| UniProt/SwissProt ID: | IRK1_HUMAN |
| Description: | potassium inwardly-rectifying channel, subfamily J, member 1 [Source:HGNC Symbol;Acc:6255] |
| Location: | chr11 q24.3 |
| Node attribute: | effector; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y337 | TKEGKyRVDFH | IRK | PhosphoSitePlus |
| S313 | CQVRTsYVPEE | HPRD; RegPhos | |
| S25 | RARLVsKDGRC | HPRD | |
| S44 | RARLVsKDGRC | SGK_group | phosphoELM; RegPhos |
| S182 | KNAVIsKRGGK | HPRD | |
| S201 | KNAVIsKRGGK | IRK | PhosphoSitePlus |
| S44 | RARLVsKDGRC | HPRD; RegPhos | |
| S294 | CQVRTsYVPEE | HPRD | |
| S201 | KNAVIsKRGGK | HPRD; RegPhos | |
| S183 | ILAKIsRPKKR | PRKCD | HPRD |
| S4 | RNVF | HPRD | |
| S164 | ILAKIsRPKKR | PRKCD | HPRD |
| S164 | LLIFQsILGVI | PKCd | RegPhos |
| S183 | ILAKIsRPKKR | IRK | PhosphoSitePlus |
| S4 | MNASSrNVF | RegPhos | |
| T193 | RAKTItFSKNA | IRK | PhosphoSitePlus |
| S200 | ANLRKsLLIGS | HPRD | |
| S44 | RARLVsKDGRC | IRK | PhosphoSitePlus |
| S219 | ANLRKsLLIGS | IRK | PhosphoSitePlus |
| T191 | KKRAKtITFSK | IRK | PhosphoSitePlus |
| S4 | __MNAsSRNVF | PhosphoSitePlus | |
| S219 | ANLRKsLLIGS | HPRD; RegPhos | |
| T234 | KLLKTtVTPEG | IRK | PhosphoSitePlus |
| S183 | ILAKIsRPKKR | PKCd | RegPhos |
| S313 | CQVRTsYVPEE | IRK | PhosphoSitePlus |
| Dephosphorylation site |
| IRK1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000376432 | S115F | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| IRK1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| IRK1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GBG12_HUMAN | IRK1_HUMAN | Gprotein -> effector | gpDB |
| GBG2_HUMAN | IRK1_HUMAN | Gprotein -> effector | gpDB |
| GBG8_HUMAN | IRK1_HUMAN | Gprotein -> effector | gpDB |
| GBG1_HUMAN | IRK1_HUMAN | Gprotein -> effector | gpDB |
| GBB1_HUMAN | IRK1_HUMAN | Gprotein -> effector | gpDB |
| GBG3_HUMAN | IRK1_HUMAN | Gprotein -> effector | gpDB |
| GBG11_HUMAN | IRK1_HUMAN | Gprotein -> effector | gpDB |
| GBG5_HUMAN | IRK1_HUMAN | Gprotein -> effector | gpDB |
| GBB3_HUMAN | IRK1_HUMAN | Gprotein -> effector | gpDB |
| GBB2_HUMAN | IRK1_HUMAN | Gprotein -> effector | gpDB |
| GBB5_HUMAN | IRK1_HUMAN | Gprotein -> effector | gpDB |
| GBG13_HUMAN | IRK1_HUMAN | Gprotein -> effector | gpDB |
| GBG10_HUMAN | IRK1_HUMAN | Gprotein -> effector | gpDB |
| KPCD_HUMAN | IRK1_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | IRK1_HUMAN | kinase -> substrate | RegPhos |
| SGK1_HUMAN | IRK1_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04971 | Gastric acid secretion |
| hsa04960 | Aldosterone-regulated sodium reabsorption |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008076 | voltage-gated potassium channel complex | TAS | cellular_component |
| GO:1900128 | regulation of G-protein activated inward rectifier | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005242 | inward rectifier potassium channel activity | IEA | molecular_function |
| GO:0072358 | cardiovascular system development | IEA | biological_process |
| GO:0007588 | excretion | TAS | biological_process |
| GO:0001822 | kidney development | IEA | biological_process |
| GO:0070294 | renal sodium ion absorption | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0006813 | potassium ion transport | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0001894 | tissue homeostasis | IEA | biological_process |
| GO:0009791 | post-embryonic development | IEA | biological_process |
| GO:0007268 | synaptic transmission | TAS | biological_process |