Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:STAT1_HUMAN
Description:signal transducer and activator of transcription 1, 91kDa [Source:HGNC Symbol;Acc:11362]
Location:chr2 q32.2
Node attribute:PPI(source); PPI(target); substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T704TGYIKtELISVPhosphoSitePlus
S727NLLPMsPEEFDHPRD; phosphoELM; RegPhos; SysPTM
Y701PKGTGyIKTELKITHPRD; RegPhos
Y701PKGTGyIKTELEGFRHPRD; RegPhos
S727NLLPMsPEEFDPRKCDHPRD; SysPTM
S727NLLPMsPEEFDCaMK2gRegPhos; SysPTM
S727NLLPMsPEEFDMSK1RegPhos; SysPTM
Y701PKGTGyIKTELLCKHPRD; RegPhos
Y701PKGTGyIKTELSrcRegPhos
Y701PKGTGyIKTELSRCphosphoELM
T699DGPKGtGYIKTPhosphoSitePlus
S727NLLPMsPEEFDRPS6KA5HPRD; SysPTM
Y170DLQDEyDFKCKSTAT_alphaPhosphoSitePlus
Y203LLKKMyLMLDNSTAT_alphaPhosphoSitePlus
Y68QLDDQySRFSLSTAT_intPhosphoSitePlus
Y701PKGTGyIKTELTYK2HPRD; RegPhos
Y701PKGTGyIKTELJAK1HPRD; phosphoELM; RegPhos
Y668PLKYLyPNIDKPhosphoSitePlus
S727NLLPMsPEEFDSTAT1_TAZ2bindPhosphoSitePlus; SysPTM
Y106MSMIIySCLKESTAT_intPhosphoSitePlus
T417QKNAGtRTNEGSTAT_bindPhosphoSitePlus
T184NREHEtNGVAKSTAT_alphaPhosphoSitePlus
S727NLLPMsPEEFDCAMK2GHPRD; SysPTM
Y701PKGTGyIKTELFGFR4HPRD; RegPhos
Y701PKGTGyIKTELFGFR3HPRD; RegPhos
Y701PKGTGyIKTELPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S727NLLPMsPEEFDPKCdRegPhos; SysPTM
S532LGPNAsPDGLISTAT_bindPhosphoSitePlus
Y701PKGTGyIKTELJAK2HPRD; phosphoELM; RegPhos

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y701DGPKGTGyIKTELISPTPN2HPRD
Y701DGPKGTGyIKTELISPTPN11HPRD
S727TDNLLPMsPEEFDEVHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000386244K366NCOSMICLung Cancer20668451
ENSP00000386244E705KCOSMICHead and Neck Cancer21798897
ENSP00000354394V734LCOSMICOvarian Cancer21720365
ENSP00000386244Q330KCOSMICHead and Neck Cancer21798893
ENSP00000354394E705KCOSMICHead and Neck Cancer21798897
ENSP00000354394K366NCOSMICLung Cancer20668451
ENSP00000354394E733*COSMICBreast Cancer20668451
ENSP00000354394K201MCOSMICCentral Nervous System Neoplasms18772890
ENSP00000386244W555CCOSMICOvarian Cancer21720365
ENSP00000386244Y681FCOSMICLung Cancer20668451
ENSP00000354394W555CCOSMICOvarian Cancer21720365
ENSP00000354394Q330KCOSMICHead and Neck Cancer21798893
ENSP00000354394Y681FCOSMICLung Cancer20668451
ENSP00000386244E733*COSMICBreast Cancer20668451
ENSP00000386244K201MCOSMICCentral Nervous System Neoplasms18772890
ENSP00000386244V734LCOSMICOvarian Cancer21720365
ENSP00000386244P491ASjoblom2006, COSMIC, HPIBreast Cancer16959974, 18428421
ENSP00000354394P491ASjoblom2006, COSMIC, HPIBreast Cancer16959974, 18428421

Differential expressed protein
STAT1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y701DGPKGTGyIKTELISmelanoma skin cancer17785551PhosphoSitePlus
S727STAT1_TAZ2bindTDNLLPMsPEEFDEVWilm's tumor16799645PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
LCK_HUMANSTAT1_HUMANkinase -> substrateHPRD; RegPhos
KS6A5_HUMANSTAT1_HUMANkinase -> substrateHPRD; RegPhos
KIT_HUMANSTAT1_HUMANkinase -> substrateHPRD; RegPhos; NetPath
JAK1_HUMANSTAT1_HUMANkinase -> substrateKEGG; HPRD; RegPhos
FGFR4_HUMANSTAT1_HUMANkinase -> substrateHPRD; RegPhos
FGFR3_HUMANSTAT1_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANSTAT1_HUMANkinase -> substrateRegPhos
KCC2G_HUMANSTAT1_HUMANkinase -> substrateHPRD
JAK2_HUMANSTAT1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
EGFR_HUMANSTAT1_HUMANkinase -> substrateHPRD; RegPhos
KPCD_HUMANSTAT1_HUMANkinase -> substrateHPRD
TYK2_HUMANSTAT1_HUMANkinase -> substrateHPRD; RegPhos
PTN11_HUMANSTAT1_HUMANphosphatase -> substrateHPRD
PTN2_HUMANSTAT1_HUMANphosphatase -> substrateHPRD
PIAS3_HUMANSTAT1_HUMANotherKEGG
STAT1_HUMANCXCL9_HUMANotherKEGG
CISH_HUMANSTAT1_HUMANotherKEGG
INAR1_HUMANSTAT1_HUMANotherKEGG
STAT1_HUMANMYC_HUMANTF -> target geneKEGG
STAT1_HUMANPIM1_HUMANTF -> target geneKEGG
STAT1_HUMANSOCS6_HUMANTF -> target geneKEGG
STAT1_HUMANCXL10_HUMANTF -> target geneKEGG
STAT1_HUMANCXL11_HUMANTF -> target geneKEGG
STAT1_HUMANCCND1_HUMANTF -> target geneKEGG
STAT1_HUMANIRF1_HUMANTF -> target geneTRANSFAC
STAT1_HUMANCCL2_HUMANTF -> target geneTRANSFAC
STAT1_HUMANCY24B_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04062Chemokine signaling pathway
hsa05200Pathways in cancer
hsa05152Tuberculosis
hsa04630Jak-STAT signaling pathway
hsa05162Measles
hsa05145Toxoplasmosis
hsa05160Hepatitis C
hsa04620Toll-like receptor signaling pathway
hsa04380Osteoclast differentiation
hsa05212Pancreatic cancer
hsa05168Herpes simplex infection
hsa05164Influenza A
hsa05140Leishmaniasis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0000979RNA polymerase II core promoter sequence-specific IDAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0006917induction of apoptosisISSbiological_process
GO:0072162metanephric mesenchymal cell differentiationISSbiological_process
GO:0060338regulation of type I interferon-mediated signalingTASbiological_process
GO:0051591response to cAMPISSbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0033209tumor necrosis factor-mediated signaling pathwayIDAbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0005730nucleolusIDAcellular_component
GO:0008015blood circulationISSbiological_process
GO:0003690double-stranded DNA bindingIDAmolecular_function
GO:0003340negative regulation of mesenchymal to epithelial tISSbiological_process
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0016525negative regulation of angiogenesisIMPbiological_process
GO:0030424axonISScellular_component
GO:0060337type I interferon-mediated signaling pathwayTASbiological_process
GO:0000790nuclear chromatinIDAcellular_component
GO:0060333interferon-gamma-mediated signaling pathwayIDAbiological_process
GO:0001937negative regulation of endothelial cell proliferatIMPbiological_process
GO:0061326renal tubule developmentIMPbiological_process
GO:0000978RNA polymerase II core promoter proximal region seIDAmolecular_function
GO:0002053positive regulation of mesenchymal cell proliferatISSbiological_process
GO:0072308negative regulation of metanephric nephron tubule ISSbiological_process
GO:0034097response to cytokine stimulusISSbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0043330response to exogenous dsRNAIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0031663lipopolysaccharide-mediated signaling pathwayIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005164tumor necrosis factor receptor bindingIPImolecular_function
GO:0000122negative regulation of transcription from RNA polyISSbiological_process
GO:0042981regulation of apoptotic processTASbiological_process
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB cIMPbiological_process
GO:0060397JAK-STAT cascade involved in growth hormone signalTASbiological_process
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0048661positive regulation of smooth muscle cell proliferISSbiological_process
GO:0043434response to peptide hormone stimulusISSbiological_process
GO:0019221cytokine-mediated signaling pathwayIEAbiological_process
GO:0030425dendriteISScellular_component
GO:0000983RNA polymerase II core promoter sequence-specific IDAmolecular_function
GO:0019048virus-host interactionIEAbiological_process
GO:0009617response to bacteriumIEAbiological_process
GO:0060334regulation of interferon-gamma-mediated signaling TASbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0007259JAK-STAT cascadeIDAbiological_process
GO:0072136metanephric mesenchymal cell proliferation involveISSbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0035458cellular response to interferon-betaIMPbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0051607defense response to virusIEAbiological_process