439TTLPRdYSTLTHPRD
S1364GSQRPsVSDDTPKC_alphaphosphoELM
Y1206AQGEGpYSSLVHPRD
S1403PRLSAsSGRSSPhosphoSitePlus
T1318IINLAtQPKRPPhosphoSitePlus
S1595LLPNHsYVFRVfn3PhosphoSitePlus
T1484HRVLStSSTLTPhosphoSitePlus
S1485RVLSTsSTLTRPhosphoSitePlus
T383PRGLRtEVTSKIntegrin_betaPhosphoSitePlus
T1530AGVPDtPTRLVHPRD; phosphoELM; RegPhos
S387RTEVTsKMFQKIntegrin_betaPhosphoSitePlus
S1465RMTTTsAAAYGPhosphoSitePlus
T1793AGGSLtRHVTQPhosphoSitePlus
Y1039QGNRDyIPVEGCalx-betaPhosphoSitePlus
T922APGYYtLTADQPhosphoSitePlus
S1360RSPSGsQRPSVPKC_alphaphosphoELM
S1761LQSEYsSITTTPhosphoSitePlus
S1325PKRPMsIPIIPPhosphoSitePlus
T1797LTRHVtQEFVSPhosphoSitePlus
T1524HDSRLtAGVPDPhosphoSitePlus
T1471AAAYGtHLSPHPhosphoSitePlus; HPRD
S1350SFLMYsDDVLRPhosphoSitePlus
S1474YGTHLsPHVPHPhosphoSitePlus; HPRD; SysPTM
S1494TRDYNsLTRSEPhosphoSitePlus
S1404YGTHLsPHVPHHPRD
Y1198EMKVCaYGAQGHPRD
S1356DDVLRsPSGSQPKCa(PKC alphaRegPhos
T982RLVNItIIKEQCalx-betaPhosphoSitePlus
Y1509TTLPRdYSTLTHPRD
S821VPYGLsLRLARSEAPhosphoSitePlus
Y1440TLPRDySTLTSHPRD
T1487LSTSStLTRDYPhosphoSitePlus
T1489TSSTLtRDYNSPhosphoSitePlus
T1099QPHSTtIIIRDPhosphoSitePlus
T1765YSSITtTHTSAPhosphoSitePlus
Y1564GYSVEyQLLNGfn3PhosphoSitePlus
S1604RVRAQsQEGWGfn3PhosphoSitePlus
S1140AKAAGsRKIHFfn3PhosphoSitePlus
S1483PHRVLsTSSTLPhosphoSitePlus
T1505HSHSTtLPRDYPhosphoSitePlus
S1209EGPYSsLVSCRPhosphoSitePlus
S102RRSQMsPQGLRIntegrin_betaPhosphoSitePlus
Y50DKDCAyCTDEMIntegrin_betaPhosphoSitePlus
Y1257AYEVCyGLVNDphosphoELM; RegPhos
S179FVDKVsVPQTDHPRD
T1098GQPHStTIIIRPhosphoSitePlus
Y1674GDIVGyLVTCEfn3PhosphoSitePlus
S1084FHVQLsNPKFGHPRD; RegPhos
S21ALISVsLSGTLPhosphoSitePlus
T1504EHSHStTLPRDPhosphoSitePlus
S1501TRSEHsHSTTLPhosphoSitePlus
T1530AGVPDtPTRLVfn3PhosphoSitePlus
Y1187ELTNLyPYCDYfn3PhosphoSitePlus
T1496DYNSLtRSEHSPhosphoSitePlus
Y855NLNEVyRQISGSEAPhosphoSitePlus
T829LARLCtENLLKSEAPhosphoSitePlus
T1513AGVPDtPTRLVHPRD
S1486VLSTSsTLTRDPhosphoSitePlus
S1345GEDYDsFLMYSPhosphoSitePlus
Y1257AYEVCyGLVNDfn3PhosphoSitePlus
Y1343QSGEDyDSFLMPhosphoSitePlus
Y1510TLPRDySTLTSPhosphoSitePlus; HPRD; SysPTM
T1804EFVSRtLTTSGPhosphoSitePlus
S1069LQEVDsLLRGRCalx-betaPhosphoSitePlus
Y921VAPGYyTLTADPhosphoSitePlus
S368FNRIRsNLDIRIntegrin_betaPhosphoSitePlus
S1517TLTSVsSHDSRPhosphoSitePlus
S1000EQPEFsVSRGDCalx-betaPhosphoSitePlus
T1514DYSTLtSVSSHPhosphoSitePlus
S1356DDVLRsPSGSQPhosphoSitePlus
Y1596LPNHSyVFRVRfn3PhosphoSitePlus
S1356DDVLRsPSGSQPKC_alphaphosphoELM
T1807SRTLTtSGTLSPhosphoSitePlus
S377IRALDsPRGLRIntegrin_betaPhosphoSitePlus
T1688GGGPAtAFRVDfn3PhosphoSitePlus
T886HTIVDtVLMAPSEAPhosphoSitePlus
S1515YSTLTsVSSHDPhosphoSitePlus
Y1188LTNLYpYCDYEHPRD
T1720KVQARtTEGFGfn3PhosphoSitePlus
S1791LEAGGsLTRHVPhosphoSitePlus
T1771THTSAtEPFLVPhosphoSitePlus
T837LLKPDtRECAQSEAPhosphoSitePlus
S1097LGQPHsTTIIIPhosphoSitePlus
T1434LPRSAtPGPPGPhosphoSitePlus
S1428GGKGGsLPRSAPhosphoSitePlus

Dephosphorylation site
ITB4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000200181K1142NCOSMICLung Cancer
ENSP00000200181A1241VCOSMICHepatocellular Carcinoma21822264

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000200181Gastric CancerMetastasiscell lineUp217022644
ENSP00000200181Oral CancerNormal vs. CancertissueUp3.519297561
ENSP00000200181Gastric CancerMetastasiscell lineUp217022644
ENSP00000200181Breast CancerNormal vs. Cancercell lineUp1.620543960
ENSP00000200181Breast CancerNormal vs. Cancercell lineUp1.620543960
ENSP00000200181Breast CancerNormal vs. Cancercell lineUp1.520543960
ENSP00000200181Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y1207fn3GAQGEGPySSLVSCRcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
SLTM_HUMANITB4_HUMANkinase -> substrateNetPath
EPHB2_HUMANITB4_HUMANkinase -> substrateNetPath
KPCA_HUMANITB4_HUMANkinase -> substrateNetPath; Robert H Newman (2013)
ZAGL2_HUMANITB4_HUMANkinase -> substrateRegPhos
KPCD_HUMANITB4_HUMANkinase -> substrateNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04810Regulation of actin cytoskeleton
hsa04512ECM-receptor interaction
hsa05414Dilated cardiomyopathy
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa04510Focal adhesion
hsa05412Arrhythmogenic right ventricular cardiomyopathy (A

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016020membraneIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0009986cell surfaceIDAcellular_component
GO:0031252cell leading edgeIDAcellular_component
GO:0008305integrin complexIEAcellular_component
GO:0004872receptor activityIEAmolecular_function
GO:0007229integrin-mediated signaling pathwayIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0009925basal plasma membraneIEAcellular_component
GO:0030056hemidesmosomeIDAcellular_component
GO:0005604basement membraneIEAcellular_component
GO:0030056hemidesmosomeIEAcellular_component
GO:0007154cell communicationIEAbiological_process
GO:0031581hemidesmosome assemblyIDAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0007155cell adhesionIEAbiological_process
GO:0005102receptor bindingIEAmolecular_function
GO:0046847filopodium assemblyIEAbiological_process
GO:0034329cell junction assemblyTASbiological_process
GO:0009611response to woundingIDAbiological_process
GO:0048870cell motilityIMPbiological_process
GO:0007160cell-matrix adhesionIEAbiological_process
GO:0007155cell adhesionNASbiological_process
GO:0007275multicellular organismal developmentIEAbiological_process


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