Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IRK1_HUMAN
Description:potassium inwardly-rectifying channel, subfamily J, member 1 [Source:HGNC Symbol;Acc:6255]
Location:chr11 q24.3
Node attribute:effector; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y337TKEGKyRVDFHIRKPhosphoSitePlus
S313CQVRTsYVPEEHPRD; RegPhos
S25RARLVsKDGRCHPRD
S44RARLVsKDGRCSGK_groupphosphoELM; RegPhos
S182KNAVIsKRGGKHPRD
S201KNAVIsKRGGKIRKPhosphoSitePlus
S44RARLVsKDGRCHPRD; RegPhos
S294CQVRTsYVPEEHPRD
S201KNAVIsKRGGKHPRD; RegPhos
S183ILAKIsRPKKRPRKCDHPRD
S4RNVFHPRD
S164ILAKIsRPKKRPRKCDHPRD
S164LLIFQsILGVIPKCdRegPhos
S183ILAKIsRPKKRIRKPhosphoSitePlus
S4MNASSrNVFRegPhos
T193RAKTItFSKNAIRKPhosphoSitePlus
S200ANLRKsLLIGSHPRD
S44RARLVsKDGRCIRKPhosphoSitePlus
S219ANLRKsLLIGSIRKPhosphoSitePlus
T191KKRAKtITFSKIRKPhosphoSitePlus
S4__MNAsSRNVFPhosphoSitePlus
S219ANLRKsLLIGSHPRD; RegPhos
T234KLLKTtVTPEGIRKPhosphoSitePlus
S183ILAKIsRPKKRPKCdRegPhos
S313CQVRTsYVPEEIRKPhosphoSitePlus

Dephosphorylation site
IRK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000376432S115FBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
IRK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IRK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG12_HUMANIRK1_HUMANGprotein -> effectorgpDB
GBG2_HUMANIRK1_HUMANGprotein -> effectorgpDB
GBG8_HUMANIRK1_HUMANGprotein -> effectorgpDB
GBG1_HUMANIRK1_HUMANGprotein -> effectorgpDB
GBB1_HUMANIRK1_HUMANGprotein -> effectorgpDB
GBG3_HUMANIRK1_HUMANGprotein -> effectorgpDB
GBG11_HUMANIRK1_HUMANGprotein -> effectorgpDB
GBG5_HUMANIRK1_HUMANGprotein -> effectorgpDB
GBB3_HUMANIRK1_HUMANGprotein -> effectorgpDB
GBB2_HUMANIRK1_HUMANGprotein -> effectorgpDB
GBB5_HUMANIRK1_HUMANGprotein -> effectorgpDB
GBG13_HUMANIRK1_HUMANGprotein -> effectorgpDB
GBG10_HUMANIRK1_HUMANGprotein -> effectorgpDB
KPCD_HUMANIRK1_HUMANkinase -> substrateHPRD
ZAGL2_HUMANIRK1_HUMANkinase -> substrateRegPhos
SGK1_HUMANIRK1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04971Gastric acid secretion
hsa04960Aldosterone-regulated sodium reabsorption

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008076voltage-gated potassium channel complexTAScellular_component
GO:1900128regulation of G-protein activated inward rectifierIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005242inward rectifier potassium channel activityIEAmolecular_function
GO:0072358cardiovascular system developmentIEAbiological_process
GO:0007588excretionTASbiological_process
GO:0001822kidney developmentIEAbiological_process
GO:0070294renal sodium ion absorptionIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0006813potassium ion transportTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0001894tissue homeostasisIEAbiological_process
GO:0009791post-embryonic developmentIEAbiological_process
GO:0007268synaptic transmissionTASbiological_process


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