| UniProt/SwissProt ID: | PTPRA_HUMAN |
| Description: | protein tyrosine phosphatase, receptor type, A [Source:HGNC Symbol;Acc:9664] |
| Location: | chr20 p13 |
| Node attribute: | substrate; phosphotase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S180 | GSHSNsKQAGS | PKCd | RegPhos |
| S189 | GSHSNsFRLSN | phosphoELM; RegPhos | |
| T214 | ARSPStNRKYP | Bravo_FIGEY | PhosphoSitePlus |
| S213 | LARSPsTNRKY | Bravo_FIGEY | PhosphoSitePlus |
| Y782 | KVVQEyIDAFS | HPRD | |
| Y271 | KEKNRyVNILP | Y_phosphatase | PhosphoSitePlus |
| S204 | LARSPsTNRKY | PRKCD | HPRD |
| Y262 | KEKNRyVNILP | HPRD | |
| S213 | LARSPsTNRKY | PRKCD | HPRD |
| S211 | PLLARsPSTNR | Bravo_FIGEY | PhosphoSitePlus |
| S766 | FQTVKsLRLQR | Y_phosphatase | PhosphoSitePlus |
| S189 | GSHSNsFRLSN | PKCd(PKC delta | RegPhos |
| S796 | YIDAFsDYANF | PhosphoSitePlus | |
| S213 | LARSPsTNRKY | PKCd(PKC delta | RegPhos |
| S213 | LARSPsTNRKY | phosphoELM | |
| S189 | GSHSNsFRLSN | BatD; Bravo_FIGEY | PhosphoSitePlus |
| S187 | QAGSHsNSFRL | HPRD; phosphoELM; RegPhos | |
| Y798 | DAFSDyAN | phosphoELM | |
| Y798 | DAFSDyANFK_ | PhosphoSitePlus | |
| S178 | QAGSHsNSFRL | HPRD | |
| Y798 | DAFSDyANFK | RegPhos | |
| S213 | LARSPsTNRKY | PKCd | RegPhos |
| S180 | GSHSNsFRLSN | PRKCD | HPRD |
| S18 | GLICVsANNAT | PhosphoSitePlus | |
| Y789 | DAFSDyAN | SRC | HPRD |
| Y271 | KEKNRyVNILP | HPRD | |
| S542 | FKKLTsIKIQN | PhosphoSitePlus | |
| Y791 | KVVQEyIDAFS | PhosphoSitePlus; HPRD | |
| S204 | DVEPQsVPLLA | PKCd | RegPhos |
| Y588 | EENTDyVNASF | phosphoELM; RegPhos | |
| Y798 | DAFSDyAN | SRC | HPRD |
| T552 | NDKMRtGNLPA | PhosphoSitePlus | |
| Y218 | STNRKyPPLPV | Bravo_FIGEY | PhosphoSitePlus |
| S189 | GSHSNsFRLSN | PRKCD | HPRD |
| Y798 | DAFSDyANFK | SRC | RegPhos |
| Y588 | EENTDyVNASF | Y_phosphatase | PhosphoSitePlus |
| S407 | QFHFTsWPDFG | Y_phosphatase | PhosphoSitePlus |
| Y781 | QTLEQyEFCYK | Y_phosphatase | PhosphoSitePlus |
| S189 | GSHSNsFRLSN | PKCd | RegPhos |
| Dephosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y798 | YIDAFSDyANFK | PTPRA | HPRD |
| Y789 | YIDAFSDyANFK | PTPRA | HPRD |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000382787 | S213R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000382787 | T214I | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000369756 | E755K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000348468 | S204R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000369756 | T214I | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000216877 | E746K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000348468 | E746K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000369756 | S213R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000216877 | S204R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000314568 | S204R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000314568 | E746K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000382787 | E755K | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| PTPRA_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PTPRA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | PTPRA_HUMAN | kinase -> substrate | RegPhos |
| KPCD_HUMAN | PTPRA_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| SRC_HUMAN | PTPRA_HUMAN | kinase -> substrate | HPRD; RegPhos |
| PTPRA_HUMAN | PTPRA_HUMAN | phosphatase -> substrate | HPRD |
| PTPRA_HUMAN | FYN_HUMAN | phosphatase -> substrate | HPRD |
| PTPRA_HUMAN | SRC_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| PTPRA_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0004725 | protein tyrosine phosphatase activity | TAS | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0006470 | protein dephosphorylation | IEA | biological_process |
| GO:0016791 | phosphatase activity | IEA | molecular_function |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0005001 | transmembrane receptor protein tyrosine phosphatas | TAS | molecular_function |
| GO:0008286 | insulin receptor signaling pathway | IEA | biological_process |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | TAS | biological_process |
| GO:0016311 | dephosphorylation | IEA | biological_process |