Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:M3K7_HUMAN
Description:mitogen-activated protein kinase kinase kinase 7 [Source:HGNC Symbol;Acc:6859]
Location:chr6 q15
Node attribute:substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S412QPRRRsIQDLTHPRD
S192TNNKGsAAWMAPkinase_TyrPhosphoSitePlus
S192TNNKGsAAWMAMAP3K7HPRD; phosphoELM; RegPhos
T187IQTHMtNNKGSMAP3K7HPRD; phosphoELM; RegPhos
T184ACDIQtHMTNNautocatalysis RegPhos
S69QIESEsERKAFHPRD
T403RIAATtAYSKPHPRD
S192TNNKGsAAWMAautocatalysis RegPhos
S454EPGQVsSRSSSPhosphoSitePlus; HPRD; phosphoELM
T178ICDFGtACDIQPkinase_TyrPhosphoSitePlus
S427EPGQVsSRSSSHPRD
Y584KSLSTyYQQCKMnd1; Ribosomal_S15PhosphoSitePlus
T184ACDIQtHMTNNPkinase_TyrPhosphoSitePlus
S389EGKRMsADMSEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T333SNKSDtNMEQVPhosphoSitePlus
S439QPRRRsIQDLTPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y585SLSTYyQQCKKMnd1; Ribosomal_S15PhosphoSitePlus
T184ACDIQtHMTNNTAK1RegPhos
T187IQTHMtNNKGSPkinase_TyrPhosphoSitePlus
T187IQTHMtNNKGSautocatalysis RegPhos
S428PGQVSsRSSSPHPRD
T444SIQDLtVTGTEPhosphoSitePlus
Y405AATTAySKPKRPhosphoSitePlus
S455PGQVSsRSSSPPhosphoSitePlus; HPRD; phosphoELM
S192TNNKGsAAWMATAK1RegPhos
T419QDLTVtGTEPGHPRD
T187IQTHMtNNKGSTAK1RegPhos
S417HRKTAsFGNILPhosphoSitePlus
T184ACDIQtHMTNNMAP3K7HPRD; phosphoELM; RegPhos
T415RGHRKtASFGNPhosphoSitePlus
T446QDLTVtGTEPGHPRD
S406ATTAYsKPKRGPhosphoSitePlus; HPRD

Dephosphorylation site
M3K7_HUMAN do not have dephosphorylation site.

Mutation site
M3K7_HUMAN do not have mutation site.

Differential expressed protein
M3K7_HUMAN is not differential expressed protein.

Hyperphosphorylation site
M3K7_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M3K7_HUMANDAXX_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANIKKA_HUMANkinase -> substrateKEGG
M3K7_HUMANBCL3_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANMP2K3_HUMANkinase -> substrateKEGG
M3K7_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
NR2C2_HUMANM3K7_HUMANkinase -> substrateRegPhos
M3K7_HUMANNP1L1_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANNLK_HUMANkinase -> substrateKEGG
M3K7_HUMANPINX1_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANUHMK1_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANSUMO4_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANFUBP1_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANMP2K6_HUMANkinase -> substrateKEGG; NetPath
M3K7_HUMANUB2L3_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANIKKB_HUMANkinase -> substrateKEGG; HPRD; NetPath
M3K7_HUMANSMAD3_HUMANkinase -> substrateHPRD
M3K7_HUMANRXRA_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANMAGA6_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANPIM1_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANUBE2N_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANRU17_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANMDFI_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANTIF1B_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANSRSF4_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
MP2K7_HUMANM3K7_HUMANkinase -> substrateKEGG
M3K7_HUMANTYDP2_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANM3K14_HUMANkinase -> substrateKEGG
ZAGL2_HUMANM3K7_HUMANkinase -> substrateRegPhos
M3K7_HUMANOTU7B_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANRUVB2_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANM3K7_HUMANkinase -> substrateRegPhos; NetPath
M3K7_HUMANRAP1A_HUMANkinase -> substrateRobert H Newman (2013)
PPM1B_HUMANM3K7_HUMANphosphatase -> substrateKEGG
KPCT_HUMANM3K7_HUMANotherKEGG
TAB2_HUMANM3K7_HUMANotherKEGG
TAB1_HUMANM3K7_HUMANotherKEGG
TRAF6_HUMANM3K7_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05140Leishmaniasis
hsa05168Herpes simplex infection
hsa05145Toxoplasmosis
hsa05169Epstein-Barr virus infection
hsa04010MAPK signaling pathway
hsa04380Osteoclast differentiation
hsa04310Wnt signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa04660T cell receptor signaling pathway
hsa04520Adherens junction
hsa04064NF-kappa B signaling pathway
hsa05162Measles
hsa04621NOD-like receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004708MAP kinase kinase activityIEAmolecular_function
GO:0004672protein kinase activityIDAmolecular_function
GO:0007254JNK cascadeIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007179transforming growth factor beta receptor signalingIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0004674protein serine/threonine kinase activityTASmolecular_function
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEAbiological_process
GO:0051403stress-activated MAPK cascadeIDAbiological_process
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0032743positive regulation of interleukin-2 productionIMPbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0045087innate immune responseTASbiological_process
GO:0016301kinase activityIEAmolecular_function
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0046330positive regulation of JNK cascadeIEAbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0050852T cell receptor signaling pathwayNASbiological_process
GO:0043966histone H3 acetylationIDAbiological_process
GO:0005829cytosolTAScellular_component
GO:0004709MAP kinase kinase kinase activityIDAmolecular_function
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0010008endosome membraneTAScellular_component
GO:0035872nucleotide-binding domain, leucine rich repeat conTASbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0000187activation of MAPK activityIDAbiological_process
GO:0043507positive regulation of JUN kinase activityIMPbiological_process
GO:0000165MAPK cascadeIEAbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0002726positive regulation of T cell cytokine productionIMPbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0070423nucleotide-binding oligomerization domain containiTASbiological_process
GO:0007249I-kappaB kinase/NF-kappaB cascadeTASbiological_process
GO:0007250activation of NF-kappaB-inducing kinase activityIMPbiological_process
GO:0007252I-kappaB phosphorylationIEAbiological_process
GO:0050870positive regulation of T cell activationICbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0008385IkappaB kinase complexIPIcellular_component
GO:0007252I-kappaB phosphorylationIDAbiological_process
GO:0005671Ada2/Gcn5/Ada3 transcription activator complexIDAcellular_component
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIMPbiological_process
GO:0001841neural tube formationIEAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0000186activation of MAPKK activityIDAbiological_process
GO:0005886plasma membraneIEAcellular_component